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Packagehl7.fhir.uv.xver-r4b.r3
Resource TypeStructureDefinition
IdStructureDefinition-ext-R4B-SubstanceDefinition.relationship.json
FHIR VersionR3
Sourcehttp://hl7.org/fhir/uv/xver-r4b.r3/0.1.0/StructureDefinition-ext-R4B-SubstanceDefinition.relationship.html
URLhttp://hl7.org/fhir/4.3/StructureDefinition/extension-SubstanceDefinition.relationship
Version0.1.0
Statusactive
Date2026-03-17T21:02:03.8104715+00:00
NameExtensionSubstanceDefinition_Relationship
TitleR4B: A link between this substance and another (new)
Realmuv
Authorityhl7
DescriptionR4B: `SubstanceDefinition.relationship` (new:BackboneElement)
PurposeThis extension is part of the cross-version definitions generated to enable use of the element `SubstanceDefinition.relationship` as defined in FHIR R4B in FHIR STU3. The source element is defined as: `SubstanceDefinition.relationship` 0..* `BackboneElement` Across FHIR versions, the element set has been mapped as: * R4B: `SubstanceDefinition.relationship` 0..* `BackboneElement` Following are the generation technical comments: Element `SubstanceDefinition.relationship` is not mapped to FHIR STU3, since FHIR R4B `SubstanceDefinition` is not mapped. Element `SubstanceDefinition.relationship` has no mapping targets in FHIR STU3. Typically, this is because the element has been added (is a new element).
TypeExtension
Kindcomplex-type

Resources that use this resource

ConceptMap
hl7.fhir.uv.xver-r4b.r3#0.1.0R4B-SubstanceDefinition-element-map-to-R3Cross-version mapping for FHIR R4B SubstanceDefinition to FHIR STU3 Basic

Resources that this resource uses

StructureDefinition
hl7.fhir.uv.xver-r4b.r5#0.1.0profile-DocumentReferenceCross-version Profile for R4B.DocumentReference for use in FHIR R5
hl7.fhir.uv.xver-r4b.r5#0.1.0profile-SubstanceDefinitionCross-version Profile for R4B.SubstanceDefinition for use in FHIR R5
ValueSet
hl7.fhir.uv.xver-r4b.r3#0.1.0R4B-substance-amount-type-for-R3Cross-version ValueSet R4B.SubstanceAmountType for use in FHIR STU3
hl7.fhir.uv.xver-r4b.r3#0.1.0R4B-substance-relationship-type-for-R3Cross-version ValueSet R4B.SubstanceRelationshipType for use in FHIR STU3

Examples of Use for Extension

No extension usage examples found


Narrative

Note: links and images are rebased to the (stated) source

Generated Narrative: StructureDefinition ext-R4B-SubstanceDefinition.relationship

NameFlagsCard.TypeDescription & Constraintsdoco
.. Extension 0..*ExtensionR4B: A link between this substance and another (new)
... Slices for extension 1..*ExtensionExtension
Slice: Unordered, Open by value:url
.... extension:substanceDefinition 0..1ExtensionR4B: A pointer to another substance, as a resource or a representational code (new)
..... url 1..1uri"substanceDefinition"
..... value[x] 0..1A pointer to another substance, as a resource or a representational code
...... valueReferenceReference(Cross-version Profile for R4B.SubstanceDefinition for use in FHIR STU3(0.1.0) | Basic)
...... valueCodeableConceptCodeableConcept
.... extension:type 1..1ExtensionR4B: For example "salt to parent", "active moiety" (new)
..... url 1..1uri"type"
..... value[x] 1..1CodeableConceptFor example "salt to parent", "active moiety"
Binding: R4BSubstanceRelationshipTypeForR3 (0.1.0) (example): The relationship between two substance types.
.... extension:isDefining 0..1ExtensionR4B: For example where an enzyme strongly bonds with a particular substance, this is a defining relationship for that enzyme, out of several possible relationships (new)
..... url 1..1uri"isDefining"
..... value[x] 0..1booleanFor example where an enzyme strongly bonds with a particular substance, this is a defining relationship for that enzyme, out of several possible relationships
.... extension:amount 0..1ExtensionR4B: A numeric factor for the relationship, e.g. that a substance salt has some percentage of active substance in relation to some other (new)
..... url 1..1uri"amount"
..... value[x] 0..1A numeric factor for the relationship, e.g. that a substance salt has some percentage of active substance in relation to some other
...... valueQuantityQuantity
...... valueRatioRatio
...... valueStringstring
.... extension:ratioHighLimitAmount 0..1ExtensionR4B: For use when the numeric has an uncertain range (new)
..... url 1..1uri"ratioHighLimitAmount"
..... value[x] 0..1RatioFor use when the numeric has an uncertain range
.... extension:comparator 0..1ExtensionR4B: An operator for the amount, for example "average", "approximately", "less than" (new)
..... url 1..1uri"comparator"
..... value[x] 0..1CodeableConceptAn operator for the amount, for example "average", "approximately", "less than"
Binding: R4BSubstanceAmountTypeForR3 (0.1.0) (example): The relationship between two substance types.
.... extension:source 0..*ExtensionR4B: Supporting literature (new)
..... url 1..1uri"source"
..... value[x] 0..1Reference(Cross-version Profile for R4B.DocumentReference for use in FHIR STU3(0.1.0) | DocumentReference)Supporting literature
... url 1..1uri"http://hl7.org/fhir/4.3/StructureDefinition/extension-SubstanceDefinition.relationship"
... value[x] 0..0Value of extension

doco Documentation for this format

Source1

{
  "resourceType": "StructureDefinition",
  "id": "ext-R4B-SubstanceDefinition.relationship",
  "text": {
    "status": "extensions",
    "div": "<!-- snip (see above) -->"
  },
  "extension": [
    {
      "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-wg",
      "valueCode": "fhir"
    },
    {
      "extension": [
        {
          "url": "packageId",
          "valueId": "hl7.fhir.uv.xver-r4b.r3"
        },
        {
          "url": "version",
          "valueString": "0.1.0"
        },
        {
          "url": "uri",
          "valueUri": "http://hl7.org/fhir/uv/xver/ImplementationGuide/hl7.fhir.uv.xver-r4b.r3"
        }
      ],
      "url": "http://hl7.org/fhir/StructureDefinition/package-source"
    },
    {
      "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fmm",
      "valueInteger": 0,
      "_valueInteger": {
        "extension": [
          {
            "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-conformance-derivedFrom",
            "valueUri": "http://hl7.org/fhir/uv/xver/ImplementationGuide/hl7.fhir.uv.xver-r4b.r3"
          }
        ]
      }
    },
    {
      "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-standards-status",
      "valueCode": "trial-use",
      "_valueCode": {
        "extension": [
          {
            "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-conformance-derivedFrom",
            "valueUri": "http://hl7.org/fhir/uv/xver/ImplementationGuide/hl7.fhir.uv.xver-r4b.r3"
          }
        ]
      }
    }
  ],
  "url": "http://hl7.org/fhir/4.3/StructureDefinition/extension-SubstanceDefinition.relationship",
  "version": "0.1.0",
  "name": "ExtensionSubstanceDefinition_Relationship",
  "title": "R4B: A link between this substance and another (new)",
  "status": "active",
  "experimental": false,
  "date": "2026-03-17T21:02:03.8104715+00:00",
  "publisher": "FHIR Infrastructure",
  "contact": [
    {
      "name": "FHIR Infrastructure",
      "telecom": [
        {
          "system": "url",
          "value": "http://www.hl7.org/Special/committees/fiwg"
        }
      ]
    }
  ],
  "description": "R4B: `SubstanceDefinition.relationship` (new:BackboneElement)",
  "jurisdiction": [
    {
      "coding": [
        {
          "system": "http://unstats.un.org/unsd/methods/m49/m49.htm",
          "code": "001",
          "display": "World"
        }
      ]
    }
  ],
  "purpose": "This extension is part of the cross-version definitions generated to enable use of the\r\nelement `SubstanceDefinition.relationship` as defined in FHIR R4B\r\nin FHIR STU3.\r\n\r\nThe source element is defined as:\r\n`SubstanceDefinition.relationship` 0..* `BackboneElement`\r\n\r\nAcross FHIR versions, the element set has been mapped as:\r\n*  R4B: `SubstanceDefinition.relationship` 0..* `BackboneElement`\r\n\r\nFollowing are the generation technical comments:\r\nElement `SubstanceDefinition.relationship` is not mapped to FHIR STU3, since FHIR R4B `SubstanceDefinition` is not mapped.\nElement `SubstanceDefinition.relationship` has no mapping targets in FHIR STU3. Typically, this is because the element has been added (is a new element).",
  "fhirVersion": "3.0.2",
  "mapping": [
    {
      "identity": "rim",
      "uri": "http://hl7.org/v3",
      "name": "RIM Mapping"
    }
  ],
  "kind": "complex-type",
  "abstract": false,
  "contextType": "resource",
  "context": [
    "Basic"
  ],
  "type": "Extension",
  "baseDefinition": "http://hl7.org/fhir/StructureDefinition/Extension",
  "derivation": "constraint",
  "snapshot": {
    "element": [
      {
        "id": "Extension",
        "path": "Extension",
        "short": "R4B: A link between this substance and another (new)",
        "definition": "R4B: `SubstanceDefinition.relationship` (new:BackboneElement)",
        "comment": "Element `SubstanceDefinition.relationship` is not mapped to FHIR STU3, since FHIR R4B `SubstanceDefinition` is not mapped.\nElement `SubstanceDefinition.relationship` has no mapping targets in FHIR STU3. Typically, this is because the element has been added (is a new element).",
        "min": 0,
        "max": "*",
        "base": {
          "path": "Extension",
          "min": 0,
          "max": "*"
        },
        "condition": [
          "ele-1"
        ],
        "constraint": [
          {
            "key": "ele-1",
            "severity": "error",
            "human": "All FHIR elements must have a @value or children",
            "expression": "hasValue() | (children().count() > id.count())",
            "xpath": "@value|f:*|h:div",
            "source": "http://hl7.org/fhir/StructureDefinition/Element"
          },
          {
            "key": "ext-1",
            "severity": "error",
            "human": "Must have either extensions or value[x], not both",
            "expression": "extension.exists() != value.exists()",
            "xpath": "exists(f:extension)!=exists(f:*[starts-with(local-name(.), 'value')])",
            "source": "http://hl7.org/fhir/StructureDefinition/Extension"
          }
        ],
        "isModifier": false
      },
      {
        "id": "Extension.id",
        "path": "Extension.id",
        "representation": [
          "xmlAttr"
        ],
        "short": "xml:id (or equivalent in JSON)",
        "definition": "unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
        "min": 0,
        "max": "1",
        "base": {
          "path": "Element.id",
          "min": 0,
          "max": "1"
        },
        "type": [
          {
            "code": "string"
          }
        ],
        "mapping": [
          {
            "identity": "rim",
            "map": "n/a"
          }
        ]
      },
      {
        "id": "Extension.extension",
        "path": "Extension.extension",
        "slicing": {
          "discriminator": [
            {
              "type": "value",
              "path": "url"
            }
          ],
          "description": "Extensions are always sliced by (at least) url",
          "ordered": false,
          "rules": "open"
        },
        "short": "Extension",
        "definition": "An Extension",
        "min": 1,
        "max": "*",
        "base": {
          "path": "Element.extension",
          "min": 0,
          "max": "*"
        },
        "type": [
          {
            "code": "Extension"
          }
        ]
      },
      {
        "id": "Extension.extension:substanceDefinition",
        "path": "Extension.extension",
        "sliceName": "substanceDefinition",
        "short": "R4B: A pointer to another substance, as a resource or a representational code (new)",
        "definition": "R4B: `SubstanceDefinition.relationship.substanceDefinition[x]` (new:CodeableConcept, Reference(SubstanceDefinition))",
        "comment": "Element `SubstanceDefinition.relationship.substanceDefinition[x]` is part of an existing definition because parent element `SubstanceDefinition.relationship` requires a cross-version extension.\nElement `SubstanceDefinition.relationship.substanceDefinition[x]` is not mapped to FHIR STU3, since FHIR R4B `SubstanceDefinition` is not mapped.\nElement `SubstanceDefinition.relationship.substanceDefinition[x]` has no mapping targets in FHIR STU3. Typically, this is because the element has been added (is a new element).",
        "requirements": "Element `SubstanceDefinition.relationship.substanceDefinition[x]` is part of an existing definition because parent element `SubstanceDefinition.relationship` requires a cross-version extension.\nElement `SubstanceDefinition.relationship.substanceDefinition[x]` is not mapped to FHIR STU3, since FHIR R4B `SubstanceDefinition` is not mapped.\nElement `SubstanceDefinition.relationship.substanceDefinition[x]` has no mapping targets in FHIR STU3. Typically, this is because the element has been added (is a new element).",
        "min": 0,
        "max": "1",
        "base": {
          "path": "Element.extension",
          "min": 0,
          "max": "*"
        },
        "type": [
          {
            "code": "Extension"
          }
        ]
      },
      {
        "id": "Extension.extension:substanceDefinition.id",
        "path": "Extension.extension.id",
        "representation": [
          "xmlAttr"
        ],
        "short": "xml:id (or equivalent in JSON)",
        "definition": "unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
        "min": 0,
        "max": "1",
        "base": {
          "path": "Element.id",
          "min": 0,
          "max": "1"
        },
        "type": [
          {
            "code": "string"
          }
        ],
        "mapping": [
          {
            "identity": "rim",
            "map": "n/a"
          }
        ]
      },
      {
        "id": "Extension.extension:substanceDefinition.extension",
        "path": "Extension.extension.extension",
        "slicing": {
          "discriminator": [
            {
              "type": "value",
              "path": "url"
            }
          ],
          "description": "Extensions are always sliced by (at least) url",
          "rules": "open"
        },
        "short": "Additional Content defined by implementations",
        "definition": "May be used to represent additional information that is not part of the basic definition of the element. In order to make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer is allowed to define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
        "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
        "alias": [
          "extensions",
          "user content"
        ],
        "min": 0,
        "max": "*",
        "base": {
          "path": "Element.extension",
          "min": 0,
          "max": "*"
        },
        "type": [
          {
            "code": "Extension"
          }
        ],
        "mapping": [
          {
            "identity": "rim",
            "map": "n/a"
          }
        ]
      },
      {
        "id": "Extension.extension:substanceDefinition.url",
        "path": "Extension.extension.url",
        "representation": [
          "xmlAttr"
        ],
        "short": "identifies the meaning of the extension",
        "definition": "Source of the definition for the extension code - a logical name or a URL.",
        "comment": "The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.",
        "min": 1,
        "max": "1",
        "base": {
          "path": "Extension.url",
          "min": 1,
          "max": "1"
        },
        "type": [
          {
            "code": "uri"
          }
        ],
        "fixedUri": "substanceDefinition",
        "mapping": [
          {
            "identity": "rim",
            "map": "N/A"
          }
        ]
      },
      {
        "id": "Extension.extension:substanceDefinition.value[x]",
        "path": "Extension.extension.value[x]",
        "short": "A pointer to another substance, as a resource or a representational code",
        "definition": "A pointer to another substance, as a resource or just a representational code.",
        "min": 0,
        "max": "1",
        "base": {
          "path": "Extension.value[x]",
          "min": 0,
          "max": "1"
        },
        "type": [
          {
            "code": "Reference",
            "targetProfile": "http://hl7.org/fhir/4.3/StructureDefinition/profile-SubstanceDefinition|0.1.0"
          },
          {
            "code": "Reference",
            "targetProfile": "http://hl7.org/fhir/StructureDefinition/Basic"
          },
          {
            "code": "CodeableConcept"
          }
        ],
        "mapping": [
          {
            "identity": "rim",
            "map": "N/A"
          }
        ]
      },
      {
        "id": "Extension.extension:type",
        "path": "Extension.extension",
        "sliceName": "type",
        "short": "R4B: For example \"salt to parent\", \"active moiety\" (new)",
        "definition": "R4B: `SubstanceDefinition.relationship.type` (new:CodeableConcept)",
        "comment": "Element `SubstanceDefinition.relationship.type` is part of an existing definition because parent element `SubstanceDefinition.relationship` requires a cross-version extension.\nElement `SubstanceDefinition.relationship.type` is not mapped to FHIR STU3, since FHIR R4B `SubstanceDefinition` is not mapped.\nElement `SubstanceDefinition.relationship.type` has no mapping targets in FHIR STU3. Typically, this is because the element has been added (is a new element).",
        "requirements": "Element `SubstanceDefinition.relationship.type` is part of an existing definition because parent element `SubstanceDefinition.relationship` requires a cross-version extension.\nElement `SubstanceDefinition.relationship.type` is not mapped to FHIR STU3, since FHIR R4B `SubstanceDefinition` is not mapped.\nElement `SubstanceDefinition.relationship.type` has no mapping targets in FHIR STU3. Typically, this is because the element has been added (is a new element).",
        "min": 1,
        "max": "1",
        "base": {
          "path": "Element.extension",
          "min": 0,
          "max": "*"
        },
        "type": [
          {
            "code": "Extension"
          }
        ]
      },
      {
        "id": "Extension.extension:type.id",
        "path": "Extension.extension.id",
        "representation": [
          "xmlAttr"
        ],
        "short": "xml:id (or equivalent in JSON)",
        "definition": "unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
        "min": 0,
        "max": "1",
        "base": {
          "path": "Element.id",
          "min": 0,
          "max": "1"
        },
        "type": [
          {
            "code": "string"
          }
        ],
        "mapping": [
          {
            "identity": "rim",
            "map": "n/a"
          }
        ]
      },
      {
        "id": "Extension.extension:type.extension",
        "path": "Extension.extension.extension",
        "slicing": {
          "discriminator": [
            {
              "type": "value",
              "path": "url"
            }
          ],
          "description": "Extensions are always sliced by (at least) url",
          "rules": "open"
        },
        "short": "Additional Content defined by implementations",
        "definition": "May be used to represent additional information that is not part of the basic definition of the element. In order to make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer is allowed to define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
        "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
        "alias": [
          "extensions",
          "user content"
        ],
        "min": 0,
        "max": "*",
        "base": {
          "path": "Element.extension",
          "min": 0,
          "max": "*"
        },
        "type": [
          {
            "code": "Extension"
          }
        ],
        "mapping": [
          {
            "identity": "rim",
            "map": "n/a"
          }
        ]
      },
      {
        "id": "Extension.extension:type.url",
        "path": "Extension.extension.url",
        "representation": [
          "xmlAttr"
        ],
        "short": "identifies the meaning of the extension",
        "definition": "Source of the definition for the extension code - a logical name or a URL.",
        "comment": "The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.",
        "min": 1,
        "max": "1",
        "base": {
          "path": "Extension.url",
          "min": 1,
          "max": "1"
        },
        "type": [
          {
            "code": "uri"
          }
        ],
        "fixedUri": "type",
        "mapping": [
          {
            "identity": "rim",
            "map": "N/A"
          }
        ]
      },
      {
        "id": "Extension.extension:type.value[x]",
        "path": "Extension.extension.value[x]",
        "short": "For example \"salt to parent\", \"active moiety\"",
        "definition": "For example \"salt to parent\", \"active moiety\", \"starting material\", \"polymorph\", \"impurity of\".",
        "min": 1,
        "max": "1",
        "base": {
          "path": "Extension.value[x]",
          "min": 0,
          "max": "1"
        },
        "type": [
          {
            "code": "CodeableConcept"
          }
        ],
        "binding": {
          "strength": "example",
          "description": "The relationship between two substance types.",
          "valueSetUri": "http://hl7.org/fhir/uv/xver/ValueSet/R4B-substance-relationship-type-for-R3|0.1.0"
        },
        "mapping": [
          {
            "identity": "rim",
            "map": "N/A"
          }
        ]
      },
      {
        "id": "Extension.extension:isDefining",
        "path": "Extension.extension",
        "sliceName": "isDefining",
        "short": "R4B: For example where an enzyme strongly bonds with a particular substance, this is a defining relationship for that enzyme, out of several possible relationships (new)",
        "definition": "R4B: `SubstanceDefinition.relationship.isDefining` (new:boolean)",
        "comment": "Element `SubstanceDefinition.relationship.isDefining` is part of an existing definition because parent element `SubstanceDefinition.relationship` requires a cross-version extension.\nElement `SubstanceDefinition.relationship.isDefining` is not mapped to FHIR STU3, since FHIR R4B `SubstanceDefinition` is not mapped.\nElement `SubstanceDefinition.relationship.isDefining` has no mapping targets in FHIR STU3. Typically, this is because the element has been added (is a new element).",
        "requirements": "Element `SubstanceDefinition.relationship.isDefining` is part of an existing definition because parent element `SubstanceDefinition.relationship` requires a cross-version extension.\nElement `SubstanceDefinition.relationship.isDefining` is not mapped to FHIR STU3, since FHIR R4B `SubstanceDefinition` is not mapped.\nElement `SubstanceDefinition.relationship.isDefining` has no mapping targets in FHIR STU3. Typically, this is because the element has been added (is a new element).",
        "min": 0,
        "max": "1",
        "base": {
          "path": "Element.extension",
          "min": 0,
          "max": "*"
        },
        "type": [
          {
            "code": "Extension"
          }
        ]
      },
      {
        "id": "Extension.extension:isDefining.id",
        "path": "Extension.extension.id",
        "representation": [
          "xmlAttr"
        ],
        "short": "xml:id (or equivalent in JSON)",
        "definition": "unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
        "min": 0,
        "max": "1",
        "base": {
          "path": "Element.id",
          "min": 0,
          "max": "1"
        },
        "type": [
          {
            "code": "string"
          }
        ],
        "mapping": [
          {
            "identity": "rim",
            "map": "n/a"
          }
        ]
      },
      {
        "id": "Extension.extension:isDefining.extension",
        "path": "Extension.extension.extension",
        "slicing": {
          "discriminator": [
            {
              "type": "value",
              "path": "url"
            }
          ],
          "description": "Extensions are always sliced by (at least) url",
          "rules": "open"
        },
        "short": "Additional Content defined by implementations",
        "definition": "May be used to represent additional information that is not part of the basic definition of the element. In order to make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer is allowed to define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
        "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
        "alias": [
          "extensions",
          "user content"
        ],
        "min": 0,
        "max": "*",
        "base": {
          "path": "Element.extension",
          "min": 0,
          "max": "*"
        },
        "type": [
          {
            "code": "Extension"
          }
        ],
        "mapping": [
          {
            "identity": "rim",
            "map": "n/a"
          }
        ]
      },
      {
        "id": "Extension.extension:isDefining.url",
        "path": "Extension.extension.url",
        "representation": [
          "xmlAttr"
        ],
        "short": "identifies the meaning of the extension",
        "definition": "Source of the definition for the extension code - a logical name or a URL.",
        "comment": "The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.",
        "min": 1,
        "max": "1",
        "base": {
          "path": "Extension.url",
          "min": 1,
          "max": "1"
        },
        "type": [
          {
            "code": "uri"
          }
        ],
        "fixedUri": "isDefining",
        "mapping": [
          {
            "identity": "rim",
            "map": "N/A"
          }
        ]
      },
      {
        "id": "Extension.extension:isDefining.value[x]",
        "path": "Extension.extension.value[x]",
        "short": "For example where an enzyme strongly bonds with a particular substance, this is a defining relationship for that enzyme, out of several possible relationships",
        "definition": "For example where an enzyme strongly bonds with a particular substance, this is a defining relationship for that enzyme, out of several possible substance relationships.",
        "min": 0,
        "max": "1",
        "base": {
          "path": "Extension.value[x]",
          "min": 0,
          "max": "1"
        },
        "type": [
          {
            "code": "boolean"
          }
        ],
        "mapping": [
          {
            "identity": "rim",
            "map": "N/A"
          }
        ]
      },
      {
        "id": "Extension.extension:amount",
        "path": "Extension.extension",
        "sliceName": "amount",
        "short": "R4B: A numeric factor for the relationship, e.g. that a substance salt has some percentage of active substance in relation to some other (new)",
        "definition": "R4B: `SubstanceDefinition.relationship.amount[x]` (new:Quantity, Ratio, string)",
        "comment": "Element `SubstanceDefinition.relationship.amount[x]` is part of an existing definition because parent element `SubstanceDefinition.relationship` requires a cross-version extension.\nElement `SubstanceDefinition.relationship.amount[x]` is not mapped to FHIR STU3, since FHIR R4B `SubstanceDefinition` is not mapped.\nElement `SubstanceDefinition.relationship.amount[x]` has no mapping targets in FHIR STU3. Typically, this is because the element has been added (is a new element).",
        "requirements": "Element `SubstanceDefinition.relationship.amount[x]` is part of an existing definition because parent element `SubstanceDefinition.relationship` requires a cross-version extension.\nElement `SubstanceDefinition.relationship.amount[x]` is not mapped to FHIR STU3, since FHIR R4B `SubstanceDefinition` is not mapped.\nElement `SubstanceDefinition.relationship.amount[x]` has no mapping targets in FHIR STU3. Typically, this is because the element has been added (is a new element).",
        "min": 0,
        "max": "1",
        "base": {
          "path": "Element.extension",
          "min": 0,
          "max": "*"
        },
        "type": [
          {
            "code": "Extension"
          }
        ]
      },
      {
        "id": "Extension.extension:amount.id",
        "path": "Extension.extension.id",
        "representation": [
          "xmlAttr"
        ],
        "short": "xml:id (or equivalent in JSON)",
        "definition": "unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
        "min": 0,
        "max": "1",
        "base": {
          "path": "Element.id",
          "min": 0,
          "max": "1"
        },
        "type": [
          {
            "code": "string"
          }
        ],
        "mapping": [
          {
            "identity": "rim",
            "map": "n/a"
          }
        ]
      },
      {
        "id": "Extension.extension:amount.extension",
        "path": "Extension.extension.extension",
        "slicing": {
          "discriminator": [
            {
              "type": "value",
              "path": "url"
            }
          ],
          "description": "Extensions are always sliced by (at least) url",
          "rules": "open"
        },
        "short": "Additional Content defined by implementations",
        "definition": "May be used to represent additional information that is not part of the basic definition of the element. In order to make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer is allowed to define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
        "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
        "alias": [
          "extensions",
          "user content"
        ],
        "min": 0,
        "max": "*",
        "base": {
          "path": "Element.extension",
          "min": 0,
          "max": "*"
        },
        "type": [
          {
            "code": "Extension"
          }
        ],
        "mapping": [
          {
            "identity": "rim",
            "map": "n/a"
          }
        ]
      },
      {
        "id": "Extension.extension:amount.url",
        "path": "Extension.extension.url",
        "representation": [
          "xmlAttr"
        ],
        "short": "identifies the meaning of the extension",
        "definition": "Source of the definition for the extension code - a logical name or a URL.",
        "comment": "The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.",
        "min": 1,
        "max": "1",
        "base": {
          "path": "Extension.url",
          "min": 1,
          "max": "1"
        },
        "type": [
          {
            "code": "uri"
          }
        ],
        "fixedUri": "amount",
        "mapping": [
          {
            "identity": "rim",
            "map": "N/A"
          }
        ]
      },
      {
        "id": "Extension.extension:amount.value[x]",
        "path": "Extension.extension.value[x]",
        "short": "A numeric factor for the relationship, e.g. that a substance salt has some percentage of active substance in relation to some other",
        "definition": "A numeric factor for the relationship, for instance to express that the salt of a substance has some percentage of the active substance in relation to some other.",
        "min": 0,
        "max": "1",
        "base": {
          "path": "Extension.value[x]",
          "min": 0,
          "max": "1"
        },
        "type": [
          {
            "code": "Quantity"
          },
          {
            "code": "Ratio"
          },
          {
            "code": "string"
          }
        ],
        "mapping": [
          {
            "identity": "rim",
            "map": "N/A"
          }
        ]
      },
      {
        "id": "Extension.extension:ratioHighLimitAmount",
        "path": "Extension.extension",
        "sliceName": "ratioHighLimitAmount",
        "short": "R4B: For use when the numeric has an uncertain range (new)",
        "definition": "R4B: `SubstanceDefinition.relationship.ratioHighLimitAmount` (new:Ratio)",
        "comment": "Element `SubstanceDefinition.relationship.ratioHighLimitAmount` is part of an existing definition because parent element `SubstanceDefinition.relationship` requires a cross-version extension.\nElement `SubstanceDefinition.relationship.ratioHighLimitAmount` is not mapped to FHIR STU3, since FHIR R4B `SubstanceDefinition` is not mapped.\nElement `SubstanceDefinition.relationship.ratioHighLimitAmount` has no mapping targets in FHIR STU3. Typically, this is because the element has been added (is a new element).",
        "requirements": "Element `SubstanceDefinition.relationship.ratioHighLimitAmount` is part of an existing definition because parent element `SubstanceDefinition.relationship` requires a cross-version extension.\nElement `SubstanceDefinition.relationship.ratioHighLimitAmount` is not mapped to FHIR STU3, since FHIR R4B `SubstanceDefinition` is not mapped.\nElement `SubstanceDefinition.relationship.ratioHighLimitAmount` has no mapping targets in FHIR STU3. Typically, this is because the element has been added (is a new element).",
        "min": 0,
        "max": "1",
        "base": {
          "path": "Element.extension",
          "min": 0,
          "max": "*"
        },
        "type": [
          {
            "code": "Extension"
          }
        ]
      },
      {
        "id": "Extension.extension:ratioHighLimitAmount.id",
        "path": "Extension.extension.id",
        "representation": [
          "xmlAttr"
        ],
        "short": "xml:id (or equivalent in JSON)",
        "definition": "unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
        "min": 0,
        "max": "1",
        "base": {
          "path": "Element.id",
          "min": 0,
          "max": "1"
        },
        "type": [
          {
            "code": "string"
          }
        ],
        "mapping": [
          {
            "identity": "rim",
            "map": "n/a"
          }
        ]
      },
      {
        "id": "Extension.extension:ratioHighLimitAmount.extension",
        "path": "Extension.extension.extension",
        "slicing": {
          "discriminator": [
            {
              "type": "value",
              "path": "url"
            }
          ],
          "description": "Extensions are always sliced by (at least) url",
          "rules": "open"
        },
        "short": "Additional Content defined by implementations",
        "definition": "May be used to represent additional information that is not part of the basic definition of the element. In order to make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer is allowed to define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
        "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
        "alias": [
          "extensions",
          "user content"
        ],
        "min": 0,
        "max": "*",
        "base": {
          "path": "Element.extension",
          "min": 0,
          "max": "*"
        },
        "type": [
          {
            "code": "Extension"
          }
        ],
        "mapping": [
          {
            "identity": "rim",
            "map": "n/a"
          }
        ]
      },
      {
        "id": "Extension.extension:ratioHighLimitAmount.url",
        "path": "Extension.extension.url",
        "representation": [
          "xmlAttr"
        ],
        "short": "identifies the meaning of the extension",
        "definition": "Source of the definition for the extension code - a logical name or a URL.",
        "comment": "The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.",
        "min": 1,
        "max": "1",
        "base": {
          "path": "Extension.url",
          "min": 1,
          "max": "1"
        },
        "type": [
          {
            "code": "uri"
          }
        ],
        "fixedUri": "ratioHighLimitAmount",
        "mapping": [
          {
            "identity": "rim",
            "map": "N/A"
          }
        ]
      },
      {
        "id": "Extension.extension:ratioHighLimitAmount.value[x]",
        "path": "Extension.extension.value[x]",
        "short": "For use when the numeric has an uncertain range",
        "definition": "For use when the numeric has an uncertain range.",
        "min": 0,
        "max": "1",
        "base": {
          "path": "Extension.value[x]",
          "min": 0,
          "max": "1"
        },
        "type": [
          {
            "code": "Ratio"
          }
        ],
        "mapping": [
          {
            "identity": "rim",
            "map": "N/A"
          }
        ]
      },
      {
        "id": "Extension.extension:comparator",
        "path": "Extension.extension",
        "sliceName": "comparator",
        "short": "R4B: An operator for the amount, for example \"average\", \"approximately\", \"less than\" (new)",
        "definition": "R4B: `SubstanceDefinition.relationship.comparator` (new:CodeableConcept)",
        "comment": "Element `SubstanceDefinition.relationship.comparator` is part of an existing definition because parent element `SubstanceDefinition.relationship` requires a cross-version extension.\nElement `SubstanceDefinition.relationship.comparator` is not mapped to FHIR STU3, since FHIR R4B `SubstanceDefinition` is not mapped.\nElement `SubstanceDefinition.relationship.comparator` has no mapping targets in FHIR STU3. Typically, this is because the element has been added (is a new element).",
        "requirements": "Element `SubstanceDefinition.relationship.comparator` is part of an existing definition because parent element `SubstanceDefinition.relationship` requires a cross-version extension.\nElement `SubstanceDefinition.relationship.comparator` is not mapped to FHIR STU3, since FHIR R4B `SubstanceDefinition` is not mapped.\nElement `SubstanceDefinition.relationship.comparator` has no mapping targets in FHIR STU3. Typically, this is because the element has been added (is a new element).",
        "min": 0,
        "max": "1",
        "base": {
          "path": "Element.extension",
          "min": 0,
          "max": "*"
        },
        "type": [
          {
            "code": "Extension"
          }
        ]
      },
      {
        "id": "Extension.extension:comparator.id",
        "path": "Extension.extension.id",
        "representation": [
          "xmlAttr"
        ],
        "short": "xml:id (or equivalent in JSON)",
        "definition": "unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
        "min": 0,
        "max": "1",
        "base": {
          "path": "Element.id",
          "min": 0,
          "max": "1"
        },
        "type": [
          {
            "code": "string"
          }
        ],
        "mapping": [
          {
            "identity": "rim",
            "map": "n/a"
          }
        ]
      },
      {
        "id": "Extension.extension:comparator.extension",
        "path": "Extension.extension.extension",
        "slicing": {
          "discriminator": [
            {
              "type": "value",
              "path": "url"
            }
          ],
          "description": "Extensions are always sliced by (at least) url",
          "rules": "open"
        },
        "short": "Additional Content defined by implementations",
        "definition": "May be used to represent additional information that is not part of the basic definition of the element. In order to make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer is allowed to define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
        "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
        "alias": [
          "extensions",
          "user content"
        ],
        "min": 0,
        "max": "*",
        "base": {
          "path": "Element.extension",
          "min": 0,
          "max": "*"
        },
        "type": [
          {
            "code": "Extension"
          }
        ],
        "mapping": [
          {
            "identity": "rim",
            "map": "n/a"
          }
        ]
      },
      {
        "id": "Extension.extension:comparator.url",
        "path": "Extension.extension.url",
        "representation": [
          "xmlAttr"
        ],
        "short": "identifies the meaning of the extension",
        "definition": "Source of the definition for the extension code - a logical name or a URL.",
        "comment": "The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.",
        "min": 1,
        "max": "1",
        "base": {
          "path": "Extension.url",
          "min": 1,
          "max": "1"
        },
        "type": [
          {
            "code": "uri"
          }
        ],
        "fixedUri": "comparator",
        "mapping": [
          {
            "identity": "rim",
            "map": "N/A"
          }
        ]
      },
      {
        "id": "Extension.extension:comparator.value[x]",
        "path": "Extension.extension.value[x]",
        "short": "An operator for the amount, for example \"average\", \"approximately\", \"less than\"",
        "definition": "An operator for the amount, for example \"average\", \"approximately\", \"less than\".",
        "min": 0,
        "max": "1",
        "base": {
          "path": "Extension.value[x]",
          "min": 0,
          "max": "1"
        },
        "type": [
          {
            "code": "CodeableConcept"
          }
        ],
        "binding": {
          "strength": "example",
          "description": "The relationship between two substance types.",
          "valueSetUri": "http://hl7.org/fhir/uv/xver/ValueSet/R4B-substance-amount-type-for-R3|0.1.0"
        },
        "mapping": [
          {
            "identity": "rim",
            "map": "N/A"
          }
        ]
      },
      {
        "id": "Extension.extension:source",
        "path": "Extension.extension",
        "sliceName": "source",
        "short": "R4B: Supporting literature (new)",
        "definition": "R4B: `SubstanceDefinition.relationship.source` (new:Reference(DocumentReference))",
        "comment": "Element `SubstanceDefinition.relationship.source` is part of an existing definition because parent element `SubstanceDefinition.relationship` requires a cross-version extension.\nElement `SubstanceDefinition.relationship.source` is not mapped to FHIR STU3, since FHIR R4B `SubstanceDefinition` is not mapped.\nElement `SubstanceDefinition.relationship.source` has no mapping targets in FHIR STU3. Typically, this is because the element has been added (is a new element).",
        "requirements": "Element `SubstanceDefinition.relationship.source` is part of an existing definition because parent element `SubstanceDefinition.relationship` requires a cross-version extension.\nElement `SubstanceDefinition.relationship.source` is not mapped to FHIR STU3, since FHIR R4B `SubstanceDefinition` is not mapped.\nElement `SubstanceDefinition.relationship.source` has no mapping targets in FHIR STU3. Typically, this is because the element has been added (is a new element).",
        "min": 0,
        "max": "*",
        "base": {
          "path": "Element.extension",
          "min": 0,
          "max": "*"
        },
        "type": [
          {
            "code": "Extension"
          }
        ]
      },
      {
        "id": "Extension.extension:source.id",
        "path": "Extension.extension.id",
        "representation": [
          "xmlAttr"
        ],
        "short": "xml:id (or equivalent in JSON)",
        "definition": "unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
        "min": 0,
        "max": "1",
        "base": {
          "path": "Element.id",
          "min": 0,
          "max": "1"
        },
        "type": [
          {
            "code": "string"
          }
        ],
        "mapping": [
          {
            "identity": "rim",
            "map": "n/a"
          }
        ]
      },
      {
        "id": "Extension.extension:source.extension",
        "path": "Extension.extension.extension",
        "slicing": {
          "discriminator": [
            {
              "type": "value",
              "path": "url"
            }
          ],
          "description": "Extensions are always sliced by (at least) url",
          "rules": "open"
        },
        "short": "Additional Content defined by implementations",
        "definition": "May be used to represent additional information that is not part of the basic definition of the element. In order to make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer is allowed to define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
        "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
        "alias": [
          "extensions",
          "user content"
        ],
        "min": 0,
        "max": "*",
        "base": {
          "path": "Element.extension",
          "min": 0,
          "max": "*"
        },
        "type": [
          {
            "code": "Extension"
          }
        ],
        "mapping": [
          {
            "identity": "rim",
            "map": "n/a"
          }
        ]
      },
      {
        "id": "Extension.extension:source.url",
        "path": "Extension.extension.url",
        "representation": [
          "xmlAttr"
        ],
        "short": "identifies the meaning of the extension",
        "definition": "Source of the definition for the extension code - a logical name or a URL.",
        "comment": "The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.",
        "min": 1,
        "max": "1",
        "base": {
          "path": "Extension.url",
          "min": 1,
          "max": "1"
        },
        "type": [
          {
            "code": "uri"
          }
        ],
        "fixedUri": "source",
        "mapping": [
          {
            "identity": "rim",
            "map": "N/A"
          }
        ]
      },
      {
        "id": "Extension.extension:source.value[x]",
        "path": "Extension.extension.value[x]",
        "short": "Supporting literature",
        "definition": "Supporting literature.",
        "min": 0,
        "max": "1",
        "base": {
          "path": "Extension.value[x]",
          "min": 0,
          "max": "1"
        },
        "type": [
          {
            "code": "Reference",
            "targetProfile": "http://hl7.org/fhir/4.3/StructureDefinition/profile-DocumentReference|0.1.0"
          },
          {
            "code": "Reference",
            "targetProfile": "http://hl7.org/fhir/StructureDefinition/DocumentReference"
          }
        ],
        "mapping": [
          {
            "identity": "rim",
            "map": "N/A"
          }
        ]
      },
      {
        "id": "Extension.url",
        "path": "Extension.url",
        "representation": [
          "xmlAttr"
        ],
        "short": "identifies the meaning of the extension",
        "definition": "Source of the definition for the extension code - a logical name or a URL.",
        "comment": "The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.",
        "min": 1,
        "max": "1",
        "base": {
          "path": "Extension.url",
          "min": 1,
          "max": "1"
        },
        "type": [
          {
            "code": "uri"
          }
        ],
        "fixedUri": "http://hl7.org/fhir/4.3/StructureDefinition/extension-SubstanceDefinition.relationship",
        "mapping": [
          {
            "identity": "rim",
            "map": "N/A"
          }
        ]
      },
      {
        "id": "Extension.value[x]",
        "path": "Extension.value[x]",
        "short": "Value of extension",
        "definition": "Value of extension - may be a resource or one of a constrained set of the data types (see Extensibility in the spec for list).",
        "min": 0,
        "max": "0",
        "base": {
          "path": "Extension.value[x]",
          "min": 0,
          "max": "1"
        },
        "type": [
          {
            "code": "base64Binary"
          },
          {
            "code": "boolean"
          },
          {
            "code": "code"
          },
          {
            "code": "date"
          },
          {
            "code": "dateTime"
          },
          {
            "code": "decimal"
          },
          {
            "code": "id"
          },
          {
            "code": "instant"
          },
          {
            "code": "integer"
          },
          {
            "code": "markdown"
          },
          {
            "code": "oid"
          },
          {
            "code": "positiveInt"
          },
          {
            "code": "string"
          },
          {
            "code": "time"
          },
          {
            "code": "unsignedInt"
          },
          {
            "code": "uri"
          },
          {
            "code": "Address"
          },
          {
            "code": "Age"
          },
          {
            "code": "Annotation"
          },
          {
            "code": "Attachment"
          },
          {
            "code": "CodeableConcept"
          },
          {
            "code": "Coding"
          },
          {
            "code": "ContactPoint"
          },
          {
            "code": "Count"
          },
          {
            "code": "Distance"
          },
          {
            "code": "Duration"
          },
          {
            "code": "HumanName"
          },
          {
            "code": "Identifier"
          },
          {
            "code": "Money"
          },
          {
            "code": "Period"
          },
          {
            "code": "Quantity"
          },
          {
            "code": "Range"
          },
          {
            "code": "Ratio"
          },
          {
            "code": "Reference"
          },
          {
            "code": "SampledData"
          },
          {
            "code": "Signature"
          },
          {
            "code": "Timing"
          },
          {
            "code": "Meta"
          }
        ],
        "mapping": [
          {
            "identity": "rim",
            "map": "N/A"
          }
        ]
      }
    ]
  },
  "differential": {
    "element": [
      {
        "id": "Extension",
        "path": "Extension",
        "short": "R4B: A link between this substance and another (new)",
        "definition": "R4B: `SubstanceDefinition.relationship` (new:BackboneElement)",
        "comment": "Element `SubstanceDefinition.relationship` is not mapped to FHIR STU3, since FHIR R4B `SubstanceDefinition` is not mapped.\nElement `SubstanceDefinition.relationship` has no mapping targets in FHIR STU3. Typically, this is because the element has been added (is a new element).",
        "min": 0,
        "max": "*",
        "base": {
          "path": "Extension",
          "min": 0,
          "max": "*"
        },
        "isModifier": false
      },
      {
        "id": "Extension.extension",
        "path": "Extension.extension",
        "slicing": {
          "discriminator": [
            {
              "type": "value",
              "path": "url"
            }
          ],
          "ordered": false,
          "rules": "open"
        },
        "min": 1,
        "max": "*",
        "base": {
          "path": "Extension.extension",
          "min": 0,
          "max": "*"
        }
      },
      {
        "id": "Extension.extension:substanceDefinition",
        "path": "Extension.extension",
        "sliceName": "substanceDefinition",
        "short": "R4B: A pointer to another substance, as a resource or a representational code (new)",
        "definition": "R4B: `SubstanceDefinition.relationship.substanceDefinition[x]` (new:CodeableConcept, Reference(SubstanceDefinition))",
        "comment": "Element `SubstanceDefinition.relationship.substanceDefinition[x]` is part of an existing definition because parent element `SubstanceDefinition.relationship` requires a cross-version extension.\nElement `SubstanceDefinition.relationship.substanceDefinition[x]` is not mapped to FHIR STU3, since FHIR R4B `SubstanceDefinition` is not mapped.\nElement `SubstanceDefinition.relationship.substanceDefinition[x]` has no mapping targets in FHIR STU3. Typically, this is because the element has been added (is a new element).",
        "requirements": "Element `SubstanceDefinition.relationship.substanceDefinition[x]` is part of an existing definition because parent element `SubstanceDefinition.relationship` requires a cross-version extension.\nElement `SubstanceDefinition.relationship.substanceDefinition[x]` is not mapped to FHIR STU3, since FHIR R4B `SubstanceDefinition` is not mapped.\nElement `SubstanceDefinition.relationship.substanceDefinition[x]` has no mapping targets in FHIR STU3. Typically, this is because the element has been added (is a new element).",
        "min": 0,
        "max": "1",
        "base": {
          "path": "Extension.extension",
          "min": 0,
          "max": "*"
        }
      },
      {
        "id": "Extension.extension:substanceDefinition.url",
        "path": "Extension.extension.url",
        "min": 1,
        "max": "1",
        "base": {
          "path": "Extension.url",
          "min": 1,
          "max": "1"
        },
        "fixedUri": "substanceDefinition"
      },
      {
        "id": "Extension.extension:substanceDefinition.value[x]",
        "path": "Extension.extension.value[x]",
        "short": "A pointer to another substance, as a resource or a representational code",
        "definition": "A pointer to another substance, as a resource or just a representational code.",
        "min": 0,
        "max": "1",
        "base": {
          "path": "Extension.value[x]",
          "min": 0,
          "max": "1"
        },
        "type": [
          {
            "code": "Reference",
            "targetProfile": "http://hl7.org/fhir/4.3/StructureDefinition/profile-SubstanceDefinition|0.1.0"
          },
          {
            "code": "Reference",
            "targetProfile": "http://hl7.org/fhir/StructureDefinition/Basic"
          },
          {
            "code": "CodeableConcept"
          }
        ]
      },
      {
        "id": "Extension.extension:type",
        "path": "Extension.extension",
        "sliceName": "type",
        "short": "R4B: For example \"salt to parent\", \"active moiety\" (new)",
        "definition": "R4B: `SubstanceDefinition.relationship.type` (new:CodeableConcept)",
        "comment": "Element `SubstanceDefinition.relationship.type` is part of an existing definition because parent element `SubstanceDefinition.relationship` requires a cross-version extension.\nElement `SubstanceDefinition.relationship.type` is not mapped to FHIR STU3, since FHIR R4B `SubstanceDefinition` is not mapped.\nElement `SubstanceDefinition.relationship.type` has no mapping targets in FHIR STU3. Typically, this is because the element has been added (is a new element).",
        "requirements": "Element `SubstanceDefinition.relationship.type` is part of an existing definition because parent element `SubstanceDefinition.relationship` requires a cross-version extension.\nElement `SubstanceDefinition.relationship.type` is not mapped to FHIR STU3, since FHIR R4B `SubstanceDefinition` is not mapped.\nElement `SubstanceDefinition.relationship.type` has no mapping targets in FHIR STU3. Typically, this is because the element has been added (is a new element).",
        "min": 1,
        "max": "1",
        "base": {
          "path": "Extension.extension",
          "min": 0,
          "max": "*"
        }
      },
      {
        "id": "Extension.extension:type.url",
        "path": "Extension.extension.url",
        "min": 1,
        "max": "1",
        "base": {
          "path": "Extension.url",
          "min": 1,
          "max": "1"
        },
        "fixedUri": "type"
      },
      {
        "id": "Extension.extension:type.value[x]",
        "path": "Extension.extension.value[x]",
        "short": "For example \"salt to parent\", \"active moiety\"",
        "definition": "For example \"salt to parent\", \"active moiety\", \"starting material\", \"polymorph\", \"impurity of\".",
        "min": 1,
        "max": "1",
        "base": {
          "path": "Extension.value[x]",
          "min": 0,
          "max": "1"
        },
        "type": [
          {
            "code": "CodeableConcept"
          }
        ],
        "binding": {
          "strength": "example",
          "description": "The relationship between two substance types.",
          "valueSetUri": "http://hl7.org/fhir/uv/xver/ValueSet/R4B-substance-relationship-type-for-R3|0.1.0"
        }
      },
      {
        "id": "Extension.extension:isDefining",
        "path": "Extension.extension",
        "sliceName": "isDefining",
        "short": "R4B: For example where an enzyme strongly bonds with a particular substance, this is a defining relationship for that enzyme, out of several possible relationships (new)",
        "definition": "R4B: `SubstanceDefinition.relationship.isDefining` (new:boolean)",
        "comment": "Element `SubstanceDefinition.relationship.isDefining` is part of an existing definition because parent element `SubstanceDefinition.relationship` requires a cross-version extension.\nElement `SubstanceDefinition.relationship.isDefining` is not mapped to FHIR STU3, since FHIR R4B `SubstanceDefinition` is not mapped.\nElement `SubstanceDefinition.relationship.isDefining` has no mapping targets in FHIR STU3. Typically, this is because the element has been added (is a new element).",
        "requirements": "Element `SubstanceDefinition.relationship.isDefining` is part of an existing definition because parent element `SubstanceDefinition.relationship` requires a cross-version extension.\nElement `SubstanceDefinition.relationship.isDefining` is not mapped to FHIR STU3, since FHIR R4B `SubstanceDefinition` is not mapped.\nElement `SubstanceDefinition.relationship.isDefining` has no mapping targets in FHIR STU3. Typically, this is because the element has been added (is a new element).",
        "min": 0,
        "max": "1",
        "base": {
          "path": "Extension.extension",
          "min": 0,
          "max": "*"
        }
      },
      {
        "id": "Extension.extension:isDefining.url",
        "path": "Extension.extension.url",
        "min": 1,
        "max": "1",
        "base": {
          "path": "Extension.url",
          "min": 1,
          "max": "1"
        },
        "fixedUri": "isDefining"
      },
      {
        "id": "Extension.extension:isDefining.value[x]",
        "path": "Extension.extension.value[x]",
        "short": "For example where an enzyme strongly bonds with a particular substance, this is a defining relationship for that enzyme, out of several possible relationships",
        "definition": "For example where an enzyme strongly bonds with a particular substance, this is a defining relationship for that enzyme, out of several possible substance relationships.",
        "min": 0,
        "max": "1",
        "base": {
          "path": "Extension.value[x]",
          "min": 0,
          "max": "1"
        },
        "type": [
          {
            "code": "boolean"
          }
        ]
      },
      {
        "id": "Extension.extension:amount",
        "path": "Extension.extension",
        "sliceName": "amount",
        "short": "R4B: A numeric factor for the relationship, e.g. that a substance salt has some percentage of active substance in relation to some other (new)",
        "definition": "R4B: `SubstanceDefinition.relationship.amount[x]` (new:Quantity, Ratio, string)",
        "comment": "Element `SubstanceDefinition.relationship.amount[x]` is part of an existing definition because parent element `SubstanceDefinition.relationship` requires a cross-version extension.\nElement `SubstanceDefinition.relationship.amount[x]` is not mapped to FHIR STU3, since FHIR R4B `SubstanceDefinition` is not mapped.\nElement `SubstanceDefinition.relationship.amount[x]` has no mapping targets in FHIR STU3. Typically, this is because the element has been added (is a new element).",
        "requirements": "Element `SubstanceDefinition.relationship.amount[x]` is part of an existing definition because parent element `SubstanceDefinition.relationship` requires a cross-version extension.\nElement `SubstanceDefinition.relationship.amount[x]` is not mapped to FHIR STU3, since FHIR R4B `SubstanceDefinition` is not mapped.\nElement `SubstanceDefinition.relationship.amount[x]` has no mapping targets in FHIR STU3. Typically, this is because the element has been added (is a new element).",
        "min": 0,
        "max": "1",
        "base": {
          "path": "Extension.extension",
          "min": 0,
          "max": "*"
        }
      },
      {
        "id": "Extension.extension:amount.url",
        "path": "Extension.extension.url",
        "min": 1,
        "max": "1",
        "base": {
          "path": "Extension.url",
          "min": 1,
          "max": "1"
        },
        "fixedUri": "amount"
      },
      {
        "id": "Extension.extension:amount.value[x]",
        "path": "Extension.extension.value[x]",
        "short": "A numeric factor for the relationship, e.g. that a substance salt has some percentage of active substance in relation to some other",
        "definition": "A numeric factor for the relationship, for instance to express that the salt of a substance has some percentage of the active substance in relation to some other.",
        "min": 0,
        "max": "1",
        "base": {
          "path": "Extension.value[x]",
          "min": 0,
          "max": "1"
        },
        "type": [
          {
            "code": "Quantity"
          },
          {
            "code": "Ratio"
          },
          {
            "code": "string"
          }
        ]
      },
      {
        "id": "Extension.extension:ratioHighLimitAmount",
        "path": "Extension.extension",
        "sliceName": "ratioHighLimitAmount",
        "short": "R4B: For use when the numeric has an uncertain range (new)",
        "definition": "R4B: `SubstanceDefinition.relationship.ratioHighLimitAmount` (new:Ratio)",
        "comment": "Element `SubstanceDefinition.relationship.ratioHighLimitAmount` is part of an existing definition because parent element `SubstanceDefinition.relationship` requires a cross-version extension.\nElement `SubstanceDefinition.relationship.ratioHighLimitAmount` is not mapped to FHIR STU3, since FHIR R4B `SubstanceDefinition` is not mapped.\nElement `SubstanceDefinition.relationship.ratioHighLimitAmount` has no mapping targets in FHIR STU3. Typically, this is because the element has been added (is a new element).",
        "requirements": "Element `SubstanceDefinition.relationship.ratioHighLimitAmount` is part of an existing definition because parent element `SubstanceDefinition.relationship` requires a cross-version extension.\nElement `SubstanceDefinition.relationship.ratioHighLimitAmount` is not mapped to FHIR STU3, since FHIR R4B `SubstanceDefinition` is not mapped.\nElement `SubstanceDefinition.relationship.ratioHighLimitAmount` has no mapping targets in FHIR STU3. Typically, this is because the element has been added (is a new element).",
        "min": 0,
        "max": "1",
        "base": {
          "path": "Extension.extension",
          "min": 0,
          "max": "*"
        }
      },
      {
        "id": "Extension.extension:ratioHighLimitAmount.url",
        "path": "Extension.extension.url",
        "min": 1,
        "max": "1",
        "base": {
          "path": "Extension.url",
          "min": 1,
          "max": "1"
        },
        "fixedUri": "ratioHighLimitAmount"
      },
      {
        "id": "Extension.extension:ratioHighLimitAmount.value[x]",
        "path": "Extension.extension.value[x]",
        "short": "For use when the numeric has an uncertain range",
        "definition": "For use when the numeric has an uncertain range.",
        "min": 0,
        "max": "1",
        "base": {
          "path": "Extension.value[x]",
          "min": 0,
          "max": "1"
        },
        "type": [
          {
            "code": "Ratio"
          }
        ]
      },
      {
        "id": "Extension.extension:comparator",
        "path": "Extension.extension",
        "sliceName": "comparator",
        "short": "R4B: An operator for the amount, for example \"average\", \"approximately\", \"less than\" (new)",
        "definition": "R4B: `SubstanceDefinition.relationship.comparator` (new:CodeableConcept)",
        "comment": "Element `SubstanceDefinition.relationship.comparator` is part of an existing definition because parent element `SubstanceDefinition.relationship` requires a cross-version extension.\nElement `SubstanceDefinition.relationship.comparator` is not mapped to FHIR STU3, since FHIR R4B `SubstanceDefinition` is not mapped.\nElement `SubstanceDefinition.relationship.comparator` has no mapping targets in FHIR STU3. Typically, this is because the element has been added (is a new element).",
        "requirements": "Element `SubstanceDefinition.relationship.comparator` is part of an existing definition because parent element `SubstanceDefinition.relationship` requires a cross-version extension.\nElement `SubstanceDefinition.relationship.comparator` is not mapped to FHIR STU3, since FHIR R4B `SubstanceDefinition` is not mapped.\nElement `SubstanceDefinition.relationship.comparator` has no mapping targets in FHIR STU3. Typically, this is because the element has been added (is a new element).",
        "min": 0,
        "max": "1",
        "base": {
          "path": "Extension.extension",
          "min": 0,
          "max": "*"
        }
      },
      {
        "id": "Extension.extension:comparator.url",
        "path": "Extension.extension.url",
        "min": 1,
        "max": "1",
        "base": {
          "path": "Extension.url",
          "min": 1,
          "max": "1"
        },
        "fixedUri": "comparator"
      },
      {
        "id": "Extension.extension:comparator.value[x]",
        "path": "Extension.extension.value[x]",
        "short": "An operator for the amount, for example \"average\", \"approximately\", \"less than\"",
        "definition": "An operator for the amount, for example \"average\", \"approximately\", \"less than\".",
        "min": 0,
        "max": "1",
        "base": {
          "path": "Extension.value[x]",
          "min": 0,
          "max": "1"
        },
        "type": [
          {
            "code": "CodeableConcept"
          }
        ],
        "binding": {
          "strength": "example",
          "description": "The relationship between two substance types.",
          "valueSetUri": "http://hl7.org/fhir/uv/xver/ValueSet/R4B-substance-amount-type-for-R3|0.1.0"
        }
      },
      {
        "id": "Extension.extension:source",
        "path": "Extension.extension",
        "sliceName": "source",
        "short": "R4B: Supporting literature (new)",
        "definition": "R4B: `SubstanceDefinition.relationship.source` (new:Reference(DocumentReference))",
        "comment": "Element `SubstanceDefinition.relationship.source` is part of an existing definition because parent element `SubstanceDefinition.relationship` requires a cross-version extension.\nElement `SubstanceDefinition.relationship.source` is not mapped to FHIR STU3, since FHIR R4B `SubstanceDefinition` is not mapped.\nElement `SubstanceDefinition.relationship.source` has no mapping targets in FHIR STU3. Typically, this is because the element has been added (is a new element).",
        "requirements": "Element `SubstanceDefinition.relationship.source` is part of an existing definition because parent element `SubstanceDefinition.relationship` requires a cross-version extension.\nElement `SubstanceDefinition.relationship.source` is not mapped to FHIR STU3, since FHIR R4B `SubstanceDefinition` is not mapped.\nElement `SubstanceDefinition.relationship.source` has no mapping targets in FHIR STU3. Typically, this is because the element has been added (is a new element).",
        "min": 0,
        "max": "*",
        "base": {
          "path": "Extension.extension",
          "min": 0,
          "max": "*"
        }
      },
      {
        "id": "Extension.extension:source.url",
        "path": "Extension.extension.url",
        "min": 1,
        "max": "1",
        "base": {
          "path": "Extension.url",
          "min": 1,
          "max": "1"
        },
        "fixedUri": "source"
      },
      {
        "id": "Extension.extension:source.value[x]",
        "path": "Extension.extension.value[x]",
        "short": "Supporting literature",
        "definition": "Supporting literature.",
        "min": 0,
        "max": "1",
        "base": {
          "path": "Extension.value[x]",
          "min": 0,
          "max": "1"
        },
        "type": [
          {
            "code": "Reference",
            "targetProfile": "http://hl7.org/fhir/4.3/StructureDefinition/profile-DocumentReference|0.1.0"
          },
          {
            "code": "Reference",
            "targetProfile": "http://hl7.org/fhir/StructureDefinition/DocumentReference"
          }
        ]
      },
      {
        "id": "Extension.url",
        "path": "Extension.url",
        "min": 1,
        "max": "1",
        "base": {
          "path": "Extension.url",
          "min": 1,
          "max": "1"
        },
        "fixedUri": "http://hl7.org/fhir/4.3/StructureDefinition/extension-SubstanceDefinition.relationship"
      },
      {
        "id": "Extension.value[x]",
        "path": "Extension.value[x]",
        "min": 0,
        "max": "0",
        "base": {
          "path": "Extension.value[x]",
          "min": 0,
          "max": "1"
        }
      }
    ]
  }
}