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FHIR IG Statistics: ValueSet/HIV.D.DE289

Packagesmart.who.int.hiv
Resource TypeValueSet
IdHIV.D.DE289
FHIR VersionR4
Sourcehttp://smart.who.int/hiv/https://build.fhir.org/ig/WorldHealthOrganization/smart-hiv/ValueSet-HIV.D.DE289.html
URLhttp://smart.who.int/hiv/ValueSet/HIV.D.DE289
Version0.4.4
Statusactive
Date2025-07-24T19:24:35+00:00
NameHIVDDE289
TitleWHO HIV clinical stage condition or symptom ValueSet
Authoritywho
DescriptionValue set of new or recurrent clinical events used to categorize HIV disease severity based at baseline and follow up

Resources that use this resource

StructureDefinition
HIVDCareTreatmentHIV.D Care-Treatment

Resources that this resource uses

CodeSystem
HIVConceptsWHO SMART HIV Concepts CodeSystem

Narrative

Note: links and images are rebased to the (stated) source

Generated Narrative: ValueSet HIV.D.DE289

  • Include these codes as defined in http://smart.who.int/hiv/CodeSystem/HIVConcepts
    CodeDisplayDefinition
    HIV.D.DE290AsymptomaticNo HIV-related symptoms reported and no clinical signs on examination
    HIV.D.DE291Persistent generalized lymphadenopathyPersistent enlarged lymph nodes >1 cm at two or more non-contiguous sites (excluding inguinal) without known cause
    HIV.D.DE292Moderate unexplained weight lossModerate unexplained weight loss (<10% of presumed or measured body weight)
    HIV.D.DE293Recurrent respiratory tract infectionsClient's symptoms include recurrent respiratory tract infections including sinusitis, tonsillitis, otitis media or pharyngitis
    HIV.D.DE294Unexplained persistent hepatosplenomegalyClient's symptoms include unexplained persistent hepatosplenomegaly
    HIV.D.DE295Herpes zosterClient's symptoms include herpes zoster
    HIV.D.DE296Angular cheilitisClient's symptoms include angular cheilitis
    HIV.D.DE297Linear gingival erythemaClient's symptoms include linear gingival erythema
    HIV.D.DE298Recurrent oral ulcerationClient's symptoms include recurrent oral ulceration
    HIV.D.DE299Papular pruritic eruptionClient's symptoms include papular pruritic eruption
    HIV.D.DE300Fungal nail infectionsClient's symptoms include fungal nail infections
    HIV.D.DE301Seborrhoeic dermatitisClient's symptoms include seborrhoeic dermatitis
    HIV.D.DE302Extensive wart virus infectionClient's symptoms include extensive wart virus infection
    HIV.D.DE303Extensive molluscum contagiosumClient's symptoms include extensive molluscum contagiosum
    HIV.D.DE304Unexplained persistent parotid enlargementClient's symptoms include unexplained persistent parotid enlargement
    HIV.D.DE305Unexplained severe weight loss in adultsUnexplained severe weight loss (>10% of presumed or measured body weight)
    HIV.D.DE306Unexplained moderate malnutrition not adequately responding to standard therapyDefined as weight-for-height < - 2 z-score or mid-upper arm circumference 115 mm to <125 mm. For children younger than five years of age: stunting is defined as severe acute malnutrition - either weight for height < -3 z-score or mid-upper arm circumference <115 mm or the presence of oedema.
    HIV.D.DE307Unexplained chronic diarrhoea for longer than 1 monthClient's symptoms include unexplained chronic diarrhoea for longer than 1 month
    HIV.D.DE308Unexplained persistent diarrhoea (14 days or more)Client's symptoms include unexplained persistent diarrhoea (14 days or more)
    HIV.D.DE309Unexplained persistent fever (above 37.5 C, intermittent or constant, for longer than one 1 month)Client's symptoms include unexplained persistent fever (above 37.5 C, intermittent or constant, for longer than one 1 month)
    HIV.D.DE310Persistent oral candidiasisClient's symptoms include persistent oral candidiasis
    HIV.D.DE311Oral hairy leukoplakiaClient has fine white small linear or corrugated lesions on lateral borders of the tongue that do not scrape off
    HIV.D.DE312Pulmonary TBClient's symptoms include pulmonary TB
    HIV.D.DE313Lymph node TBClient's symptoms include lymph node TB
    HIV.D.DE314Severe bacterial infections (such as pneumonia, empyema, pyomyositis, bone or joint infection, meningitis, bacteraemia)Client's symptoms include severe bacterial infections (such as pneumonia, empyema, pyomyositis, bone or joint infection, meningitis, bacteraemia)
    HIV.D.DE315Severe recurrent bacterial pneumoniaClient's symptoms include severe recurrent bacterial pneumonia
    HIV.D.DE316Acute necrotizing ulcerative stomatitisClient's symptoms include acute necrotizing ulcerative stomatitis
    HIV.D.DE317Acute necrotizing ulcerative gingivitisClient's symptoms include acute necrotizing ulcerative gingivitis
    HIV.D.DE318Acute necrotizing ulcerative periodontitisClient's symptoms include acute necrotizing ulcerative periodontitis
    HIV.D.DE319Unexplained anaemia (<8 g/dL)Client's symptoms include unexplained anaemia (<8 g/dL)
    HIV.D.DE320Neutropaenia (<0.5 x 10^9/L)Client's symptoms include neutropaenia (<0.5 x 10^9/L)
    HIV.D.DE321Chronic thrombocytopaenia (<50 x 10^9/L)Client's symptoms include chronic thrombocytopaenia (<50 x 10^9/L)
    HIV.D.DE322Symptomatic lymphoid interstitial pneumonitisClient's symptoms include symptomatic lymphoid interstitial pneumonitis
    HIV.D.DE323Chronic HIV-associated lung disease, including bronchiectasisClient's symptoms include chronic HIV-associated lung disease, including bronchiectasis
    HIV.D.DE324HIV wasting syndromeUnexplained involuntary weight loss (>10% baseline body weight), with obvious wasting or body mass index <18.5; PLUS EITHER unexplained chronic reported for longer than one month; OR reports of fever or night sweats for more than one month without other cause and lack of response to antibiotics or antimalarial agents; malaria must be excluded in malarious areas.
    HIV.D.DE325Unexplained severe wasting not responding to standard therapyClient has unexplained severe wasting not responding to standard therapy . For under 5 years old, defined as weight-for-height < -3 z-score
    HIV.D.DE326Unexplained stunting not responding to standard therapyClient has unexplained stunting not responding to standard therapy . For under 5 years old, defined as length-for- age/height-for-age < -2 z-score
    HIV.D.DE327Unexplained severe malnutrition not responding to standard therapyClient has unexplained severe malnutrition not responding to standard therapy . For under 5 years old, weight for height < -3 z-score or mid-upper arm circumference <115 mm or the presence of oedema
    HIV.D.DE328Pneumocystis (jirovecii) pneumoniaClient's symptoms include pneumocystis (jirovecii) pneumonia
    HIV.D.DE329Recurrent severe bacterial pneumoniaClient's symptoms include recurrent severe bacterial pneumonia
    HIV.D.DE330Recurrent severe bacterial infections (such as empyema, pyomyositis, bone or joint infection, meningitis, but excluding pneumonia)Client's symptoms include recurrent severe bacterial infections (such as empyema, pyomyositis, bone or joint infection, meningitis, but excluding pneumonia)
    HIV.D.DE331EmpyemaClient's symptoms include recurrent empyema
    HIV.D.DE332PyomyositisClient's symptoms include recurrent pyomyositis
    HIV.D.DE333Bone or joint infectionClient's symptoms include recurrent bone or joint infections
    HIV.D.DE334MeningitisClient's symptoms include recurrent meningitis
    HIV.D.DE335Chronic herpes simplex infection (orolabial or cutaneous of more than 1 month duration or visceral at any site)Client's symptoms include chronic herpes simplex infection (orolabial or cutaneous of more than 1 month duration or visceral at any site)
    HIV.D.DE336Chronic herpes simplex infection (orolabial, genital or anorectal of more than 1 month in duration or visceral at any site)Client's symptoms include chronic herpes simplex infection (orolabial, genital or anorectal of more than one month in duration or visceral at any site)
    HIV.D.DE337Oesophageal candidiasis (or candidiasis of trachea, bronchi or lungs)Client's symptoms include oesophageal candidiasis (or candidiasis of trachea, bronchi or lungs)
    HIV.D.DE338Extrapulmonary TBClient's symptoms include extrapulmonary tuberculosis
    HIV.D.DE339Kaposi sarcomaClient's symptoms include Kaposi sarcoma
    HIV.D.DE340Cytomegalovirus infection (retinitis or infection of other organs)Client's symptoms include cytomegalovirus infection (retinitis or infection of other organs)
    HIV.D.DE341Central nervous system toxoplasmosisClient's symptoms include central nervous system toxoplasmosis
    HIV.D.DE342HIV encephalopathyClient's symptoms include HIV encephalopathy
    HIV.D.DE343Extrapulmonary cryptococcosis, including meningitisClient's symptoms include extrapulmonary cryptococcosis, including meningitis
    HIV.D.DE344Disseminated nontuberculous mycobacterial infectionClient's symptoms include disseminated nontuberculous mycobacterial infection
    HIV.D.DE345Progressive multifocal leukoencephalopathyClient's symptoms include progressive multifocal leukoencephalopathy
    HIV.D.DE346Chronic cryptosporidiosisClient's symptoms include chronic cryptosporidiosis
    HIV.D.DE347Chronic cryptosporidiosis (with diarrhoea)Client's symptoms include chronic cryptosporidiosis (with diarrhoea)
    HIV.D.DE348Chronic isosporiasisClient's symptoms include chronic isosporiasis
    HIV.D.DE349Disseminated mycosis (extrapulmonary histoplasmosis, coccidioidomycosis)Client's symptoms include disseminated mycosis (extrapulmonary histoplasmosis, coccidioidomycosis)
    HIV.D.DE350Disseminated endemic mycosis (extrapulmonary histoplasmosis, coccidioidomycosis, penicilliosis)Client's symptoms include disseminated endemic mycosis (extrapulmonary histoplasmosis, coccidioidomycosis, penicilliosis)
    HIV.D.DE351Cerebral lymphomaClient's symptoms include cerebral lymphoma
    HIV.D.DE352B-cell non-Hodgkin lymphomaClient's symptoms include b-cell non-Hodgkin lymphoma
    HIV.D.DE353HIV-associated nephropathy or cardiomyopathyClient's symptoms include HIV- associated nephropathy or cardiomyopathy
    HIV.D.DE354Recurrent septicaemia (including nontyphoidal Salmonella)Client's symptoms include recurrent bacteraemia (septicaemia) (including nontyphoidal salmonella)
    HIV.D.DE355Invasive cervical carcinomaClient's symptoms include invasive cervical carcinoma
    HIV.D.DE356Atypical disseminated leishmaniasisClient's symptoms include atypical disseminated leishmaniasis
    HIV.D.DE357NeutropeniaClient's symptoms include neutropenia, an abnormally low count of a type of white blood cell (neutrophils)

Source

{
  "resourceType": "ValueSet",
  "id": "HIV.D.DE289",
  "meta": {
    "profile": [
      "http://hl7.org/fhir/uv/crmi/StructureDefinition/crmi-shareablevalueset",
      "http://hl7.org/fhir/uv/crmi/StructureDefinition/crmi-publishablevalueset",
      "http://hl7.org/fhir/uv/crmi/StructureDefinition/crmi-computablevalueset"
    ]
  },
  "text": {
    "status": "extensions",
    "div": "<!-- snip (see above) -->"
  },
  "url": "http://smart.who.int/hiv/ValueSet/HIV.D.DE289",
  "version": "0.4.4",
  "name": "HIVDDE289",
  "title": "WHO HIV clinical stage condition or symptom ValueSet",
  "status": "active",
  "experimental": true,
  "date": "2025-07-24T19:24:35+00:00",
  "publisher": "WHO",
  "contact": [
    {
      "name": "WHO",
      "telecom": [
        {
          "system": "url",
          "value": "http://who.int"
        }
      ]
    }
  ],
  "description": "Value set of new or recurrent clinical events used to categorize HIV disease severity based at baseline and follow up",
  "compose": {
    "include": [
      {
        "system": "http://smart.who.int/hiv/CodeSystem/HIVConcepts",
        "concept": [
          {
            "code": "HIV.D.DE290",
            "display": "Asymptomatic"
          },
          {
            "code": "HIV.D.DE291",
            "display": "Persistent generalized lymphadenopathy"
          },
          {
            "code": "HIV.D.DE292",
            "display": "Moderate unexplained weight loss"
          },
          {
            "code": "HIV.D.DE293",
            "display": "Recurrent respiratory tract infections"
          },
          {
            "code": "HIV.D.DE294",
            "display": "Unexplained persistent hepatosplenomegaly"
          },
          {
            "code": "HIV.D.DE295",
            "display": "Herpes zoster"
          },
          {
            "code": "HIV.D.DE296",
            "display": "Angular cheilitis"
          },
          {
            "code": "HIV.D.DE297",
            "display": "Linear gingival erythema"
          },
          {
            "code": "HIV.D.DE298",
            "display": "Recurrent oral ulceration"
          },
          {
            "code": "HIV.D.DE299",
            "display": "Papular pruritic eruption"
          },
          {
            "code": "HIV.D.DE300",
            "display": "Fungal nail infections"
          },
          {
            "code": "HIV.D.DE301",
            "display": "Seborrhoeic dermatitis"
          },
          {
            "code": "HIV.D.DE302",
            "display": "Extensive wart virus infection"
          },
          {
            "code": "HIV.D.DE303",
            "display": "Extensive molluscum contagiosum"
          },
          {
            "code": "HIV.D.DE304",
            "display": "Unexplained persistent parotid enlargement"
          },
          {
            "code": "HIV.D.DE305",
            "display": "Unexplained severe weight loss in adults"
          },
          {
            "code": "HIV.D.DE306",
            "display": "Unexplained moderate malnutrition not adequately responding to standard therapy"
          },
          {
            "code": "HIV.D.DE307",
            "display": "Unexplained chronic diarrhoea for longer than 1 month"
          },
          {
            "code": "HIV.D.DE308",
            "display": "Unexplained persistent diarrhoea (14 days or more)"
          },
          {
            "code": "HIV.D.DE309",
            "display": "Unexplained persistent fever (above 37.5 C, intermittent or constant, for longer than one 1 month)"
          },
          {
            "code": "HIV.D.DE310",
            "display": "Persistent oral candidiasis"
          },
          {
            "code": "HIV.D.DE311",
            "display": "Oral hairy leukoplakia"
          },
          {
            "code": "HIV.D.DE312",
            "display": "Pulmonary TB"
          },
          {
            "code": "HIV.D.DE313",
            "display": "Lymph node TB"
          },
          {
            "code": "HIV.D.DE314",
            "display": "Severe bacterial infections (such as pneumonia, empyema, pyomyositis, bone or joint infection, meningitis, bacteraemia)"
          },
          {
            "code": "HIV.D.DE315",
            "display": "Severe recurrent bacterial pneumonia"
          },
          {
            "code": "HIV.D.DE316",
            "display": "Acute necrotizing ulcerative stomatitis"
          },
          {
            "code": "HIV.D.DE317",
            "display": "Acute necrotizing ulcerative gingivitis"
          },
          {
            "code": "HIV.D.DE318",
            "display": "Acute necrotizing ulcerative periodontitis"
          },
          {
            "code": "HIV.D.DE319",
            "display": "Unexplained anaemia (<8 g/dL)"
          },
          {
            "code": "HIV.D.DE320",
            "display": "Neutropaenia (<0.5 x 10^9/L)"
          },
          {
            "code": "HIV.D.DE321",
            "display": "Chronic thrombocytopaenia (<50 x 10^9/L)"
          },
          {
            "code": "HIV.D.DE322",
            "display": "Symptomatic lymphoid interstitial pneumonitis"
          },
          {
            "code": "HIV.D.DE323",
            "display": "Chronic HIV-associated lung disease, including bronchiectasis"
          },
          {
            "code": "HIV.D.DE324",
            "display": "HIV wasting syndrome"
          },
          {
            "code": "HIV.D.DE325",
            "display": "Unexplained severe wasting not responding to standard therapy"
          },
          {
            "code": "HIV.D.DE326",
            "display": "Unexplained stunting not responding to standard therapy"
          },
          {
            "code": "HIV.D.DE327",
            "display": "Unexplained severe malnutrition not responding to standard therapy"
          },
          {
            "code": "HIV.D.DE328",
            "display": "Pneumocystis (jirovecii) pneumonia"
          },
          {
            "code": "HIV.D.DE329",
            "display": "Recurrent severe bacterial pneumonia"
          },
          {
            "code": "HIV.D.DE330",
            "display": "Recurrent severe bacterial infections (such as empyema, pyomyositis, bone or joint infection, meningitis, but excluding pneumonia)"
          },
          {
            "code": "HIV.D.DE331",
            "display": "Empyema"
          },
          {
            "code": "HIV.D.DE332",
            "display": "Pyomyositis"
          },
          {
            "code": "HIV.D.DE333",
            "display": "Bone or joint infection"
          },
          {
            "code": "HIV.D.DE334",
            "display": "Meningitis"
          },
          {
            "code": "HIV.D.DE335",
            "display": "Chronic herpes simplex infection (orolabial or cutaneous of more than 1 month duration or visceral at any site)"
          },
          {
            "code": "HIV.D.DE336",
            "display": "Chronic herpes simplex infection (orolabial, genital or anorectal of more than 1 month in duration or visceral at any site)"
          },
          {
            "code": "HIV.D.DE337",
            "display": "Oesophageal candidiasis (or candidiasis of trachea, bronchi or lungs)"
          },
          {
            "code": "HIV.D.DE338",
            "display": "Extrapulmonary TB"
          },
          {
            "code": "HIV.D.DE339",
            "display": "Kaposi sarcoma"
          },
          {
            "code": "HIV.D.DE340",
            "display": "Cytomegalovirus infection (retinitis or infection of other organs)"
          },
          {
            "code": "HIV.D.DE341",
            "display": "Central nervous system toxoplasmosis"
          },
          {
            "code": "HIV.D.DE342",
            "display": "HIV encephalopathy"
          },
          {
            "code": "HIV.D.DE343",
            "display": "Extrapulmonary cryptococcosis, including meningitis"
          },
          {
            "code": "HIV.D.DE344",
            "display": "Disseminated nontuberculous mycobacterial infection"
          },
          {
            "code": "HIV.D.DE345",
            "display": "Progressive multifocal leukoencephalopathy"
          },
          {
            "code": "HIV.D.DE346",
            "display": "Chronic cryptosporidiosis"
          },
          {
            "code": "HIV.D.DE347",
            "display": "Chronic cryptosporidiosis (with diarrhoea)"
          },
          {
            "code": "HIV.D.DE348",
            "display": "Chronic isosporiasis"
          },
          {
            "code": "HIV.D.DE349",
            "display": "Disseminated mycosis (extrapulmonary histoplasmosis, coccidioidomycosis)"
          },
          {
            "code": "HIV.D.DE350",
            "display": "Disseminated endemic mycosis (extrapulmonary histoplasmosis, coccidioidomycosis, penicilliosis)"
          },
          {
            "code": "HIV.D.DE351",
            "display": "Cerebral lymphoma"
          },
          {
            "code": "HIV.D.DE352",
            "display": "B-cell non-Hodgkin lymphoma"
          },
          {
            "code": "HIV.D.DE353",
            "display": "HIV-associated nephropathy or cardiomyopathy"
          },
          {
            "code": "HIV.D.DE354",
            "display": "Recurrent septicaemia (including nontyphoidal Salmonella)"
          },
          {
            "code": "HIV.D.DE355",
            "display": "Invasive cervical carcinoma"
          },
          {
            "code": "HIV.D.DE356",
            "display": "Atypical disseminated leishmaniasis"
          },
          {
            "code": "HIV.D.DE357",
            "display": "Neutropenia"
          }
        ]
      }
    ]
  }
}