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Source1

{
  "resourceType": "Group",
  "id": "588218",
  "meta": {
    "versionId": "7",
    "lastUpdated": "2026-08-15T16:32:10.010Z",
    "profile": [
      "http://hl7.org/fhir/uv/ebm/StructureDefinition/pico-specification"
    ]
  },
  "text": {
    "status": "extensions",
    "div": "<!-- snip (see above) -->"
  },
  "extension": [
    {
      "url": "http://hl7.org/fhir/StructureDefinition/artifact-author",
      "valueContactDetail": {
        "name": "Khalid Shahin"
      }
    },
    {
      "url": "http://hl7.org/fhir/uv/ebm/StructureDefinition/artifact-recorder",
      "valueContactDetail": {
        "name": "Khalid Shahin"
      }
    },
    {
      "url": "http://hl7.org/fhir/uv/ebm/StructureDefinition/cite-as",
      "valueMarkdown": "PICO: Intensive versus standard blood-pressure control for major adverse cardiovascular events in adults at increased cardiovascular risk [Database Entry: FHIR Group Resource]. Contributors: Khalid Shahin [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 588218. Revised 2026-08-15. Available at: https://fevir.net/resources/Group/588218. Computable resource at: https://fevir.net/resources/Group/588218#json."
    },
    {
      "url": "http://hl7.org/fhir/uv/ebm/StructureDefinition/artifact-publication-status",
      "valueCodeableConcept": {
        "coding": [
          {
            "system": "http://terminology.hl7.org/CodeSystem/cited-artifact-status-type",
            "code": "active",
            "display": "Active"
          }
        ]
      }
    }
  ],
  "url": "https://fevir.net/resources/Group/588218",
  "identifier": [
    {
      "type": {
        "coding": [
          {
            "system": "http://terminology.hl7.org/CodeSystem/v2-0203",
            "code": "ACSN",
            "display": "Accession ID"
          }
        ],
        "text": "FEvIR Object Identifier"
      },
      "system": "https://fevir.net/FOI",
      "value": "588218",
      "assigner": {
        "display": "Computable Publishing LLC"
      }
    },
    {
      "use": "official",
      "system": "http://example.org/fhir/sid/pico-register",
      "value": "PICO-2026-0142"
    }
  ],
  "title": "PICO: Intensive versus standard blood-pressure control for major adverse cardiovascular events in adults at increased cardiovascular risk",
  "status": "active",
  "publisher": "Computable Publishing LLC",
  "contact": [
    {
      "telecom": [
        {
          "system": "email",
          "value": "support@computablepublishing.com"
        }
      ]
    }
  ],
  "description": "This Group Resource is referenced in an example for the EBMonFHIR Implementation Guide.",
  "copyright": "Copyright the Authors else Computable Publishing LLC. Noncommercial use permitted with CC BY-NC-SA 4.0 (https://creativecommons.org/licenses/by-nc-sa/4.0/). Commercial use permitted as agreed in Terms of Use (https://fevir.net/termsofuse).",
  "membership": "conceptual",
  "combinationMethod": "all-of",
  "characteristic": [
    {
      "code": {
        "coding": [
          {
            "system": "https://fevir.net/resources/CodeSystem/179423",
            "code": "population",
            "display": "Population"
          }
        ]
      },
      "valueCodeableConcept": {
        "coding": [
          {
            "system": "http://snomed.info/sct",
            "code": "38341003",
            "display": "Hypertensive disorder, systemic arterial"
          }
        ],
        "text": "Hypertension with systolic blood pressure 130-180 mmHg and at least one additional cardiovascular risk factor"
      },
      "exclude": false,
      "description": "Adults with a measured systolic blood pressure between 130 and 180 mmHg inclusive, together with at least one of: clinical or subclinical cardiovascular disease, chronic kidney disease with eGFR 20-59 mL/min/1.73 m2, a 10-year Framingham risk score of 15 percent or greater, or age 75 years or older."
    },
    {
      "code": {
        "coding": [
          {
            "system": "http://terminology.hl7.org/CodeSystem/usage-context-type",
            "code": "age",
            "display": "Age Range"
          }
        ]
      },
      "valueRange": {
        "low": {
          "value": 50,
          "unit": "years",
          "system": "http://unitsofmeasure.org",
          "code": "a"
        }
      },
      "exclude": false,
      "description": "Aged 50 years or older at the time of eligibility assessment. No upper age limit is applied."
    },
    {
      "code": {
        "coding": [
          {
            "system": "https://fevir.net/resources/CodeSystem/179423",
            "code": "intervention",
            "display": "Intervention"
          }
        ]
      },
      "valueCodeableConcept": {
        "text": "Intensive blood-pressure control: antihypertensive therapy titrated to a systolic target below 120 mmHg"
      },
      "exclude": false,
      "description": "Any antihypertensive regimen titrated at monthly intervals to achieve and maintain a systolic blood pressure below 120 mmHg. The specific agents used are not constrained by this question."
    },
    {
      "code": {
        "coding": [
          {
            "system": "https://fevir.net/resources/CodeSystem/179423",
            "code": "comparator",
            "display": "Comparator"
          }
        ]
      },
      "valueCodeableConcept": {
        "text": "Standard blood-pressure control: antihypertensive therapy titrated to a systolic target below 140 mmHg"
      },
      "exclude": false,
      "description": "Any antihypertensive regimen titrated to achieve and maintain a systolic blood pressure below 140 mmHg, reflecting the guideline-recommended target in force at the time the question was formulated."
    },
    {
      "code": {
        "coding": [
          {
            "system": "https://fevir.net/resources/CodeSystem/179423",
            "code": "outcome-measure",
            "display": "Outcome Measure"
          }
        ]
      },
      "valueCodeableConcept": {
        "text": "Major adverse cardiovascular events: composite of myocardial infarction, other acute coronary syndrome, stroke, acute decompensated heart failure, or death from cardiovascular causes"
      },
      "exclude": false,
      "description": "Time to first occurrence of any component of the composite, adjudicated by a committee unaware of treatment assignment. Individual components are reported as separate outcome measures in the evidence report.",
      "relativeTime": [
        {
          "offsetDuration": {
            "value": 5,
            "unit": "years",
            "system": "http://unitsofmeasure.org",
            "code": "a"
          }
        }
      ]
    }
  ]
}