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Narrative

Note: links and images are rebased to the (stated) source

Source1

{
  "resourceType": "Observation",
  "id": "ROS1-Fusion-therapuDrug",
  "meta": {
    "profile": [
      "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication"
    ]
  },
  "text": {
    "status": "extensions",
    "div": "<!-- snip (see above) -->"
  },
  "status": "final",
  "category": [
    {
      "coding": [
        {
          "system": "http://terminology.hl7.org/CodeSystem/observation-category",
          "code": "laboratory"
        }
      ]
    },
    {
      "coding": [
        {
          "system": "http://terminology.hl7.org/CodeSystem/v2-0074",
          "code": "GE"
        }
      ]
    }
  ],
  "code": {
    "coding": [
      {
        "system": "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
        "code": "therapeutic-implication"
      }
    ]
  },
  "subject": {
    "reference": "Patient/somaticPatient"
  },
  "effectiveDateTime": "2023-02-01",
  "performer": [
    {
      "reference": "Practitioner/pathologistPractitioner"
    }
  ],
  "derivedFrom": [
    {
      "reference": "Observation/ROS1-Fusion-var"
    }
  ],
  "component": [
    {
      "code": {
        "coding": [
          {
            "system": "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
            "code": "therapeutic-implication",
            "display": "Therapeutic Implication"
          }
        ]
      },
      "valueCodeableConcept": {
        "coding": [
          {
            "system": "http://loinc.org",
            "code": "LA6677-4",
            "display": "Responsive"
          }
        ],
        "text": "cancer sensitive to crizotinib"
      }
    },
    {
      "code": {
        "coding": [
          {
            "system": "http://loinc.org",
            "code": "81259-4"
          }
        ]
      },
      "valueCodeableConcept": {
        "coding": [
          {
            "system": "http://snomed.info/sct",
            "code": "254637007",
            "display": "Non-small cell lung cancer (disorder)"
          }
        ],
        "text": "Non-small cell lung cancer"
      }
    },
    {
      "extension": [
        {
          "url": "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/workflow-relatedArtifactComponent",
          "valueRelatedArtifact": {
            "type": "citation",
            "url": "https://civicdb.org/molecular-profiles/2562/summary"
          }
        }
      ],
      "code": {
        "coding": [
          {
            "system": "http://loinc.org",
            "code": "51963-7",
            "display": "Medication assessed"
          }
        ]
      },
      "valueCodeableConcept": {
        "text": "Crizotinib"
      }
    },
    {
      "extension": [
        {
          "url": "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/workflow-relatedArtifactComponent",
          "valueRelatedArtifact": {
            "type": "citation",
            "url": "https://civicdb.org/evidence/7282/summary"
          }
        }
      ],
      "code": {
        "coding": [
          {
            "system": "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
            "code": "conclusion-string"
          }
        ]
      },
      "valueString": "Non-small cell lung cancer positive for ROS1 fusions are sensitive to crizotinib"
    },
    {
      "extension": [
        {
          "url": "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/workflow-relatedArtifactComponent",
          "valueRelatedArtifact": {
            "type": "citation",
            "url": "https://www.jmdjournal.org/cms/attachment/ee43a71b-81de-4cb3-ac5e-2fb9a7d41491/gr2.jpg"
          }
        }
      ],
      "code": {
        "coding": [
          {
            "system": "http://loinc.org",
            "code": "93044-6",
            "display": "Level of evidence"
          }
        ]
      },
      "valueCodeableConcept": {
        "text": "Tier I - Level A"
      }
    }
  ]
}