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Source1

{
  "resourceType": "Bundle",
  "type": "collection",
  "timestamp": "2026-02-10T18:48:22.081+00:00",
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                "valueCode": "IG_DEPENDENCY_VERSION_WARNING"
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            "code": "business-rule",
            "details": {
              "text": "The ImplementationGuide is based on FHIR version 6.0.0-ballot3 but package hl7.terminology.r5#7.0.1 is based on FHIR version 5.0.0. In general, this version mismatch should be avoided - some tools will try to make this work with variable degrees of success, but others will not even try"
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                "valueCode": "IG_DEPENDENCY_CLASH_PACKAGEID"
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            ],
            "severity": "error",
            "code": "business-rule",
            "details": {
              "text": "The canonical URL http://hl7.org/fhir/extensions/ImplementationGuide/hl7.fhir.uv.extensions points to the package hl7.fhir.uv.extensions which is inconsistent with the stated packageId of hl7.fhir.uv.extensions.r5"
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      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/CodeSystem-amino-acid",
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        "resourceType": "OperationOutcome",
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      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/CodeSystem-coordinate-origin",
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        "resourceType": "OperationOutcome",
        "id": "CodeSystem-coordinate-origin"
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      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/CodeSystem-encodings",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "CodeSystem-encodings"
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      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/CodeSystem-molecular-definition-focus",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "CodeSystem-molecular-definition-focus"
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      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/CodeSystem-molecule-type",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "CodeSystem-molecule-type"
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      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/CodeSystem-normalization-method",
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        "resourceType": "OperationOutcome",
        "id": "CodeSystem-normalization-method"
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      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/CodeSystem-nucleotide-dna",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "CodeSystem-nucleotide-dna"
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      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/CodeSystem-nucleotide-rna",
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        "resourceType": "OperationOutcome",
        "id": "CodeSystem-nucleotide-rna"
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      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/CodeSystem-strand-orientation",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "CodeSystem-strand-orientation"
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      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/CodeSystem-topology",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "CodeSystem-topology"
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      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/DocumentReference-example-genomicfile-af1961831-url",
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        "resourceType": "OperationOutcome",
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      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/DocumentReference-example-genomicfile-cyp2c19-accession",
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        "resourceType": "OperationOutcome",
        "id": "DocumentReference-example-genomicfile-cyp2c19-accession"
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        "resourceType": "OperationOutcome",
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      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/DocumentReference-example-genomicfile-hla00001",
      "resource": {
        "resourceType": "OperationOutcome",
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      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/DocumentReference-example-genomicfile-mw7162561",
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                "valueInteger": 64
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-message-id",
                "valueCode": "http://hl7.org/fhir/StructureDefinition/Coding#cod-1"
              }
            ],
            "severity": "warning",
            "code": "invariant",
            "details": {
              "text": "Constraint failed: cod-1: 'A Coding SHOULD NOT have a display unless a code is also present.  Computation on Coding.display alone is generally unsafe.  Consider using CodeableConcept.text (code.exists().not() implies display.exists().not())' (defined in http://hl7.org/fhir/StructureDefinition/Coding)"
            },
            "expression": [
              "MolecularDefinition/example-allelesliced-vkorc1-31096368c: MolecularDefinition.representation[0].code[0].coding[0]"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/MolecularDefinition-example-allelesliced-vkorc1-31096368t",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "MolecularDefinition-example-allelesliced-vkorc1-31096368t",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 62
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 10
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-message-id",
                "valueCode": "Coding_has_no_system__cannot_validate"
              }
            ],
            "severity": "warning",
            "code": "invalid",
            "details": {
              "text": "Coding has no system. A code with no system has no defined meaning, and it cannot be validated. A system should be provided"
            },
            "expression": [
              "MolecularDefinition/example-allelesliced-vkorc1-31096368t: MolecularDefinition.representation[0].code[0].coding[0]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 64
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-message-id",
                "valueCode": "http://hl7.org/fhir/StructureDefinition/Coding#cod-1"
              }
            ],
            "severity": "warning",
            "code": "invariant",
            "details": {
              "text": "Constraint failed: cod-1: 'A Coding SHOULD NOT have a display unless a code is also present.  Computation on Coding.display alone is generally unsafe.  Consider using CodeableConcept.text (code.exists().not() implies display.exists().not())' (defined in http://hl7.org/fhir/StructureDefinition/Coding)"
            },
            "expression": [
              "MolecularDefinition/example-allelesliced-vkorc1-31096368t: MolecularDefinition.representation[0].code[0].coding[0]"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/MolecularDefinition-example-genomic-cyp2c19-accession",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "MolecularDefinition-example-genomic-cyp2c19-accession",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 32
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 10
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "MolecularDefinition/example-genomic-cyp2c19-accession: MolecularDefinition.representation[0].code[0].coding[0]"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/MolecularDefinition-example-genotype-cyp2c19-1002-and-3",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "MolecularDefinition-example-genotype-cyp2c19-1002-and-3"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/MolecularDefinition-example-genotype-cyp2c19-1b-and-1c",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "MolecularDefinition-example-genotype-cyp2c19-1b-and-1c"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/MolecularDefinition-example-genotype-hla-00001-and-2",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "MolecularDefinition-example-genotype-hla-00001-and-2"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/MolecularDefinition-example-genotype-vkorc1-31096368c-and-31096368c",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "MolecularDefinition-example-genotype-vkorc1-31096368c-and-31096368c"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/MolecularDefinition-example-genotype-vkorc1-31096368c-and-31096368t",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "MolecularDefinition-example-genotype-vkorc1-31096368c-and-31096368t"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/MolecularDefinition-example-genotype-vkorc1-31096368t-and-31096368t",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "MolecularDefinition-example-genotype-vkorc1-31096368t-and-31096368t"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/MolecularDefinition-example-haplotype-cyp2c19-1002",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "MolecularDefinition-example-haplotype-cyp2c19-1002"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/MolecularDefinition-example-haplotype-cyp2c19-1b",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "MolecularDefinition-example-haplotype-cyp2c19-1b"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/MolecularDefinition-example-haplotype-cyp2c19-1c",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "MolecularDefinition-example-haplotype-cyp2c19-1c"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/MolecularDefinition-example-haplotype-cyp2c19-3002",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "MolecularDefinition-example-haplotype-cyp2c19-3002"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/MolecularDefinition-example-haplotype-hla-00001",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "MolecularDefinition-example-haplotype-hla-00001"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/MolecularDefinition-example-haplotype-hla-00002",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "MolecularDefinition-example-haplotype-hla-00002"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/MolecularDefinition-example-haplotype-vkorc1-31096368c",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "MolecularDefinition-example-haplotype-vkorc1-31096368c"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/MolecularDefinition-example-haplotype-vkorc1-31096368t",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "MolecularDefinition-example-haplotype-vkorc1-31096368t"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/MolecularDefinition-example-sequence-a-aa-iupac",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "MolecularDefinition-example-sequence-a-aa-iupac"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/MolecularDefinition-example-sequence-a-dna-iupac",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "MolecularDefinition-example-sequence-a-dna-iupac"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/MolecularDefinition-example-sequence-c-dna-iupac",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "MolecularDefinition-example-sequence-c-dna-iupac"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/MolecularDefinition-example-sequence-cgg",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "MolecularDefinition-example-sequence-cgg"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/MolecularDefinition-example-sequence-cyp2c19-accession",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "MolecularDefinition-example-sequence-cyp2c19-accession"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/MolecularDefinition-example-sequence-cyp2c19-attached",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "MolecularDefinition-example-sequence-cyp2c19-attached"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/MolecularDefinition-example-sequence-cyp2c19-concatenated-regions",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "MolecularDefinition-example-sequence-cyp2c19-concatenated-regions"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/MolecularDefinition-example-sequence-cyp2c19-downstream-region",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "MolecularDefinition-example-sequence-cyp2c19-downstream-region"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/MolecularDefinition-example-sequence-cyp2c19-gene-region",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "MolecularDefinition-example-sequence-cyp2c19-gene-region"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/MolecularDefinition-example-sequence-cyp2c19-upstream-region",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "MolecularDefinition-example-sequence-cyp2c19-upstream-region"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/MolecularDefinition-example-sequence-cyp2c19-url",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "MolecularDefinition-example-sequence-cyp2c19-url"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/MolecularDefinition-example-sequence-fmr1-cgg-20x-edited-contained",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "MolecularDefinition-example-sequence-fmr1-cgg-20x-edited-contained"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/MolecularDefinition-example-sequence-fmr1-cgg-20x-edited-referenced",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "MolecularDefinition-example-sequence-fmr1-cgg-20x-edited-referenced"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/MolecularDefinition-example-sequence-fmr1-cgg-20x-repeat",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "MolecularDefinition-example-sequence-fmr1-cgg-20x-repeat"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/MolecularDefinition-example-sequence-hla000011",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "MolecularDefinition-example-sequence-hla000011"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/MolecularDefinition-example-sequence-nc00000714-url",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "MolecularDefinition-example-sequence-nc00000714-url"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/MolecularDefinition-example-sequence-nc00001610-url",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "MolecularDefinition-example-sequence-nc00001610-url"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/MolecularDefinition-example-sequence-nm0007694-url",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "MolecularDefinition-example-sequence-nm0007694-url"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/MolecularDefinition-example-variation-cyp2c19-1015-spdi-coded",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "MolecularDefinition-example-variation-cyp2c19-1015-spdi-coded"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/MolecularDefinition-example-variation-cyp2c19-1015-spdi",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "MolecularDefinition-example-variation-cyp2c19-1015-spdi"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/MolecularDefinition-example-variation-cyp2c19-1015-vcf",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "MolecularDefinition-example-variation-cyp2c19-1015-vcf"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/MolecularDefinition-example-variation-cyp2c19-1015-vrs",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "MolecularDefinition-example-variation-cyp2c19-1015-vrs"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/MolecularDefinition-example-variation-cyp2c19-991-hgvs",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "MolecularDefinition-example-variation-cyp2c19-991-hgvs",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 83
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 10
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-message-id",
                "valueCode": "Unknown_Code_in_Version"
              }
            ],
            "severity": "error",
            "code": "code-invalid",
            "details": {
              "text": "Unknown code 'NM_000769.4:c.991A' in the CodeSystem 'http://varnomen.hgvs.org' version '2.0'"
            },
            "expression": [
              "MolecularDefinition/example-variation-cyp2c19-991-hgvs: MolecularDefinition.representation[0].code[0].coding[0].code"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/MolecularDefinition-example-variation-tri-allelic-ABCB1-coded",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "MolecularDefinition-example-variation-tri-allelic-ABCB1-coded"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/MolecularDefinition-example-variation-tri-allelic-ABCB1",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "MolecularDefinition-example-variation-tri-allelic-ABCB1"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/StructureDefinition-allele",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "StructureDefinition-allele",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 79563
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-message-id",
                "valueCode": "http://hl7.org/fhir/StructureDefinition/ElementDefinition#eld-31"
              }
            ],
            "severity": "warning",
            "code": "invariant",
            "details": {
              "text": "Constraint failed: eld-31: 'additionalBindings should have a key (key.exists())' (defined in http://hl7.org/fhir/StructureDefinition/ElementDefinition) (Best Practice Recommendation)"
            },
            "expression": [
              "StructureDefinition/allele: StructureDefinition.snapshot.element[4].binding.additional[0]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 167896
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-message-id",
                "valueCode": "http://hl7.org/fhir/StructureDefinition/ElementDefinition#eld-31"
              }
            ],
            "severity": "warning",
            "code": "invariant",
            "details": {
              "text": "Constraint failed: eld-31: 'additionalBindings should have a key (key.exists())' (defined in http://hl7.org/fhir/StructureDefinition/ElementDefinition) (Best Practice Recommendation)"
            },
            "expression": [
              "StructureDefinition/allele: StructureDefinition.snapshot.element[82].binding.additional[0]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 168028
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-message-id",
                "valueCode": "http://hl7.org/fhir/StructureDefinition/ElementDefinition#eld-31"
              }
            ],
            "severity": "warning",
            "code": "invariant",
            "details": {
              "text": "Constraint failed: eld-31: 'additionalBindings should have a key (key.exists())' (defined in http://hl7.org/fhir/StructureDefinition/ElementDefinition) (Best Practice Recommendation)"
            },
            "expression": [
              "StructureDefinition/allele: StructureDefinition.snapshot.element[82].binding.additional[1]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 168163
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-message-id",
                "valueCode": "http://hl7.org/fhir/StructureDefinition/ElementDefinition#eld-31"
              }
            ],
            "severity": "warning",
            "code": "invariant",
            "details": {
              "text": "Constraint failed: eld-31: 'additionalBindings should have a key (key.exists())' (defined in http://hl7.org/fhir/StructureDefinition/ElementDefinition) (Best Practice Recommendation)"
            },
            "expression": [
              "StructureDefinition/allele: StructureDefinition.snapshot.element[82].binding.additional[2]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 168300
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-message-id",
                "valueCode": "http://hl7.org/fhir/StructureDefinition/ElementDefinition#eld-31"
              }
            ],
            "severity": "warning",
            "code": "invariant",
            "details": {
              "text": "Constraint failed: eld-31: 'additionalBindings should have a key (key.exists())' (defined in http://hl7.org/fhir/StructureDefinition/ElementDefinition) (Best Practice Recommendation)"
            },
            "expression": [
              "StructureDefinition/allele: StructureDefinition.snapshot.element[82].binding.additional[3]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 168433
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-message-id",
                "valueCode": "http://hl7.org/fhir/StructureDefinition/ElementDefinition#eld-31"
              }
            ],
            "severity": "warning",
            "code": "invariant",
            "details": {
              "text": "Constraint failed: eld-31: 'additionalBindings should have a key (key.exists())' (defined in http://hl7.org/fhir/StructureDefinition/ElementDefinition) (Best Practice Recommendation)"
            },
            "expression": [
              "StructureDefinition/allele: StructureDefinition.snapshot.element[82].binding.additional[4]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 168564
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-message-id",
                "valueCode": "http://hl7.org/fhir/StructureDefinition/ElementDefinition#eld-31"
              }
            ],
            "severity": "warning",
            "code": "invariant",
            "details": {
              "text": "Constraint failed: eld-31: 'additionalBindings should have a key (key.exists())' (defined in http://hl7.org/fhir/StructureDefinition/ElementDefinition) (Best Practice Recommendation)"
            },
            "expression": [
              "StructureDefinition/allele: StructureDefinition.snapshot.element[82].binding.additional[5]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 168697
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-message-id",
                "valueCode": "http://hl7.org/fhir/StructureDefinition/ElementDefinition#eld-31"
              }
            ],
            "severity": "warning",
            "code": "invariant",
            "details": {
              "text": "Constraint failed: eld-31: 'additionalBindings should have a key (key.exists())' (defined in http://hl7.org/fhir/StructureDefinition/ElementDefinition) (Best Practice Recommendation)"
            },
            "expression": [
              "StructureDefinition/allele: StructureDefinition.snapshot.element[82].binding.additional[6]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 168828
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-message-id",
                "valueCode": "http://hl7.org/fhir/StructureDefinition/ElementDefinition#eld-31"
              }
            ],
            "severity": "warning",
            "code": "invariant",
            "details": {
              "text": "Constraint failed: eld-31: 'additionalBindings should have a key (key.exists())' (defined in http://hl7.org/fhir/StructureDefinition/ElementDefinition) (Best Practice Recommendation)"
            },
            "expression": [
              "StructureDefinition/allele: StructureDefinition.snapshot.element[82].binding.additional[7]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 256234
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-message-id",
                "valueCode": "http://hl7.org/fhir/StructureDefinition/ElementDefinition#eld-31"
              }
            ],
            "severity": "warning",
            "code": "invariant",
            "details": {
              "text": "Constraint failed: eld-31: 'additionalBindings should have a key (key.exists())' (defined in http://hl7.org/fhir/StructureDefinition/ElementDefinition) (Best Practice Recommendation)"
            },
            "expression": [
              "StructureDefinition/allele: StructureDefinition.snapshot.element[155].binding.additional[0]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 256366
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-message-id",
                "valueCode": "http://hl7.org/fhir/StructureDefinition/ElementDefinition#eld-31"
              }
            ],
            "severity": "warning",
            "code": "invariant",
            "details": {
              "text": "Constraint failed: eld-31: 'additionalBindings should have a key (key.exists())' (defined in http://hl7.org/fhir/StructureDefinition/ElementDefinition) (Best Practice Recommendation)"
            },
            "expression": [
              "StructureDefinition/allele: StructureDefinition.snapshot.element[155].binding.additional[1]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 256501
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-message-id",
                "valueCode": "http://hl7.org/fhir/StructureDefinition/ElementDefinition#eld-31"
              }
            ],
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            "code": "invariant",
            "details": {
              "text": "Constraint failed: eld-31: 'additionalBindings should have a key (key.exists())' (defined in http://hl7.org/fhir/StructureDefinition/ElementDefinition) (Best Practice Recommendation)"
            },
            "expression": [
              "StructureDefinition/allele: StructureDefinition.snapshot.element[155].binding.additional[2]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 256638
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-message-id",
                "valueCode": "http://hl7.org/fhir/StructureDefinition/ElementDefinition#eld-31"
              }
            ],
            "severity": "warning",
            "code": "invariant",
            "details": {
              "text": "Constraint failed: eld-31: 'additionalBindings should have a key (key.exists())' (defined in http://hl7.org/fhir/StructureDefinition/ElementDefinition) (Best Practice Recommendation)"
            },
            "expression": [
              "StructureDefinition/allele: StructureDefinition.snapshot.element[155].binding.additional[3]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 256771
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-message-id",
                "valueCode": "http://hl7.org/fhir/StructureDefinition/ElementDefinition#eld-31"
              }
            ],
            "severity": "warning",
            "code": "invariant",
            "details": {
              "text": "Constraint failed: eld-31: 'additionalBindings should have a key (key.exists())' (defined in http://hl7.org/fhir/StructureDefinition/ElementDefinition) (Best Practice Recommendation)"
            },
            "expression": [
              "StructureDefinition/allele: StructureDefinition.snapshot.element[155].binding.additional[4]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 256902
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-message-id",
                "valueCode": "http://hl7.org/fhir/StructureDefinition/ElementDefinition#eld-31"
              }
            ],
            "severity": "warning",
            "code": "invariant",
            "details": {
              "text": "Constraint failed: eld-31: 'additionalBindings should have a key (key.exists())' (defined in http://hl7.org/fhir/StructureDefinition/ElementDefinition) (Best Practice Recommendation)"
            },
            "expression": [
              "StructureDefinition/allele: StructureDefinition.snapshot.element[155].binding.additional[5]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 257035
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-message-id",
                "valueCode": "http://hl7.org/fhir/StructureDefinition/ElementDefinition#eld-31"
              }
            ],
            "severity": "warning",
            "code": "invariant",
            "details": {
              "text": "Constraint failed: eld-31: 'additionalBindings should have a key (key.exists())' (defined in http://hl7.org/fhir/StructureDefinition/ElementDefinition) (Best Practice Recommendation)"
            },
            "expression": [
              "StructureDefinition/allele: StructureDefinition.snapshot.element[155].binding.additional[6]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 257166
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-message-id",
                "valueCode": "http://hl7.org/fhir/StructureDefinition/ElementDefinition#eld-31"
              }
            ],
            "severity": "warning",
            "code": "invariant",
            "details": {
              "text": "Constraint failed: eld-31: 'additionalBindings should have a key (key.exists())' (defined in http://hl7.org/fhir/StructureDefinition/ElementDefinition) (Best Practice Recommendation)"
            },
            "expression": [
              "StructureDefinition/allele: StructureDefinition.snapshot.element[155].binding.additional[7]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 345350
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-message-id",
                "valueCode": "http://hl7.org/fhir/StructureDefinition/ElementDefinition#eld-31"
              }
            ],
            "severity": "warning",
            "code": "invariant",
            "details": {
              "text": "Constraint failed: eld-31: 'additionalBindings should have a key (key.exists())' (defined in http://hl7.org/fhir/StructureDefinition/ElementDefinition) (Best Practice Recommendation)"
            },
            "expression": [
              "StructureDefinition/allele: StructureDefinition.snapshot.element[228].binding.additional[0]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 345482
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-message-id",
                "valueCode": "http://hl7.org/fhir/StructureDefinition/ElementDefinition#eld-31"
              }
            ],
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            "code": "invariant",
            "details": {
              "text": "Constraint failed: eld-31: 'additionalBindings should have a key (key.exists())' (defined in http://hl7.org/fhir/StructureDefinition/ElementDefinition) (Best Practice Recommendation)"
            },
            "expression": [
              "StructureDefinition/allele: StructureDefinition.snapshot.element[228].binding.additional[1]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 345617
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-message-id",
                "valueCode": "http://hl7.org/fhir/StructureDefinition/ElementDefinition#eld-31"
              }
            ],
            "severity": "warning",
            "code": "invariant",
            "details": {
              "text": "Constraint failed: eld-31: 'additionalBindings should have a key (key.exists())' (defined in http://hl7.org/fhir/StructureDefinition/ElementDefinition) (Best Practice Recommendation)"
            },
            "expression": [
              "StructureDefinition/allele: StructureDefinition.snapshot.element[228].binding.additional[2]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 345754
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-message-id",
                "valueCode": "http://hl7.org/fhir/StructureDefinition/ElementDefinition#eld-31"
              }
            ],
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            "code": "invariant",
            "details": {
              "text": "Constraint failed: eld-31: 'additionalBindings should have a key (key.exists())' (defined in http://hl7.org/fhir/StructureDefinition/ElementDefinition) (Best Practice Recommendation)"
            },
            "expression": [
              "StructureDefinition/allele: StructureDefinition.snapshot.element[228].binding.additional[3]"
            ]
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          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 345887
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-message-id",
                "valueCode": "http://hl7.org/fhir/StructureDefinition/ElementDefinition#eld-31"
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            ],
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            "details": {
              "text": "Constraint failed: eld-31: 'additionalBindings should have a key (key.exists())' (defined in http://hl7.org/fhir/StructureDefinition/ElementDefinition) (Best Practice Recommendation)"
            },
            "expression": [
              "StructureDefinition/allele: StructureDefinition.snapshot.element[228].binding.additional[4]"
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          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 346018
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-message-id",
                "valueCode": "http://hl7.org/fhir/StructureDefinition/ElementDefinition#eld-31"
              }
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            "code": "invariant",
            "details": {
              "text": "Constraint failed: eld-31: 'additionalBindings should have a key (key.exists())' (defined in http://hl7.org/fhir/StructureDefinition/ElementDefinition) (Best Practice Recommendation)"
            },
            "expression": [
              "StructureDefinition/allele: StructureDefinition.snapshot.element[228].binding.additional[5]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 346151
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-message-id",
                "valueCode": "http://hl7.org/fhir/StructureDefinition/ElementDefinition#eld-31"
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            "code": "invariant",
            "details": {
              "text": "Constraint failed: eld-31: 'additionalBindings should have a key (key.exists())' (defined in http://hl7.org/fhir/StructureDefinition/ElementDefinition) (Best Practice Recommendation)"
            },
            "expression": [
              "StructureDefinition/allele: StructureDefinition.snapshot.element[228].binding.additional[6]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 346282
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-message-id",
                "valueCode": "http://hl7.org/fhir/StructureDefinition/ElementDefinition#eld-31"
              }
            ],
            "severity": "warning",
            "code": "invariant",
            "details": {
              "text": "Constraint failed: eld-31: 'additionalBindings should have a key (key.exists())' (defined in http://hl7.org/fhir/StructureDefinition/ElementDefinition) (Best Practice Recommendation)"
            },
            "expression": [
              "StructureDefinition/allele: StructureDefinition.snapshot.element[228].binding.additional[7]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 423151
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-message-id",
                "valueCode": "http://hl7.org/fhir/StructureDefinition/ElementDefinition#eld-31"
              }
            ],
            "severity": "warning",
            "code": "invariant",
            "details": {
              "text": "Constraint failed: eld-31: 'additionalBindings should have a key (key.exists())' (defined in http://hl7.org/fhir/StructureDefinition/ElementDefinition) (Best Practice Recommendation)"
            },
            "expression": [
              "StructureDefinition/allele: StructureDefinition.differential.element[11].binding.additional[0]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 423283
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-message-id",
                "valueCode": "http://hl7.org/fhir/StructureDefinition/ElementDefinition#eld-31"
              }
            ],
            "severity": "warning",
            "code": "invariant",
            "details": {
              "text": "Constraint failed: eld-31: 'additionalBindings should have a key (key.exists())' (defined in http://hl7.org/fhir/StructureDefinition/ElementDefinition) (Best Practice Recommendation)"
            },
            "expression": [
              "StructureDefinition/allele: StructureDefinition.differential.element[11].binding.additional[1]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 423418
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-message-id",
                "valueCode": "http://hl7.org/fhir/StructureDefinition/ElementDefinition#eld-31"
              }
            ],
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            "code": "invariant",
            "details": {
              "text": "Constraint failed: eld-31: 'additionalBindings should have a key (key.exists())' (defined in http://hl7.org/fhir/StructureDefinition/ElementDefinition) (Best Practice Recommendation)"
            },
            "expression": [
              "StructureDefinition/allele: StructureDefinition.differential.element[11].binding.additional[2]"
            ]
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          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 423555
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-message-id",
                "valueCode": "http://hl7.org/fhir/StructureDefinition/ElementDefinition#eld-31"
              }
            ],
            "severity": "warning",
            "code": "invariant",
            "details": {
              "text": "Constraint failed: eld-31: 'additionalBindings should have a key (key.exists())' (defined in http://hl7.org/fhir/StructureDefinition/ElementDefinition) (Best Practice Recommendation)"
            },
            "expression": [
              "StructureDefinition/allele: StructureDefinition.differential.element[11].binding.additional[3]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 423688
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-message-id",
                "valueCode": "http://hl7.org/fhir/StructureDefinition/ElementDefinition#eld-31"
              }
            ],
            "severity": "warning",
            "code": "invariant",
            "details": {
              "text": "Constraint failed: eld-31: 'additionalBindings should have a key (key.exists())' (defined in http://hl7.org/fhir/StructureDefinition/ElementDefinition) (Best Practice Recommendation)"
            },
            "expression": [
              "StructureDefinition/allele: StructureDefinition.differential.element[11].binding.additional[4]"
            ]
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          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 423819
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-message-id",
                "valueCode": "http://hl7.org/fhir/StructureDefinition/ElementDefinition#eld-31"
              }
            ],
            "severity": "warning",
            "code": "invariant",
            "details": {
              "text": "Constraint failed: eld-31: 'additionalBindings should have a key (key.exists())' (defined in http://hl7.org/fhir/StructureDefinition/ElementDefinition) (Best Practice Recommendation)"
            },
            "expression": [
              "StructureDefinition/allele: StructureDefinition.differential.element[11].binding.additional[5]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 423952
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-message-id",
                "valueCode": "http://hl7.org/fhir/StructureDefinition/ElementDefinition#eld-31"
              }
            ],
            "severity": "warning",
            "code": "invariant",
            "details": {
              "text": "Constraint failed: eld-31: 'additionalBindings should have a key (key.exists())' (defined in http://hl7.org/fhir/StructureDefinition/ElementDefinition) (Best Practice Recommendation)"
            },
            "expression": [
              "StructureDefinition/allele: StructureDefinition.differential.element[11].binding.additional[6]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 424083
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-message-id",
                "valueCode": "http://hl7.org/fhir/StructureDefinition/ElementDefinition#eld-31"
              }
            ],
            "severity": "warning",
            "code": "invariant",
            "details": {
              "text": "Constraint failed: eld-31: 'additionalBindings should have a key (key.exists())' (defined in http://hl7.org/fhir/StructureDefinition/ElementDefinition) (Best Practice Recommendation)"
            },
            "expression": [
              "StructureDefinition/allele: StructureDefinition.differential.element[11].binding.additional[7]"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/StructureDefinition-genotype",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "StructureDefinition-genotype",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 33651
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-message-id",
                "valueCode": "http://hl7.org/fhir/StructureDefinition/ElementDefinition#eld-31"
              }
            ],
            "severity": "warning",
            "code": "invariant",
            "details": {
              "text": "Constraint failed: eld-31: 'additionalBindings should have a key (key.exists())' (defined in http://hl7.org/fhir/StructureDefinition/ElementDefinition) (Best Practice Recommendation)"
            },
            "expression": [
              "StructureDefinition/genotype: StructureDefinition.snapshot.element[4].binding.additional[0]"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/StructureDefinition-haplotype",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "StructureDefinition-haplotype",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 35584
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-message-id",
                "valueCode": "http://hl7.org/fhir/StructureDefinition/ElementDefinition#eld-31"
              }
            ],
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            "code": "invariant",
            "details": {
              "text": "Constraint failed: eld-31: 'additionalBindings should have a key (key.exists())' (defined in http://hl7.org/fhir/StructureDefinition/ElementDefinition) (Best Practice Recommendation)"
            },
            "expression": [
              "StructureDefinition/haplotype: StructureDefinition.snapshot.element[4].binding.additional[0]"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/StructureDefinition-sequence",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "StructureDefinition-sequence",
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          {
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              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
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              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 36811
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              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
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              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-message-id",
                "valueCode": "http://hl7.org/fhir/StructureDefinition/ElementDefinition#eld-31"
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            "details": {
              "text": "Constraint failed: eld-31: 'additionalBindings should have a key (key.exists())' (defined in http://hl7.org/fhir/StructureDefinition/ElementDefinition) (Best Practice Recommendation)"
            },
            "expression": [
              "StructureDefinition/sequence: StructureDefinition.snapshot.element[4].binding.additional[0]"
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          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1
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              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 124536
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              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
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              {
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              "text": "Constraint failed: eld-31: 'additionalBindings should have a key (key.exists())' (defined in http://hl7.org/fhir/StructureDefinition/ElementDefinition) (Best Practice Recommendation)"
            },
            "expression": [
              "StructureDefinition/sequence: StructureDefinition.snapshot.element[82].binding.additional[0]"
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            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1
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              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 124668
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-message-id",
                "valueCode": "http://hl7.org/fhir/StructureDefinition/ElementDefinition#eld-31"
              }
            ],
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              "text": "Constraint failed: eld-31: 'additionalBindings should have a key (key.exists())' (defined in http://hl7.org/fhir/StructureDefinition/ElementDefinition) (Best Practice Recommendation)"
            },
            "expression": [
              "StructureDefinition/sequence: StructureDefinition.snapshot.element[82].binding.additional[1]"
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          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
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              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 124803
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
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              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-message-id",
                "valueCode": "http://hl7.org/fhir/StructureDefinition/ElementDefinition#eld-31"
              }
            ],
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            "code": "invariant",
            "details": {
              "text": "Constraint failed: eld-31: 'additionalBindings should have a key (key.exists())' (defined in http://hl7.org/fhir/StructureDefinition/ElementDefinition) (Best Practice Recommendation)"
            },
            "expression": [
              "StructureDefinition/sequence: StructureDefinition.snapshot.element[82].binding.additional[2]"
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          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 124940
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              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
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              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-message-id",
                "valueCode": "http://hl7.org/fhir/StructureDefinition/ElementDefinition#eld-31"
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              "text": "Constraint failed: eld-31: 'additionalBindings should have a key (key.exists())' (defined in http://hl7.org/fhir/StructureDefinition/ElementDefinition) (Best Practice Recommendation)"
            },
            "expression": [
              "StructureDefinition/sequence: StructureDefinition.snapshot.element[82].binding.additional[3]"
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                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
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              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
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              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-message-id",
                "valueCode": "http://hl7.org/fhir/StructureDefinition/ElementDefinition#eld-31"
              }
            ],
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            "details": {
              "text": "Constraint failed: eld-31: 'additionalBindings should have a key (key.exists())' (defined in http://hl7.org/fhir/StructureDefinition/ElementDefinition) (Best Practice Recommendation)"
            },
            "expression": [
              "StructureDefinition/sequence: StructureDefinition.snapshot.element[82].binding.additional[4]"
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          {
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                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1
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              {
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              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
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              {
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              "text": "Constraint failed: eld-31: 'additionalBindings should have a key (key.exists())' (defined in http://hl7.org/fhir/StructureDefinition/ElementDefinition) (Best Practice Recommendation)"
            },
            "expression": [
              "StructureDefinition/sequence: StructureDefinition.snapshot.element[82].binding.additional[5]"
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                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1
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              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
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              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
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              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-message-id",
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              "text": "Constraint failed: eld-31: 'additionalBindings should have a key (key.exists())' (defined in http://hl7.org/fhir/StructureDefinition/ElementDefinition) (Best Practice Recommendation)"
            },
            "expression": [
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                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
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              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
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              {
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            },
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                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
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                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
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              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
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              {
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              "text": "Constraint failed: eld-31: 'additionalBindings should have a key (key.exists())' (defined in http://hl7.org/fhir/StructureDefinition/ElementDefinition) (Best Practice Recommendation)"
            },
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              "text": "Constraint failed: eld-31: 'additionalBindings should have a key (key.exists())' (defined in http://hl7.org/fhir/StructureDefinition/ElementDefinition) (Best Practice Recommendation)"
            },
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              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-message-id",
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              "text": "Constraint failed: eld-31: 'additionalBindings should have a key (key.exists())' (defined in http://hl7.org/fhir/StructureDefinition/ElementDefinition) (Best Practice Recommendation)"
            },
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                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
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                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-message-id",
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              "text": "Constraint failed: eld-31: 'additionalBindings should have a key (key.exists())' (defined in http://hl7.org/fhir/StructureDefinition/ElementDefinition) (Best Practice Recommendation)"
            },
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              "text": "Constraint failed: eld-31: 'additionalBindings should have a key (key.exists())' (defined in http://hl7.org/fhir/StructureDefinition/ElementDefinition) (Best Practice Recommendation)"
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      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/StructureDefinition-variation",
      "resource": {
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                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
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                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
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              "text": "Constraint failed: eld-31: 'additionalBindings should have a key (key.exists())' (defined in http://hl7.org/fhir/StructureDefinition/ElementDefinition) (Best Practice Recommendation)"
            },
            "expression": [
              "StructureDefinition/variation: StructureDefinition.snapshot.element[4].binding.additional[0]"
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    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/ValueSet-amino-acid-1letter-ambiguous",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "ValueSet-amino-acid-1letter-ambiguous"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/ValueSet-amino-acid-1letter-unambiguous",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "ValueSet-amino-acid-1letter-unambiguous"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/ValueSet-amino-acid-3letter-ambiguous",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "ValueSet-amino-acid-3letter-ambiguous"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/ValueSet-amino-acid-3letter-unambiguous",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "ValueSet-amino-acid-3letter-unambiguous"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/ValueSet-coordinate-origin",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "ValueSet-coordinate-origin"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/ValueSet-encodings",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "ValueSet-encodings"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/ValueSet-molecular-definition-focus",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "ValueSet-molecular-definition-focus"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/ValueSet-molecule-type",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "ValueSet-molecule-type"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/ValueSet-normalization-method",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "ValueSet-normalization-method"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/ValueSet-nucleotide-dna-1letter-ambiguous",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "ValueSet-nucleotide-dna-1letter-ambiguous"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/ValueSet-nucleotide-dna-1letter-unambiguous",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "ValueSet-nucleotide-dna-1letter-unambiguous"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/ValueSet-nucleotide-dna-1letter-with-n",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "ValueSet-nucleotide-dna-1letter-with-n"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/ValueSet-nucleotide-rna-1letter-unambiguous",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "ValueSet-nucleotide-rna-1letter-unambiguous"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/ValueSet-strand-orientation",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "ValueSet-strand-orientation"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/molecular-definition-data-types/OperationOutcome/ValueSet-topology",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "ValueSet-topology"
      }
    }
  ]
}