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Packagenictiz.nl.gbb
Resource TypeStructureDefinition
IdStructureDefinition-LogicalModelReaction.json
FHIR VersionR4
Sourcehttp://ig.nictiz.nl/gbb/1.0.0-alpha.2/StructureDefinition-LogicalModelReaction.html
URLhttp://ig.nictiz.nl/gbb/StructureDefinition/LogicalModelReaction
Version1.0.0-alpha.2
Statusdraft
Date2026-10-26T15:40:52+01:00
NameLogicalModelpartReaction
TitleLogicalModelpart.Reaction
Realmnl
Typehttp://ig.nictiz.nl/gbb/StructureDefinition/Reaction
Kindlogical

Resources that use this resource

StructureDefinition
nictiz.nl.gbb#1.0.0-alpha.2LogicalModelAllergyIntoleranceLogicalModelAllergyIntolerance

Resources that this resource uses

ValueSet
hl7.fhir.uv.ips#currentallergy-reaction-uv-ipsAllergy Reaction - IPS
nictiz.nl.gbb#1.0.0-alpha.22.16.840.1.113883.2.4.3.11.60.153.11.29ManifestatieVanReactieWaardelijst
nictiz.nl.gbb#1.0.0-alpha.22.16.840.1.113883.2.4.3.11.60.153.11.44ZekerheidStatusCodelijst
nictiz.nl.gbb#1.0.0-alpha.22.16.840.1.113883.2.4.3.11.60.153.11.47SpecifiekeStofAllergeneStoffenCodelijst
nictiz.nl.gbb#1.0.0-alpha.22.16.840.1.113883.2.4.3.11.60.153.11.49SpecifiekeStofHPKCodelijst
nictiz.nl.gbb#1.0.0-alpha.22.16.840.1.113883.2.4.3.11.60.153.11.50SpecifiekeStofSNKCodelijst
nictiz.nl.gbb#1.0.0-alpha.22.16.840.1.113883.2.4.3.11.60.153.11.51SpecifiekeStofSSKCodelijst
nictiz.nl.gbb#1.0.0-alpha.22.16.840.1.113883.2.4.3.11.60.153.11.52SpecifiekeStofThesaurus122Codelijst
myhealth.eu.fhir.mvc-package#9.1.0eHDSIAllergenNoDrugeHDSI Allergen No Drug

Narrative

Note: links and images are rebased to the (stated) source


Dutch


Gegenereerde narrative: StructureDefinition LogicalModelReaction

Taal: en

NaamMarkeringenKard.TypeOmschrijving & constraintsdoco
Reaction 0..*BaseRootconcept van het subbouwblok Reactie.
Reaction.specificSubstance SO Dit element heeft verplichtingen en moet worden ondersteund. 0..1CodeableConceptMeer specifieke aanduiding van de stof die de reactie opriep.
Binding: http://terminology.ehdsi.eu/ValueSet/eHDSIAllergenNoDrug (example): eHDSI Allergen No Drug
Additionele bindingsDoel
SpecifiekeStofThesaurus122CodelijstComponent
SpecifiekeStofSSKCodelijstComponent
SpecifiekeStofSNKCodelijstComponent
SpecifiekeStofHPKCodelijstComponent
SpecifiekeStofAllergeneStoffenCodelijstComponent
VerplichtingenActor
SHOULD:populate-if-knownOntsluitendSysteem
SHALL:no-errorVerwerkendSysteem
Reaction.certainty SO Dit element heeft verplichtingen en moet worden ondersteund. 0..1CodeableConceptDe mate van klinische zekerheid dat de manifestatie in dit reactie-incident werd veroorzaakt door blootstelling aan de geïdentificeerde specifieke stof.
Binding: AllergyIntoleranceVerificationStatusCodes (required): AllergyIntolerance Verification Status Codes
Additionele bindingsDoel
ZekerheidStatusCodelijstComponent
VerplichtingenActor
SHOULD:populate-if-knownOntsluitendSysteem
SHALL:no-errorVerwerkendSysteem
Reaction.manifestation SO Dit element heeft verplichtingen en moet worden ondersteund. 1..*CodeableConceptKlinische symptomen en/of bevindingen die worden waargenomen bij of in verband worden gebracht met de ongewenste reactie.
Binding: Allergy Reaction - IPS (preferred): Allergy Reaction - IPS
Additionele bindingsDoel
ManifestatieVanReactieWaardelijstComponent

VerplichtingenActor
SHALL:able-to-populateRegistrerendSysteem
SHALL:populateOntsluitendSysteem
SHALL:handleVerwerkendSysteem
Reaction.reactionDescription SO Dit element heeft verplichtingen en moet worden ondersteund. 0..1stringTekstuele beschrijving van de reactie als geheel, inclusief eventuele details over de manifestatie.
VerplichtingenActor
SHOULD:populate-if-knownOntsluitendSysteem
SHALL:no-errorVerwerkendSysteem
Reaction.reactionDateTime SO Dit element heeft verplichtingen en moet worden ondersteund. 0..1dateTimeDatum en tijd waarop de reactie plaats gevonden heeft.
VerplichtingenActor
SHALL:able-to-populateRegistrerendSysteem
SHALL:populateOntsluitendSysteem
SHALL:handleVerwerkendSysteem
Reaction.severity SO Dit element heeft verplichtingen en moet worden ondersteund. 0..1CodeableConceptKlinische beoordeling van de ernst van het reactie-incident als geheel, waarbij mogelijk meerdere verschillende manifestaties worden meegewogen.
Binding: AllergyIntoleranceSeverity (required): AllergyIntoleranceSeverity
VerplichtingenActor
SHOULD:populate-if-knownOntsluitendSysteem
SHALL:no-errorVerwerkendSysteem
Reaction.routeOfExposure SO Dit element heeft verplichtingen en moet worden ondersteund. 0..1CodeableConceptWijze waarop de patiënt is blootgesteld aan de geïdentificeerde specifieke stof.
Binding: SNOMEDCTRouteCodes (preferred): SNOMED CT Route Codes
VerplichtingenActor
SHOULD:populate-if-knownOntsluitendSysteem
SHALL:no-errorVerwerkendSysteem
Reaction.note SO Dit element heeft verplichtingen en moet worden ondersteund. 0..*stringTekstuele omschrijving van de reactie van de allergie of intolerantie, en/of aanvullende vrije tekst over de reactie allergie of intolerantie, voor zover deze niet in andere velden is vastgelegd.
VerplichtingenActor
SHOULD:populate-if-knownOntsluitendSysteem
SHALL:no-errorVerwerkendSysteem

doco Documentatie voor dit formaat

English


Generated Narrative: StructureDefinition LogicalModelReaction

Language: en

NameFlagsCard.TypeDescription & Constraintsdoco
Reaction 0..*BaseRoot concept of the Reaction sub information model.
Reaction.specificSubstance SO This element has obligations and must be supported. 0..1CodeableConceptMore specific indication of the substance that caused the reaction.
Binding: http://terminology.ehdsi.eu/ValueSet/eHDSIAllergenNoDrug (example): eHDSI Allergen No Drug
Additional BindingsPurpose
SpecifiekeStofThesaurus122CodelijstComponent
SpecifiekeStofSSKCodelijstComponent
SpecifiekeStofSNKCodelijstComponent
SpecifiekeStofHPKCodelijstComponent
SpecifiekeStofAllergeneStoffenCodelijstComponent
ObligationsActor
SHOULD:populate-if-knownOntsluitendSysteem
SHALL:no-errorVerwerkendSysteem
Reaction.certainty SO This element has obligations and must be supported. 0..1CodeableConceptThe level of clinical certainty that the manifestation in this reaction incident was caused by exposure to the specific substance.
Binding: AllergyIntoleranceVerificationStatusCodes (required): AllergyIntolerance Verification Status Codes
Additional BindingsPurpose
ZekerheidStatusCodelijstComponent
ObligationsActor
SHOULD:populate-if-knownOntsluitendSysteem
SHALL:no-errorVerwerkendSysteem
Reaction.manifestation SO This element has obligations and must be supported. 1..*CodeableConceptClinical symptoms and/or findings observed with or associated with the adverse reaction.
Binding: Allergy Reaction - IPS (preferred): Allergy Reaction - IPS
Additional BindingsPurpose
ManifestatieVanReactieWaardelijstComponent

ObligationsActor
SHALL:able-to-populateRegistrerendSysteem
SHALL:populateOntsluitendSysteem
SHALL:handleVerwerkendSysteem
Reaction.reactionDescription SO This element has obligations and must be supported. 0..1stringTextual description of the response as a whole, including any details about the manifestation.
ObligationsActor
SHOULD:populate-if-knownOntsluitendSysteem
SHALL:no-errorVerwerkendSysteem
Reaction.reactionDateTime SO This element has obligations and must be supported. 0..1dateTimeDate and time at which the reaction took place.
ObligationsActor
SHALL:able-to-populateRegistrerendSysteem
SHALL:populateOntsluitendSysteem
SHALL:handleVerwerkendSysteem
Reaction.severity SO This element has obligations and must be supported. 0..1CodeableConceptClinical assessment of the severity of the reaction incident as a whole, taking into account possible multiple different manifestations.
Binding: AllergyIntoleranceSeverity (required): AllergyIntoleranceSeverity
ObligationsActor
SHOULD:populate-if-knownOntsluitendSysteem
SHALL:no-errorVerwerkendSysteem
Reaction.routeOfExposure SO This element has obligations and must be supported. 0..1CodeableConceptManner in which the patient was exposed to the identified specific substance.
Binding: SNOMEDCTRouteCodes (preferred): SNOMED CT Route Codes
ObligationsActor
SHOULD:populate-if-knownOntsluitendSysteem
SHALL:no-errorVerwerkendSysteem
Reaction.note SO This element has obligations and must be supported. 0..*stringTextual description of the undesired reaction and/or additional information on the undesired reaction for as far as not covered in more specific fields.
ObligationsActor
SHOULD:populate-if-knownOntsluitendSysteem
SHALL:no-errorVerwerkendSysteem

doco Documentation for this format

Source1

{
  "resourceType": "StructureDefinition",
  "id": "LogicalModelReaction",
  "language": "en",
  "text": {
    "status": "extensions",
    "div": "<!-- snip (see above) -->"
  },
  "extension": [
    {
      "url": "http://hl7.org/fhir/StructureDefinition/resource-effectivePeriod",
      "valuePeriod": {
        "start": "2026-09-23T00:00:00Z"
      }
    }
  ],
  "url": "http://ig.nictiz.nl/gbb/StructureDefinition/LogicalModelReaction",
  "identifier": [
    {
      "use": "official",
      "system": "urn:ietf:rfc:3986",
      "value": "urn:oid:2.16.840.1.113883.2.4.3.11.60.153.4.39"
    }
  ],
  "version": "1.0.0-alpha.2",
  "name": "LogicalModelpartReaction",
  "_name": {
    "extension": [
      {
        "extension": [
          {
            "url": "lang",
            "valueCode": "nl"
          },
          {
            "url": "content",
            "valueString": "LogischModelpartReactie"
          }
        ],
        "url": "http://hl7.org/fhir/StructureDefinition/translation"
      }
    ]
  },
  "title": "LogicalModelpart.Reaction",
  "_title": {
    "extension": [
      {
        "extension": [
          {
            "url": "lang",
            "valueCode": "nl"
          },
          {
            "url": "content",
            "valueString": "LogischModelpartReactie"
          }
        ],
        "url": "http://hl7.org/fhir/StructureDefinition/translation"
      }
    ]
  },
  "status": "draft",
  "date": "2026-10-26T15:40:52+01:00",
  "publisher": "Nictiz",
  "contact": [
    {
      "name": "Nictiz",
      "telecom": [
        {
          "system": "url",
          "value": "https://nictiz.nl"
        }
      ]
    }
  ],
  "fhirVersion": "4.0.1",
  "mapping": [
    {
      "identity": "Reaction",
      "uri": "http://nictiz.nl/gbb/Requirements/Reaction",
      "name": "Reaction"
    }
  ],
  "kind": "logical",
  "abstract": false,
  "type": "http://ig.nictiz.nl/gbb/StructureDefinition/Reaction",
  "baseDefinition": "http://hl7.org/fhir/StructureDefinition/Base",
  "derivation": "specialization",
  "snapshot": {
    "extension": [
      {
        "url": "http://hl7.org/fhir/tools/StructureDefinition/snapshot-base-version",
        "valueString": "4.0.1"
      }
    ],
    "element": [
      {
        "id": "Reaction",
        "path": "Reaction",
        "short": "Root concept of the Reaction sub information model.",
        "_short": {
          "extension": [
            {
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "nl"
                },
                {
                  "url": "content",
                  "valueMarkdown": "Rootconcept van het subbouwblok Reactie."
                }
              ],
              "url": "http://hl7.org/fhir/StructureDefinition/translation"
            }
          ]
        },
        "definition": "Root concept of the Reaction sub information model. This root concept contains all data elements of the Reaction. This sub building block can solely be used with the general building block AllergyIntolerance.",
        "_definition": {
          "extension": [
            {
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "nl"
                },
                {
                  "url": "content",
                  "valueMarkdown": "Rootconcept van het subbouwblok Reactie. Dit rootconcept bevat alle gegevenselementen van de reactie welke horen bij het bovenliggende generieke bouwblok AllergieIntolerantie. Dit subbouwblok mag alleen gebruikt worden in combinatie met het generieke bouwblok AllergieIntolerantie."
                }
              ],
              "url": "http://hl7.org/fhir/StructureDefinition/translation"
            }
          ]
        },
        "alias": [
          "Reactie"
        ],
        "min": 0,
        "max": "*",
        "base": {
          "path": "Base",
          "min": 0,
          "max": "*"
        },
        "isModifier": false
      },
      {
        "id": "Reaction.specificSubstance",
        "extension": [
          {
            "extension": [
              {
                "url": "code",
                "valueCode": "SHOULD:populate-if-known"
              },
              {
                "url": "actor",
                "valueCanonical": "http://ig.nictiz.nl/gbb/ActorDefinition/ExchangingSystem"
              },
              {
                "url": "http://hl7.org/fhir/tools/StructureDefinition/snapshot-source",
                "valueCanonical": "http://ig.nictiz.nl/gbb/StructureDefinition/LogicalModelReaction|1.0.0-alpha.2"
              }
            ],
            "url": "http://hl7.org/fhir/StructureDefinition/obligation"
          },
          {
            "extension": [
              {
                "url": "code",
                "valueCode": "SHALL:no-error"
              },
              {
                "url": "actor",
                "valueCanonical": "http://ig.nictiz.nl/gbb/ActorDefinition/ConsumingSystem"
              },
              {
                "url": "http://hl7.org/fhir/tools/StructureDefinition/snapshot-source",
                "valueCanonical": "http://ig.nictiz.nl/gbb/StructureDefinition/LogicalModelReaction|1.0.0-alpha.2"
              }
            ],
            "url": "http://hl7.org/fhir/StructureDefinition/obligation"
          }
        ],
        "path": "Reaction.specificSubstance",
        "short": "More specific indication of the substance that caused the reaction.",
        "_short": {
          "extension": [
            {
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "nl"
                },
                {
                  "url": "content",
                  "valueMarkdown": "Meer specifieke aanduiding van de stof die de reactie opriep."
                }
              ],
              "url": "http://hl7.org/fhir/StructureDefinition/translation"
            }
          ]
        },
        "definition": "More specific indication of the substance that caused the reaction. This can be a specific substance from a group of substances to which the patient is allergic or hypersensitive.",
        "_definition": {
          "extension": [
            {
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "nl"
                },
                {
                  "url": "content",
                  "valueMarkdown": "Meer specifieke aanduiding van de stof die de reactie opriep. Dit kan een specifieke stof uit een groep stoffen zijn waarvoor de patiënt allergisch of overgevoelig is."
                }
              ],
              "url": "http://hl7.org/fhir/StructureDefinition/translation"
            }
          ]
        },
        "alias": [
          "SpecifiekeStof"
        ],
        "min": 0,
        "max": "1",
        "base": {
          "path": "Reaction.specificSubstance",
          "min": 0,
          "max": "1"
        },
        "type": [
          {
            "code": "CodeableConcept"
          }
        ],
        "mustSupport": true,
        "binding": {
          "extension": [
            {
              "extension": [
                {
                  "url": "key",
                  "valueId": "f4bce1b1-3f43-4c10-bce1-b13f43bc10b5"
                },
                {
                  "url": "purpose",
                  "valueCode": "component"
                },
                {
                  "url": "valueSet",
                  "valueCanonical": "http://ig.nictiz.nl/gbb/ValueSet/2.16.840.1.113883.2.4.3.11.60.153.11.52"
                }
              ],
              "url": "http://hl7.org/fhir/tools/StructureDefinition/additional-binding"
            },
            {
              "extension": [
                {
                  "url": "key",
                  "valueId": "5a34bfdb-30ed-46e6-b4bf-db30ed76e616"
                },
                {
                  "url": "purpose",
                  "valueCode": "component"
                },
                {
                  "url": "valueSet",
                  "valueCanonical": "http://ig.nictiz.nl/gbb/ValueSet/2.16.840.1.113883.2.4.3.11.60.153.11.51"
                }
              ],
              "url": "http://hl7.org/fhir/tools/StructureDefinition/additional-binding"
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            {
              "extension": [
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                  "valueId": "667977e1-d7e5-4046-b977-e1d7e510460a"
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                {
                  "url": "valueSet",
                  "valueCanonical": "http://ig.nictiz.nl/gbb/ValueSet/2.16.840.1.113883.2.4.3.11.60.153.11.50"
                }
              ],
              "url": "http://hl7.org/fhir/tools/StructureDefinition/additional-binding"
            },
            {
              "extension": [
                {
                  "url": "key",
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                  "valueCode": "component"
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                {
                  "url": "valueSet",
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                }
              ],
              "url": "http://hl7.org/fhir/tools/StructureDefinition/additional-binding"
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            {
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                {
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                },
                {
                  "url": "purpose",
                  "valueCode": "component"
                },
                {
                  "url": "valueSet",
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                }
              ],
              "url": "http://hl7.org/fhir/tools/StructureDefinition/additional-binding"
            }
          ],
          "strength": "example",
          "description": "eHDSI Allergen No Drug",
          "valueSet": "http://terminology.ehdsi.eu/ValueSet/eHDSIAllergenNoDrug"
        },
        "mapping": [
          {
            "identity": "Reaction",
            "map": "EU-10"
          }
        ]
      },
      {
        "id": "Reaction.certainty",
        "extension": [
          {
            "extension": [
              {
                "url": "code",
                "valueCode": "SHOULD:populate-if-known"
              },
              {
                "url": "actor",
                "valueCanonical": "http://ig.nictiz.nl/gbb/ActorDefinition/ExchangingSystem"
              },
              {
                "url": "http://hl7.org/fhir/tools/StructureDefinition/snapshot-source",
                "valueCanonical": "http://ig.nictiz.nl/gbb/StructureDefinition/LogicalModelReaction|1.0.0-alpha.2"
              }
            ],
            "url": "http://hl7.org/fhir/StructureDefinition/obligation"
          },
          {
            "extension": [
              {
                "url": "code",
                "valueCode": "SHALL:no-error"
              },
              {
                "url": "actor",
                "valueCanonical": "http://ig.nictiz.nl/gbb/ActorDefinition/ConsumingSystem"
              },
              {
                "url": "http://hl7.org/fhir/tools/StructureDefinition/snapshot-source",
                "valueCanonical": "http://ig.nictiz.nl/gbb/StructureDefinition/LogicalModelReaction|1.0.0-alpha.2"
              }
            ],
            "url": "http://hl7.org/fhir/StructureDefinition/obligation"
          }
        ],
        "path": "Reaction.certainty",
        "short": "The level of clinical certainty that the manifestation in this reaction incident was caused by exposure to the specific substance.",
        "_short": {
          "extension": [
            {
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "nl"
                },
                {
                  "url": "content",
                  "valueMarkdown": "De mate van klinische zekerheid dat de manifestatie in dit reactie-incident werd veroorzaakt door blootstelling aan de geïdentificeerde specifieke stof."
                }
              ],
              "url": "http://hl7.org/fhir/StructureDefinition/translation"
            }
          ]
        },
        "definition": "The level of clinical certainty that the manifestation in this reaction incident was caused by exposure to the specific substance.",
        "_definition": {
          "extension": [
            {
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "nl"
                },
                {
                  "url": "content",
                  "valueMarkdown": "De mate van klinische zekerheid dat de manifestatie in dit reactie-incident werd veroorzaakt door blootstelling aan de geïdentificeerde specifieke stof."
                }
              ],
              "url": "http://hl7.org/fhir/StructureDefinition/translation"
            }
          ]
        },
        "alias": [
          "MateVanZekerheid"
        ],
        "min": 0,
        "max": "1",
        "base": {
          "path": "Reaction.certainty",
          "min": 0,
          "max": "1"
        },
        "type": [
          {
            "code": "CodeableConcept"
          }
        ],
        "mustSupport": true,
        "binding": {
          "extension": [
            {
              "extension": [
                {
                  "url": "key",
                  "valueId": "3c0c8f66-bdf9-44b8-8c8f-66bdf9f4b8af"
                },
                {
                  "url": "purpose",
                  "valueCode": "component"
                },
                {
                  "url": "valueSet",
                  "valueCanonical": "http://ig.nictiz.nl/gbb/ValueSet/2.16.840.1.113883.2.4.3.11.60.153.11.44"
                }
              ],
              "url": "http://hl7.org/fhir/tools/StructureDefinition/additional-binding"
            }
          ],
          "strength": "required",
          "description": "AllergyIntolerance Verification Status Codes",
          "valueSet": "http://hl7.org/fhir/ValueSet/allergyintolerance-verification"
        },
        "mapping": [
          {
            "identity": "Reaction",
            "map": "NL-06-02"
          }
        ]
      },
      {
        "id": "Reaction.manifestation",
        "extension": [
          {
            "extension": [
              {
                "url": "code",
                "valueCode": "SHALL:able-to-populate"
              },
              {
                "url": "actor",
                "valueCanonical": "http://ig.nictiz.nl/gbb/ActorDefinition/RegistrationSystem"
              },
              {
                "url": "http://hl7.org/fhir/tools/StructureDefinition/snapshot-source",
                "valueCanonical": "http://ig.nictiz.nl/gbb/StructureDefinition/LogicalModelReaction|1.0.0-alpha.2"
              }
            ],
            "url": "http://hl7.org/fhir/StructureDefinition/obligation"
          },
          {
            "extension": [
              {
                "url": "code",
                "valueCode": "SHALL:populate"
              },
              {
                "url": "actor",
                "valueCanonical": "http://ig.nictiz.nl/gbb/ActorDefinition/ExchangingSystem"
              },
              {
                "url": "http://hl7.org/fhir/tools/StructureDefinition/snapshot-source",
                "valueCanonical": "http://ig.nictiz.nl/gbb/StructureDefinition/LogicalModelReaction|1.0.0-alpha.2"
              }
            ],
            "url": "http://hl7.org/fhir/StructureDefinition/obligation"
          },
          {
            "extension": [
              {
                "url": "code",
                "valueCode": "SHALL:handle"
              },
              {
                "url": "actor",
                "valueCanonical": "http://ig.nictiz.nl/gbb/ActorDefinition/ConsumingSystem"
              },
              {
                "url": "http://hl7.org/fhir/tools/StructureDefinition/snapshot-source",
                "valueCanonical": "http://ig.nictiz.nl/gbb/StructureDefinition/LogicalModelReaction|1.0.0-alpha.2"
              }
            ],
            "url": "http://hl7.org/fhir/StructureDefinition/obligation"
          }
        ],
        "path": "Reaction.manifestation",
        "short": "Clinical symptoms and/or findings observed with or associated with the adverse reaction.",
        "_short": {
          "extension": [
            {
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "nl"
                },
                {
                  "url": "content",
                  "valueMarkdown": "Klinische symptomen en/of bevindingen die worden waargenomen bij of in verband worden gebracht met de ongewenste reactie."
                }
              ],
              "url": "http://hl7.org/fhir/StructureDefinition/translation"
            }
          ]
        },
        "definition": "Clinical symptoms and/or findings observed with or associated with the adverse reaction. The manifestation can be recorded as a single word, a word group, or a brief description. For example: nausea, skin rash.",
        "_definition": {
          "extension": [
            {
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "nl"
                },
                {
                  "url": "content",
                  "valueMarkdown": "Klinische symptomen en/of bevindingen die worden waargenomen bij of in verband worden gebracht met de ongewenste reactie. De manifestatie kan worden vastgelegd als één woord, een woordgroep of een korte beschrijving. Bijvoorbeeld: misselijkheid, huiduitslag."
                }
              ],
              "url": "http://hl7.org/fhir/StructureDefinition/translation"
            }
          ]
        },
        "alias": [
          "ManifestatieVanReactie"
        ],
        "min": 1,
        "max": "*",
        "base": {
          "path": "Reaction.manifestation",
          "min": 1,
          "max": "*"
        },
        "type": [
          {
            "code": "CodeableConcept"
          }
        ],
        "mustSupport": true,
        "binding": {
          "extension": [
            {
              "extension": [
                {
                  "url": "key",
                  "valueId": "d56b7a8a-7682-4c26-ab7a-8a76823c263a"
                },
                {
                  "url": "purpose",
                  "valueCode": "component"
                },
                {
                  "url": "valueSet",
                  "valueCanonical": "http://ig.nictiz.nl/gbb/ValueSet/2.16.840.1.113883.2.4.3.11.60.153.11.29"
                }
              ],
              "url": "http://hl7.org/fhir/tools/StructureDefinition/additional-binding"
            }
          ],
          "strength": "preferred",
          "description": "Allergy Reaction - IPS",
          "valueSet": "http://hl7.org/fhir/uv/ips/ValueSet/allergy-reaction-uv-ips"
        },
        "mapping": [
          {
            "identity": "Reaction",
            "map": "EU-11"
          }
        ]
      },
      {
        "id": "Reaction.reactionDescription",
        "extension": [
          {
            "extension": [
              {
                "url": "code",
                "valueCode": "SHOULD:populate-if-known"
              },
              {
                "url": "actor",
                "valueCanonical": "http://ig.nictiz.nl/gbb/ActorDefinition/ExchangingSystem"
              },
              {
                "url": "http://hl7.org/fhir/tools/StructureDefinition/snapshot-source",
                "valueCanonical": "http://ig.nictiz.nl/gbb/StructureDefinition/LogicalModelReaction|1.0.0-alpha.2"
              }
            ],
            "url": "http://hl7.org/fhir/StructureDefinition/obligation"
          },
          {
            "extension": [
              {
                "url": "code",
                "valueCode": "SHALL:no-error"
              },
              {
                "url": "actor",
                "valueCanonical": "http://ig.nictiz.nl/gbb/ActorDefinition/ConsumingSystem"
              },
              {
                "url": "http://hl7.org/fhir/tools/StructureDefinition/snapshot-source",
                "valueCanonical": "http://ig.nictiz.nl/gbb/StructureDefinition/LogicalModelReaction|1.0.0-alpha.2"
              }
            ],
            "url": "http://hl7.org/fhir/StructureDefinition/obligation"
          }
        ],
        "path": "Reaction.reactionDescription",
        "short": "Textual description of the response as a whole, including any details about the manifestation.",
        "_short": {
          "extension": [
            {
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "nl"
                },
                {
                  "url": "content",
                  "valueMarkdown": "Tekstuele beschrijving van de reactie als geheel, inclusief eventuele details over de manifestatie."
                }
              ],
              "url": "http://hl7.org/fhir/StructureDefinition/translation"
            }
          ]
        },
        "definition": "Textual description of the response as a whole, including any details about the manifestation.",
        "_definition": {
          "extension": [
            {
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "nl"
                },
                {
                  "url": "content",
                  "valueMarkdown": "Tekstuele beschrijving van de reactie als geheel, inclusief eventuele details over de manifestatie."
                }
              ],
              "url": "http://hl7.org/fhir/StructureDefinition/translation"
            }
          ]
        },
        "alias": [
          "ReactieBeschrijving"
        ],
        "min": 0,
        "max": "1",
        "base": {
          "path": "Reaction.reactionDescription",
          "min": 0,
          "max": "1"
        },
        "type": [
          {
            "code": "string"
          }
        ],
        "mustSupport": true,
        "mapping": [
          {
            "identity": "Reaction",
            "map": "NL-04-02"
          }
        ]
      },
      {
        "id": "Reaction.reactionDateTime",
        "extension": [
          {
            "extension": [
              {
                "url": "code",
                "valueCode": "SHALL:able-to-populate"
              },
              {
                "url": "actor",
                "valueCanonical": "http://ig.nictiz.nl/gbb/ActorDefinition/RegistrationSystem"
              },
              {
                "url": "http://hl7.org/fhir/tools/StructureDefinition/snapshot-source",
                "valueCanonical": "http://ig.nictiz.nl/gbb/StructureDefinition/LogicalModelReaction|1.0.0-alpha.2"
              }
            ],
            "url": "http://hl7.org/fhir/StructureDefinition/obligation"
          },
          {
            "extension": [
              {
                "url": "code",
                "valueCode": "SHALL:populate"
              },
              {
                "url": "actor",
                "valueCanonical": "http://ig.nictiz.nl/gbb/ActorDefinition/ExchangingSystem"
              },
              {
                "url": "http://hl7.org/fhir/tools/StructureDefinition/snapshot-source",
                "valueCanonical": "http://ig.nictiz.nl/gbb/StructureDefinition/LogicalModelReaction|1.0.0-alpha.2"
              }
            ],
            "url": "http://hl7.org/fhir/StructureDefinition/obligation"
          },
          {
            "extension": [
              {
                "url": "code",
                "valueCode": "SHALL:handle"
              },
              {
                "url": "actor",
                "valueCanonical": "http://ig.nictiz.nl/gbb/ActorDefinition/ConsumingSystem"
              },
              {
                "url": "http://hl7.org/fhir/tools/StructureDefinition/snapshot-source",
                "valueCanonical": "http://ig.nictiz.nl/gbb/StructureDefinition/LogicalModelReaction|1.0.0-alpha.2"
              }
            ],
            "url": "http://hl7.org/fhir/StructureDefinition/obligation"
          }
        ],
        "path": "Reaction.reactionDateTime",
        "short": "Date and time at which the reaction took place.",
        "_short": {
          "extension": [
            {
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "nl"
                },
                {
                  "url": "content",
                  "valueMarkdown": "Datum en tijd waarop de reactie plaats gevonden heeft."
                }
              ],
              "url": "http://hl7.org/fhir/StructureDefinition/translation"
            }
          ]
        },
        "definition": "Date and time at which the reaction took place. This may also be just the date or a partial date, in the event that the exact date is unknown.",
        "_definition": {
          "extension": [
            {
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "nl"
                },
                {
                  "url": "content",
                  "valueMarkdown": "Datum en tijd waarop de reactie plaats gevonden heeft. Dit mag ook alleen een datum of een gedeeltelijke datum zijn, indien dit niet nauwkeuriger bekend is."
                }
              ],
              "url": "http://hl7.org/fhir/StructureDefinition/translation"
            }
          ]
        },
        "alias": [
          "ReactieDatumTijd"
        ],
        "min": 0,
        "max": "1",
        "base": {
          "path": "Reaction.reactionDateTime",
          "min": 0,
          "max": "1"
        },
        "type": [
          {
            "code": "dateTime"
          }
        ],
        "mustSupport": true,
        "mapping": [
          {
            "identity": "Reaction",
            "map": "EU-13"
          }
        ]
      },
      {
        "id": "Reaction.severity",
        "extension": [
          {
            "extension": [
              {
                "url": "code",
                "valueCode": "SHOULD:populate-if-known"
              },
              {
                "url": "actor",
                "valueCanonical": "http://ig.nictiz.nl/gbb/ActorDefinition/ExchangingSystem"
              },
              {
                "url": "http://hl7.org/fhir/tools/StructureDefinition/snapshot-source",
                "valueCanonical": "http://ig.nictiz.nl/gbb/StructureDefinition/LogicalModelReaction|1.0.0-alpha.2"
              }
            ],
            "url": "http://hl7.org/fhir/StructureDefinition/obligation"
          },
          {
            "extension": [
              {
                "url": "code",
                "valueCode": "SHALL:no-error"
              },
              {
                "url": "actor",
                "valueCanonical": "http://ig.nictiz.nl/gbb/ActorDefinition/ConsumingSystem"
              },
              {
                "url": "http://hl7.org/fhir/tools/StructureDefinition/snapshot-source",
                "valueCanonical": "http://ig.nictiz.nl/gbb/StructureDefinition/LogicalModelReaction|1.0.0-alpha.2"
              }
            ],
            "url": "http://hl7.org/fhir/StructureDefinition/obligation"
          }
        ],
        "path": "Reaction.severity",
        "short": "Clinical assessment of the severity of the reaction incident as a whole, taking into account possible multiple different manifestations.",
        "_short": {
          "extension": [
            {
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "nl"
                },
                {
                  "url": "content",
                  "valueMarkdown": "Klinische beoordeling van de ernst van het reactie-incident als geheel, waarbij mogelijk meerdere verschillende manifestaties worden meegewogen."
                }
              ],
              "url": "http://hl7.org/fhir/StructureDefinition/translation"
            }
          ]
        },
        "definition": "Clinical assessment of the severity of the reaction incident as a whole, taking into account possible multiple different manifestations.",
        "_definition": {
          "extension": [
            {
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "nl"
                },
                {
                  "url": "content",
                  "valueMarkdown": "Klinische beoordeling van de ernst van het reactie-incident als geheel, waarbij mogelijk meerdere verschillende manifestaties worden meegewogen."
                }
              ],
              "url": "http://hl7.org/fhir/StructureDefinition/translation"
            }
          ]
        },
        "alias": [
          "Ernst"
        ],
        "min": 0,
        "max": "1",
        "base": {
          "path": "Reaction.severity",
          "min": 0,
          "max": "1"
        },
        "type": [
          {
            "code": "CodeableConcept"
          }
        ],
        "mustSupport": true,
        "binding": {
          "strength": "required",
          "description": "AllergyIntoleranceSeverity",
          "valueSet": "http://hl7.org/fhir/ValueSet/reaction-event-severity"
        },
        "mapping": [
          {
            "identity": "Reaction",
            "map": "EU-12"
          }
        ]
      },
      {
        "id": "Reaction.routeOfExposure",
        "extension": [
          {
            "extension": [
              {
                "url": "code",
                "valueCode": "SHOULD:populate-if-known"
              },
              {
                "url": "actor",
                "valueCanonical": "http://ig.nictiz.nl/gbb/ActorDefinition/ExchangingSystem"
              },
              {
                "url": "http://hl7.org/fhir/tools/StructureDefinition/snapshot-source",
                "valueCanonical": "http://ig.nictiz.nl/gbb/StructureDefinition/LogicalModelReaction|1.0.0-alpha.2"
              }
            ],
            "url": "http://hl7.org/fhir/StructureDefinition/obligation"
          },
          {
            "extension": [
              {
                "url": "code",
                "valueCode": "SHALL:no-error"
              },
              {
                "url": "actor",
                "valueCanonical": "http://ig.nictiz.nl/gbb/ActorDefinition/ConsumingSystem"
              },
              {
                "url": "http://hl7.org/fhir/tools/StructureDefinition/snapshot-source",
                "valueCanonical": "http://ig.nictiz.nl/gbb/StructureDefinition/LogicalModelReaction|1.0.0-alpha.2"
              }
            ],
            "url": "http://hl7.org/fhir/StructureDefinition/obligation"
          }
        ],
        "path": "Reaction.routeOfExposure",
        "short": "Manner in which the patient was exposed to the identified specific substance.",
        "_short": {
          "extension": [
            {
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "nl"
                },
                {
                  "url": "content",
                  "valueMarkdown": "Wijze waarop de patiënt is blootgesteld aan de geïdentificeerde specifieke stof."
                }
              ],
              "url": "http://hl7.org/fhir/StructureDefinition/translation"
            }
          ]
        },
        "definition": "Manner in which the patient was exposed to the identified specific substance.",
        "_definition": {
          "extension": [
            {
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "nl"
                },
                {
                  "url": "content",
                  "valueMarkdown": "Wijze waarop de patiënt is blootgesteld aan de geïdentificeerde specifieke stof."
                }
              ],
              "url": "http://hl7.org/fhir/StructureDefinition/translation"
            }
          ]
        },
        "alias": [
          "WijzeVanBlootstelling"
        ],
        "min": 0,
        "max": "1",
        "base": {
          "path": "Reaction.routeOfExposure",
          "min": 0,
          "max": "1"
        },
        "type": [
          {
            "code": "CodeableConcept"
          }
        ],
        "mustSupport": true,
        "binding": {
          "strength": "preferred",
          "description": "SNOMED CT Route Codes",
          "valueSet": "http://hl7.org/fhir/ValueSet/route-codes"
        },
        "mapping": [
          {
            "identity": "Reaction",
            "map": "NL-20"
          }
        ]
      },
      {
        "id": "Reaction.note",
        "extension": [
          {
            "extension": [
              {
                "url": "code",
                "valueCode": "SHOULD:populate-if-known"
              },
              {
                "url": "actor",
                "valueCanonical": "http://ig.nictiz.nl/gbb/ActorDefinition/ExchangingSystem"
              },
              {
                "url": "http://hl7.org/fhir/tools/StructureDefinition/snapshot-source",
                "valueCanonical": "http://ig.nictiz.nl/gbb/StructureDefinition/LogicalModelReaction|1.0.0-alpha.2"
              }
            ],
            "url": "http://hl7.org/fhir/StructureDefinition/obligation"
          },
          {
            "extension": [
              {
                "url": "code",
                "valueCode": "SHALL:no-error"
              },
              {
                "url": "actor",
                "valueCanonical": "http://ig.nictiz.nl/gbb/ActorDefinition/ConsumingSystem"
              },
              {
                "url": "http://hl7.org/fhir/tools/StructureDefinition/snapshot-source",
                "valueCanonical": "http://ig.nictiz.nl/gbb/StructureDefinition/LogicalModelReaction|1.0.0-alpha.2"
              }
            ],
            "url": "http://hl7.org/fhir/StructureDefinition/obligation"
          }
        ],
        "path": "Reaction.note",
        "short": "Textual description of the undesired reaction and/or additional information on the undesired reaction for as far as not covered in more specific fields.",
        "_short": {
          "extension": [
            {
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "nl"
                },
                {
                  "url": "content",
                  "valueMarkdown": "Tekstuele omschrijving van de reactie van de allergie of intolerantie, en/of aanvullende vrije tekst over de reactie allergie of intolerantie, voor zover deze niet in andere velden is vastgelegd."
                }
              ],
              "url": "http://hl7.org/fhir/StructureDefinition/translation"
            }
          ]
        },
        "definition": "Textual description of the undesired reaction and/or additional information on the undesired reaction for as far as not covered in more specific fields.",
        "_definition": {
          "extension": [
            {
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "nl"
                },
                {
                  "url": "content",
                  "valueMarkdown": "Tekstuele omschrijving van de reactie van de allergie of intolerantie, en/of aanvullende vrije tekst over de reactie allergie of intolerantie, voor zover deze niet in andere velden is vastgelegd."
                }
              ],
              "url": "http://hl7.org/fhir/StructureDefinition/translation"
            }
          ]
        },
        "alias": [
          "Opmerking"
        ],
        "min": 0,
        "max": "*",
        "base": {
          "path": "Reaction.note",
          "min": 0,
          "max": "*"
        },
        "type": [
          {
            "code": "string"
          }
        ],
        "mustSupport": true,
        "mapping": [
          {
            "identity": "Reaction",
            "map": "NL-04-04"
          }
        ]
      }
    ]
  },
  "differential": {
    "element": [
      {
        "id": "Reaction",
        "path": "Reaction",
        "short": "Root concept of the Reaction sub information model.",
        "_short": {
          "extension": [
            {
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "nl"
                },
                {
                  "url": "content",
                  "valueMarkdown": "Rootconcept van het subbouwblok Reactie."
                }
              ],
              "url": "http://hl7.org/fhir/StructureDefinition/translation"
            }
          ]
        },
        "definition": "Root concept of the Reaction sub information model. This root concept contains all data elements of the Reaction. This sub building block can solely be used with the general building block AllergyIntolerance.",
        "_definition": {
          "extension": [
            {
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "nl"
                },
                {
                  "url": "content",
                  "valueMarkdown": "Rootconcept van het subbouwblok Reactie. Dit rootconcept bevat alle gegevenselementen van de reactie welke horen bij het bovenliggende generieke bouwblok AllergieIntolerantie. Dit subbouwblok mag alleen gebruikt worden in combinatie met het generieke bouwblok AllergieIntolerantie."
                }
              ],
              "url": "http://hl7.org/fhir/StructureDefinition/translation"
            }
          ]
        },
        "alias": [
          "Reactie"
        ],
        "min": 0,
        "max": "*",
        "base": {
          "path": "Reaction",
          "min": 0,
          "max": "*"
        }
      },
      {
        "id": "Reaction.specificSubstance",
        "extension": [
          {
            "extension": [
              {
                "url": "code",
                "valueCode": "SHOULD:populate-if-known"
              },
              {
                "url": "actor",
                "valueCanonical": "http://ig.nictiz.nl/gbb/ActorDefinition/ExchangingSystem"
              }
            ],
            "url": "http://hl7.org/fhir/StructureDefinition/obligation"
          },
          {
            "extension": [
              {
                "url": "code",
                "valueCode": "SHALL:no-error"
              },
              {
                "url": "actor",
                "valueCanonical": "http://ig.nictiz.nl/gbb/ActorDefinition/ConsumingSystem"
              }
            ],
            "url": "http://hl7.org/fhir/StructureDefinition/obligation"
          }
        ],
        "path": "Reaction.specificSubstance",
        "short": "More specific indication of the substance that caused the reaction.",
        "_short": {
          "extension": [
            {
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "nl"
                },
                {
                  "url": "content",
                  "valueMarkdown": "Meer specifieke aanduiding van de stof die de reactie opriep."
                }
              ],
              "url": "http://hl7.org/fhir/StructureDefinition/translation"
            }
          ]
        },
        "definition": "More specific indication of the substance that caused the reaction. This can be a specific substance from a group of substances to which the patient is allergic or hypersensitive.",
        "_definition": {
          "extension": [
            {
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "nl"
                },
                {
                  "url": "content",
                  "valueMarkdown": "Meer specifieke aanduiding van de stof die de reactie opriep. Dit kan een specifieke stof uit een groep stoffen zijn waarvoor de patiënt allergisch of overgevoelig is."
                }
              ],
              "url": "http://hl7.org/fhir/StructureDefinition/translation"
            }
          ]
        },
        "alias": [
          "SpecifiekeStof"
        ],
        "min": 0,
        "max": "1",
        "base": {
          "path": "Reaction.specificSubstance",
          "min": 0,
          "max": "1"
        },
        "type": [
          {
            "code": "CodeableConcept"
          }
        ],
        "mustSupport": true,
        "binding": {
          "extension": [
            {
              "extension": [
                {
                  "url": "key",
                  "valueId": "f4bce1b1-3f43-4c10-bce1-b13f43bc10b5"
                },
                {
                  "url": "purpose",
                  "valueCode": "component"
                },
                {
                  "url": "valueSet",
                  "valueCanonical": "http://ig.nictiz.nl/gbb/ValueSet/2.16.840.1.113883.2.4.3.11.60.153.11.52"
                }
              ],
              "url": "http://hl7.org/fhir/tools/StructureDefinition/additional-binding"
            },
            {
              "extension": [
                {
                  "url": "key",
                  "valueId": "5a34bfdb-30ed-46e6-b4bf-db30ed76e616"
                },
                {
                  "url": "purpose",
                  "valueCode": "component"
                },
                {
                  "url": "valueSet",
                  "valueCanonical": "http://ig.nictiz.nl/gbb/ValueSet/2.16.840.1.113883.2.4.3.11.60.153.11.51"
                }
              ],
              "url": "http://hl7.org/fhir/tools/StructureDefinition/additional-binding"
            },
            {
              "extension": [
                {
                  "url": "key",
                  "valueId": "667977e1-d7e5-4046-b977-e1d7e510460a"
                },
                {
                  "url": "purpose",
                  "valueCode": "component"
                },
                {
                  "url": "valueSet",
                  "valueCanonical": "http://ig.nictiz.nl/gbb/ValueSet/2.16.840.1.113883.2.4.3.11.60.153.11.50"
                }
              ],
              "url": "http://hl7.org/fhir/tools/StructureDefinition/additional-binding"
            },
            {
              "extension": [
                {
                  "url": "key",
                  "valueId": "84a4b945-7226-4886-a4b9-457226c88617"
                },
                {
                  "url": "purpose",
                  "valueCode": "component"
                },
                {
                  "url": "valueSet",
                  "valueCanonical": "http://ig.nictiz.nl/gbb/ValueSet/2.16.840.1.113883.2.4.3.11.60.153.11.49"
                }
              ],
              "url": "http://hl7.org/fhir/tools/StructureDefinition/additional-binding"
            },
            {
              "extension": [
                {
                  "url": "key",
                  "valueId": "fa6f2531-75be-4b3e-af25-3175be5b3e99"
                },
                {
                  "url": "purpose",
                  "valueCode": "component"
                },
                {
                  "url": "valueSet",
                  "valueCanonical": "http://ig.nictiz.nl/gbb/ValueSet/2.16.840.1.113883.2.4.3.11.60.153.11.47"
                }
              ],
              "url": "http://hl7.org/fhir/tools/StructureDefinition/additional-binding"
            }
          ],
          "strength": "example",
          "description": "eHDSI Allergen No Drug",
          "valueSet": "http://terminology.ehdsi.eu/ValueSet/eHDSIAllergenNoDrug"
        },
        "mapping": [
          {
            "identity": "Reaction",
            "map": "EU-10"
          }
        ]
      },
      {
        "id": "Reaction.certainty",
        "extension": [
          {
            "extension": [
              {
                "url": "code",
                "valueCode": "SHOULD:populate-if-known"
              },
              {
                "url": "actor",
                "valueCanonical": "http://ig.nictiz.nl/gbb/ActorDefinition/ExchangingSystem"
              }
            ],
            "url": "http://hl7.org/fhir/StructureDefinition/obligation"
          },
          {
            "extension": [
              {
                "url": "code",
                "valueCode": "SHALL:no-error"
              },
              {
                "url": "actor",
                "valueCanonical": "http://ig.nictiz.nl/gbb/ActorDefinition/ConsumingSystem"
              }
            ],
            "url": "http://hl7.org/fhir/StructureDefinition/obligation"
          }
        ],
        "path": "Reaction.certainty",
        "short": "The level of clinical certainty that the manifestation in this reaction incident was caused by exposure to the specific substance.",
        "_short": {
          "extension": [
            {
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "nl"
                },
                {
                  "url": "content",
                  "valueMarkdown": "De mate van klinische zekerheid dat de manifestatie in dit reactie-incident werd veroorzaakt door blootstelling aan de geïdentificeerde specifieke stof."
                }
              ],
              "url": "http://hl7.org/fhir/StructureDefinition/translation"
            }
          ]
        },
        "definition": "The level of clinical certainty that the manifestation in this reaction incident was caused by exposure to the specific substance.",
        "_definition": {
          "extension": [
            {
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "nl"
                },
                {
                  "url": "content",
                  "valueMarkdown": "De mate van klinische zekerheid dat de manifestatie in dit reactie-incident werd veroorzaakt door blootstelling aan de geïdentificeerde specifieke stof."
                }
              ],
              "url": "http://hl7.org/fhir/StructureDefinition/translation"
            }
          ]
        },
        "alias": [
          "MateVanZekerheid"
        ],
        "min": 0,
        "max": "1",
        "base": {
          "path": "Reaction.certainty",
          "min": 0,
          "max": "1"
        },
        "type": [
          {
            "code": "CodeableConcept"
          }
        ],
        "mustSupport": true,
        "binding": {
          "extension": [
            {
              "extension": [
                {
                  "url": "key",
                  "valueId": "3c0c8f66-bdf9-44b8-8c8f-66bdf9f4b8af"
                },
                {
                  "url": "purpose",
                  "valueCode": "component"
                },
                {
                  "url": "valueSet",
                  "valueCanonical": "http://ig.nictiz.nl/gbb/ValueSet/2.16.840.1.113883.2.4.3.11.60.153.11.44"
                }
              ],
              "url": "http://hl7.org/fhir/tools/StructureDefinition/additional-binding"
            }
          ],
          "strength": "required",
          "description": "AllergyIntolerance Verification Status Codes",
          "valueSet": "http://hl7.org/fhir/ValueSet/allergyintolerance-verification"
        },
        "mapping": [
          {
            "identity": "Reaction",
            "map": "NL-06-02"
          }
        ]
      },
      {
        "id": "Reaction.manifestation",
        "extension": [
          {
            "extension": [
              {
                "url": "code",
                "valueCode": "SHALL:able-to-populate"
              },
              {
                "url": "actor",
                "valueCanonical": "http://ig.nictiz.nl/gbb/ActorDefinition/RegistrationSystem"
              }
            ],
            "url": "http://hl7.org/fhir/StructureDefinition/obligation"
          },
          {
            "extension": [
              {
                "url": "code",
                "valueCode": "SHALL:populate"
              },
              {
                "url": "actor",
                "valueCanonical": "http://ig.nictiz.nl/gbb/ActorDefinition/ExchangingSystem"
              }
            ],
            "url": "http://hl7.org/fhir/StructureDefinition/obligation"
          },
          {
            "extension": [
              {
                "url": "code",
                "valueCode": "SHALL:handle"
              },
              {
                "url": "actor",
                "valueCanonical": "http://ig.nictiz.nl/gbb/ActorDefinition/ConsumingSystem"
              }
            ],
            "url": "http://hl7.org/fhir/StructureDefinition/obligation"
          }
        ],
        "path": "Reaction.manifestation",
        "short": "Clinical symptoms and/or findings observed with or associated with the adverse reaction.",
        "_short": {
          "extension": [
            {
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "nl"
                },
                {
                  "url": "content",
                  "valueMarkdown": "Klinische symptomen en/of bevindingen die worden waargenomen bij of in verband worden gebracht met de ongewenste reactie."
                }
              ],
              "url": "http://hl7.org/fhir/StructureDefinition/translation"
            }
          ]
        },
        "definition": "Clinical symptoms and/or findings observed with or associated with the adverse reaction. The manifestation can be recorded as a single word, a word group, or a brief description. For example: nausea, skin rash.",
        "_definition": {
          "extension": [
            {
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "nl"
                },
                {
                  "url": "content",
                  "valueMarkdown": "Klinische symptomen en/of bevindingen die worden waargenomen bij of in verband worden gebracht met de ongewenste reactie. De manifestatie kan worden vastgelegd als één woord, een woordgroep of een korte beschrijving. Bijvoorbeeld: misselijkheid, huiduitslag."
                }
              ],
              "url": "http://hl7.org/fhir/StructureDefinition/translation"
            }
          ]
        },
        "alias": [
          "ManifestatieVanReactie"
        ],
        "min": 1,
        "max": "*",
        "base": {
          "path": "Reaction.manifestation",
          "min": 1,
          "max": "*"
        },
        "type": [
          {
            "code": "CodeableConcept"
          }
        ],
        "mustSupport": true,
        "binding": {
          "extension": [
            {
              "extension": [
                {
                  "url": "key",
                  "valueId": "d56b7a8a-7682-4c26-ab7a-8a76823c263a"
                },
                {
                  "url": "purpose",
                  "valueCode": "component"
                },
                {
                  "url": "valueSet",
                  "valueCanonical": "http://ig.nictiz.nl/gbb/ValueSet/2.16.840.1.113883.2.4.3.11.60.153.11.29"
                }
              ],
              "url": "http://hl7.org/fhir/tools/StructureDefinition/additional-binding"
            }
          ],
          "strength": "preferred",
          "description": "Allergy Reaction - IPS",
          "valueSet": "http://hl7.org/fhir/uv/ips/ValueSet/allergy-reaction-uv-ips"
        },
        "mapping": [
          {
            "identity": "Reaction",
            "map": "EU-11"
          }
        ]
      },
      {
        "id": "Reaction.reactionDescription",
        "extension": [
          {
            "extension": [
              {
                "url": "code",
                "valueCode": "SHOULD:populate-if-known"
              },
              {
                "url": "actor",
                "valueCanonical": "http://ig.nictiz.nl/gbb/ActorDefinition/ExchangingSystem"
              }
            ],
            "url": "http://hl7.org/fhir/StructureDefinition/obligation"
          },
          {
            "extension": [
              {
                "url": "code",
                "valueCode": "SHALL:no-error"
              },
              {
                "url": "actor",
                "valueCanonical": "http://ig.nictiz.nl/gbb/ActorDefinition/ConsumingSystem"
              }
            ],
            "url": "http://hl7.org/fhir/StructureDefinition/obligation"
          }
        ],
        "path": "Reaction.reactionDescription",
        "short": "Textual description of the response as a whole, including any details about the manifestation.",
        "_short": {
          "extension": [
            {
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "nl"
                },
                {
                  "url": "content",
                  "valueMarkdown": "Tekstuele beschrijving van de reactie als geheel, inclusief eventuele details over de manifestatie."
                }
              ],
              "url": "http://hl7.org/fhir/StructureDefinition/translation"
            }
          ]
        },
        "definition": "Textual description of the response as a whole, including any details about the manifestation.",
        "_definition": {
          "extension": [
            {
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "nl"
                },
                {
                  "url": "content",
                  "valueMarkdown": "Tekstuele beschrijving van de reactie als geheel, inclusief eventuele details over de manifestatie."
                }
              ],
              "url": "http://hl7.org/fhir/StructureDefinition/translation"
            }
          ]
        },
        "alias": [
          "ReactieBeschrijving"
        ],
        "min": 0,
        "max": "1",
        "base": {
          "path": "Reaction.reactionDescription",
          "min": 0,
          "max": "1"
        },
        "type": [
          {
            "code": "string"
          }
        ],
        "mustSupport": true,
        "mapping": [
          {
            "identity": "Reaction",
            "map": "NL-04-02"
          }
        ]
      },
      {
        "id": "Reaction.reactionDateTime",
        "extension": [
          {
            "extension": [
              {
                "url": "code",
                "valueCode": "SHALL:able-to-populate"
              },
              {
                "url": "actor",
                "valueCanonical": "http://ig.nictiz.nl/gbb/ActorDefinition/RegistrationSystem"
              }
            ],
            "url": "http://hl7.org/fhir/StructureDefinition/obligation"
          },
          {
            "extension": [
              {
                "url": "code",
                "valueCode": "SHALL:populate"
              },
              {
                "url": "actor",
                "valueCanonical": "http://ig.nictiz.nl/gbb/ActorDefinition/ExchangingSystem"
              }
            ],
            "url": "http://hl7.org/fhir/StructureDefinition/obligation"
          },
          {
            "extension": [
              {
                "url": "code",
                "valueCode": "SHALL:handle"
              },
              {
                "url": "actor",
                "valueCanonical": "http://ig.nictiz.nl/gbb/ActorDefinition/ConsumingSystem"
              }
            ],
            "url": "http://hl7.org/fhir/StructureDefinition/obligation"
          }
        ],
        "path": "Reaction.reactionDateTime",
        "short": "Date and time at which the reaction took place.",
        "_short": {
          "extension": [
            {
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "nl"
                },
                {
                  "url": "content",
                  "valueMarkdown": "Datum en tijd waarop de reactie plaats gevonden heeft."
                }
              ],
              "url": "http://hl7.org/fhir/StructureDefinition/translation"
            }
          ]
        },
        "definition": "Date and time at which the reaction took place. This may also be just the date or a partial date, in the event that the exact date is unknown.",
        "_definition": {
          "extension": [
            {
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "nl"
                },
                {
                  "url": "content",
                  "valueMarkdown": "Datum en tijd waarop de reactie plaats gevonden heeft. Dit mag ook alleen een datum of een gedeeltelijke datum zijn, indien dit niet nauwkeuriger bekend is."
                }
              ],
              "url": "http://hl7.org/fhir/StructureDefinition/translation"
            }
          ]
        },
        "alias": [
          "ReactieDatumTijd"
        ],
        "min": 0,
        "max": "1",
        "base": {
          "path": "Reaction.reactionDateTime",
          "min": 0,
          "max": "1"
        },
        "type": [
          {
            "code": "dateTime"
          }
        ],
        "mustSupport": true,
        "mapping": [
          {
            "identity": "Reaction",
            "map": "EU-13"
          }
        ]
      },
      {
        "id": "Reaction.severity",
        "extension": [
          {
            "extension": [
              {
                "url": "code",
                "valueCode": "SHOULD:populate-if-known"
              },
              {
                "url": "actor",
                "valueCanonical": "http://ig.nictiz.nl/gbb/ActorDefinition/ExchangingSystem"
              }
            ],
            "url": "http://hl7.org/fhir/StructureDefinition/obligation"
          },
          {
            "extension": [
              {
                "url": "code",
                "valueCode": "SHALL:no-error"
              },
              {
                "url": "actor",
                "valueCanonical": "http://ig.nictiz.nl/gbb/ActorDefinition/ConsumingSystem"
              }
            ],
            "url": "http://hl7.org/fhir/StructureDefinition/obligation"
          }
        ],
        "path": "Reaction.severity",
        "short": "Clinical assessment of the severity of the reaction incident as a whole, taking into account possible multiple different manifestations.",
        "_short": {
          "extension": [
            {
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "nl"
                },
                {
                  "url": "content",
                  "valueMarkdown": "Klinische beoordeling van de ernst van het reactie-incident als geheel, waarbij mogelijk meerdere verschillende manifestaties worden meegewogen."
                }
              ],
              "url": "http://hl7.org/fhir/StructureDefinition/translation"
            }
          ]
        },
        "definition": "Clinical assessment of the severity of the reaction incident as a whole, taking into account possible multiple different manifestations.",
        "_definition": {
          "extension": [
            {
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "nl"
                },
                {
                  "url": "content",
                  "valueMarkdown": "Klinische beoordeling van de ernst van het reactie-incident als geheel, waarbij mogelijk meerdere verschillende manifestaties worden meegewogen."
                }
              ],
              "url": "http://hl7.org/fhir/StructureDefinition/translation"
            }
          ]
        },
        "alias": [
          "Ernst"
        ],
        "min": 0,
        "max": "1",
        "base": {
          "path": "Reaction.severity",
          "min": 0,
          "max": "1"
        },
        "type": [
          {
            "code": "CodeableConcept"
          }
        ],
        "mustSupport": true,
        "binding": {
          "strength": "required",
          "description": "AllergyIntoleranceSeverity",
          "valueSet": "http://hl7.org/fhir/ValueSet/reaction-event-severity"
        },
        "mapping": [
          {
            "identity": "Reaction",
            "map": "EU-12"
          }
        ]
      },
      {
        "id": "Reaction.routeOfExposure",
        "extension": [
          {
            "extension": [
              {
                "url": "code",
                "valueCode": "SHOULD:populate-if-known"
              },
              {
                "url": "actor",
                "valueCanonical": "http://ig.nictiz.nl/gbb/ActorDefinition/ExchangingSystem"
              }
            ],
            "url": "http://hl7.org/fhir/StructureDefinition/obligation"
          },
          {
            "extension": [
              {
                "url": "code",
                "valueCode": "SHALL:no-error"
              },
              {
                "url": "actor",
                "valueCanonical": "http://ig.nictiz.nl/gbb/ActorDefinition/ConsumingSystem"
              }
            ],
            "url": "http://hl7.org/fhir/StructureDefinition/obligation"
          }
        ],
        "path": "Reaction.routeOfExposure",
        "short": "Manner in which the patient was exposed to the identified specific substance.",
        "_short": {
          "extension": [
            {
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "nl"
                },
                {
                  "url": "content",
                  "valueMarkdown": "Wijze waarop de patiënt is blootgesteld aan de geïdentificeerde specifieke stof."
                }
              ],
              "url": "http://hl7.org/fhir/StructureDefinition/translation"
            }
          ]
        },
        "definition": "Manner in which the patient was exposed to the identified specific substance.",
        "_definition": {
          "extension": [
            {
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "nl"
                },
                {
                  "url": "content",
                  "valueMarkdown": "Wijze waarop de patiënt is blootgesteld aan de geïdentificeerde specifieke stof."
                }
              ],
              "url": "http://hl7.org/fhir/StructureDefinition/translation"
            }
          ]
        },
        "alias": [
          "WijzeVanBlootstelling"
        ],
        "min": 0,
        "max": "1",
        "base": {
          "path": "Reaction.routeOfExposure",
          "min": 0,
          "max": "1"
        },
        "type": [
          {
            "code": "CodeableConcept"
          }
        ],
        "mustSupport": true,
        "binding": {
          "strength": "preferred",
          "description": "SNOMED CT Route Codes",
          "valueSet": "http://hl7.org/fhir/ValueSet/route-codes"
        },
        "mapping": [
          {
            "identity": "Reaction",
            "map": "NL-20"
          }
        ]
      },
      {
        "id": "Reaction.note",
        "extension": [
          {
            "extension": [
              {
                "url": "code",
                "valueCode": "SHOULD:populate-if-known"
              },
              {
                "url": "actor",
                "valueCanonical": "http://ig.nictiz.nl/gbb/ActorDefinition/ExchangingSystem"
              }
            ],
            "url": "http://hl7.org/fhir/StructureDefinition/obligation"
          },
          {
            "extension": [
              {
                "url": "code",
                "valueCode": "SHALL:no-error"
              },
              {
                "url": "actor",
                "valueCanonical": "http://ig.nictiz.nl/gbb/ActorDefinition/ConsumingSystem"
              }
            ],
            "url": "http://hl7.org/fhir/StructureDefinition/obligation"
          }
        ],
        "path": "Reaction.note",
        "short": "Textual description of the undesired reaction and/or additional information on the undesired reaction for as far as not covered in more specific fields.",
        "_short": {
          "extension": [
            {
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "nl"
                },
                {
                  "url": "content",
                  "valueMarkdown": "Tekstuele omschrijving van de reactie van de allergie of intolerantie, en/of aanvullende vrije tekst over de reactie allergie of intolerantie, voor zover deze niet in andere velden is vastgelegd."
                }
              ],
              "url": "http://hl7.org/fhir/StructureDefinition/translation"
            }
          ]
        },
        "definition": "Textual description of the undesired reaction and/or additional information on the undesired reaction for as far as not covered in more specific fields.",
        "_definition": {
          "extension": [
            {
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "nl"
                },
                {
                  "url": "content",
                  "valueMarkdown": "Tekstuele omschrijving van de reactie van de allergie of intolerantie, en/of aanvullende vrije tekst over de reactie allergie of intolerantie, voor zover deze niet in andere velden is vastgelegd."
                }
              ],
              "url": "http://hl7.org/fhir/StructureDefinition/translation"
            }
          ]
        },
        "alias": [
          "Opmerking"
        ],
        "min": 0,
        "max": "*",
        "base": {
          "path": "Reaction.note",
          "min": 0,
          "max": "*"
        },
        "type": [
          {
            "code": "string"
          }
        ],
        "mustSupport": true,
        "mapping": [
          {
            "identity": "Reaction",
            "map": "NL-04-04"
          }
        ]
      }
    ]
  }
}