Package | hl7.fhir.uv.genomics-reporting |
Resource Type | OperationDefinition |
Id | find-subject-tx-implications |
FHIR Version | R4 |
Source | http://hl7.org/fhir/uv/genomics-reporting/https://build.fhir.org/ig/HL7/genomics-reporting/OperationDefinition-find-subject-tx-implications.html |
URL | http://hl7.org/fhir/uv/genomics-reporting/OperationDefinition/find-subject-tx-implications |
Version | 4.0.0-ballot |
Status | active |
Date | 2025-06-24T17:31:37+00:00 |
Name | FindSubjectTxImplications |
Title | Find Subject Treatment Implications |
Realm | uv |
Authority | hl7 |
Description | Retrieves genetic therapeutic implications for variants/haplotypes/genotypes. |
Type | true |
Kind | operation |
No resources found
No resources found
Note: links and images are rebased to the (stated) source
Generated Narrative: OperationDefinition find-subject-tx-implications
Use | Name | Scope | Cardinality | Type | Binding | Documentation |
IN | subject | 1..1 | string (reference) | The subject of interest. | ||
IN | variants | 0..* | string (string) | List of variants from which implications are derived. Must be in HGVS or SPDI format. | ||
IN | ranges | 0..* | string (special) | List of regions to be searched for variants. Must be in zero-based RefSeq:Integer-range format (e.g. 'NC_000007.14:55174721-55174820'). | ||
IN | haplotypes | 0..* | string (token) | List of haplotypes and/or genotypes from which implications are derived. Must be in token or codesystem|code format. | ||
IN | treatments | 0..* | string (token) | List of medications and/or other therapeutic interventions for which implications are sought. Must be in token or codesystem|code format. | ||
IN | conditions | 0..* | string (token) | List of conditions for which implications are sought. Must be in token or codesystem|code format. | ||
IN | testIdentifiers | 0..* | string (token) | Supply a list of test identifiers. Only results originating from one of these tests will be returned. | ||
IN | testDateRange | 0..1 | Period | Supply a date range. Only results generated during this range will be returned. | ||
IN | specimenIdentifiers | 0..* | string (token) | Supply a list of specimen identifiers. Only results derived from one of these specimens will be returned. | ||
IN | genomicSourceClass | 0..1 | string (token) | Enables an App to limit results to those that are 'germline' or 'somatic'. Default is to include variants irrespective of genomic source class. | ||
OUT | implication | 0..* | Observation | Implications must conform to [Profile: http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication]. The target(s) of the implication's derivedFrom shall also be included in the response. | ||
OUT | variant | 0..* | Observation | Variants must conform to [Profile: http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/variant]. | ||
OUT | haplotype | 0..* | Observation | Haplotypes must conform to [Profile: http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/haplotype]. | ||
OUT | genotype | 0..* | Observation | Genotypes must conform to [Profile: http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genotype]. |
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Must be in HGVS or SPDI format.", "type": "string", "searchType": "string" }, { "name": "ranges", "use": "in", "min": 0, "max": "*", "documentation": "List of regions to be searched for variants. Must be in zero-based RefSeq:Integer-range format (e.g. 'NC_000007.14:55174721-55174820').", "type": "string", "searchType": "special" }, { "name": "haplotypes", "use": "in", "min": 0, "max": "*", "documentation": "List of haplotypes and/or genotypes from which implications are derived. Must be in token or codesystem|code format.", "type": "string", "searchType": "token" }, { "name": "treatments", "use": "in", "min": 0, "max": "*", "documentation": "List of medications and/or other therapeutic interventions for which implications are sought. Must be in token or codesystem|code format.", "type": "string", "searchType": "token" }, { "name": "conditions", "use": "in", "min": 0, "max": "*", "documentation": "List of conditions for which implications are sought. Must be in token or codesystem|code format.", "type": "string", "searchType": "token" }, { "name": "testIdentifiers", "use": "in", "min": 0, "max": "*", "documentation": "Supply a list of test identifiers. Only results originating from one of these tests will be returned.", "type": "string", "searchType": "token" }, { "name": "testDateRange", "use": "in", "min": 0, "max": "1", "documentation": "Supply a date range. Only results generated during this range will be returned.", "type": "Period" }, { "name": "specimenIdentifiers", "use": "in", "min": 0, "max": "*", "documentation": "Supply a list of specimen identifiers. Only results derived from one of these specimens will be returned.", "type": "string", "searchType": "token" }, { "name": "genomicSourceClass", "use": "in", "min": 0, "max": "1", "documentation": "Enables an App to limit results to those that are 'germline' or 'somatic'. Default is to include variants irrespective of genomic source class.", "type": "string", "searchType": "token" }, { "extension": [ { "url": "http://hl7.org/fhir/StructureDefinition/operationdefinition-profile", "valueUri": "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication" } ], "name": "implication", "use": "out", "min": 0, "max": "*", "documentation": "Implications must conform to [Profile: http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication]. The target(s) of the implication's derivedFrom shall also be included in the response.", "type": "Observation" }, { "extension": [ { "url": "http://hl7.org/fhir/StructureDefinition/operationdefinition-profile", "valueUri": "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/variant" } ], "name": "variant", "use": "out", "min": 0, "max": "*", "documentation": "Variants must conform to [Profile: http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/variant].", "type": "Observation" }, { "extension": [ { "url": "http://hl7.org/fhir/StructureDefinition/operationdefinition-profile", "valueUri": "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/haplotype" } ], "name": "haplotype", "use": "out", "min": 0, "max": "*", "documentation": "Haplotypes must conform to [Profile: http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/haplotype].", "type": "Observation" }, { "extension": [ { "url": "http://hl7.org/fhir/StructureDefinition/operationdefinition-profile", "valueUri": "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genotype" } ], "name": "genotype", "use": "out", "min": 0, "max": "*", "documentation": "Genotypes must conform to [Profile: http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genotype].", "type": "Observation" } ] }