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Source1

{
  "resourceType": "MedicationKnowledge",
  "id": "example-drug-clarithromycin-25mg-granule-suspension",
  "meta": {
    "profile": [
      "http://hl7.org/fhir/uv/order-catalog/StructureDefinition/DrugKnowledge"
    ]
  },
  "language": "en-US",
  "text": {
    "status": "extensions",
    "div": "<!-- snip (see above) -->"
  },
  "extension": [
    {
      "url": "http://hl7.org/fhir/uv/order-catalog/StructureDefinition/CatalogReference",
      "valueReference": {
        "reference": "Composition/example-medication-catalog-header"
      }
    }
  ],
  "code": {
    "coding": [
      {
        "system": "http://snomed.info/sct",
        "code": "769316002",
        "display": "Clarithromycin 25 mg/mL oral suspension"
      }
    ]
  },
  "intendedJurisdiction": [
    {
      "text": "Healthyland"
    }
  ],
  "name": [
    "CLARITHROMYCINE GENERIC-LAB 25 mg/ml, granules for oral suspension"
  ],
  "productType": [
    {
      "text": "Generic product"
    }
  ],
  "indicationGuideline": [
    {
      "indication": [
        {
          "reference": {
            "reference": "ClinicalUseDefinition/example-bacterial-pharyngitis-indication"
          }
        },
        {
          "reference": {
            "reference": "ClinicalUseDefinition/example-acute-otitis-media-indication"
          }
        },
        {
          "reference": {
            "reference": "ClinicalUseDefinition/example-bacterial-sinusitis-indication"
          }
        }
      ],
      "dosingGuideline": [
        {
          "patientCharacteristic": [
            {
              "type": {
                "coding": [
                  {
                    "system": "http://loinc.org",
                    "code": "30525-0",
                    "display": "Age"
                  }
                ]
              },
              "valueRange": {
                "low": {
                  "value": 0.5,
                  "unit": "years",
                  "system": "http://unitsofmeasure.org",
                  "code": "a"
                },
                "high": {
                  "value": 12,
                  "unit": "years",
                  "system": "http://unitsofmeasure.org",
                  "code": "a"
                }
              }
            }
          ]
        }
      ]
    }
  ],
  "medicineClassification": [
    {
      "type": {
        "text": "Anatomical Therapeutic Chemical (ATC)"
      },
      "sourceUri": "https://www.whocc.no/atc/structure_and_principles/",
      "classification": [
        {
          "coding": [
            {
              "system": "http://www.whocc.no/atc",
              "code": "J01FA09",
              "display": "Clarithromycin"
            }
          ]
        }
      ]
    },
    {
      "type": {
        "text": "SNOMED CT drug dispositions"
      },
      "sourceUri": "https://confluence.ihtsdotools.org/display/DOCEG/SNOMED+CT+Editorial+Guide+-+Pharmaceutical+and+Biologic+Product",
      "classification": [
        {
          "coding": [
            {
              "system": "http://snomed.info/sct",
              "code": "346325008",
              "display": "Medicinal product acting as antibacterial agent (product)"
            }
          ]
        }
      ]
    }
  ],
  "packaging": [
    {
      "cost": [
        {
          "effectiveDate": [
            {
              "start": "2021-02-01"
            }
          ],
          "type": {
            "text": "public price"
          },
          "source": "Healthyland Drug Administration",
          "costMoney": {
            "value": 5.18,
            "currency": "EUR"
          }
        },
        {
          "effectiveDate": [
            {
              "start": "2020-09-30",
              "end": "2021-01-31"
            }
          ],
          "type": {
            "text": "public price"
          },
          "source": "Healthyland Drug Administration",
          "costMoney": {
            "value": 5.2,
            "currency": "EUR"
          }
        },
        {
          "effectiveDate": [
            {
              "start": "2010-03-01"
            }
          ],
          "type": {
            "text": "manufacturers' cost"
          },
          "source": "Healthyland Drug Administration",
          "costMoney": {
            "value": 4.4,
            "currency": "EUR"
          }
        }
      ],
      "packagedProduct": {
        "reference": "PackagedProductDefinition/example-drug-package-clarithromycin"
      }
    }
  ],
  "clinicalUseIssue": [
    {
      "reference": "ClinicalUseDefinition/example-allergy-contraindication"
    }
  ],
  "definitional": {
    "doseForm": {
      "coding": [
        {
          "system": "http://snomed.info/sct",
          "code": "385029002",
          "display": "Granules for oral suspension"
        },
        {
          "system": "http://standardterms.edqm.eu",
          "code": "10113000",
          "display": "Granules for oral suspension"
        }
      ]
    },
    "intendedRoute": [
      {
        "coding": [
          {
            "system": "http://snomed.info/sct",
            "code": "26643006",
            "display": "Oral route"
          }
        ]
      }
    ],
    "ingredient": [
      {
        "item": {
          "concept": {
            "coding": [
              {
                "system": "http://snomed.info/sct",
                "code": "387487009",
                "display": "Clarithromycin"
              }
            ]
          }
        },
        "type": {
          "coding": [
            {
              "system": "http://terminology.hl7.org/CodeSystem/v3-RoleClass",
              "code": "ACTIB",
              "display": "active ingredient - basis of strength"
            }
          ]
        },
        "strengthRatio": {
          "numerator": {
            "value": 25,
            "unit": "milligram",
            "system": "http://unitsofmeasure.org",
            "code": "mg"
          },
          "denominator": {
            "value": 1,
            "unit": "milliliter",
            "system": "http://unitsofmeasure.org",
            "code": "mL"
          }
        }
      },
      {
        "item": {
          "concept": {
            "coding": [
              {
                "system": "http://snomed.info/sct",
                "code": "11320009",
                "display": "Sucrose"
              }
            ]
          }
        },
        "type": {
          "coding": [
            {
              "system": "http://terminology.hl7.org/CodeSystem/v3-RoleClass",
              "code": "IACT",
              "display": "inactive ingredient"
            }
          ]
        }
      }
    ]
  }
}