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Source1

{
  "resourceType": "Observation",
  "id": "observation-her2-fish-example",
  "meta": {
    "profile": [
      "https://hl7.lt/fhir/lab/StructureDefinition/her2-fish-observation-lt-lab"
    ]
  },
  "language": "en",
  "text": {
    "status": "generated",
    "div": "<!-- snip (see above) -->"
  },
  "status": "final",
  "code": {
    "coding": [
      {
        "system": "http://loinc.org",
        "code": "31150-6",
        "display": "ERBB2 gene duplication [Presence] in Tissue by FISH"
      }
    ]
  },
  "subject": {
    "reference": "Patient/patient-example"
  },
  "effectiveDateTime": "2025-01-20T14:00:00+02:00",
  "performer": [
    {
      "reference": "Practitioner/practitioner-example"
    }
  ],
  "method": {
    "text": "FISH"
  },
  "specimen": {
    "reference": "Specimen/specimen-right-breast-example"
  },
  "component": [
    {
      "code": {
        "coding": [
          {
            "system": "http://loinc.org",
            "code": "85318-4",
            "display": "ERBB2 gene duplication [Presence] in Breast cancer specimen by FISH"
          }
        ]
      },
      "valueQuantity": {
        "value": 2.1,
        "unit": "copies/nucleus",
        "system": "http://unitsofmeasure.org",
        "code": "{copies}/nucleus"
      }
    },
    {
      "code": {
        "coding": [
          {
            "system": "http://loinc.org",
            "code": "85319-2",
            "display": "HER2 [Presence] in Breast cancer specimen by Immune stain"
          }
        ]
      },
      "valueQuantity": {
        "value": 1.8,
        "unit": "copies/nucleus",
        "system": "http://unitsofmeasure.org",
        "code": "{copies}/nucleus"
      }
    },
    {
      "code": {
        "coding": [
          {
            "system": "http://loinc.org",
            "code": "49683-6",
            "display": "ERBB2 gene copy number/Chromosome 17 copy number in Tissue by FISH"
          }
        ]
      },
      "valueQuantity": {
        "value": 1.17,
        "unit": "ratio",
        "system": "http://unitsofmeasure.org",
        "code": "{ratio}"
      }
    },
    {
      "code": {
        "coding": [
          {
            "system": "http://loinc.org",
            "code": "85320-0",
            "display": "Foci [Type] in Breast cancer specimen by Light microscopy"
          }
        ]
      },
      "valueCodeableConcept": {
        "coding": [
          {
            "system": "https://tx.hl7.lt/fhir/CodeSystem/her2-fish-result",
            "code": "negative",
            "display": "Negative (HER2<4, HER2/CEP17<2)"
          }
        ]
      }
    }
  ]
}