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Packagehl7.fhir.uv.genomics-reporting.r4
Resource TypeBundle
Idvalidation-oo.json
FHIR VersionR4

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No narrative content found in resource


Source1

{
  "resourceType": "Bundle",
  "type": "collection",
  "timestamp": "2024-12-12T21:26:44.587+00:00",
  "entry": [
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/ImplementationGuide-hl7.fhir.uv.genomics-reporting",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "ImplementationGuide-hl7.fhir.uv.genomics-reporting"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Bundle-bundle-CG-IG-HLA-FullBundle-01",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Bundle-bundle-CG-IG-HLA-FullBundle-01",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
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              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
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              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ebi.ac.uk/ipd/imgt/hla' version '3.23' could not be found, so the code cannot be validated. Valid versions: []"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[5].resource/*MolecularSequence/CG-IG-HLA-FullBundle-01-6*/.referenceSeq.referenceSeqId.coding[0].system"
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          },
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            "extension": [
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                "valueString": "TerminologyEngine"
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            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ebi.ac.uk/ipd/imgt/hla' version '3.23' could not be found, so the code cannot be validated. Valid versions: []"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[6].resource/*MolecularSequence/CG-IG-HLA-FullBundle-01-7*/.referenceSeq.referenceSeqId.coding[0].system"
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                "valueString": "TerminologyEngine"
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            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ebi.ac.uk/ipd/imgt/hla' version '3.23' could not be found, so the code cannot be validated. Valid versions: []"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[7].resource/*MolecularSequence/CG-IG-HLA-FullBundle-01-8*/.referenceSeq.referenceSeqId.coding[0].system"
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            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ebi.ac.uk/ipd/imgt/hla' version '3.23' could not be found, so the code cannot be validated. Valid versions: []"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[8].resource/*MolecularSequence/CG-IG-HLA-FullBundle-01-9*/.referenceSeq.referenceSeqId.coding[0].system"
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              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
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                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
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            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ebi.ac.uk/ipd/imgt/hla' version '3.23' could not be found, so the code cannot be validated. Valid versions: []"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[9].resource/*Observation/CG-IG-HLA-FullBundle-01-10*/.value.ofType(CodeableConcept).coding[0].system"
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          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
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              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
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              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/gtr' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[9].resource/*Observation/CG-IG-HLA-FullBundle-01-10*/.method.coding[0].system"
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          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
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              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
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              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[9].resource/*Observation/CG-IG-HLA-FullBundle-01-10*/.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
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          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
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                "valueString": "TerminologyEngine"
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            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/gtr' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[9].resource/*Observation/CG-IG-HLA-FullBundle-01-10*/.method.coding[0]"
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                "valueString": "TerminologyEngine"
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              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[9].resource/*Observation/CG-IG-HLA-FullBundle-01-10*/.component[0].value.ofType(CodeableConcept)"
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                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
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            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[9].resource/*Observation/CG-IG-HLA-FullBundle-01-10*/.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 491
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 10
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ebi.ac.uk/ipd/imgt/hla' version '3.23' could not be found, so the code cannot be validated. Valid versions: []"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[10].resource/*Observation/CG-IG-HLA-FullBundle-01-11*/.value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 501
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 10
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/gtr' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[10].resource/*Observation/CG-IG-HLA-FullBundle-01-11*/.method.coding[0].system"
            ]
          },
          {
            "extension": [
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                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
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              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
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              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[10].resource/*Observation/CG-IG-HLA-FullBundle-01-11*/.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
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                "valueString": "TerminologyEngine"
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            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/gtr' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[10].resource/*Observation/CG-IG-HLA-FullBundle-01-11*/.method.coding[0]"
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          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 537
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[10].resource/*Observation/CG-IG-HLA-FullBundle-01-11*/.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 537
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[10].resource/*Observation/CG-IG-HLA-FullBundle-01-11*/.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 611
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 10
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://glstring.org' version '1.0' could not be found, so the code cannot be validated. Valid versions: []"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[11].resource/*Observation/CG-IG-HLA-FullBundle-01-12*/.value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 620
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 10
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/gtr' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[11].resource/*Observation/CG-IG-HLA-FullBundle-01-12*/.method.coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
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              {
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                "valueString": "TerminologyEngine"
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            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[11].resource/*Observation/CG-IG-HLA-FullBundle-01-12*/.component[0].value.ofType(CodeableConcept).coding[0].system"
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          {
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                "valueString": "TerminologyEngine"
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            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[11].resource/*Observation/CG-IG-HLA-FullBundle-01-12*/.component[0].value.ofType(CodeableConcept)"
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          {
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                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
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              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
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            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[11].resource/*Observation/CG-IG-HLA-FullBundle-01-12*/.component[0].value.ofType(CodeableConcept)"
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          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 681
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 12
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ebi.ac.uk/ipd/imgt/hla' version '3.23' could not be found, so the code cannot be validated. Valid versions: []"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[12].resource/*MolecularSequence/CG-IG-HLA-FullBundle-01-13*/.referenceSeq.referenceSeqId.coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 709
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 12
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ebi.ac.uk/ipd/imgt/hla' version '3.23' could not be found, so the code cannot be validated. Valid versions: []"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[13].resource/*MolecularSequence/CG-IG-HLA-FullBundle-01-14*/.referenceSeq.referenceSeqId.coding[0].system"
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          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 737
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 12
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ebi.ac.uk/ipd/imgt/hla' version '3.23' could not be found, so the code cannot be validated. Valid versions: []"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[14].resource/*MolecularSequence/CG-IG-HLA-FullBundle-01-15*/.referenceSeq.referenceSeqId.coding[0].system"
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          {
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                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
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              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ebi.ac.uk/ipd/imgt/hla' version '3.23' could not be found, so the code cannot be validated. Valid versions: []"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[15].resource/*MolecularSequence/CG-IG-HLA-FullBundle-01-16*/.referenceSeq.referenceSeqId.coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 835
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 10
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ebi.ac.uk/ipd/imgt/hla' version '3.23' could not be found, so the code cannot be validated. Valid versions: []"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[16].resource/*Observation/CG-IG-HLA-FullBundle-01-17*/.value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 845
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 10
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/gtr' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[16].resource/*Observation/CG-IG-HLA-FullBundle-01-17*/.method.coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 881
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[16].resource/*Observation/CG-IG-HLA-FullBundle-01-17*/.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 845
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 10
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/gtr' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[16].resource/*Observation/CG-IG-HLA-FullBundle-01-17*/.method.coding[0]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 881
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[16].resource/*Observation/CG-IG-HLA-FullBundle-01-17*/.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 881
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[16].resource/*Observation/CG-IG-HLA-FullBundle-01-17*/.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 948
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 10
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ebi.ac.uk/ipd/imgt/hla' version '3.23' could not be found, so the code cannot be validated. Valid versions: []"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[17].resource/*Observation/CG-IG-HLA-FullBundle-01-18*/.value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 958
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 10
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/gtr' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[17].resource/*Observation/CG-IG-HLA-FullBundle-01-18*/.method.coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 994
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[17].resource/*Observation/CG-IG-HLA-FullBundle-01-18*/.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 958
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 10
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/gtr' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[17].resource/*Observation/CG-IG-HLA-FullBundle-01-18*/.method.coding[0]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 994
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[17].resource/*Observation/CG-IG-HLA-FullBundle-01-18*/.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 994
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[17].resource/*Observation/CG-IG-HLA-FullBundle-01-18*/.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1068
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 10
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://glstring.org' version '1.0' could not be found, so the code cannot be validated. Valid versions: []"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[18].resource/*Observation/CG-IG-HLA-FullBundle-01-19*/.value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1077
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 10
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/gtr' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[18].resource/*Observation/CG-IG-HLA-FullBundle-01-19*/.method.coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1113
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[18].resource/*Observation/CG-IG-HLA-FullBundle-01-19*/.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1113
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[18].resource/*Observation/CG-IG-HLA-FullBundle-01-19*/.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1113
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[18].resource/*Observation/CG-IG-HLA-FullBundle-01-19*/.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1138
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 12
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ebi.ac.uk/ipd/imgt/hla' version '3.23' could not be found, so the code cannot be validated. Valid versions: []"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[19].resource/*MolecularSequence/CG-IG-HLA-FullBundle-01-20*/.referenceSeq.referenceSeqId.coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1166
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 12
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ebi.ac.uk/ipd/imgt/hla' version '3.23' could not be found, so the code cannot be validated. Valid versions: []"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[20].resource/*MolecularSequence/CG-IG-HLA-FullBundle-01-21*/.referenceSeq.referenceSeqId.coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1194
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 12
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ebi.ac.uk/ipd/imgt/hla' version '3.23' could not be found, so the code cannot be validated. Valid versions: []"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[21].resource/*MolecularSequence/CG-IG-HLA-FullBundle-01-22*/.referenceSeq.referenceSeqId.coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1222
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 12
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ebi.ac.uk/ipd/imgt/hla' version '3.23' could not be found, so the code cannot be validated. Valid versions: []"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[22].resource/*MolecularSequence/CG-IG-HLA-FullBundle-01-23*/.referenceSeq.referenceSeqId.coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1292
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 10
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ebi.ac.uk/ipd/imgt/hla' version '3.23' could not be found, so the code cannot be validated. Valid versions: []"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[23].resource/*Observation/CG-IG-HLA-FullBundle-01-24*/.value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1302
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 10
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/gtr' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[23].resource/*Observation/CG-IG-HLA-FullBundle-01-24*/.method.coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1338
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[23].resource/*Observation/CG-IG-HLA-FullBundle-01-24*/.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1302
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 10
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/gtr' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[23].resource/*Observation/CG-IG-HLA-FullBundle-01-24*/.method.coding[0]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1338
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[23].resource/*Observation/CG-IG-HLA-FullBundle-01-24*/.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1338
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[23].resource/*Observation/CG-IG-HLA-FullBundle-01-24*/.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1405
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 10
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ebi.ac.uk/ipd/imgt/hla' version '3.23' could not be found, so the code cannot be validated. Valid versions: []"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[24].resource/*Observation/CG-IG-HLA-FullBundle-01-25*/.value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1415
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 10
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/gtr' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[24].resource/*Observation/CG-IG-HLA-FullBundle-01-25*/.method.coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1451
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[24].resource/*Observation/CG-IG-HLA-FullBundle-01-25*/.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1415
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 10
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/gtr' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[24].resource/*Observation/CG-IG-HLA-FullBundle-01-25*/.method.coding[0]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1451
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[24].resource/*Observation/CG-IG-HLA-FullBundle-01-25*/.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1451
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[24].resource/*Observation/CG-IG-HLA-FullBundle-01-25*/.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1525
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 10
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://glstring.org' version '1.0' could not be found, so the code cannot be validated. Valid versions: []"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[25].resource/*Observation/CG-IG-HLA-FullBundle-01-26*/.value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1534
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 10
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/gtr' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[25].resource/*Observation/CG-IG-HLA-FullBundle-01-26*/.method.coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1570
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[25].resource/*Observation/CG-IG-HLA-FullBundle-01-26*/.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1570
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[25].resource/*Observation/CG-IG-HLA-FullBundle-01-26*/.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1570
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[25].resource/*Observation/CG-IG-HLA-FullBundle-01-26*/.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1625
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ebi.ac.uk/ipd/imgt/hla' version '3.23' could not be found, so the code cannot be validated. Valid versions: []"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[26].resource/*DiagnosticReport/CG-IG-HLA-FullBundle-01-27*/.extension[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1597
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 10
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-CG-IG-HLA-FullBundle-01: Bundle.entry[26].resource/*DiagnosticReport/CG-IG-HLA-FullBundle-01-27*/.code.coding[1].system"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Bundle-bundle-CYP2C19",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Bundle-bundle-CYP2C19",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 94
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-CYP2C19: Bundle.entry[0].resource/*Observation/dv-5c7e9e1ca62b5*/.component[1].value.ofType(CodeableConcept).coding[0].system"
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          {
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                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 276
              },
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                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
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              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-CYP2C19: Bundle.entry[1].resource/*Observation/dv-5c7e9e1ca6342*/.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
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                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 458
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-CYP2C19: Bundle.entry[2].resource/*Observation/dv-5c7e9e1ca63bf*/.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 640
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-CYP2C19: Bundle.entry[3].resource/*Observation/dv-5c7e9e1ca643a*/.component[1].value.ofType(CodeableConcept).coding[0].system"
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          },
          {
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                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
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              },
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                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
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              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-CYP2C19: Bundle.entry[4].resource/*Observation/dv-5c7e9e1ca64b5*/.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
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                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
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              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-CYP2C19: Bundle.entry[5].resource/*Observation/dv-5c7e9e1ca6531*/.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1186
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
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              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-CYP2C19: Bundle.entry[6].resource/*Observation/dv-5c7e9e1ca65ac*/.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1368
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-CYP2C19: Bundle.entry[7].resource/*Observation/dv-5c7e9e1ca6627*/.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1550
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-CYP2C19: Bundle.entry[8].resource/*Observation/dv-5c7e9e1ca66a1*/.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1732
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
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              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-CYP2C19: Bundle.entry[9].resource/*Observation/dv-5c7e9e1ca671c*/.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
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            "extension": [
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                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1914
              },
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                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
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              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-CYP2C19: Bundle.entry[10].resource/*Observation/dv-5c7e9e1ca6797*/.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 2096
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
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              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
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                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-CYP2C19: Bundle.entry[66].resource/*Observation/dv-5c7e9e1ca8618*/.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 12288
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-CYP2C19: Bundle.entry[67].resource/*Observation/dv-5c7e9e1ca869c*/.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 12470
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-CYP2C19: Bundle.entry[68].resource/*Observation/dv-5c7e9e1ca871e*/.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 12652
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-CYP2C19: Bundle.entry[69].resource/*Observation/dv-5c7e9e1ca879f*/.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 12834
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-CYP2C19: Bundle.entry[70].resource/*Observation/dv-5c7e9e1ca8820*/.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 13016
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-CYP2C19: Bundle.entry[71].resource/*Observation/dv-5c7e9e1ca88a5*/.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 13198
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-CYP2C19: Bundle.entry[72].resource/*Observation/dv-5c7e9e1ca8927*/.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 13380
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-CYP2C19: Bundle.entry[73].resource/*Observation/dv-5c7e9e1ca89a8*/.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Bundle-bundle-cgexample-withGrouping",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Bundle-bundle-cgexample-withGrouping",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 234
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/clinvar' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-cgexample-withGrouping: Bundle.entry[5].resource/*Observation/discrete-variant-1a*/.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 253
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-cgexample-withGrouping: Bundle.entry[5].resource/*Observation/discrete-variant-1a*/.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 272
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-cgexample-withGrouping: Bundle.entry[5].resource/*Observation/discrete-variant-1a*/.component[2].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 290
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-cgexample-withGrouping: Bundle.entry[5].resource/*Observation/discrete-variant-1a*/.component[3].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 326
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/projects/SNP' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-cgexample-withGrouping: Bundle.entry[5].resource/*Observation/discrete-variant-1a*/.component[5].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 253
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-cgexample-withGrouping: Bundle.entry[5].resource/*Observation/discrete-variant-1a*/.component[1].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 253
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-cgexample-withGrouping: Bundle.entry[5].resource/*Observation/discrete-variant-1a*/.component[1].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 646
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://purl.obolibrary.org/obo/mondo.owl' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-cgexample-withGrouping: Bundle.entry[6].resource/*Observation/dis-path-1a*/.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 893
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/clinvar' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-cgexample-withGrouping: Bundle.entry[9].resource/*Observation/complex-component-D-1a*/.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 912
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-cgexample-withGrouping: Bundle.entry[9].resource/*Observation/complex-component-D-1a*/.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1050
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/clinvar' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-cgexample-withGrouping: Bundle.entry[10].resource/*Observation/complex-component-E-1a*/.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1069
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-cgexample-withGrouping: Bundle.entry[10].resource/*Observation/complex-component-E-1a*/.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1107
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-message-id",
                "valueCode": "Reference_REF_MultipleMatches"
              }
            ],
            "severity": "warning",
            "code": "structure",
            "details": {
              "text": "Found multiple matching profiles for Task/usage-1a among choices: http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/followup-recommendation|3.0.0, http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/medication-recommendation|3.0.0"
            },
            "expression": [
              "Bundle/bundle-cgexample-withGrouping: Bundle.entry[11].resource/*Observation/pharmPanel-1a*/.extension[0].value.ofType(Reference)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1213
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 10
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ebi.ac.uk/ipd/imgt/hla' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-cgexample-withGrouping: Bundle.entry[12].resource/*Observation/haplotype-1a*/.value.ofType(CodeableConcept).coding[0]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1278
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 10
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.pharmvar.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-cgexample-withGrouping: Bundle.entry[13].resource/*Observation/genotype-1a*/.value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1305
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-cgexample-withGrouping: Bundle.entry[13].resource/*Observation/genotype-1a*/.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1324
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-cgexample-withGrouping: Bundle.entry[13].resource/*Observation/genotype-1a*/.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1278
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 10
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.pharmvar.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-cgexample-withGrouping: Bundle.entry[13].resource.value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1305
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-cgexample-withGrouping: Bundle.entry[13].resource.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1305
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-cgexample-withGrouping: Bundle.entry[13].resource.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1305
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-cgexample-withGrouping: Bundle.entry[13].resource.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1324
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-cgexample-withGrouping: Bundle.entry[13].resource.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1324
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-cgexample-withGrouping: Bundle.entry[13].resource.component[1].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1324
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-cgexample-withGrouping: Bundle.entry[13].resource.component[1].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Bundle-bundle-cgexample",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Bundle-bundle-cgexample",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 230
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/clinvar' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-cgexample: Bundle.entry[5].resource/*Observation/discrete-variant*/.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 249
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-cgexample: Bundle.entry[5].resource/*Observation/discrete-variant*/.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 268
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-cgexample: Bundle.entry[5].resource/*Observation/discrete-variant*/.component[2].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 286
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-cgexample: Bundle.entry[5].resource/*Observation/discrete-variant*/.component[3].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 322
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/projects/SNP' version '137' could not be found, so the code cannot be validated. Valid versions: []"
            },
            "expression": [
              "Bundle/bundle-cgexample: Bundle.entry[5].resource/*Observation/discrete-variant*/.component[5].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 249
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-cgexample: Bundle.entry[5].resource/*Observation/discrete-variant*/.component[1].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 249
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-cgexample: Bundle.entry[5].resource/*Observation/discrete-variant*/.component[1].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 671
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://purl.obolibrary.org/obo/mondo.owl' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-cgexample: Bundle.entry[6].resource/*Observation/dis-path*/.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 918
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/clinvar' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-cgexample: Bundle.entry[9].resource/*Observation/complex-component-D*/.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 937
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-cgexample: Bundle.entry[9].resource/*Observation/complex-component-D*/.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1075
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/clinvar' version '???' could not be found, so the code cannot be validated. Valid versions: []"
            },
            "expression": [
              "Bundle/bundle-cgexample: Bundle.entry[10].resource/*Observation/complex-component-E*/.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1095
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-cgexample: Bundle.entry[10].resource/*Observation/complex-component-E*/.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1172
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 10
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ebi.ac.uk/ipd/imgt/hla' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-cgexample: Bundle.entry[11].resource/*Observation/haplotype*/.value.ofType(CodeableConcept).coding[0]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1237
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 10
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.pharmvar.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-cgexample: Bundle.entry[12].resource/*Observation/genotype*/.value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1264
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-cgexample: Bundle.entry[12].resource/*Observation/genotype*/.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1283
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-cgexample: Bundle.entry[12].resource/*Observation/genotype*/.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1264
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-cgexample: Bundle.entry[12].resource/*Observation/genotype*/.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1264
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-cgexample: Bundle.entry[12].resource/*Observation/genotype*/.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1283
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-cgexample: Bundle.entry[12].resource/*Observation/genotype*/.component[1].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1283
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-cgexample: Bundle.entry[12].resource/*Observation/genotype*/.component[1].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Bundle-bundle-complexVariant-nonHGVS",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Bundle-bundle-complexVariant-nonHGVS",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 74
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-complexVariant-nonHGVS: Bundle.entry[0].resource/*Observation/Inline-Instance-for-complexVariant-nonHGVS-1*/.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 221
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-complexVariant-nonHGVS: Bundle.entry[1].resource/*Observation/Inline-Instance-for-complexVariant-nonHGVS-2*/.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 347
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 10
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/clinvar' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-complexVariant-nonHGVS: Bundle.entry[2].resource/*Observation/Inline-Instance-for-complexVariant-nonHGVS-3*/.value.ofType(CodeableConcept).coding[0].system"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Bundle-bundle-compound-heterozygote",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Bundle-bundle-compound-heterozygote",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 263
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 10
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/clinvar' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-compound-heterozygote: Bundle.entry[2].resource/*Observation/Inline-Instance-for-compound-heterozygote-3*/.value.ofType(CodeableConcept).coding[0].system"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Bundle-bundle-oncology-diagnostic",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Bundle-bundle-oncology-diagnostic",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 304
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/clinvar' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-oncology-diagnostic: Bundle.entry[4].resource/*Observation/Inline-Instance-for-oncology-diagnostic-5*/.component[2].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 344
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-oncology-diagnostic: Bundle.entry[4].resource/*Observation/Inline-Instance-for-oncology-diagnostic-5*/.component[4].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 344
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-oncology-diagnostic: Bundle.entry[4].resource/*Observation/Inline-Instance-for-oncology-diagnostic-5*/.component[4].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 344
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-oncology-diagnostic: Bundle.entry[4].resource/*Observation/Inline-Instance-for-oncology-diagnostic-5*/.component[4].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Bundle-bundle-oncology-report-example",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Bundle-bundle-oncology-report-example",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 188
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[3].resource/*Observation/Inline-Instance-for-oncology-report-example-4*/.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 248
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[3].resource/*Observation/Inline-Instance-for-oncology-report-example-4*/.component[4].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 288
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[3].resource/*Observation/Inline-Instance-for-oncology-report-example-4*/.component[6].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 188
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[3].resource/*Observation/Inline-Instance-for-oncology-report-example-4*/.component[1].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 188
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[3].resource/*Observation/Inline-Instance-for-oncology-report-example-4*/.component[1].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 248
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[3].resource/*Observation/Inline-Instance-for-oncology-report-example-4*/.component[4].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 248
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[3].resource/*Observation/Inline-Instance-for-oncology-report-example-4*/.component[4].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 453
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[4].resource/*Observation/Inline-Instance-for-oncology-report-example-5*/.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 513
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[4].resource/*Observation/Inline-Instance-for-oncology-report-example-5*/.component[4].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 533
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[4].resource/*Observation/Inline-Instance-for-oncology-report-example-5*/.component[5].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 453
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[4].resource/*Observation/Inline-Instance-for-oncology-report-example-5*/.component[1].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 453
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[4].resource/*Observation/Inline-Instance-for-oncology-report-example-5*/.component[1].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 513
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[4].resource/*Observation/Inline-Instance-for-oncology-report-example-5*/.component[4].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 513
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[4].resource/*Observation/Inline-Instance-for-oncology-report-example-5*/.component[4].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 698
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[5].resource/*Observation/Inline-Instance-for-oncology-report-example-6*/.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 758
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[5].resource/*Observation/Inline-Instance-for-oncology-report-example-6*/.component[4].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 798
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[5].resource/*Observation/Inline-Instance-for-oncology-report-example-6*/.component[6].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 698
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[5].resource/*Observation/Inline-Instance-for-oncology-report-example-6*/.component[1].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 698
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[5].resource/*Observation/Inline-Instance-for-oncology-report-example-6*/.component[1].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 758
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[5].resource/*Observation/Inline-Instance-for-oncology-report-example-6*/.component[4].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 758
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[5].resource/*Observation/Inline-Instance-for-oncology-report-example-6*/.component[4].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 963
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[6].resource/*Observation/Inline-Instance-for-oncology-report-example-7*/.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1023
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[6].resource/*Observation/Inline-Instance-for-oncology-report-example-7*/.component[4].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1043
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[6].resource/*Observation/Inline-Instance-for-oncology-report-example-7*/.component[5].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 963
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[6].resource/*Observation/Inline-Instance-for-oncology-report-example-7*/.component[1].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 963
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[6].resource/*Observation/Inline-Instance-for-oncology-report-example-7*/.component[1].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1023
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[6].resource/*Observation/Inline-Instance-for-oncology-report-example-7*/.component[4].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1023
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[6].resource/*Observation/Inline-Instance-for-oncology-report-example-7*/.component[4].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1208
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[7].resource/*Observation/Inline-Instance-for-oncology-report-example-8*/.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1268
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[7].resource/*Observation/Inline-Instance-for-oncology-report-example-8*/.component[4].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1288
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[7].resource/*Observation/Inline-Instance-for-oncology-report-example-8*/.component[5].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1208
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[7].resource/*Observation/Inline-Instance-for-oncology-report-example-8*/.component[1].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1208
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[7].resource/*Observation/Inline-Instance-for-oncology-report-example-8*/.component[1].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1268
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[7].resource/*Observation/Inline-Instance-for-oncology-report-example-8*/.component[4].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1268
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[7].resource/*Observation/Inline-Instance-for-oncology-report-example-8*/.component[4].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1453
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[8].resource/*Observation/Inline-Instance-for-oncology-report-example-9*/.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1513
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[8].resource/*Observation/Inline-Instance-for-oncology-report-example-9*/.component[4].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1533
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[8].resource/*Observation/Inline-Instance-for-oncology-report-example-9*/.component[5].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1453
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[8].resource/*Observation/Inline-Instance-for-oncology-report-example-9*/.component[1].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1453
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[8].resource/*Observation/Inline-Instance-for-oncology-report-example-9*/.component[1].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1513
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[8].resource/*Observation/Inline-Instance-for-oncology-report-example-9*/.component[4].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1513
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[8].resource/*Observation/Inline-Instance-for-oncology-report-example-9*/.component[4].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1698
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[9].resource/*Observation/Inline-Instance-for-oncology-report-example-10*/.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1757
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[9].resource/*Observation/Inline-Instance-for-oncology-report-example-10*/.component[4].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1796
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[9].resource/*Observation/Inline-Instance-for-oncology-report-example-10*/.component[6].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1698
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[9].resource/*Observation/Inline-Instance-for-oncology-report-example-10*/.component[1].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1698
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[9].resource/*Observation/Inline-Instance-for-oncology-report-example-10*/.component[1].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1757
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[9].resource/*Observation/Inline-Instance-for-oncology-report-example-10*/.component[4].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1757
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[9].resource/*Observation/Inline-Instance-for-oncology-report-example-10*/.component[4].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1961
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[10].resource/*Observation/Inline-Instance-for-oncology-report-example-11*/.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 2020
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[10].resource/*Observation/Inline-Instance-for-oncology-report-example-11*/.component[4].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 2059
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[10].resource/*Observation/Inline-Instance-for-oncology-report-example-11*/.component[6].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1961
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[10].resource/*Observation/Inline-Instance-for-oncology-report-example-11*/.component[1].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1961
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[10].resource/*Observation/Inline-Instance-for-oncology-report-example-11*/.component[1].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 2020
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[10].resource/*Observation/Inline-Instance-for-oncology-report-example-11*/.component[4].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 2020
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[10].resource/*Observation/Inline-Instance-for-oncology-report-example-11*/.component[4].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 2224
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[11].resource/*Observation/Inline-Instance-for-oncology-report-example-12*/.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 2283
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[11].resource/*Observation/Inline-Instance-for-oncology-report-example-12*/.component[4].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 2322
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[11].resource/*Observation/Inline-Instance-for-oncology-report-example-12*/.component[6].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 2224
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[11].resource/*Observation/Inline-Instance-for-oncology-report-example-12*/.component[1].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 2224
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[11].resource/*Observation/Inline-Instance-for-oncology-report-example-12*/.component[1].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 2283
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[11].resource/*Observation/Inline-Instance-for-oncology-report-example-12*/.component[4].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 2283
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[11].resource/*Observation/Inline-Instance-for-oncology-report-example-12*/.component[4].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 2487
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[12].resource/*Observation/Inline-Instance-for-oncology-report-example-13*/.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 2546
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[12].resource/*Observation/Inline-Instance-for-oncology-report-example-13*/.component[4].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 2566
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[12].resource/*Observation/Inline-Instance-for-oncology-report-example-13*/.component[5].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 2487
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[12].resource/*Observation/Inline-Instance-for-oncology-report-example-13*/.component[1].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 2487
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-oncology-report-example: Bundle.entry[12].resource/*Observation/Inline-Instance-for-oncology-report-example-13*/.component[1].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 2546
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
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            "code": "code-invalid",
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              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
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              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
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              "Bundle/bundle-oncologyexamples-r4-withGrouping: Bundle.entry[7].resource/*Observation/Inline-Instance-for-oncologyexamples-r4-withGrouping-8*/.component[2].value.ofType(CodeableConcept).coding[0].system"
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            "code": "code-invalid",
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              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
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            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 418
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-oncologyexamples-r4: Bundle.entry[5].resource/*Observation/Inline-Instance-for-oncologyexamples-r4-6*/.component[3].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 418
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-oncologyexamples-r4: Bundle.entry[5].resource/*Observation/Inline-Instance-for-oncologyexamples-r4-6*/.component[3].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 418
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-oncologyexamples-r4: Bundle.entry[5].resource/*Observation/Inline-Instance-for-oncologyexamples-r4-6*/.component[3].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 573
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-oncologyexamples-r4: Bundle.entry[6].resource/*Observation/Inline-Instance-for-oncologyexamples-r4-7*/.component[3].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 573
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-oncologyexamples-r4: Bundle.entry[6].resource/*Observation/Inline-Instance-for-oncologyexamples-r4-7*/.component[3].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 573
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-oncologyexamples-r4: Bundle.entry[6].resource/*Observation/Inline-Instance-for-oncologyexamples-r4-7*/.component[3].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 708
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-oncologyexamples-r4: Bundle.entry[7].resource/*Observation/Inline-Instance-for-oncologyexamples-r4-8*/.component[2].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 708
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-oncologyexamples-r4: Bundle.entry[7].resource/*Observation/Inline-Instance-for-oncologyexamples-r4-8*/.component[2].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 708
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-oncologyexamples-r4: Bundle.entry[7].resource/*Observation/Inline-Instance-for-oncologyexamples-r4-8*/.component[2].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Bundle-bundle-pgxexample",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Bundle-bundle-pgxexample",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 37
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-message-id",
                "valueCode": "Reference_REF_MultipleMatches"
              }
            ],
            "severity": "warning",
            "code": "structure",
            "details": {
              "text": "Found multiple matching profiles for Task/med-usage-impact-task-pgx-example among choices: http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/followup-recommendation|3.0.0, http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/medication-recommendation|3.0.0"
            },
            "expression": [
              "Bundle/bundle-pgxexample: Bundle.entry[0].resource/*DiagnosticReport/pgx-report*/.extension[0].value.ofType(Reference)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 303
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 10
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.pharmvar.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-pgxexample: Bundle.entry[6].resource/*Observation/genotype-pgx-example*/.value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 334
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-pgxexample: Bundle.entry[6].resource/*Observation/genotype-pgx-example*/.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 303
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 10
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.pharmvar.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-pgxexample: Bundle.entry[6].resource.value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 334
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-pgxexample: Bundle.entry[6].resource.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 334
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-pgxexample: Bundle.entry[6].resource.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 334
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-pgxexample: Bundle.entry[6].resource.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 399
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 10
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.pharmvar.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-pgxexample: Bundle.entry[7].resource/*Observation/haplotype-1-pgx-example*/.value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 427
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-pgxexample: Bundle.entry[7].resource/*Observation/haplotype-1-pgx-example*/.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 427
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-pgxexample: Bundle.entry[7].resource/*Observation/haplotype-1-pgx-example*/.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 427
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-pgxexample: Bundle.entry[7].resource/*Observation/haplotype-1-pgx-example*/.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 492
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 10
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.pharmvar.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-pgxexample: Bundle.entry[8].resource/*Observation/haplotype-2-pgx-example*/.value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 520
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-pgxexample: Bundle.entry[8].resource/*Observation/haplotype-2-pgx-example*/.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 520
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-pgxexample: Bundle.entry[8].resource/*Observation/haplotype-2-pgx-example*/.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 520
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-pgxexample: Bundle.entry[8].resource/*Observation/haplotype-2-pgx-example*/.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 613
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-pgxexample: Bundle.entry[9].resource/*Observation/variant-1-pgx-example*/.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 632
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/projects/SNP' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-pgxexample: Bundle.entry[9].resource/*Observation/variant-1-pgx-example*/.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 613
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-pgxexample: Bundle.entry[9].resource/*Observation/variant-1-pgx-example*/.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 613
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-pgxexample: Bundle.entry[9].resource/*Observation/variant-1-pgx-example*/.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 766
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-pgxexample: Bundle.entry[10].resource/*Observation/variant-2-pgx-example*/.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 786
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-pgxexample: Bundle.entry[10].resource/*Observation/variant-2-pgx-example*/.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 804
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/projects/SNP' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-pgxexample: Bundle.entry[10].resource/*Observation/variant-2-pgx-example*/.component[2].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 766
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-pgxexample: Bundle.entry[10].resource/*Observation/variant-2-pgx-example*/.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 766
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Bundle/bundle-pgxexample: Bundle.entry[10].resource/*Observation/variant-2-pgx-example*/.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 871
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 12
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-pgxexample: Bundle.entry[11].resource/*MolecularSequence/sequence-1-pgx-example*/.referenceSeq.referenceSeqId.coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 897
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 12
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-pgxexample: Bundle.entry[12].resource/*MolecularSequence/sequence-2-pgx-example*/.referenceSeq.referenceSeqId.coding[0].system"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Bundle-bundle-sequence-phase-relation-CYP2C19",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Bundle-bundle-sequence-phase-relation-CYP2C19",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 94
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-sequence-phase-relation-CYP2C19: Bundle.entry[0].resource/*Observation/dv-5c7e9e1ca8252*/.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 276
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Bundle/bundle-sequence-phase-relation-CYP2C19: Bundle.entry[1].resource/*Observation/dv-5c7e9e1ca82e4*/.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/CodeSystem-clinvar-evidence-level-custom-cs",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "CodeSystem-clinvar-evidence-level-custom-cs"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/CodeSystem-coded-annotation-types-cs",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "CodeSystem-coded-annotation-types-cs"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/CodeSystem-genomic-study-change-type-cs",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "CodeSystem-genomic-study-change-type-cs"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/CodeSystem-genomic-study-data-format-cs",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "CodeSystem-genomic-study-data-format-cs"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/CodeSystem-genomic-study-method-type-cs",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "CodeSystem-genomic-study-method-type-cs"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/CodeSystem-genomic-study-status-cs",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "CodeSystem-genomic-study-status-cs"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/CodeSystem-genomic-study-type-cs",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "CodeSystem-genomic-study-type-cs"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/CodeSystem-molecular-biomarker-ontology-cs",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "CodeSystem-molecular-biomarker-ontology-cs"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/CodeSystem-pharmgkb-evidence-level-custom-cs",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "CodeSystem-pharmgkb-evidence-level-custom-cs"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/CodeSystem-sequence-phase-relationship-cs",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "CodeSystem-sequence-phase-relationship-cs"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/CodeSystem-tbd-codes-cs",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "CodeSystem-tbd-codes-cs"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/CodeSystem-variant-confidence-status-cs",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "CodeSystem-variant-confidence-status-cs"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/ConceptMap-GenomicStudyStatusMap",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "ConceptMap-GenomicStudyStatusMap"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/ConceptMap-dna-change-type-map",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "ConceptMap-dna-change-type-map",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 4669
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-message-id",
                "valueCode": "CONCEPTMAP_GROUP_TARGET_INCOMPLETE"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "Target Code System http://www.sequenceontology.org doesn't have all content (content = not-present), so the target codes cannot be checked"
            },
            "expression": [
              "ConceptMap/dna-change-type-map: ConceptMap.group[0].target"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 3844
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              }
            ],
            "severity": "warning",
            "code": "business-rule",
            "details": {
              "text": "The code 'SO:0002073' comes from the system http://www.sequenceontology.org which could not be found, so it's not known whether it's valid in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs'"
            },
            "expression": [
              "ConceptMap/dna-change-type-map: ConceptMap.group[0].element[0].target[0].code"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 3980
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              }
            ],
            "severity": "warning",
            "code": "business-rule",
            "details": {
              "text": "The code 'SO:0000159' comes from the system http://www.sequenceontology.org which could not be found, so it's not known whether it's valid in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs'"
            },
            "expression": [
              "ConceptMap/dna-change-type-map: ConceptMap.group[0].element[1].target[0].code"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 4105
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              }
            ],
            "severity": "warning",
            "code": "business-rule",
            "details": {
              "text": "The code 'SO:1000035' comes from the system http://www.sequenceontology.org which could not be found, so it's not known whether it's valid in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs'"
            },
            "expression": [
              "ConceptMap/dna-change-type-map: ConceptMap.group[0].element[2].target[0].code"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 4231
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              }
            ],
            "severity": "warning",
            "code": "business-rule",
            "details": {
              "text": "The code 'SO:0000667' comes from the system http://www.sequenceontology.org which could not be found, so it's not known whether it's valid in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs'"
            },
            "expression": [
              "ConceptMap/dna-change-type-map: ConceptMap.group[0].element[3].target[0].code"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 4364
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              }
            ],
            "severity": "warning",
            "code": "business-rule",
            "details": {
              "text": "The code 'SO:1000032' comes from the system http://www.sequenceontology.org which could not be found, so it's not known whether it's valid in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs'"
            },
            "expression": [
              "ConceptMap/dna-change-type-map: ConceptMap.group[0].element[4].target[0].code"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 4485
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              }
            ],
            "severity": "warning",
            "code": "business-rule",
            "details": {
              "text": "The code 'SO:1000036' comes from the system http://www.sequenceontology.org which could not be found, so it's not known whether it's valid in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs'"
            },
            "expression": [
              "ConceptMap/dna-change-type-map: ConceptMap.group[0].element[5].target[0].code"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 4612
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              }
            ],
            "severity": "warning",
            "code": "business-rule",
            "details": {
              "text": "The code 'SO:1000002' comes from the system http://www.sequenceontology.org which could not be found, so it's not known whether it's valid in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs'"
            },
            "expression": [
              "ConceptMap/dna-change-type-map: ConceptMap.group[0].element[6].target[0].code"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Device-triodenovo-software",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Device-triodenovo-software"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/DiagnosticReport-GenomicReportExample01",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "DiagnosticReport-GenomicReportExample01"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/DiagnosticReport-PGxGenomicReportEMERGE-withGrouping",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "DiagnosticReport-PGxGenomicReportEMERGE-withGrouping",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 9
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 4
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://example.org/hgsc.bcm.edu/lab-test-codes/' could not be found, so the code cannot be validated"
            },
            "expression": [
              "DiagnosticReport/PGxGenomicReportEMERGE-withGrouping: DiagnosticReport.code.coding[1]"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/DiagnosticReport-PGxGenomicReportEMERGE",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "DiagnosticReport-PGxGenomicReportEMERGE",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 9
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 4
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://example.org/hgsc.bcm.edu/lab-test-codes/' could not be found, so the code cannot be validated"
            },
            "expression": [
              "DiagnosticReport/PGxGenomicReportEMERGE: DiagnosticReport.code.coding[1]"
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          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/DiagnosticReport-diagnosticreport-hla-glstring-r4",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "DiagnosticReport-diagnosticreport-hla-glstring-r4",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
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              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
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              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "DiagnosticReport/diagnosticreport-hla-glstring-r4: DiagnosticReport.code.coding[1].system"
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          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/DiagnosticReport-somaticReport",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "DiagnosticReport-somaticReport"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/DocumentReference-CNVAnalysis-called",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "DocumentReference-CNVAnalysis-called"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/DocumentReference-FullGenome-GRCh38",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "DocumentReference-FullGenome-GRCh38"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/DocumentReference-SimpleVariantAnalysis-called",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "DocumentReference-SimpleVariantAnalysis-called"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/DocumentReference-UncallableRegions",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "DocumentReference-UncallableRegions"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/DocumentReference-WES-FullSequencedRegion-GRCh38",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "DocumentReference-WES-FullSequencedRegion-GRCh38"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/DocumentReference-WES-UncallableRegions-GRCh38",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "DocumentReference-WES-UncallableRegions-GRCh38"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/DocumentReference-genomicFileFatherBAM",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "DocumentReference-genomicFileFatherBAM"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/DocumentReference-genomicFileMotherBAM",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "DocumentReference-genomicFileMotherBAM"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/DocumentReference-genomicFileProbandBAM",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "DocumentReference-genomicFileProbandBAM"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/DocumentReference-genomicFileProbandVCF",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "DocumentReference-genomicFileProbandVCF"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/DocumentReference-genomicVCFfile-cnv",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "DocumentReference-genomicVCFfile-cnv"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/DocumentReference-genomicVCFfile-simple",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "DocumentReference-genomicVCFfile-simple"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/DocumentReference-somaticVCFfile",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "DocumentReference-somaticVCFfile"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/MedicationStatement-MedicationStatementWarfarin",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "MedicationStatement-MedicationStatementWarfarin"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-ATR-insertion-molc",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-ATR-insertion-molc",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 81
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/ATR-insertion-molc: Observation.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 100
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/ATR-insertion-molc: Observation.component[2].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 100
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/molecular-consequence-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/ATR-insertion-molc: Observation.component[2].value.ofType(CodeableConcept)"
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          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 100
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/molecular-consequence-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/ATR-insertion-molc: Observation.component[2].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 119
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/ATR-insertion-molc: Observation.component[3].value.ofType(CodeableConcept).coding[0].system"
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          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 119
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/functional-effect-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/ATR-insertion-molc: Observation.component[3].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 119
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/functional-effect-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/ATR-insertion-molc: Observation.component[3].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-ATR-insertion-significance",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-ATR-insertion-significance"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-ATR-insertion-var",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-ATR-insertion-var",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/ATR-insertion-var: Observation.component[0].value.ofType(CodeableConcept).coding[0].system"
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          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 79
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
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              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/ATR-insertion-var: Observation.component[2].value.ofType(CodeableConcept).coding[0].system"
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          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 79
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
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              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
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          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
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              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
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              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
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            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
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                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
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              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
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              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
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          {
            "extension": [
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                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
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              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
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                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
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            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
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          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
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              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
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              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
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          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 183
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/ATR-insertion-var: Observation.component[8].value.ofType(CodeableConcept).coding[0].system"
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          }
        ]
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    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-AnnotationExample",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-AnnotationExample"
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    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-EGFR-L858R-molc",
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        "resourceType": "OperationOutcome",
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                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
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                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
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            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
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          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
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              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
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                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
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            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/molecular-consequence-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
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          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
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              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
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              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/molecular-consequence-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
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    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-EGFR-L858R-significance",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-EGFR-L858R-significance"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-EGFR-L858R-therapuDrug1",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-EGFR-L858R-therapuDrug1"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-EGFR-L858R-therapuDrug2",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-EGFR-L858R-therapuDrug2"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-EGFR-L858R-var",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-EGFR-L858R-var",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 76
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/EGFR-L858R-var: Observation.component[2].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 76
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/EGFR-L858R-var: Observation.component[2].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 76
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/EGFR-L858R-var: Observation.component[2].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 113
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/EGFR-L858R-var: Observation.component[4].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 113
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/EGFR-L858R-var: Observation.component[4].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 113
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/EGFR-L858R-var: Observation.component[4].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-ExampleGermlineCNV",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-ExampleGermlineCNV",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/ExampleGermlineCNV: Observation.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/ExampleGermlineCNV: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/ExampleGermlineCNV: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 94
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/ExampleGermlineCNV: Observation.component[3].value.ofType(CodeableConcept).coding[0].system"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-ExampleGermlineDEL",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-ExampleGermlineDEL",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/ExampleGermlineDEL: Observation.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/ExampleGermlineDEL: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/ExampleGermlineDEL: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 113
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/ExampleGermlineDEL: Observation.component[4].value.ofType(CodeableConcept).coding[0].system"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-ExampleGermlineINV",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-ExampleGermlineINV",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/ExampleGermlineINV: Observation.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/ExampleGermlineINV: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/ExampleGermlineINV: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 113
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/ExampleGermlineINV: Observation.component[4].value.ofType(CodeableConcept).coding[0].system"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-ExampleSomaticCNV",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-ExampleSomaticCNV",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/ExampleSomaticCNV: Observation.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/ExampleSomaticCNV: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/ExampleSomaticCNV: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 94
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/ExampleSomaticCNV: Observation.component[3].value.ofType(CodeableConcept).coding[0].system"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-ExampleSomaticDEL",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-ExampleSomaticDEL",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/ExampleSomaticDEL: Observation.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/ExampleSomaticDEL: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/ExampleSomaticDEL: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 94
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/ExampleSomaticDEL: Observation.component[3].value.ofType(CodeableConcept).coding[0].system"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-ExampleSomaticINV",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-ExampleSomaticINV",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/ExampleSomaticINV: Observation.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/ExampleSomaticINV: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/ExampleSomaticINV: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 94
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/ExampleSomaticINV: Observation.component[3].value.ofType(CodeableConcept).coding[0].system"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-Genotype-Clinical-Trial-Example-using-haplotypes",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-Genotype-Clinical-Trial-Example-using-haplotypes",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/Genotype-Clinical-Trial-Example-using-haplotypes: Observation.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/Genotype-Clinical-Trial-Example-using-haplotypes: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/Genotype-Clinical-Trial-Example-using-haplotypes: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-GenotypeExample1",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-GenotypeExample1",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 44
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 4
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/clinvar' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/GenotypeExample1: Observation.value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 64
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/GenotypeExample1: Observation.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 64
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/GenotypeExample1: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 64
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/GenotypeExample1: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-GenotypeExamplePharmVar",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-GenotypeExamplePharmVar",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/GenotypeExamplePharmVar: Observation.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/GenotypeExamplePharmVar: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/GenotypeExamplePharmVar: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-GrouperEx01",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-GrouperEx01"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-GrouperEx02",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-GrouperEx02"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-GrouperEx03",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-GrouperEx03"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-HER2byImmuneStainExample",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-HER2byImmuneStainExample",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 38
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/HER2byImmuneStainExample: Observation.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 38
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/HER2byImmuneStainExample: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 38
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/HER2byImmuneStainExample: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-HER2byImmunoassayExample",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-HER2byImmunoassayExample",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 38
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/HER2byImmunoassayExample: Observation.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 38
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/HER2byImmunoassayExample: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 38
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/HER2byImmunoassayExample: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-HLA-A-haplotype1",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-HLA-A-haplotype1",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 68
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 4
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ebi.ac.uk/ipd/imgt/hla' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/HLA-A-haplotype1: Observation.value.ofType(CodeableConcept).coding[0]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 46
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/HLA-A-haplotype1: Observation.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 46
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/HLA-A-haplotype1: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 46
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/HLA-A-haplotype1: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-HLA-A-haplotype2",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-HLA-A-haplotype2",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 68
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 4
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ebi.ac.uk/ipd/imgt/hla' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/HLA-A-haplotype2: Observation.value.ofType(CodeableConcept).coding[0]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 46
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/HLA-A-haplotype2: Observation.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 46
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/HLA-A-haplotype2: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 46
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/HLA-A-haplotype2: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-HLA-B-haplotype1",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-HLA-B-haplotype1",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 68
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 4
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ebi.ac.uk/ipd/imgt/hla' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/HLA-B-haplotype1: Observation.value.ofType(CodeableConcept).coding[0]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 46
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/HLA-B-haplotype1: Observation.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 46
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/HLA-B-haplotype1: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 46
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/HLA-B-haplotype1: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-HLA-B-haplotype2",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-HLA-B-haplotype2",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 68
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 4
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ebi.ac.uk/ipd/imgt/hla' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/HLA-B-haplotype2: Observation.value.ofType(CodeableConcept).coding[0]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 46
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/HLA-B-haplotype2: Observation.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 46
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/HLA-B-haplotype2: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 46
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/HLA-B-haplotype2: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-HLA-C-haplotype1",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-HLA-C-haplotype1",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 68
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 4
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ebi.ac.uk/ipd/imgt/hla' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/HLA-C-haplotype1: Observation.value.ofType(CodeableConcept).coding[0]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 46
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/HLA-C-haplotype1: Observation.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 46
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/HLA-C-haplotype1: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 46
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/HLA-C-haplotype1: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-HLA-C-haplotype2",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-HLA-C-haplotype2",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 68
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 4
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ebi.ac.uk/ipd/imgt/hla' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/HLA-C-haplotype2: Observation.value.ofType(CodeableConcept).coding[0]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 46
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/HLA-C-haplotype2: Observation.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 46
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/HLA-C-haplotype2: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 46
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/HLA-C-haplotype2: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-HaplotypeExamplePharmVar01",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-HaplotypeExamplePharmVar01",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 65
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 4
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.pharmvar.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/HaplotypeExamplePharmVar01: Observation.value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/HaplotypeExamplePharmVar01: Observation.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/HaplotypeExamplePharmVar01: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/HaplotypeExamplePharmVar01: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-HaplotypeExamplePharmVar02",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-HaplotypeExamplePharmVar02",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 65
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 4
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.pharmvar.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/HaplotypeExamplePharmVar02: Observation.value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/HaplotypeExamplePharmVar02: Observation.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/HaplotypeExamplePharmVar02: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/HaplotypeExamplePharmVar02: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-HaplotypeSet-Clinical-Trial-Example-1of2",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-HaplotypeSet-Clinical-Trial-Example-1of2",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 65
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 4
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/clinvar' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/HaplotypeSet-Clinical-Trial-Example-1of2: Observation.value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/HaplotypeSet-Clinical-Trial-Example-1of2: Observation.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/HaplotypeSet-Clinical-Trial-Example-1of2: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/HaplotypeSet-Clinical-Trial-Example-1of2: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-HaplotypeSet-Clinical-Trial-Example-2of2",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-HaplotypeSet-Clinical-Trial-Example-2of2",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 65
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 4
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/clinvar' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/HaplotypeSet-Clinical-Trial-Example-2of2: Observation.value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/HaplotypeSet-Clinical-Trial-Example-2of2: Observation.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/HaplotypeSet-Clinical-Trial-Example-2of2: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/HaplotypeSet-Clinical-Trial-Example-2of2: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-ISCN-CMLExample",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-ISCN-CMLExample",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 65
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'https://iscn.karger.com' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/ISCN-CMLExample: Observation.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-ISCN-CMLImplication",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-ISCN-CMLImplication"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-ISCN-NormalExample",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-ISCN-NormalExample",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 65
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'https://iscn.karger.com' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/ISCN-NormalExample: Observation.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-MSH2-del-disease",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-MSH2-del-disease"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-MSH2-del-molc",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-MSH2-del-molc",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 80
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/MSH2-del-molc: Observation.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 80
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/molecular-consequence-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/MSH2-del-molc: Observation.component[1].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 80
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/molecular-consequence-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/MSH2-del-molc: Observation.component[1].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-MSH2-del-var",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-MSH2-del-var",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/MSH2-del-var: Observation.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 63
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/MSH2-del-var: Observation.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 63
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/MSH2-del-var: Observation.component[1].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 63
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/MSH2-del-var: Observation.component[1].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 82
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/MSH2-del-var: Observation.component[2].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 82
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/MSH2-del-var: Observation.component[2].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 82
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/MSH2-del-var: Observation.component[2].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 101
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/clinvar' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/MSH2-del-var: Observation.component[3].value.ofType(CodeableConcept).coding[0].system"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-MSIExample",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-MSIExample"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-MicrosatelliteInstabilityExample01",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-MicrosatelliteInstabilityExample01"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-MultipleRepeatExpansions",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-MultipleRepeatExpansions",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 47
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/MultipleRepeatExpansions: Observation.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 47
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/MultipleRepeatExpansions: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 47
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/MultipleRepeatExpansions: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 81
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/MultipleRepeatExpansions: Observation.component[2].value.ofType(CodeableConcept).coding[0].system"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-NOTCH1-significance",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-NOTCH1-significance"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-NOTCH1-uncertain-molc",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-NOTCH1-uncertain-molc",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 81
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/NOTCH1-uncertain-molc: Observation.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 100
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/NOTCH1-uncertain-molc: Observation.component[2].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 100
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/molecular-consequence-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/NOTCH1-uncertain-molc: Observation.component[2].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 100
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/molecular-consequence-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/NOTCH1-uncertain-molc: Observation.component[2].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-NOTCH1-uncertain-var",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-NOTCH1-uncertain-var",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 63
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/NOTCH1-uncertain-var: Observation.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 115
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/NOTCH1-uncertain-var: Observation.component[4].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 115
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/NOTCH1-uncertain-var: Observation.component[4].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 115
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/NOTCH1-uncertain-var: Observation.component[4].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 182
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/NOTCH1-uncertain-var: Observation.component[8].value.ofType(CodeableConcept).coding[0].system"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-NTHL1-snv-disease",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-NTHL1-snv-disease"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-NTHL1-snv-molc",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-NTHL1-snv-molc",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 80
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/NTHL1-snv-molc: Observation.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 80
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/molecular-consequence-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/NTHL1-snv-molc: Observation.component[1].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 80
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/molecular-consequence-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/NTHL1-snv-molc: Observation.component[1].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-NTHL1-snv-var",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-NTHL1-snv-var",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 63
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/NTHL1-snv-var: Observation.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 63
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/NTHL1-snv-var: Observation.component[1].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 63
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/NTHL1-snv-var: Observation.component[1].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 100
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/NTHL1-snv-var: Observation.component[3].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 100
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/NTHL1-snv-var: Observation.component[3].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 100
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/NTHL1-snv-var: Observation.component[3].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 119
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/clinvar' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/NTHL1-snv-var: Observation.component[4].value.ofType(CodeableConcept).coding[0].system"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-PDL1Example",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-PDL1Example",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 83
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/PDL1Example: Observation.component[2].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 83
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/PDL1Example: Observation.component[2].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 83
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/PDL1Example: Observation.component[2].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-Pgx-geno-1001",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-Pgx-geno-1001",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 56
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 4
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/clinvar' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/Pgx-geno-1001: Observation.value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/Pgx-geno-1001: Observation.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/Pgx-geno-1001: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/Pgx-geno-1001: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-Pgx-geno-1002",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-Pgx-geno-1002",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/Pgx-geno-1002: Observation.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/Pgx-geno-1002: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/Pgx-geno-1002: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-Pgx-geno-1003",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-Pgx-geno-1003",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/Pgx-geno-1003: Observation.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/Pgx-geno-1003: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/Pgx-geno-1003: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-Pgx-var-1011",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-Pgx-var-1011",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/Pgx-var-1011: Observation.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 161
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/Pgx-var-1011: Observation.component[7].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 161
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/Pgx-var-1011: Observation.component[7].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 161
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/Pgx-var-1011: Observation.component[7].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 180
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/Pgx-var-1011: Observation.component[8].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 180
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/Pgx-var-1011: Observation.component[8].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 180
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/Pgx-var-1011: Observation.component[8].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-Pgx-var-1012",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-Pgx-var-1012",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/Pgx-var-1012: Observation.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 161
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/Pgx-var-1012: Observation.component[7].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 161
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/Pgx-var-1012: Observation.component[7].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 161
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/Pgx-var-1012: Observation.component[7].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 180
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/Pgx-var-1012: Observation.component[8].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 180
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/Pgx-var-1012: Observation.component[8].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 180
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/Pgx-var-1012: Observation.component[8].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-Pgx-var-1013",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-Pgx-var-1013",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/Pgx-var-1013: Observation.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 161
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/Pgx-var-1013: Observation.component[7].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 161
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/Pgx-var-1013: Observation.component[7].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 161
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/Pgx-var-1013: Observation.component[7].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 180
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/Pgx-var-1013: Observation.component[8].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 180
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/Pgx-var-1013: Observation.component[8].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 180
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/Pgx-var-1013: Observation.component[8].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-Pgx-var-1014",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-Pgx-var-1014",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/Pgx-var-1014: Observation.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 161
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/Pgx-var-1014: Observation.component[7].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 161
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/Pgx-var-1014: Observation.component[7].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 161
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/Pgx-var-1014: Observation.component[7].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 180
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/Pgx-var-1014: Observation.component[8].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 180
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/Pgx-var-1014: Observation.component[8].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 180
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/Pgx-var-1014: Observation.component[8].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-Pgx-var-1015",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-Pgx-var-1015",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 101
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/Pgx-var-1015: Observation.component[3].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 101
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/Pgx-var-1015: Observation.component[3].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 101
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/Pgx-var-1015: Observation.component[3].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 120
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/Pgx-var-1015: Observation.component[4].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 120
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/Pgx-var-1015: Observation.component[4].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 120
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/Pgx-var-1015: Observation.component[4].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-Pgx-var-1016",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-Pgx-var-1016",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/Pgx-var-1016: Observation.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 161
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/Pgx-var-1016: Observation.component[7].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 161
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/Pgx-var-1016: Observation.component[7].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 161
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/Pgx-var-1016: Observation.component[7].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 180
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/Pgx-var-1016: Observation.component[8].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 180
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/Pgx-var-1016: Observation.component[8].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 180
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/Pgx-var-1016: Observation.component[8].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-Pgx-var-1017",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-Pgx-var-1017",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/Pgx-var-1017: Observation.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 161
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/Pgx-var-1017: Observation.component[7].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 161
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/Pgx-var-1017: Observation.component[7].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 161
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/Pgx-var-1017: Observation.component[7].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 180
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/Pgx-var-1017: Observation.component[8].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 180
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/Pgx-var-1017: Observation.component[8].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 180
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/Pgx-var-1017: Observation.component[8].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-Pgx-var-1018",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-Pgx-var-1018",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/Pgx-var-1018: Observation.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 161
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/Pgx-var-1018: Observation.component[7].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 161
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/Pgx-var-1018: Observation.component[7].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 161
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/Pgx-var-1018: Observation.component[7].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 180
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/Pgx-var-1018: Observation.component[8].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 180
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/Pgx-var-1018: Observation.component[8].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 180
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/Pgx-var-1018: Observation.component[8].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-Pgx-var-1019",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-Pgx-var-1019",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 101
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/Pgx-var-1019: Observation.component[3].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 101
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/Pgx-var-1019: Observation.component[3].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 101
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/Pgx-var-1019: Observation.component[3].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 120
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/Pgx-var-1019: Observation.component[4].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 120
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/Pgx-var-1019: Observation.component[4].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 120
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/Pgx-var-1019: Observation.component[4].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-Pgx-var-1020",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-Pgx-var-1020",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/Pgx-var-1020: Observation.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 161
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/Pgx-var-1020: Observation.component[7].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 161
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/Pgx-var-1020: Observation.component[7].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 161
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/Pgx-var-1020: Observation.component[7].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 180
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/Pgx-var-1020: Observation.component[8].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 180
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/Pgx-var-1020: Observation.component[8].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 180
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/Pgx-var-1020: Observation.component[8].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-Pgx-var-1021",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-Pgx-var-1021",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/Pgx-var-1021: Observation.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 161
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/Pgx-var-1021: Observation.component[7].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 161
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/Pgx-var-1021: Observation.component[7].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 161
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/Pgx-var-1021: Observation.component[7].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 180
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/Pgx-var-1021: Observation.component[8].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 180
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/Pgx-var-1021: Observation.component[8].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 180
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/Pgx-var-1021: Observation.component[8].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-PolyGenicDiagnosticImpExample",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-PolyGenicDiagnosticImpExample"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-ROS1-Fusion-disease",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-ROS1-Fusion-disease"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-ROS1-Fusion-therapuDrug",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-ROS1-Fusion-therapuDrug"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-ROS1-Fusion-therapuTrial",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-ROS1-Fusion-therapuTrial",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 80
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://clinicaltrials.gov' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/ROS1-Fusion-therapuTrial: Observation.component[2].value.ofType(CodeableConcept).coding[0].system"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-ROS1-Fusion-var",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-ROS1-Fusion-var",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 58
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/ROS1-Fusion-var: Observation.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 58
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/ROS1-Fusion-var: Observation.component[1].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 58
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/ROS1-Fusion-var: Observation.component[1].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-ROS1-Fusion",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-ROS1-Fusion",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 60
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/ROS1-Fusion: Observation.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 60
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/functional-effect-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/ROS1-Fusion: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 60
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/functional-effect-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/ROS1-Fusion: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-RepeatExpansion",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-RepeatExpansion",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 47
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/RepeatExpansion: Observation.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 47
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/RepeatExpansion: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 47
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/RepeatExpansion: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 81
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/RepeatExpansion: Observation.component[2].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 137
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/clinvar' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/RepeatExpansion: Observation.component[5].value.ofType(CodeableConcept).coding[0].system"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-SNVexample",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-SNVexample",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 81
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/SNVexample: Observation.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 81
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/SNVexample: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 81
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/SNVexample: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 194
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/SNVexample: Observation.component[6].value.ofType(CodeableConcept).coding[0].system"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-STAG2-insertion-molc",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-STAG2-insertion-molc",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 81
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/STAG2-insertion-molc: Observation.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 100
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/STAG2-insertion-molc: Observation.component[2].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
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            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/molecular-consequence-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
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    {
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    {
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            ],
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            "severity": "warning",
            "code": "code-invalid",
            "details": {
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            "code": "code-invalid",
            "details": {
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              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
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            "severity": "warning",
            "code": "not-found",
            "details": {
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        "resourceType": "OperationOutcome",
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      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-TMB-therapuDrug",
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        "resourceType": "OperationOutcome",
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      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-TMBExample",
      "resource": {
        "resourceType": "OperationOutcome",
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        "resourceType": "OperationOutcome",
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                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
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    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-Therapeutic-Implication-Clinical-Trial-Somatic",
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            "severity": "warning",
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    {
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        "resourceType": "OperationOutcome",
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        "resourceType": "OperationOutcome",
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            "code": "code-invalid",
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              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
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    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-VariantExample2",
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                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
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            "severity": "warning",
            "code": "not-found",
            "details": {
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    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-ZFHX3-significance",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-ZFHX3-significance"
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    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-ZFHX3-uncertain-molc",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-ZFHX3-uncertain-molc",
        "issue": [
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            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
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              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
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              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
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            "expression": [
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                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
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            "code": "not-found",
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            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/molecular-consequence-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
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                "valueString": "TerminologyEngine"
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            "severity": "warning",
            "code": "code-invalid",
            "details": {
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    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-ZFHX3-uncertain-var",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-ZFHX3-uncertain-var",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 63
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/ZFHX3-uncertain-var: Observation.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 115
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/ZFHX3-uncertain-var: Observation.component[4].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 115
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/ZFHX3-uncertain-var: Observation.component[4].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 115
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/ZFHX3-uncertain-var: Observation.component[4].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 182
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/ZFHX3-uncertain-var: Observation.component[8].value.ofType(CodeableConcept).coding[0].system"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-diagnosticImplication-interact-smn1-smn2",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-diagnosticImplication-interact-smn1-smn2"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-genotype-hla-a-glstring-r4",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-genotype-hla-a-glstring-r4",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 52
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 4
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://glstring.org' version '1.0' could not be found, so the code cannot be validated. Valid versions: []"
            },
            "expression": [
              "Observation/genotype-hla-a-glstring-r4: Observation.value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 83
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/genotype-hla-a-glstring-r4: Observation.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 83
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/genotype-hla-a-glstring-r4: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 83
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/genotype-hla-a-glstring-r4: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-haplotype-hla-a-1-r4",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-haplotype-hla-a-1-r4",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 52
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 4
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ebi.ac.uk/ipd/imgt/hla' version '3.31.0' could not be found, so the code cannot be validated. Valid versions: []"
            },
            "expression": [
              "Observation/haplotype-hla-a-1-r4: Observation.value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 75
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/haplotype-hla-a-1-r4: Observation.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 75
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/haplotype-hla-a-1-r4: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 75
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/haplotype-hla-a-1-r4: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-molec-conseq1",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-molec-conseq1",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 51
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 6
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://example.org/pcingola.github.io/SnpEff/se_inputoutput/#impact-prediction' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/molec-conseq1: Observation.interpretation[0].coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 72
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/molec-conseq1: Observation.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 91
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/molec-conseq1: Observation.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 91
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/molec-conseq1: Observation.component[1].value.ofType(CodeableConcept).coding[1].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 91
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/molecular-consequence-vs|3.0.0' because the code system http://www.sequenceontology.org, http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/molec-conseq1: Observation.component[1].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 91
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/molecular-consequence-vs|3.0.0' because the code system http://www.sequenceontology.org, http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/molec-conseq1: Observation.component[1].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 115
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/molec-conseq1: Observation.component[2].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 115
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/functional-effect-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/molec-conseq1: Observation.component[2].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 115
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/functional-effect-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/molec-conseq1: Observation.component[2].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-molec-conseq2",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-molec-conseq2",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 51
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 6
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://example.org/pcingola.github.io/SnpEff/se_inputoutput/#impact-prediction' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/molec-conseq2: Observation.interpretation[0].coding[0]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 92
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/molec-conseq2: Observation.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 111
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/molec-conseq2: Observation.component[2].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 111
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/molecular-consequence-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/molec-conseq2: Observation.component[2].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 111
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/molecular-consequence-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/molec-conseq2: Observation.component[2].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-molec-conseq3",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-molec-conseq3",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 51
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 6
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://example.org/pcingola.github.io/SnpEff/se_inputoutput/#impact-prediction' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/molec-conseq3: Observation.interpretation[0].coding[0]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 92
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/molec-conseq3: Observation.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 111
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/molec-conseq3: Observation.component[2].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 111
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/molecular-consequence-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/molec-conseq3: Observation.component[2].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 111
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/molecular-consequence-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/molec-conseq3: Observation.component[2].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-molec-conseq4",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-molec-conseq4",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 51
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 6
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://example.org/pcingola.github.io/SnpEff/se_inputoutput/#impact-prediction' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/molec-conseq4: Observation.interpretation[0].coding[0]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 72
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/molec-conseq4: Observation.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 91
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/molec-conseq4: Observation.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 91
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/molecular-consequence-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/molec-conseq4: Observation.component[1].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 91
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/molecular-consequence-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/molec-conseq4: Observation.component[1].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-obs-idh-ex",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-obs-idh-ex",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 75
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://purl.obolibrary.org/obo/mondo.owl' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/obs-idh-ex: Observation.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 95
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://human-phenotype-ontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/obs-idh-ex: Observation.component[2].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 95
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/condition-inheritance-mode-vs|3.0.0' because the code system http://human-phenotype-ontology.org was not found"
            },
            "expression": [
              "Observation/obs-idh-ex: Observation.component[2].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 95
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://human-phenotype-ontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/condition-inheritance-mode-vs|3.0.0' because the code system http://human-phenotype-ontology.org was not found"
            },
            "expression": [
              "Observation/obs-idh-ex: Observation.component[2].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-obs1-interact-smn1-smn2",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-obs1-interact-smn1-smn2",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/obs1-interact-smn1-smn2: Observation.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/obs1-interact-smn1-smn2: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/obs1-interact-smn1-smn2: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 64
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/obs1-interact-smn1-smn2: Observation.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 64
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/obs1-interact-smn1-smn2: Observation.component[1].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 64
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Observation/obs1-interact-smn1-smn2: Observation.component[1].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 117
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/obs1-interact-smn1-smn2: Observation.component[4].value.ofType(CodeableConcept).coding[0].system"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Observation-obs2-interact-smn1-smn2",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Observation-obs2-interact-smn1-smn2",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Observation/obs2-interact-smn1-smn2: Observation.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/obs2-interact-smn1-smn2: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Observation/obs2-interact-smn1-smn2: Observation.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 64
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
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    {
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        "resourceType": "OperationOutcome",
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      "resource": {
        "resourceType": "OperationOutcome",
        "id": "OperationDefinition-find-subject-haplotypes"
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    {
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      "resource": {
        "resourceType": "OperationOutcome",
        "id": "OperationDefinition-find-subject-molecular-consequences"
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    {
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      "resource": {
        "resourceType": "OperationOutcome",
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    {
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      "resource": {
        "resourceType": "OperationOutcome",
        "id": "OperationDefinition-find-subject-specific-variants"
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    {
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      "resource": {
        "resourceType": "OperationOutcome",
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      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/OperationDefinition-find-subject-structural-subsuming-variants",
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        "resourceType": "OperationOutcome",
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      "resource": {
        "resourceType": "OperationOutcome",
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        "resourceType": "OperationOutcome",
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    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Organization-ExampleOrg",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Organization-ExampleOrg"
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    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Organization-performingOrganization",
      "resource": {
        "resourceType": "OperationOutcome",
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    {
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        "resourceType": "OperationOutcome",
        "id": "Parameters-FindPopulationSpecificHaplotypesOutput"
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      "resource": {
        "resourceType": "OperationOutcome",
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        "resourceType": "OperationOutcome",
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      "resource": {
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    {
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            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
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            "details": {
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    {
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            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.pharmvar.org' could not be found, so the code cannot be validated"
            },
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          {
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            "severity": "warning",
            "code": "code-invalid",
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            "extension": [
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                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
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                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
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            "extension": [
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                "valueString": "TerminologyEngine"
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            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
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            "expression": [
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              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 18
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Parameters/FindSubjectHaplotypesOutput: Parameters.parameter[1].part[1].resource/*Observation/GenotypeCYP2C19*/.component[0].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Parameters-FindSubjectMolecConseqOutput",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Parameters-FindSubjectMolecConseqOutput",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 61
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 12
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://example.org/pcingola.github.io/SnpEff/se_inputoutput/#impact-prediction' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Parameters/FindSubjectMolecConseqOutput: Parameters.parameter[0].resource/*Observation/MC1*/.interpretation[0].coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 82
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Parameters/FindSubjectMolecConseqOutput: Parameters.parameter[0].resource/*Observation/MC1*/.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 101
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Parameters/FindSubjectMolecConseqOutput: Parameters.parameter[0].resource/*Observation/MC1*/.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 101
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Parameters/FindSubjectMolecConseqOutput: Parameters.parameter[0].resource/*Observation/MC1*/.component[1].value.ofType(CodeableConcept).coding[1].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 125
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Parameters/FindSubjectMolecConseqOutput: Parameters.parameter[0].resource/*Observation/MC1*/.component[2].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 101
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/molecular-consequence-vs|3.0.0' because the code system http://www.sequenceontology.org, http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Parameters/FindSubjectMolecConseqOutput: Parameters.parameter[0].resource/*Observation/MC1*/.component[1].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 101
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/molecular-consequence-vs|3.0.0' because the code system http://www.sequenceontology.org, http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Parameters/FindSubjectMolecConseqOutput: Parameters.parameter[0].resource/*Observation/MC1*/.component[1].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 125
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/functional-effect-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Parameters/FindSubjectMolecConseqOutput: Parameters.parameter[0].resource/*Observation/MC1*/.component[2].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 125
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/functional-effect-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Parameters/FindSubjectMolecConseqOutput: Parameters.parameter[0].resource/*Observation/MC1*/.component[2].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 194
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 12
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://example.org/pcingola.github.io/SnpEff/se_inputoutput/#impact-prediction' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Parameters/FindSubjectMolecConseqOutput: Parameters.parameter[1].resource/*Observation/MC2*/.interpretation[0].coding[0]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 235
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Parameters/FindSubjectMolecConseqOutput: Parameters.parameter[1].resource/*Observation/MC2*/.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 254
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Parameters/FindSubjectMolecConseqOutput: Parameters.parameter[1].resource/*Observation/MC2*/.component[2].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 254
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/molecular-consequence-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Parameters/FindSubjectMolecConseqOutput: Parameters.parameter[1].resource/*Observation/MC2*/.component[2].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 254
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/molecular-consequence-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Parameters/FindSubjectMolecConseqOutput: Parameters.parameter[1].resource/*Observation/MC2*/.component[2].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 323
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 12
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://example.org/pcingola.github.io/SnpEff/se_inputoutput/#impact-prediction' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Parameters/FindSubjectMolecConseqOutput: Parameters.parameter[2].resource/*Observation/MC3*/.interpretation[0].coding[0]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 364
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Parameters/FindSubjectMolecConseqOutput: Parameters.parameter[2].resource/*Observation/MC3*/.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 383
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Parameters/FindSubjectMolecConseqOutput: Parameters.parameter[2].resource/*Observation/MC3*/.component[2].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 383
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/molecular-consequence-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Parameters/FindSubjectMolecConseqOutput: Parameters.parameter[2].resource/*Observation/MC3*/.component[2].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 383
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/molecular-consequence-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Parameters/FindSubjectMolecConseqOutput: Parameters.parameter[2].resource/*Observation/MC3*/.component[2].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 452
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 12
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://example.org/pcingola.github.io/SnpEff/se_inputoutput/#impact-prediction' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Parameters/FindSubjectMolecConseqOutput: Parameters.parameter[3].resource/*Observation/MC4*/.interpretation[0].coding[0]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 473
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Parameters/FindSubjectMolecConseqOutput: Parameters.parameter[3].resource/*Observation/MC4*/.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 492
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Parameters/FindSubjectMolecConseqOutput: Parameters.parameter[3].resource/*Observation/MC4*/.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 492
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/molecular-consequence-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Parameters/FindSubjectMolecConseqOutput: Parameters.parameter[3].resource/*Observation/MC4*/.component[1].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 492
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/molecular-consequence-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Parameters/FindSubjectMolecConseqOutput: Parameters.parameter[3].resource/*Observation/MC4*/.component[1].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 596
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Parameters/FindSubjectMolecConseqOutput: Parameters.parameter[0].resource/*Observation/MC1*/.derivedFrom[0].parameter[0].resource/*Observation/variantExampleMC*/.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Parameters-FindSubjectSpecificHaplotypesOutput",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Parameters-FindSubjectSpecificHaplotypesOutput",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 67
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://glstring.org' version '1.0' could not be found, so the code cannot be validated. Valid versions: []"
            },
            "expression": [
              "Parameters/FindSubjectSpecificHaplotypesOutput: Parameters.parameter[0].part[2].resource/*Observation/Genotype7*/.value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 91
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 18
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Parameters/FindSubjectSpecificHaplotypesOutput: Parameters.parameter[0].part[2].resource/*Observation/Genotype7*/.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 91
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 18
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Parameters/FindSubjectSpecificHaplotypesOutput: Parameters.parameter[0].part[2].resource/*Observation/Genotype7*/.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 91
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 18
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Parameters/FindSubjectSpecificHaplotypesOutput: Parameters.parameter[0].part[2].resource/*Observation/Genotype7*/.component[0].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Parameters-FindSubjectSpecificVariantsOutput",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Parameters-FindSubjectSpecificVariantsOutput",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 159
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 18
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Parameters/FindSubjectSpecificVariantsOutput: Parameters.parameter[4].part[2].resource/*Observation/dv-5a7f781e83514*/.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Parameters-FindSubjectStructuralIntersectingVariantsOutput",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Parameters-FindSubjectStructuralIntersectingVariantsOutput",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 87
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 18
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Parameters/FindSubjectStructuralIntersectingVariantsOutput: Parameters.parameter[0].part[2].resource/*Observation/dv-fff9d40035a04*/.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 107
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 18
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Parameters/FindSubjectStructuralIntersectingVariantsOutput: Parameters.parameter[0].part[2].resource/*Observation/dv-fff9d40035a04*/.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 87
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 18
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Parameters/FindSubjectStructuralIntersectingVariantsOutput: Parameters.parameter[0].part[2].resource/*Observation/dv-fff9d40035a04*/.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 87
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 18
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Parameters/FindSubjectStructuralIntersectingVariantsOutput: Parameters.parameter[0].part[2].resource/*Observation/dv-fff9d40035a04*/.component[0].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Parameters-FindSubjectStructuralSubsumingVariantsOutput",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Parameters-FindSubjectStructuralSubsumingVariantsOutput",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 87
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 18
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Parameters/FindSubjectStructuralSubsumingVariantsOutput: Parameters.parameter[0].part[2].resource/*Observation/dv-64c82675925d4*/.component[0].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 107
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 18
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Parameters/FindSubjectStructuralSubsumingVariantsOutput: Parameters.parameter[0].part[2].resource/*Observation/dv-64c82675925d4*/.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 87
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 18
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Parameters/FindSubjectStructuralSubsumingVariantsOutput: Parameters.parameter[0].part[2].resource/*Observation/dv-64c82675925d4*/.component[0].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 87
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 18
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/dna-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Parameters/FindSubjectStructuralSubsumingVariantsOutput: Parameters.parameter[0].part[2].resource/*Observation/dv-64c82675925d4*/.component[0].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Parameters-FindSubjectTxImplicationsOutput",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Parameters-FindSubjectTxImplicationsOutput",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 194
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 14
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Parameters/FindSubjectTxImplicationsOutput: Parameters.parameter[1].resource/*Observation/variantExample*/.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Parameters-FindSubjectVariantsOutput",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Parameters-FindSubjectVariantsOutput",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 120
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 18
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.ncbi.nlm.nih.gov/refseq' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Parameters/FindSubjectVariantsOutput: Parameters.parameter[1].part[2].resource/*Observation/dv-5a7f781e83514*/.component[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Patient-CGPatientExample01",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Patient-CGPatientExample01"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Patient-ExamplePatient",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Patient-ExamplePatient"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Patient-HG00403",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Patient-HG00403"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Patient-denovoChild",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Patient-denovoChild"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Patient-denovoFather",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Patient-denovoFather"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Patient-denovoMother",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Patient-denovoMother"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Patient-genomicPatient",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Patient-genomicPatient"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Patient-somaticPatient",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Patient-somaticPatient"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Practitioner-orderingPractitioner",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Practitioner-orderingPractitioner"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Practitioner-pathologistPractitioner",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Practitioner-pathologistPractitioner"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Practitioner-practitioner02",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Practitioner-practitioner02"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Practitioner-supervisorPractitioner",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Practitioner-supervisorPractitioner"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Procedure-PGXGenomicStudy",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Procedure-PGXGenomicStudy"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Procedure-PGXGenomicStudyAnalysis",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Procedure-PGXGenomicStudyAnalysis",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 51
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 12
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Procedure/PGXGenomicStudyAnalysis: Procedure.extension[2].extension[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 51
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 12
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Procedure/PGXGenomicStudyAnalysis: Procedure.extension[2].extension[1].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 51
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 12
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Procedure/PGXGenomicStudyAnalysis: Procedure.extension[2].extension[1].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 63
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 12
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Procedure/PGXGenomicStudyAnalysis: Procedure.extension[2].extension[2].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 63
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 12
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Procedure/PGXGenomicStudyAnalysis: Procedure.extension[2].extension[2].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 63
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 12
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Procedure/PGXGenomicStudyAnalysis: Procedure.extension[2].extension[2].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 75
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 12
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Procedure/PGXGenomicStudyAnalysis: Procedure.extension[2].extension[3].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 75
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 12
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Procedure/PGXGenomicStudyAnalysis: Procedure.extension[2].extension[3].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 75
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 12
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Procedure/PGXGenomicStudyAnalysis: Procedure.extension[2].extension[3].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Procedure-SequencingProcedure",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Procedure-SequencingProcedure"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Procedure-analysisTumorNormalDNA",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Procedure-analysisTumorNormalDNA",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 30
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 12
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Procedure/analysisTumorNormalDNA: Procedure.extension[0].extension[1].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 30
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 12
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Procedure/analysisTumorNormalDNA: Procedure.extension[0].extension[1].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 30
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 12
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Procedure/analysisTumorNormalDNA: Procedure.extension[0].extension[1].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 42
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 12
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Procedure/analysisTumorNormalDNA: Procedure.extension[0].extension[2].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 42
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 12
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Procedure/analysisTumorNormalDNA: Procedure.extension[0].extension[2].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 42
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 12
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Procedure/analysisTumorNormalDNA: Procedure.extension[0].extension[2].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 54
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 12
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Procedure/analysisTumorNormalDNA: Procedure.extension[0].extension[3].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 54
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 12
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Procedure/analysisTumorNormalDNA: Procedure.extension[0].extension[3].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 54
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 12
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.genenames.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc-vs|3.0.0' because the code system http://www.genenames.org was not found"
            },
            "expression": [
              "Procedure/analysisTumorNormalDNA: Procedure.extension[0].extension[3].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 98
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Procedure/analysisTumorNormalDNA: Procedure.extension[3].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 98
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/genomic-study-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Procedure/analysisTumorNormalDNA: Procedure.extension[3].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 98
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/genomic-study-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Procedure/analysisTumorNormalDNA: Procedure.extension[3].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 110
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Procedure/analysisTumorNormalDNA: Procedure.extension[4].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 110
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/genomic-study-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Procedure/analysisTumorNormalDNA: Procedure.extension[4].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 110
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/genomic-study-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Procedure/analysisTumorNormalDNA: Procedure.extension[4].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 122
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Procedure/analysisTumorNormalDNA: Procedure.extension[5].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 122
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/genomic-study-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Procedure/analysisTumorNormalDNA: Procedure.extension[5].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 122
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/genomic-study-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Procedure/analysisTumorNormalDNA: Procedure.extension[5].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 134
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Procedure/analysisTumorNormalDNA: Procedure.extension[6].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 134
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/genomic-study-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Procedure/analysisTumorNormalDNA: Procedure.extension[6].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 134
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/genomic-study-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Procedure/analysisTumorNormalDNA: Procedure.extension[6].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Procedure-analysisTumorRNA",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Procedure-analysisTumorRNA",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 44
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Procedure/analysisTumorRNA: Procedure.extension[2].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 44
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/genomic-study-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Procedure/analysisTumorRNA: Procedure.extension[2].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 44
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/genomic-study-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Procedure/analysisTumorRNA: Procedure.extension[2].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 56
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Procedure/analysisTumorRNA: Procedure.extension[3].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 56
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/genomic-study-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Procedure/analysisTumorRNA: Procedure.extension[3].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 56
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/genomic-study-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Procedure/analysisTumorRNA: Procedure.extension[3].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Procedure-genomicstudy-trio2",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Procedure-genomicstudy-trio2"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Procedure-genomicstudyanalysis-trio2",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Procedure-genomicstudyanalysis-trio2"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Procedure-lungMass-analysis1",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Procedure-lungMass-analysis1",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Procedure/lungMass-analysis1: Procedure.extension[2].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/genomic-study-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Procedure/lungMass-analysis1: Procedure.extension[2].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/genomic-study-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Procedure/lungMass-analysis1: Procedure.extension[2].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 57
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Procedure/lungMass-analysis1: Procedure.extension[3].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 57
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/genomic-study-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Procedure/lungMass-analysis1: Procedure.extension[3].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 57
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/genomic-study-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Procedure/lungMass-analysis1: Procedure.extension[3].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 69
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Procedure/lungMass-analysis1: Procedure.extension[4].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 69
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/genomic-study-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Procedure/lungMass-analysis1: Procedure.extension[4].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 69
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/genomic-study-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Procedure/lungMass-analysis1: Procedure.extension[4].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Procedure-lungMass-analysis2",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Procedure-lungMass-analysis2",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated"
            },
            "expression": [
              "Procedure/lungMass-analysis2: Procedure.extension[2].value.ofType(CodeableConcept).coding[0].system"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/genomic-study-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Procedure/lungMass-analysis2: Procedure.extension[2].value.ofType(CodeableConcept)"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 45
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 8
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "code-invalid",
            "details": {
              "text": "A definition for CodeSystem 'http://www.sequenceontology.org' could not be found, so the code cannot be validated; Unable to check whether the code is in the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/genomic-study-change-type-vs|3.0.0' because the code system http://www.sequenceontology.org was not found"
            },
            "expression": [
              "Procedure/lungMass-analysis2: Procedure.extension[2].value.ofType(CodeableConcept)"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Procedure-lungMass",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Procedure-lungMass"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Procedure-somaticStudy",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Procedure-somaticStudy"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/RiskAssessment-GenRiskDiabetesT2",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "RiskAssessment-GenRiskDiabetesT2"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/ServiceRequest-ExampleServiceRequest",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "ServiceRequest-ExampleServiceRequest"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/ServiceRequest-GenomicServiceRequestExample01",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "ServiceRequest-GenomicServiceRequestExample01"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/ServiceRequest-eMERGEServiceRequest",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "ServiceRequest-eMERGEServiceRequest",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 5
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 4
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "not-found",
            "details": {
              "text": "A definition for CodeSystem 'http://example.org/hgsc.bcm.edu/lab-test-codes/' could not be found, so the code cannot be validated"
            },
            "expression": [
              "ServiceRequest/eMERGEServiceRequest: ServiceRequest.code.coding[0]"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/ServiceRequest-genomicServiceRequest",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "ServiceRequest-genomicServiceRequest"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/ServiceRequest-servicerequest-hla-a-r4",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "ServiceRequest-servicerequest-hla-a-r4"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/ServiceRequest-somaticServiceRequest",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "ServiceRequest-somaticServiceRequest"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Specimen-ExampleSpecimen",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Specimen-ExampleSpecimen"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Specimen-GenomicSpecimenExample01",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Specimen-GenomicSpecimenExample01"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Specimen-GenomicSpecimenExample02",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Specimen-GenomicSpecimenExample02"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Specimen-genomicSpecimen",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Specimen-genomicSpecimen"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Specimen-normalSpecimen",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Specimen-normalSpecimen"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Specimen-specimen-hla-r4",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Specimen-specimen-hla-r4"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Specimen-tumorSpecimen",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Specimen-tumorSpecimen"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/StructureDefinition-annotation-code",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "StructureDefinition-annotation-code"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/StructureDefinition-coded-annotation",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "StructureDefinition-coded-annotation"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/StructureDefinition-diagnostic-implication",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "StructureDefinition-diagnostic-implication",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              }
            ],
            "severity": "warning",
            "code": "business-rule",
            "details": {
              "text": "The definition for the element 'Observation.component.value[x]' binds to the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/evidence-level-example-vs' which is experimental, but this structure is not labeled as experimental"
            },
            "expression": [
              "StructureDefinition/diagnostic-implication: StructureDefinition.snapshot.element[83].binding"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/StructureDefinition-finding",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "StructureDefinition-finding"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/StructureDefinition-followup-recommendation",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "StructureDefinition-followup-recommendation"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/StructureDefinition-genomic-base",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "StructureDefinition-genomic-base"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/StructureDefinition-genomic-data-file",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "StructureDefinition-genomic-data-file"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/StructureDefinition-genomic-report-note",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "StructureDefinition-genomic-report-note"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/StructureDefinition-genomic-report",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "StructureDefinition-genomic-report"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/StructureDefinition-genomic-risk-assessment",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "StructureDefinition-genomic-risk-assessment"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/StructureDefinition-genomic-study-analysis-change-type",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "StructureDefinition-genomic-study-analysis-change-type"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/StructureDefinition-genomic-study-analysis-device",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "StructureDefinition-genomic-study-analysis-device"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/StructureDefinition-genomic-study-analysis-ext",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "StructureDefinition-genomic-study-analysis-ext"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/StructureDefinition-genomic-study-analysis-focus",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "StructureDefinition-genomic-study-analysis-focus"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/StructureDefinition-genomic-study-analysis-genome-build",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "StructureDefinition-genomic-study-analysis-genome-build"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/StructureDefinition-genomic-study-analysis-genomic-source-class",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "StructureDefinition-genomic-study-analysis-genomic-source-class"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/StructureDefinition-genomic-study-analysis-input",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "StructureDefinition-genomic-study-analysis-input"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/StructureDefinition-genomic-study-analysis-method-type",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "StructureDefinition-genomic-study-analysis-method-type"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/StructureDefinition-genomic-study-analysis-metrics",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "StructureDefinition-genomic-study-analysis-metrics"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/StructureDefinition-genomic-study-analysis-output",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "StructureDefinition-genomic-study-analysis-output"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/StructureDefinition-genomic-study-analysis-protocol-performed",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "StructureDefinition-genomic-study-analysis-protocol-performed"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/StructureDefinition-genomic-study-analysis-regions",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "StructureDefinition-genomic-study-analysis-regions"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/StructureDefinition-genomic-study-analysis-specimen",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "StructureDefinition-genomic-study-analysis-specimen"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/StructureDefinition-genomic-study-analysis-title",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "StructureDefinition-genomic-study-analysis-title"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/StructureDefinition-genomic-study-analysis",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "StructureDefinition-genomic-study-analysis"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/StructureDefinition-genomic-study-reference",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "StructureDefinition-genomic-study-reference"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/StructureDefinition-genomic-study-referrer-ext",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "StructureDefinition-genomic-study-referrer-ext"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/StructureDefinition-genomic-study",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "StructureDefinition-genomic-study",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              }
            ],
            "severity": "warning",
            "code": "business-rule",
            "details": {
              "text": "The definition for the element 'Procedure.code' binds to the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/genomic-study-type-vs' which is experimental, but this structure is not labeled as experimental"
            },
            "expression": [
              "StructureDefinition/genomic-study: StructureDefinition.differential.element[13].binding"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              }
            ],
            "severity": "warning",
            "code": "business-rule",
            "details": {
              "text": "The definition for the element 'Procedure.code' binds to the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/genomic-study-type-vs' which is experimental, but this structure is not labeled as experimental"
            },
            "expression": [
              "StructureDefinition/genomic-study: StructureDefinition.snapshot.element[23].binding"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/StructureDefinition-genotype",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "StructureDefinition-genotype"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/StructureDefinition-haplotype",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "StructureDefinition-haplotype"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/StructureDefinition-implication",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "StructureDefinition-implication",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              }
            ],
            "severity": "warning",
            "code": "business-rule",
            "details": {
              "text": "The definition for the element 'Observation.component.value[x]' binds to the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/evidence-level-example-vs' which is experimental, but this structure is not labeled as experimental"
            },
            "expression": [
              "StructureDefinition/implication: StructureDefinition.differential.element[13].binding"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              }
            ],
            "severity": "warning",
            "code": "business-rule",
            "details": {
              "text": "The definition for the element 'Observation.component.value[x]' binds to the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/evidence-level-example-vs' which is experimental, but this structure is not labeled as experimental"
            },
            "expression": [
              "StructureDefinition/implication: StructureDefinition.snapshot.element[82].binding"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/StructureDefinition-medication-assessed-reference",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "StructureDefinition-medication-assessed-reference"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/StructureDefinition-medication-recommendation",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "StructureDefinition-medication-recommendation"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/StructureDefinition-molecular-biomarker",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "StructureDefinition-molecular-biomarker",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              }
            ],
            "severity": "warning",
            "code": "business-rule",
            "details": {
              "text": "The definition for the element 'Observation.component.value[x]' binds to the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/molecular-biomarker-category-vs' which is experimental, but this structure is not labeled as experimental"
            },
            "expression": [
              "StructureDefinition/molecular-biomarker: StructureDefinition.differential.element[18].binding"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              }
            ],
            "severity": "warning",
            "code": "business-rule",
            "details": {
              "text": "The definition for the element 'Observation.component.value[x]' binds to the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/molecular-biomarker-category-vs' which is experimental, but this structure is not labeled as experimental"
            },
            "expression": [
              "StructureDefinition/molecular-biomarker: StructureDefinition.snapshot.element[82].binding"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/StructureDefinition-molecular-consequence",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "StructureDefinition-molecular-consequence",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              }
            ],
            "severity": "warning",
            "code": "business-rule",
            "details": {
              "text": "The definition for the element 'Observation.component.value[x]' binds to the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/evidence-level-example-vs' which is experimental, but this structure is not labeled as experimental"
            },
            "expression": [
              "StructureDefinition/molecular-consequence: StructureDefinition.snapshot.element[82].binding"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/StructureDefinition-recommended-action",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "StructureDefinition-recommended-action"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/StructureDefinition-repeat-motif-order",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "StructureDefinition-repeat-motif-order"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/StructureDefinition-sequence-phase-relationship",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "StructureDefinition-sequence-phase-relationship"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/StructureDefinition-therapeutic-implication",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "StructureDefinition-therapeutic-implication",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              }
            ],
            "severity": "warning",
            "code": "business-rule",
            "details": {
              "text": "The definition for the element 'Observation.component.value[x]' binds to the value set 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/evidence-level-example-vs' which is experimental, but this structure is not labeled as experimental"
            },
            "expression": [
              "StructureDefinition/therapeutic-implication: StructureDefinition.snapshot.element[82].binding"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/StructureDefinition-therapy-assessed-reference",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "StructureDefinition-therapy-assessed-reference"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/StructureDefinition-variant",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "StructureDefinition-variant"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/StructureDefinition-workflow-relatedArtifactComponent",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "StructureDefinition-workflow-relatedArtifactComponent"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Task-MedicationRecommendationExample1",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Task-MedicationRecommendationExample1"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Task-PGxRecEx01",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Task-PGxRecEx01"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Task-PGxRecEx02",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Task-PGxRecEx02"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Task-PGxRecEx03",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Task-PGxRecEx03"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Task-PGxRecEx04",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Task-PGxRecEx04"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/Task-PGxRecEx05",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "Task-PGxRecEx05"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/ValueSet-coded-annotation-types-vs",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "ValueSet-coded-annotation-types-vs"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/ValueSet-condition-inheritance-mode-vs",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "ValueSet-condition-inheritance-mode-vs",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-line",
                "valueInteger": 1
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-col",
                "valueInteger": 2739
              },
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              }
            ],
            "severity": "warning",
            "code": "business-rule",
            "details": {
              "text": "The code 'HP:0000006' is not valid in the system http://human-phenotype-ontology.org (Unable to evaluate based on code system with status = not-present)"
            },
            "expression": [
              "ValueSet/condition-inheritance-mode-vs: ValueSet.compose.include[0].concept[0]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              }
            ],
            "severity": "warning",
            "code": "business-rule",
            "details": {
              "text": "The code 'HP:0000007' is not valid in the system http://human-phenotype-ontology.org (A definition for CodeSystem 'http://human-phenotype-ontology.org' could not be found, so the code cannot be validated)"
            },
            "expression": [
              "ValueSet/condition-inheritance-mode-vs: ValueSet.compose.include[0].concept[1]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              }
            ],
            "severity": "warning",
            "code": "business-rule",
            "details": {
              "text": "The code 'HP:0001417' is not valid in the system http://human-phenotype-ontology.org (A definition for CodeSystem 'http://human-phenotype-ontology.org' could not be found, so the code cannot be validated)"
            },
            "expression": [
              "ValueSet/condition-inheritance-mode-vs: ValueSet.compose.include[0].concept[2]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              }
            ],
            "severity": "warning",
            "code": "business-rule",
            "details": {
              "text": "The code 'HP:0001419' is not valid in the system http://human-phenotype-ontology.org (A definition for CodeSystem 'http://human-phenotype-ontology.org' could not be found, so the code cannot be validated)"
            },
            "expression": [
              "ValueSet/condition-inheritance-mode-vs: ValueSet.compose.include[0].concept[3]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              }
            ],
            "severity": "warning",
            "code": "business-rule",
            "details": {
              "text": "The code 'HP:0001423' is not valid in the system http://human-phenotype-ontology.org (A definition for CodeSystem 'http://human-phenotype-ontology.org' could not be found, so the code cannot be validated)"
            },
            "expression": [
              "ValueSet/condition-inheritance-mode-vs: ValueSet.compose.include[0].concept[4]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              }
            ],
            "severity": "warning",
            "code": "business-rule",
            "details": {
              "text": "The code 'HP:0001426' is not valid in the system http://human-phenotype-ontology.org (A definition for CodeSystem 'http://human-phenotype-ontology.org' could not be found, so the code cannot be validated)"
            },
            "expression": [
              "ValueSet/condition-inheritance-mode-vs: ValueSet.compose.include[0].concept[5]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              }
            ],
            "severity": "warning",
            "code": "business-rule",
            "details": {
              "text": "The code 'HP:0001427' is not valid in the system http://human-phenotype-ontology.org (A definition for CodeSystem 'http://human-phenotype-ontology.org' could not be found, so the code cannot be validated)"
            },
            "expression": [
              "ValueSet/condition-inheritance-mode-vs: ValueSet.compose.include[0].concept[6]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              }
            ],
            "severity": "warning",
            "code": "business-rule",
            "details": {
              "text": "The code 'HP:0001442' is not valid in the system http://human-phenotype-ontology.org (A definition for CodeSystem 'http://human-phenotype-ontology.org' could not be found, so the code cannot be validated)"
            },
            "expression": [
              "ValueSet/condition-inheritance-mode-vs: ValueSet.compose.include[0].concept[7]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              }
            ],
            "severity": "warning",
            "code": "business-rule",
            "details": {
              "text": "The code 'HP:0001450' is not valid in the system http://human-phenotype-ontology.org (A definition for CodeSystem 'http://human-phenotype-ontology.org' could not be found, so the code cannot be validated)"
            },
            "expression": [
              "ValueSet/condition-inheritance-mode-vs: ValueSet.compose.include[0].concept[8]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              }
            ],
            "severity": "warning",
            "code": "business-rule",
            "details": {
              "text": "The code 'HP:0001470' is not valid in the system http://human-phenotype-ontology.org (A definition for CodeSystem 'http://human-phenotype-ontology.org' could not be found, so the code cannot be validated)"
            },
            "expression": [
              "ValueSet/condition-inheritance-mode-vs: ValueSet.compose.include[0].concept[9]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              }
            ],
            "severity": "warning",
            "code": "business-rule",
            "details": {
              "text": "The code 'HP:0003743' is not valid in the system http://human-phenotype-ontology.org (A definition for CodeSystem 'http://human-phenotype-ontology.org' could not be found, so the code cannot be validated)"
            },
            "expression": [
              "ValueSet/condition-inheritance-mode-vs: ValueSet.compose.include[0].concept[10]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              }
            ],
            "severity": "warning",
            "code": "business-rule",
            "details": {
              "text": "The code 'HP:0003745' is not valid in the system http://human-phenotype-ontology.org (A definition for CodeSystem 'http://human-phenotype-ontology.org' could not be found, so the code cannot be validated)"
            },
            "expression": [
              "ValueSet/condition-inheritance-mode-vs: ValueSet.compose.include[0].concept[11]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              }
            ],
            "severity": "warning",
            "code": "business-rule",
            "details": {
              "text": "The code 'HP:0010983' is not valid in the system http://human-phenotype-ontology.org (A definition for CodeSystem 'http://human-phenotype-ontology.org' could not be found, so the code cannot be validated)"
            },
            "expression": [
              "ValueSet/condition-inheritance-mode-vs: ValueSet.compose.include[0].concept[12]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              }
            ],
            "severity": "warning",
            "code": "business-rule",
            "details": {
              "text": "The code 'HP:0012274' is not valid in the system http://human-phenotype-ontology.org (A definition for CodeSystem 'http://human-phenotype-ontology.org' could not be found, so the code cannot be validated)"
            },
            "expression": [
              "ValueSet/condition-inheritance-mode-vs: ValueSet.compose.include[0].concept[13]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              }
            ],
            "severity": "warning",
            "code": "business-rule",
            "details": {
              "text": "The code 'HP:0012275' is not valid in the system http://human-phenotype-ontology.org (A definition for CodeSystem 'http://human-phenotype-ontology.org' could not be found, so the code cannot be validated)"
            },
            "expression": [
              "ValueSet/condition-inheritance-mode-vs: ValueSet.compose.include[0].concept[14]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              }
            ],
            "severity": "warning",
            "code": "business-rule",
            "details": {
              "text": "The code 'HP:0025352' is not valid in the system http://human-phenotype-ontology.org (A definition for CodeSystem 'http://human-phenotype-ontology.org' could not be found, so the code cannot be validated)"
            },
            "expression": [
              "ValueSet/condition-inheritance-mode-vs: ValueSet.compose.include[0].concept[15]"
            ]
          },
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "InstanceValidator"
              }
            ],
            "severity": "warning",
            "code": "business-rule",
            "details": {
              "text": "The code 'HP:0032113' is not valid in the system http://human-phenotype-ontology.org (A definition for CodeSystem 'http://human-phenotype-ontology.org' could not be found, so the code cannot be validated)"
            },
            "expression": [
              "ValueSet/condition-inheritance-mode-vs: ValueSet.compose.include[0].concept[16]"
            ]
          },
          {
            "extension": [
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                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "exception",
            "details": {
              "text": "Error from http://tx.fhir.org/r4: Unable to provide support for code system http://human-phenotype-ontology.org"
            },
            "expression": [
              "ValueSet.where(id = 'condition-inheritance-mode-vs')"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/ValueSet-dna-change-type-vs",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "ValueSet-dna-change-type-vs",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "exception",
            "details": {
              "text": "Error from http://tx.fhir.org/r4: Unable to provide support for code system http://www.sequenceontology.org"
            },
            "expression": [
              "ValueSet.where(id = 'dna-change-type-vs')"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/ValueSet-evidence-level-example-vs",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "ValueSet-evidence-level-example-vs"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/ValueSet-functional-effect-vs",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "ValueSet-functional-effect-vs",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "exception",
            "details": {
              "text": "Error from http://tx.fhir.org/r4: Unable to provide support for code system http://www.sequenceontology.org"
            },
            "expression": [
              "ValueSet.where(id = 'functional-effect-vs')"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/ValueSet-genetic-therapeutic-implications-vs",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "ValueSet-genetic-therapeutic-implications-vs"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/ValueSet-genomic-study-change-type-vs",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "ValueSet-genomic-study-change-type-vs",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "exception",
            "details": {
              "text": "Error from http://tx.fhir.org/r4: Unable to provide support for code system http://www.sequenceontology.org"
            },
            "expression": [
              "ValueSet.where(id = 'genomic-study-change-type-vs')"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/ValueSet-genomic-study-data-format-vs",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "ValueSet-genomic-study-data-format-vs"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/ValueSet-genomic-study-method-type-vs",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "ValueSet-genomic-study-method-type-vs"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/ValueSet-genomic-study-status-vs",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "ValueSet-genomic-study-status-vs"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/ValueSet-genomic-study-type-vs",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "ValueSet-genomic-study-type-vs"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/ValueSet-hgnc-vs",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "ValueSet-hgnc-vs",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "exception",
            "details": {
              "text": "Error from http://tx.fhir.org/r4: Unable to provide support for code system http://www.genenames.org"
            },
            "expression": [
              "ValueSet.where(id = 'hgnc-vs')"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/ValueSet-hgvs-vs",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "ValueSet-hgvs-vs"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/ValueSet-molecular-biomarker-category-vs",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "ValueSet-molecular-biomarker-category-vs"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/ValueSet-molecular-biomarker-code-vs",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "ValueSet-molecular-biomarker-code-vs"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/ValueSet-molecular-consequence-vs",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "ValueSet-molecular-consequence-vs",
        "issue": [
          {
            "extension": [
              {
                "url": "http://hl7.org/fhir/StructureDefinition/operationoutcome-issue-source",
                "valueString": "TerminologyEngine"
              }
            ],
            "severity": "warning",
            "code": "exception",
            "details": {
              "text": "Error from http://tx.fhir.org/r4: Unable to provide support for code system http://www.sequenceontology.org"
            },
            "expression": [
              "ValueSet.where(id = 'molecular-consequence-vs')"
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/ValueSet-sequence-phase-relationship-vs",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "ValueSet-sequence-phase-relationship-vs"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/ValueSet-tbd-codes-vs",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "ValueSet-tbd-codes-vs"
      }
    },
    {
      "fullUrl": "http://hl7.org/fhir/uv/genomics-reporting/OperationOutcome/ValueSet-variant-confidence-status-vs",
      "resource": {
        "resourceType": "OperationOutcome",
        "id": "ValueSet-variant-confidence-status-vs"
      }
    }
  ]
}