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{
  "resourceType": "StructureDefinition",
  "id": "SubstanceSpecificationNOMA2.0.1",
  "url": "https://example.org/fhir/StructureDefinition/2.0.0/SubstanceSpecificationNOMA",
  "version": "2.0.0",
  "name": "SubstanceSpecificationNOMA",
  "status": "active",
  "description": "Representing the Substances in the Norwegian Substance database",
  "fhirVersion": "4.0.1",
  "kind": "resource",
  "abstract": false,
  "type": "SubstanceSpecification",
  "baseDefinition": "http://hl7.org/fhir/StructureDefinition/SubstanceSpecification",
  "derivation": "constraint",
  "differential": {
    "element": [
      {
        "id": "SubstanceSpecification",
        "path": "SubstanceSpecification",
        "comment": "Based on ISO 11238",
        "alias": [
          "SubstanceDefinition (FHIR R5)"
        ]
      },
      {
        "id": "SubstanceSpecification.identifier",
        "path": "SubstanceSpecification.identifier",
        "short": "Indentifier for the substance.",
        "definition": "Identifier by which this substance is known, specific to NoMA's FHIR API\r\nUrl (preliminary): http://legemiddelverket.no/fhir/SAFEST/SafestSubstanceDefinitionID  \r\nAlternative (business) identifiers - SMS ID, UniiCode and FEST ID - are provided in the extension. since the identifier attribute can provide at most one identifier.",
        "min": 1
      },
      {
        "id": "SubstanceSpecification.identifier.system",
        "path": "SubstanceSpecification.identifier.system",
        "definition": "The namespace is preliminary and will be replaced with a stable \"GUPRI\"",
        "fixedUri": "http://legemiddelverket.no/fhir/SAFEST/SafestSubstanceDefinitionID"
      },
      {
        "id": "SubstanceSpecification.type",
        "path": "SubstanceSpecification.type",
        "short": "High level categorization, e.g. chemical, polymer or nucleic acid",
        "definition": "High level categorization, e.g. chemical, polymer or nucleic acid.",
        "alias": [
          "category"
        ],
        "binding": {
          "strength": "example",
          "description": "SPOR RMS Substance Types",
          "valueSet": "https://spor.ema.europa.eu/rmswi/#/lists/100000075826/terms"
        }
      },
      {
        "id": "SubstanceSpecification.type.coding.system",
        "path": "SubstanceSpecification.type.coding.system",
        "definition": "The identification of the code system that defines the meaning of the symbol in the code.\r\nThe system URL is preliminary and will be replaced with a stable \"GUPRI\"",
        "fixedUri": "https://api.legemiddelverket.no/FHIR-R4/CodeSystem/905de22c-b0f9-4ad5-bfcb-08e1d6fef20d"
      },
      {
        "id": "SubstanceSpecification.status",
        "path": "SubstanceSpecification.status",
        "max": "0"
      },
      {
        "id": "SubstanceSpecification.domain",
        "path": "SubstanceSpecification.domain",
        "max": "0"
      },
      {
        "id": "SubstanceSpecification.description",
        "path": "SubstanceSpecification.description",
        "max": "0"
      },
      {
        "id": "SubstanceSpecification.source",
        "path": "SubstanceSpecification.source",
        "max": "0"
      },
      {
        "id": "SubstanceSpecification.comment",
        "path": "SubstanceSpecification.comment",
        "max": "0"
      },
      {
        "id": "SubstanceSpecification.moiety",
        "path": "SubstanceSpecification.moiety",
        "max": "0"
      },
      {
        "id": "SubstanceSpecification.property",
        "path": "SubstanceSpecification.property",
        "max": "0"
      },
      {
        "id": "SubstanceSpecification.referenceInformation",
        "path": "SubstanceSpecification.referenceInformation",
        "max": "0"
      },
      {
        "id": "SubstanceSpecification.structure",
        "path": "SubstanceSpecification.structure",
        "max": "0"
      },
      {
        "id": "SubstanceSpecification.code",
        "path": "SubstanceSpecification.code",
        "max": "0"
      },
      {
        "id": "SubstanceSpecification.name",
        "path": "SubstanceSpecification.name",
        "definition": "Names applicable to this substance.. Provided in Norwegian, English and (if exists) Latin"
      },
      {
        "id": "SubstanceSpecification.name.extension",
        "path": "SubstanceSpecification.name.extension",
        "alias": [
          "alias"
        ]
      },
      {
        "id": "SubstanceSpecification.name.extension:alias",
        "path": "SubstanceSpecification.name.extension",
        "sliceName": "alias",
        "type": [
          {
            "code": "Extension",
            "profile": [
              "https://example.org/fhir/StructureDefinition/SubstanceSpecificationNameAliasNOMA"
            ]
          }
        ],
        "isModifier": false
      },
      {
        "id": "SubstanceSpecification.name.language",
        "path": "SubstanceSpecification.name.language",
        "definition": "Language of the name. Norwegian, English or (if exists) Latin"
      },
      {
        "id": "SubstanceSpecification.molecularWeight",
        "path": "SubstanceSpecification.molecularWeight",
        "max": "0"
      },
      {
        "id": "SubstanceSpecification.relationship.relationship",
        "path": "SubstanceSpecification.relationship.relationship",
        "alias": [
          "type"
        ]
      },
      {
        "id": "SubstanceSpecification.relationship.amount[x]",
        "path": "SubstanceSpecification.relationship.amount[x]",
        "slicing": {
          "discriminator": [
            {
              "type": "type",
              "path": "$this"
            }
          ],
          "rules": "open"
        },
        "max": "0"
      },
      {
        "id": "SubstanceSpecification.relationship.amount[x]:amountQuantity",
        "path": "SubstanceSpecification.relationship.amount[x]",
        "sliceName": "amountQuantity",
        "max": "0",
        "type": [
          {
            "code": "Quantity"
          }
        ]
      },
      {
        "id": "SubstanceSpecification.relationship.amount[x]:amountRange",
        "path": "SubstanceSpecification.relationship.amount[x]",
        "sliceName": "amountRange",
        "max": "0",
        "type": [
          {
            "code": "Range"
          }
        ]
      },
      {
        "id": "SubstanceSpecification.relationship.amount[x]:amountRatio",
        "path": "SubstanceSpecification.relationship.amount[x]",
        "sliceName": "amountRatio",
        "max": "0",
        "type": [
          {
            "code": "Ratio"
          }
        ]
      },
      {
        "id": "SubstanceSpecification.relationship.amount[x]:amountString",
        "path": "SubstanceSpecification.relationship.amount[x]",
        "sliceName": "amountString",
        "max": "0",
        "type": [
          {
            "code": "string"
          }
        ]
      },
      {
        "id": "SubstanceSpecification.nucleicAcid",
        "path": "SubstanceSpecification.nucleicAcid",
        "max": "0"
      },
      {
        "id": "SubstanceSpecification.polymer",
        "path": "SubstanceSpecification.polymer",
        "max": "0"
      },
      {
        "id": "SubstanceSpecification.protein",
        "path": "SubstanceSpecification.protein",
        "max": "0"
      },
      {
        "id": "SubstanceSpecification.sourceMaterial",
        "path": "SubstanceSpecification.sourceMaterial",
        "max": "0"
      },
      {
        "id": "SubstanceSpecification.extension",
        "path": "SubstanceSpecification.extension",
        "slicing": {
          "discriminator": [
            {
              "type": "value",
              "path": "url"
            }
          ],
          "ordered": true,
          "rules": "open"
        },
        "min": 1,
        "type": [
          {
            "code": "Extension"
          }
        ],
        "mustSupport": false,
        "isModifier": false
      },
      {
        "id": "SubstanceSpecification.extension:SMSID",
        "path": "SubstanceSpecification.extension",
        "sliceName": "SMSID",
        "short": "SPOR SMS ID",
        "definition": "The substance ID in the [EMA SPOR substances management services](https://spor.ema.europa.eu/smswi/#/). \r\nIdentifies substnaces in EU marketing authorisations.",
        "comment": "URL (preliminary): http://legemiddelverket.no/fhir/SAFEST/SMSID",
        "requirements": "Provides ability to map substances between different substance master data systems",
        "type": [
          {
            "code": "Extension",
            "profile": [
              "http://legemiddelverket.no/fhir/StructureDefinition/IdentifierExtension"
            ]
          }
        ],
        "meaningWhenMissing": "SPOR does not contain the relevant substance",
        "isModifier": false
      },
      {
        "id": "SubstanceSpecification.extension:UniiCode",
        "path": "SubstanceSpecification.extension",
        "sliceName": "UniiCode",
        "short": "GSRS Substance ID",
        "definition": "The Unique Ingredient Identifier (UNII) generated by the [Global Substance Registration System (GSRS)](https://gsrs.ncats.nih.gov/) of the US Food and Drug Administration.",
        "comment": "URL (preliminary): http://legemiddelverket.no/fhir/SAFEST/UniiCode",
        "requirements": "Provides ability to map substances between different susbtance master data systems",
        "type": [
          {
            "code": "Extension",
            "profile": [
              "http://legemiddelverket.no/fhir/StructureDefinition/IdentifierExtension"
            ]
          }
        ],
        "meaningWhenMissing": "GSRS does not contain the relevant substance",
        "isModifier": false
      },
      {
        "id": "SubstanceSpecification.extension:FestId",
        "path": "SubstanceSpecification.extension",
        "sliceName": "FestId",
        "short": "FEST substance ID",
        "definition": "The substance ID in the [FEST medicinal product master data](https://www.dmp.no/om-oss/distribusjon-av-legemiddeldata/fest)",
        "comment": "URL (preliminary): http://legemiddelverket.no/FEST/SubstansID",
        "min": 1,
        "type": [
          {
            "code": "Extension",
            "profile": [
              "http://legemiddelverket.no/fhir/StructureDefinition/IdentifierExtension"
            ]
          }
        ],
        "isModifier": false
      },
      {
        "id": "SubstanceSpecification.extension:classification",
        "path": "SubstanceSpecification.extension",
        "sliceName": "classification",
        "short": "Classifies the substance",
        "definition": "Optional xtension for classifying substances.",
        "comment": "##### Published (optional) classification categories:\r\n\r\n###### **E-Number**\r\nThe substance's [E-number(s)](https://ec.europa.eu/food/food-feed-portal/screen/food-additives/search). A substance can have multiple e-numbers.\r\nCardinality: 0..*  \r\nCode: The E-number  \r\nDisplay: The E-number name (substance)  \r\nUrl (preliminary): https://simplifier.net/safest/e-number\r\n###### **Is Therapeutic**\r\nWhether the substance is therapeutic (only published when \"true\").  \r\nCardinality: 0..1  \r\nCode: \"true\"  \r\nDisplay: \"Er terapautisk del\"  \r\nUrl (preliminary): https://simplifier.net/safest/activemoiety\r\n###### **Is Prodrug**\r\nWhether the substance is a prodrug (only published when \"true\")  \r\nCardinality: 0..1  \r\nCode: \"true\"  \r\nDisplay: \"Er prodrug\"  \r\nUrl (preliminary): ttps://simplifier.net/safest/prodrug\r\n###### **Is Complex**\r\nWhether the substance is complex (only published when \"true\")  \r\nCardinality: 0..1  \r\nCode: \"true\"  \r\nDisplay: \"Er kompleks\"  \r\nUrl (preliminary): https://simplifier.net/safest/complex  \r\n###### **ATC codes**\r\nAll the substance's ATC code(s). Human codes only.\r\nCardinality: 0..*  \r\nCode: The ATC code  \r\nDisplay: The (substance) name  \r\nUrls (preliminary), one per first-level ATC:  \r\n\r\n| First-level ATC category | Url |\r\n| :------- | :------ |\r\n| Alimentary tract and metabolism | https://api.legemiddelverket.no/FHIR-R4/CodeSystem/dcedfe5f-d7dd-43f4-a351-8744395249dd |\r\n| Blood and blood forming organs | https://api.legemiddelverket.no/FHIR-R4/CodeSystem/127f5448-fa44-4da4-9589-438749da0158 |\r\n| Cardiovascular system | https://api.legemiddelverket.no/FHIR-R4/CodeSystem/e104a7eb-e832-4d57-946d-d402b71ecc22 |\r\n| Dermatologicals | https://api.legemiddelverket.no/FHIR-R4/CodeSystem/f5a60497-f1c5-4163-ad34-a3c614d2f6b4 |\r\n| Genito urinary system and sex hormones | https://api.legemiddelverket.no/FHIR-R4/CodeSystem/1fd6dad4-6b05-44ee-9a61-9409927bf195 |\r\n| Systemic hormonal preparations, excl. sex hormones and insulins | https://api.legemiddelverket.no/FHIR-R4/CodeSystem/bd343711-ab45-4ebd-9f2c-b128f422645e |\r\n| Antiinfectives for systemic use | https://api.legemiddelverket.no/FHIR-R4/CodeSystem/e9f15a26-d384-48c2-a74d-3fa95f44a9dc |\r\n| Antineoplastic and immunomodulating agents | https://api.legemiddelverket.no/FHIR-R4/CodeSystem/849bc27b-a66d-49ad-9389-d8f19d63b480 |\r\n| Musculo-skeletal system | https://api.legemiddelverket.no/FHIR-R4/CodeSystem/82311936-f7e3-4c24-8821-229f055f7c64 |\r\n| Nervous system |  https://api.legemiddelverket.no/FHIR-R4/CodeSystem/f7949a93-d26e-4235-ac5d-d2b898a7aad4 |\r\n| Antiparasitic products, insecticides and repellents | https://api.legemiddelverket.no/FHIR-R4/CodeSystem/a9a04ea3-c412-4c27-b191-fddb4ae4d162 |\r\n| Respiratory system | https://api.legemiddelverket.no/FHIR-R4/CodeSystem/451f509c-f18b-48e1-ac75-d1852b846eee |\r\n| Sensory organs | https://api.legemiddelverket.no/FHIR-R4/CodeSystem/2949f36e-6b6f-496a-96c8-c61429e75797 |\r\n| Various | https://api.legemiddelverket.no/FHIR-R4/CodeSystem/e5390228-1602-4bef-8ca9-fca1771de4d1 |",
        "type": [
          {
            "code": "Extension",
            "profile": [
              "http://legemiddelverket.no/fhir/StructureDefinition/substancespecification-classification"
            ]
          }
        ],
        "isModifier": false
      }
    ]
  }
}