FHIR IG analytics| Package | hl7.fhir.uv.ebm |
| Resource Type | Composition |
| Id | Composition-236537.json |
| FHIR Version | R6 |
No resources found
No resources found
Note: links and images are rebased to the (stated) source
Generated Narrative: Composition 236537
version: 78; Last updated: 2025-10-21 14:50:13+0000; Language: en
Profile: SummaryOfFindings
url: https://fevir.net/resources/Composition/236537
identifier: FEvIR Object Identifier/236537, FEvIR Linking Identifier/MAGIC-5288-j1Wqrn-summary-of-findings-85390-85789
status: Final
type: Summary of Findings
date: 2025-10-21 14:50:13+0000
author: Qiukui Hao
title: SummaryOfFindings: GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk
custodian: Computable Publishing LLC
relatesTo
type: Part Of
target: MAGICapp Conversion Report: SGLT2 inhibitors and GLP-1 RA for type 2 diabetes (Identifier: FEvIR Linking Identifier/MAGIC-5288-j1Wqrn-conversion-report)
relatesTo
type: Part Of
relatesTo
type: Cite As
target:
SummaryOfFindings: GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk [Database Entry: FHIR Composition Resource]. Contributors: Qiukui Hao [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 236537. Revised 2025-10-21. Available at: https://fevir.net/resources/Composition/236537. Computable resource at: https://fevir.net/resources/Composition/236537#json.
FHIR
FHIRsmith{
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},
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"text": {
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"div": "<!-- snip (see above) -->"
},
"url": "https://fevir.net/resources/Composition/236537",
"identifier": [
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"text": "FEvIR Object Identifier"
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{
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"text": "FEvIR Linking Identifier"
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],
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],
"text": "Summary of Findings"
},
"date": "2025-10-21T14:50:13.423Z",
"author": [
{
"display": "Qiukui Hao"
}
],
"title": "SummaryOfFindings: GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk",
"custodian": {
"reference": "Organization/118079",
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"display": "Computable Publishing LLC"
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},
"display": "MAGICapp Conversion Report: SGLT2 inhibitors and GLP-1 RA for type 2 diabetes"
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{
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"display": "ComparativeEvidenceSynthesisReport: GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
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},
{
"type": "cite-as",
"targetMarkdown": "SummaryOfFindings: GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk [Database Entry: FHIR Composition Resource]. Contributors: Qiukui Hao [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 236537. Revised 2025-10-21. Available at: https://fevir.net/resources/Composition/236537. Computable resource at: https://fevir.net/resources/Composition/236537#json."
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],
"section": [
{
"title": "Column Headers",
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"text": {
"status": "empty",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>[No narrative text.]</p></div>"
},
"section": [
{
"title": "Outcome Measure",
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"text": {
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"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>Outcome</p></div>"
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},
{
"title": "Sample Size",
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{
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"code": "sample-size",
"display": "Sample Size"
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]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>Sample Size</p></div>"
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},
{
"title": "Result Without Treatment",
"code": {
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{
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},
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"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>Result Without Treatment</p></div>"
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},
{
"title": "Result With Treatment--Observed",
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"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "result-with-intervention-alone",
"display": "Result with intervention alone"
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]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>Result With Treatment (Observed)</p></div>"
}
},
{
"title": "Result With Treatment--Derived",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "result-with-intervention-alone-calculated",
"display": "Result with intervention alone (calculated)"
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],
"text": "result with intervention with calculated value derived from the control group and effect estimate"
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>Result With Treatment (Calculated)</p></div>"
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},
{
"title": "Effect Estimate",
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"coding": [
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"system": "https://fevir.net/resources/CodeSystem/179423",
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]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>Effect Estimate</p></div>"
}
},
{
"title": "Certainty of Evidence",
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{
"system": "https://fevir.net/resources/CodeSystem/179423",
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]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>Certainty of Evidence</p></div>"
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},
{
"title": "Assertion",
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{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "assertion",
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]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>What this means</p></div>"
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}
]
},
{
"title": "Summary of Findings",
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{
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"text": {
"status": "empty",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>[No data.]</p></div>"
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"section": [
{
"title": "All-cause mortality",
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},
"focus": {
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"identifier": {
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"assigner": {
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},
"display": "OutcomeDefinition: All-cause mortality"
},
"section": [
{
"title": "Outcome",
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"display": "Outcome Measure"
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]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>OutcomeDefinition: All-cause mortality</p></div>"
},
"entry": [
{
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},
{
"title": "Sample Size",
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{
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"code": "sample-size",
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]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>34 studies, 69035 participants</p></div>"
},
"entry": [
{
"reference": "Evidence/236540",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313876-comparative-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived Evidence: All-cause mortality with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Result Without Treatment",
"code": {
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{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "result-with-comparator-alone",
"display": "Result with comparator alone"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>12%</p></div>"
},
"entry": [
{
"reference": "Evidence/236541",
"type": "Evidence",
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"type": {
"text": "FEvIR Linking Identifier"
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"system": "https://fevir.net/FLI",
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"assigner": {
"display": "Computable Publishing LLC"
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},
"display": "MAGIC-derived ComparatorOnlyEvidence: All-cause mortality in Standard care Group in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Result With Treatment--Observed",
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{
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"code": "result-with-intervention-alone",
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]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>10.7%</p></div>"
},
"entry": [
{
"reference": "Evidence/293872",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313876-intervention-only-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived InterventionOnlyEvidence: All-cause mortality in GLP-1 RA Group in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Result With Treatment--Derived",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "result-with-intervention-alone-calculated",
"display": "Result with intervention alone (calculated)"
}
],
"text": "result with intervention with calculated value derived from the control group and effect estimate"
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>10.71%</p></div>"
},
"entry": [
{
"reference": "Evidence/236541",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313876-comparator-only-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived ComparatorOnlyEvidence: All-cause mortality in Standard care Group in Adults with type 2 diabetes with moderate CV risk"
},
{
"reference": "Evidence/236540",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313876-comparative-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived Evidence: All-cause mortality with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Effect Estimate",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "result-with-intervention-vs-comparator",
"display": "Result with intervention vs. comparator"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>-1.29% (-1.83% to -0.64%)</p></div>"
},
"entry": [
{
"reference": "Evidence/236540",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313876-comparative-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived Evidence: All-cause mortality with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Certainty of Evidence",
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{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "certainty-of-evidence",
"display": "Certainty of Evidence"
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]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>Moderate certainty -- Due to serious imprecision</p></div>"
},
"entry": [
{
"reference": "Evidence/236540",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313876-comparative-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived Evidence: All-cause mortality with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Assertion",
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"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "assertion",
"display": "Assertion"
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]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>GLP-1 receptor agonists probably reduce the risk of death compared with standard care.</p></div>"
},
"entry": [
{
"reference": "Evidence/236540",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
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"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313876-comparative-evidence",
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"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived Evidence: All-cause mortality with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
}
]
},
{
"title": "Cardiovascular mortality",
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"value": "MAGIC-5288-j1Wqrn-313877",
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"display": "Computable Publishing LLC"
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},
"display": "OutcomeDefinition: Cardiovascular mortality"
},
"section": [
{
"title": "Outcome",
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"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "outcome-measure",
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}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>OutcomeDefinition: Cardiovascular mortality</p></div>"
},
"entry": [
{
"reference": "EvidenceVariable/236542",
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},
"display": "OutcomeDefinition: Cardiovascular mortality"
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]
},
{
"title": "Sample Size",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "sample-size",
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]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>20 studies, 63455 participants</p></div>"
},
"entry": [
{
"reference": "Evidence/236543",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
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"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313877-comparative-evidence",
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"display": "Computable Publishing LLC"
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},
"display": "MAGIC-derived Evidence: Cardiovascular mortality with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Result Without Treatment",
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{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "result-with-comparator-alone",
"display": "Result with comparator alone"
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]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>7.9%</p></div>"
},
"entry": [
{
"reference": "Evidence/236544",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
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"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313877-comparator-only-evidence",
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"display": "Computable Publishing LLC"
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},
"display": "MAGIC-derived ComparatorOnlyEvidence: Cardiovascular mortality in Standard care Group in Adults with type 2 diabetes with moderate CV risk"
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]
},
{
"title": "Result With Treatment--Observed",
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{
"system": "https://fevir.net/resources/CodeSystem/179423",
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]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>7%</p></div>"
},
"entry": [
{
"reference": "Evidence/293873",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
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"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313877-intervention-only-evidence",
"assigner": {
"display": "Computable Publishing LLC"
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},
"display": "MAGIC-derived InterventionOnlyEvidence: Cardiovascular mortality in GLP-1 RA Group in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Result With Treatment--Derived",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "result-with-intervention-alone-calculated",
"display": "Result with intervention alone (calculated)"
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],
"text": "result with intervention with calculated value derived from the control group and effect estimate"
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>7.02%</p></div>"
},
"entry": [
{
"reference": "Evidence/236544",
"type": "Evidence",
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"type": {
"text": "FEvIR Linking Identifier"
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"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313877-comparator-only-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived ComparatorOnlyEvidence: Cardiovascular mortality in Standard care Group in Adults with type 2 diabetes with moderate CV risk"
},
{
"reference": "Evidence/236543",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313877-comparative-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived Evidence: Cardiovascular mortality with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Effect Estimate",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "result-with-intervention-vs-comparator",
"display": "Result with intervention vs. comparator"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>-0.88% (-1.48% to -0.29%)</p></div>"
},
"entry": [
{
"reference": "Evidence/236543",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313877-comparative-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived Evidence: Cardiovascular mortality with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Certainty of Evidence",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "certainty-of-evidence",
"display": "Certainty of Evidence"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>Moderate certainty -- Due to serious imprecision</p></div>"
},
"entry": [
{
"reference": "Evidence/236543",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313877-comparative-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived Evidence: Cardiovascular mortality with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Assertion",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "assertion",
"display": "Assertion"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>GLP-1 receptor agonists probably reduce the risk of cardiovascular death compared with standard care.</p></div>"
},
"entry": [
{
"reference": "Evidence/236543",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313877-comparative-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived Evidence: Cardiovascular mortality with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
}
]
},
{
"title": "Nonfatal myocardial infarction",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "summary-of-findings-entry-for-a-single-outcome",
"display": "Summary of findings entry for a single outcome"
}
]
},
"focus": {
"reference": "EvidenceVariable/236545",
"type": "EvidenceVariable",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-313878",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "OutcomeDefinition: Nonfatal myocardial infarction"
},
"section": [
{
"title": "Outcome",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "outcome-measure",
"display": "Outcome Measure"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>OutcomeDefinition: Nonfatal myocardial infarction</p></div>"
},
"entry": [
{
"reference": "EvidenceVariable/236545",
"type": "EvidenceVariable",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-313878",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "OutcomeDefinition: Nonfatal myocardial infarction"
}
]
},
{
"title": "Sample Size",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "sample-size",
"display": "Sample Size"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>32 studies, 67956 participants</p></div>"
},
"entry": [
{
"reference": "Evidence/236546",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313878-comparative-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived Evidence: Nonfatal myocardial infarction with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Result Without Treatment",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "result-with-comparator-alone",
"display": "Result with comparator alone"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>10.8%</p></div>"
},
"entry": [
{
"reference": "Evidence/236547",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313878-comparator-only-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived ComparatorOnlyEvidence: Nonfatal myocardial infarction in Standard care Group in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Result With Treatment--Observed",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "result-with-intervention-alone",
"display": "Result with intervention alone"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>10%</p></div>"
},
"entry": [
{
"reference": "Evidence/293874",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313878-intervention-only-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived InterventionOnlyEvidence: Nonfatal myocardial infarction in GLP-1 RA Group in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Result With Treatment--Derived",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "result-with-intervention-alone-calculated",
"display": "Result with intervention alone (calculated)"
}
],
"text": "result with intervention with calculated value derived from the control group and effect estimate"
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>10.02%</p></div>"
},
"entry": [
{
"reference": "Evidence/236547",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313878-comparator-only-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived ComparatorOnlyEvidence: Nonfatal myocardial infarction in Standard care Group in Adults with type 2 diabetes with moderate CV risk"
},
{
"reference": "Evidence/236546",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313878-comparative-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived Evidence: Nonfatal myocardial infarction with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Effect Estimate",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "result-with-intervention-vs-comparator",
"display": "Result with intervention vs. comparator"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>-0.78% (-1.47% to -0.1%)</p></div>"
},
"entry": [
{
"reference": "Evidence/236546",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313878-comparative-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived Evidence: Nonfatal myocardial infarction with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Certainty of Evidence",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "certainty-of-evidence",
"display": "Certainty of Evidence"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>Moderate certainty -- Due to serious imprecision</p></div>"
},
"entry": [
{
"reference": "Evidence/236546",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313878-comparative-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived Evidence: Nonfatal myocardial infarction with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Assertion",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "assertion",
"display": "Assertion"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>GLP-1 receptor agonists probably reduce the risk of nonfatal myocardial infarction compared with standard care.</p></div>"
},
"entry": [
{
"reference": "Evidence/236546",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313878-comparative-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived Evidence: Nonfatal myocardial infarction with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
}
]
},
{
"title": "Nonfatal stroke",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "summary-of-findings-entry-for-a-single-outcome",
"display": "Summary of findings entry for a single outcome"
}
]
},
"focus": {
"reference": "EvidenceVariable/236548",
"type": "EvidenceVariable",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-313879",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "OutcomeDefinition: Nonfatal stroke"
},
"section": [
{
"title": "Outcome",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "outcome-measure",
"display": "Outcome Measure"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>OutcomeDefinition: Nonfatal stroke</p></div>"
},
"entry": [
{
"reference": "EvidenceVariable/236548",
"type": "EvidenceVariable",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-313879",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "OutcomeDefinition: Nonfatal stroke"
}
]
},
{
"title": "Sample Size",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "sample-size",
"display": "Sample Size"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>29 studies, 66900 participants</p></div>"
},
"entry": [
{
"reference": "Evidence/236549",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313879-comparative-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived Evidence: Nonfatal stroke with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Result Without Treatment",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "result-with-comparator-alone",
"display": "Result with comparator alone"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>10.8%</p></div>"
},
"entry": [
{
"reference": "Evidence/236550",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313879-comparator-only-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived ComparatorOnlyEvidence: Nonfatal stroke in Standard care Group in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Result With Treatment--Observed",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "result-with-intervention-alone",
"display": "Result with intervention alone"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>9.2%</p></div>"
},
"entry": [
{
"reference": "Evidence/293875",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313879-intervention-only-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived InterventionOnlyEvidence: Nonfatal stroke in GLP-1 RA Group in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Result With Treatment--Derived",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "result-with-intervention-alone-calculated",
"display": "Result with intervention alone (calculated)"
}
],
"text": "result with intervention with calculated value derived from the control group and effect estimate"
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>9.23%</p></div>"
},
"entry": [
{
"reference": "Evidence/236550",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313879-comparator-only-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived ComparatorOnlyEvidence: Nonfatal stroke in Standard care Group in Adults with type 2 diabetes with moderate CV risk"
},
{
"reference": "Evidence/236549",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313879-comparative-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived Evidence: Nonfatal stroke with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Effect Estimate",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "result-with-intervention-vs-comparator",
"display": "Result with intervention vs. comparator"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>-1.57% (-2.37% to -0.68%)</p></div>"
},
"entry": [
{
"reference": "Evidence/236549",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313879-comparative-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived Evidence: Nonfatal stroke with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Certainty of Evidence",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "certainty-of-evidence",
"display": "Certainty of Evidence"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>Moderate certainty -- Due to serious imprecision</p></div>"
},
"entry": [
{
"reference": "Evidence/236549",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313879-comparative-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived Evidence: Nonfatal stroke with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Assertion",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "assertion",
"display": "Assertion"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>GLP-1 receptor agonists probably reduce the risk of nonfatal stroke compared with standard care.</p></div>"
},
"entry": [
{
"reference": "Evidence/236549",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313879-comparative-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived Evidence: Nonfatal stroke with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
}
]
},
{
"title": "End-stage kidney disease",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "summary-of-findings-entry-for-a-single-outcome",
"display": "Summary of findings entry for a single outcome"
}
]
},
"focus": {
"reference": "EvidenceVariable/236551",
"type": "EvidenceVariable",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-313880",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "OutcomeDefinition: End-stage kidney disease"
},
"section": [
{
"title": "Outcome",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "outcome-measure",
"display": "Outcome Measure"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>OutcomeDefinition: End-stage kidney disease</p></div>"
},
"entry": [
{
"reference": "EvidenceVariable/236551",
"type": "EvidenceVariable",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-313880",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "OutcomeDefinition: End-stage kidney disease"
}
]
},
{
"title": "Sample Size",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "sample-size",
"display": "Sample Size"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>4 studies, 10762 participants</p></div>"
},
"entry": [
{
"reference": "Evidence/236552",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313880-comparative-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived Evidence: End-stage kidney disease with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Result Without Treatment",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "result-with-comparator-alone",
"display": "Result with comparator alone"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>2%</p></div>"
},
"entry": [
{
"reference": "Evidence/236553",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313880-comparator-only-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived ComparatorOnlyEvidence: End-stage kidney disease in Standard care Group in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Result With Treatment--Observed",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "result-with-intervention-alone",
"display": "Result with intervention alone"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>1.6%</p></div>"
},
"entry": [
{
"reference": "Evidence/293876",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313880-intervention-only-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived InterventionOnlyEvidence: End-stage kidney disease in GLP-1 RA Group in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Result With Treatment--Derived",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "result-with-intervention-alone-calculated",
"display": "Result with intervention alone (calculated)"
}
],
"text": "result with intervention with calculated value derived from the control group and effect estimate"
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>1.57%</p></div>"
},
"entry": [
{
"reference": "Evidence/236553",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313880-comparator-only-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived ComparatorOnlyEvidence: End-stage kidney disease in Standard care Group in Adults with type 2 diabetes with moderate CV risk"
},
{
"reference": "Evidence/236552",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313880-comparative-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived Evidence: End-stage kidney disease with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Effect Estimate",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "result-with-intervention-vs-comparator",
"display": "Result with intervention vs. comparator"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>-0.43% (-0.65% to -0.16%)</p></div>"
},
"entry": [
{
"reference": "Evidence/236552",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313880-comparative-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived Evidence: End-stage kidney disease with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Certainty of Evidence",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "certainty-of-evidence",
"display": "Certainty of Evidence"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>High certainty</p></div>"
},
"entry": [
{
"reference": "Evidence/236552",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313880-comparative-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived Evidence: End-stage kidney disease with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Assertion",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "assertion",
"display": "Assertion"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>There is no important difference between GLP-1 receptor agonists and standard care.</p></div>"
},
"entry": [
{
"reference": "Evidence/236552",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313880-comparative-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived Evidence: End-stage kidney disease with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
}
]
},
{
"title": "Heart failure",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "summary-of-findings-entry-for-a-single-outcome",
"display": "Summary of findings entry for a single outcome"
}
]
},
"focus": {
"reference": "EvidenceVariable/236554",
"type": "EvidenceVariable",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-313881",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "OutcomeDefinition: Heart failure"
},
"section": [
{
"title": "Outcome",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "outcome-measure",
"display": "Outcome Measure"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>OutcomeDefinition: Heart failure</p></div>"
},
"entry": [
{
"reference": "EvidenceVariable/236554",
"type": "EvidenceVariable",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-313881",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "OutcomeDefinition: Heart failure"
}
]
},
{
"title": "Sample Size",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "sample-size",
"display": "Sample Size"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>13 studies, 46696 participants</p></div>"
},
"entry": [
{
"reference": "Evidence/236555",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313881-comparative-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived Evidence: Heart failure with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Result Without Treatment",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "result-with-comparator-alone",
"display": "Result with comparator alone"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>8%</p></div>"
},
"entry": [
{
"reference": "Evidence/236556",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313881-comparator-only-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived ComparatorOnlyEvidence: Heart failure in Standard care Group in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Result With Treatment--Observed",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "result-with-intervention-alone",
"display": "Result with intervention alone"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>7.6%</p></div>"
},
"entry": [
{
"reference": "Evidence/293877",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313881-intervention-only-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived InterventionOnlyEvidence: Heart failure in GLP-1 RA Group in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Result With Treatment--Derived",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "result-with-intervention-alone-calculated",
"display": "Result with intervention alone (calculated)"
}
],
"text": "result with intervention with calculated value derived from the control group and effect estimate"
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>7.56%</p></div>"
},
"entry": [
{
"reference": "Evidence/236556",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313881-comparator-only-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived ComparatorOnlyEvidence: Heart failure in Standard care Group in Adults with type 2 diabetes with moderate CV risk"
},
{
"reference": "Evidence/236555",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313881-comparative-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived Evidence: Heart failure with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Effect Estimate",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "result-with-intervention-vs-comparator",
"display": "Result with intervention vs. comparator"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>-0.44% (-1.12% to 0.22%)</p></div>"
},
"entry": [
{
"reference": "Evidence/236555",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313881-comparative-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived Evidence: Heart failure with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Certainty of Evidence",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "certainty-of-evidence",
"display": "Certainty of Evidence"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>Moderate certainty -- Due to serious imprecision</p></div>"
},
"entry": [
{
"reference": "Evidence/236555",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313881-comparative-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived Evidence: Heart failure with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Assertion",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "assertion",
"display": "Assertion"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>GLP-1 receptor agonists probably reduce the risk of heart failure compared with standard care.</p></div>"
},
"entry": [
{
"reference": "Evidence/236555",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313881-comparative-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived Evidence: Heart failure with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
}
]
},
{
"title": "Serious hyperglycaemia",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "summary-of-findings-entry-for-a-single-outcome",
"display": "Summary of findings entry for a single outcome"
}
]
},
"focus": {
"reference": "EvidenceVariable/236557",
"type": "EvidenceVariable",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-313882",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "OutcomeDefinition: Serious hyperglycaemia"
},
"section": [
{
"title": "Outcome",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "outcome-measure",
"display": "Outcome Measure"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>OutcomeDefinition: Serious hyperglycaemia</p></div>"
},
"entry": [
{
"reference": "EvidenceVariable/236557",
"type": "EvidenceVariable",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-313882",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "OutcomeDefinition: Serious hyperglycaemia"
}
]
},
{
"title": "Sample Size",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "sample-size",
"display": "Sample Size"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>12 studies, 30066 participants</p></div>"
},
"entry": [
{
"reference": "Evidence/236558",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313882-comparative-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived Evidence: Serious hyperglycaemia with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Result Without Treatment",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "result-with-comparator-alone",
"display": "Result with comparator alone"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>2.5%</p></div>"
},
"entry": [
{
"reference": "Evidence/236559",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313882-comparator-only-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived ComparatorOnlyEvidence: Serious hyperglycaemia in Standard care Group in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Result With Treatment--Observed",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "result-with-intervention-alone",
"display": "Result with intervention alone"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>1%</p></div>"
},
"entry": [
{
"reference": "Evidence/293878",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313882-intervention-only-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived InterventionOnlyEvidence: Serious hyperglycaemia in GLP-1 RA Group in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Result With Treatment--Derived",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "result-with-intervention-alone-calculated",
"display": "Result with intervention alone (calculated)"
}
],
"text": "result with intervention with calculated value derived from the control group and effect estimate"
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>1.02%</p></div>"
},
"entry": [
{
"reference": "Evidence/236559",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313882-comparator-only-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived ComparatorOnlyEvidence: Serious hyperglycaemia in Standard care Group in Adults with type 2 diabetes with moderate CV risk"
},
{
"reference": "Evidence/236558",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313882-comparative-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived Evidence: Serious hyperglycaemia with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Effect Estimate",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "result-with-intervention-vs-comparator",
"display": "Result with intervention vs. comparator"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>-1.48% (-1.86% to -0.89%)</p></div>"
},
"entry": [
{
"reference": "Evidence/236558",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313882-comparative-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived Evidence: Serious hyperglycaemia with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Certainty of Evidence",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "certainty-of-evidence",
"display": "Certainty of Evidence"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>High certainty</p></div>"
},
"entry": [
{
"reference": "Evidence/236558",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313882-comparative-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived Evidence: Serious hyperglycaemia with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Assertion",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "assertion",
"display": "Assertion"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>GLP-1 receptor agonists reduce the risk of serious hyperglycaemia compared with standard care.</p></div>"
},
"entry": [
{
"reference": "Evidence/236558",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313882-comparative-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived Evidence: Serious hyperglycaemia with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
}
]
},
{
"title": "Severe gastrointestinal events",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "summary-of-findings-entry-for-a-single-outcome",
"display": "Summary of findings entry for a single outcome"
}
]
},
"focus": {
"reference": "EvidenceVariable/236560",
"type": "EvidenceVariable",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-313883",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "OutcomeDefinition: Severe gastrointestinal events"
},
"section": [
{
"title": "Outcome",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "outcome-measure",
"display": "Outcome Measure"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>OutcomeDefinition: Severe gastrointestinal events</p></div>"
},
"entry": [
{
"reference": "EvidenceVariable/236560",
"type": "EvidenceVariable",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-313883",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "OutcomeDefinition: Severe gastrointestinal events"
}
]
},
{
"title": "Sample Size",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "sample-size",
"display": "Sample Size"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>7 studies, 24638 participants</p></div>"
},
"entry": [
{
"reference": "Evidence/236561",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313883-comparative-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived Evidence: Severe gastrointestinal events with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Result Without Treatment",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "result-with-comparator-alone",
"display": "Result with comparator alone"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>4.4%</p></div>"
},
"entry": [
{
"reference": "Evidence/236562",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313883-comparator-only-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived ComparatorOnlyEvidence: Severe gastrointestinal events in Standard care Group in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Result With Treatment--Observed",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "result-with-intervention-alone",
"display": "Result with intervention alone"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>10.2%</p></div>"
},
"entry": [
{
"reference": "Evidence/293879",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313883-intervention-only-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived InterventionOnlyEvidence: Severe gastrointestinal events in GLP-1 RA Group in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Result With Treatment--Derived",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "result-with-intervention-alone-calculated",
"display": "Result with intervention alone (calculated)"
}
],
"text": "result with intervention with calculated value derived from the control group and effect estimate"
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>10.17%</p></div>"
},
"entry": [
{
"reference": "Evidence/236562",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313883-comparator-only-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived ComparatorOnlyEvidence: Severe gastrointestinal events in Standard care Group in Adults with type 2 diabetes with moderate CV risk"
},
{
"reference": "Evidence/236561",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313883-comparative-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived Evidence: Severe gastrointestinal events with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Effect Estimate",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "result-with-intervention-vs-comparator",
"display": "Result with intervention vs. comparator"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>5.77% (0.92% to 14.22%)</p></div>"
},
"entry": [
{
"reference": "Evidence/236561",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313883-comparative-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived Evidence: Severe gastrointestinal events with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Certainty of Evidence",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "certainty-of-evidence",
"display": "Certainty of Evidence"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>Low certainty -- Due to inconsistency and serious imprecision.</p></div>"
},
"entry": [
{
"reference": "Evidence/236561",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313883-comparative-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived Evidence: Severe gastrointestinal events with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Assertion",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "assertion",
"display": "Assertion"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>GLP-1 receptor agonists may increase the risk of severe gastrointestinal events compared with standard care.</p></div>"
},
"entry": [
{
"reference": "Evidence/236561",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-dichotomous-outcome-313883-comparative-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived Evidence: Severe gastrointestinal events with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
}
]
},
{
"title": "Health-related quality of life",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "summary-of-findings-entry-for-a-single-outcome",
"display": "Summary of findings entry for a single outcome"
}
]
},
"focus": {
"reference": "EvidenceVariable/236563",
"type": "EvidenceVariable",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-109569",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "OutcomeDefinition: Health-related quality of life"
},
"section": [
{
"title": "Outcome",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "outcome-measure",
"display": "Outcome Measure"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>OutcomeDefinition: Health-related quality of life</p></div>"
},
"entry": [
{
"reference": "EvidenceVariable/236563",
"type": "EvidenceVariable",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-109569",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "OutcomeDefinition: Health-related quality of life"
}
]
},
{
"title": "Sample Size",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "sample-size",
"display": "Sample Size"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>[No sample size data.]</p></div>"
},
"entry": [
{
"reference": "Evidence/236564",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-continuous-outcome-109569-comparative-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived Evidence: Health-related quality of life with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Result Without Treatment",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "result-with-comparator-alone",
"display": "Result with comparator alone"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>[Not a proportion.]</p></div>"
},
"entry": [
{
"reference": "Evidence/236565",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-continuous-outcome-109569-comparator-only-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived ComparatorOnlyEvidence: Health-related quality of life in Standard care Group in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Result With Treatment--Observed",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "result-with-intervention-alone",
"display": "Result with intervention alone"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>[Not a proportion.]</p></div>"
},
"entry": [
{
"reference": "Evidence/293880",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-continuous-outcome-109569-intervention-only-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived InterventionOnlyEvidence: Health-related quality of life in GLP-1 RA Group in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Result With Treatment--Derived",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "result-with-intervention-alone-calculated",
"display": "Result with intervention alone (calculated)"
}
],
"text": "result with intervention with calculated value derived from the control group and effect estimate"
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>[Not a proportion.]</p></div>"
},
"entry": [
{
"reference": "Evidence/236565",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-continuous-outcome-109569-comparator-only-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived ComparatorOnlyEvidence: Health-related quality of life in Standard care Group in Adults with type 2 diabetes with moderate CV risk"
},
{
"reference": "Evidence/236564",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-continuous-outcome-109569-comparative-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived Evidence: Health-related quality of life with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Effect Estimate",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "result-with-intervention-vs-comparator",
"display": "Result with intervention vs. comparator"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>[Not a difference in proportions.]</p></div>"
},
"entry": [
{
"reference": "Evidence/236564",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-continuous-outcome-109569-comparative-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived Evidence: Health-related quality of life with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Certainty of Evidence",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "certainty-of-evidence",
"display": "Certainty of Evidence"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>Low certainty -- Due to very serious imprecision</p></div>"
},
"entry": [
{
"reference": "Evidence/236564",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-continuous-outcome-109569-comparative-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived Evidence: Health-related quality of life with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Assertion",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "assertion",
"display": "Assertion"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>GLP-1 receptor agonists may have little or no impact on health-related quality of life.</p></div>"
},
"entry": [
{
"reference": "Evidence/236564",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-continuous-outcome-109569-comparative-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived Evidence: Health-related quality of life with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
}
]
},
{
"title": "Body weight",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "summary-of-findings-entry-for-a-single-outcome",
"display": "Summary of findings entry for a single outcome"
}
]
},
"focus": {
"reference": "EvidenceVariable/236566",
"type": "EvidenceVariable",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-109570",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "OutcomeDefinition: Body weight"
},
"section": [
{
"title": "Outcome",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "outcome-measure",
"display": "Outcome Measure"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>OutcomeDefinition: Body weight</p></div>"
},
"entry": [
{
"reference": "EvidenceVariable/236566",
"type": "EvidenceVariable",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-109570",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "OutcomeDefinition: Body weight"
}
]
},
{
"title": "Sample Size",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "sample-size",
"display": "Sample Size"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>60 studies, 44432 participants</p></div>"
},
"entry": [
{
"reference": "Evidence/236567",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-continuous-outcome-109570-comparative-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived Evidence: Body weight with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Result Without Treatment",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "result-with-comparator-alone",
"display": "Result with comparator alone"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>[Not a proportion.]</p></div>"
},
"entry": [
{
"reference": "Evidence/236568",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-continuous-outcome-109570-comparator-only-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived ComparatorOnlyEvidence: Body weight in Standard care Group in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Result With Treatment--Observed",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "result-with-intervention-alone",
"display": "Result with intervention alone"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>[Not a proportion.]</p></div>"
},
"entry": [
{
"reference": "Evidence/293881",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-continuous-outcome-109570-intervention-only-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived InterventionOnlyEvidence: Body weight in GLP-1 RA Group in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Result With Treatment--Derived",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "result-with-intervention-alone-calculated",
"display": "Result with intervention alone (calculated)"
}
],
"text": "result with intervention with calculated value derived from the control group and effect estimate"
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>[Not a proportion.]</p></div>"
},
"entry": [
{
"reference": "Evidence/236568",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-continuous-outcome-109570-comparator-only-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived ComparatorOnlyEvidence: Body weight in Standard care Group in Adults with type 2 diabetes with moderate CV risk"
},
{
"reference": "Evidence/236567",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-continuous-outcome-109570-comparative-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived Evidence: Body weight with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Effect Estimate",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "result-with-intervention-vs-comparator",
"display": "Result with intervention vs. comparator"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>[Not a difference in proportions.]</p></div>"
},
"entry": [
{
"reference": "Evidence/236567",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-continuous-outcome-109570-comparative-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived Evidence: Body weight with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Certainty of Evidence",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "certainty-of-evidence",
"display": "Certainty of Evidence"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>Low certainty -- Due to very serious inconsistency</p></div>"
},
"entry": [
{
"reference": "Evidence/236567",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-continuous-outcome-109570-comparative-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived Evidence: Body weight with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
},
{
"title": "Assertion",
"code": {
"coding": [
{
"system": "https://fevir.net/resources/CodeSystem/179423",
"code": "assertion",
"display": "Assertion"
}
]
},
"text": {
"status": "generated",
"div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>GLP-1 receptor agonists may reduce body weight compared with standard care.</p></div>"
},
"entry": [
{
"reference": "Evidence/236567",
"type": "Evidence",
"identifier": {
"type": {
"text": "FEvIR Linking Identifier"
},
"system": "https://fevir.net/FLI",
"value": "MAGIC-5288-j1Wqrn-continuous-outcome-109570-comparative-evidence",
"assigner": {
"display": "Computable Publishing LLC"
}
},
"display": "MAGIC-derived Evidence: Body weight with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk"
}
]
}
]
}
]
}
]
}