FHIR IG analytics| Package | hl7.fhir.uv.ebm |
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| FHIR Version | R6 |
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Generated Narrative: Citation 179628
version: 19; Last updated: 2025-10-13 12:34:35+0000
Profile: JournalArticleCitation
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identifier: FEvIR Object Identifier/179628, https://pubmed.ncbi.nlm.nih.gov/14706014, Uniform Resource Identifier (URI)/urn:oid:2.16.840.1.113883.4.642.40.44.15.16
version: 1.0.0-ballot3
title: 14706014 Chemohormonal therapy as primary treatment for metastatic prostate cancer: a randomized study of estramustine phosphate plus luteinizing hormone-releasing hormone agonist versus flutamide plus luteinizing hormone-releasing hormone agonist.
status: Active
date: 2026-02-10 14:00:26+0000
author: Computable Publishing®: MEDLINE-to-FEvIR Converter:
publisher: HL7 International / Clinical Decision Support
contact: HL7 International / Clinical Decision Support: http://www.hl7.org/Special/committees/dss
description:
This Citation Resource is referenced in an example for the EBMonFHIR Implementation Guide.
| Code | Value[x] |
| Citation Classification Type: fevir-platform-use (FEvIR Platform Use) | Medline Base |
jurisdiction: World
copyright:
https://creativecommons.org/licenses/by-nc-sa/4.0/
approvalDate: 2004-06-15
lastReviewDate: 2019-09-22
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https://pubmed.ncbi.nlm.nih.gov/14706014,https://doi.org/10.1111/j.1442-2042.2004.t01-1-00748.x, pii/748Titles
Type Text Primary title Chemohormonal therapy as primary treatment for metastatic prostate cancer: a randomized study of estramustine phosphate plus luteinizing hormone-releasing hormone agonist versus flutamide plus luteinizing hormone-releasing hormone agonist.
Abstracts
Type Text Primary human use BACKGROUND: The present study was undertaken mainly to investigate whether chemohormonal therapy with estramustine phosphate plus luteinizing hormone-releasing hormone (LHRH) agonist has a more beneficial effect than the hormonal therapy with flutamide plus LHRH agonist for newly diagnosed patients with metastatic prostate cancer. METHODS: A total of 57 patients with metastatic prostate cancer aged 59-80 years (median 74 years) were entered in the study and were randomized to the treatment of estramustine phosphate (560 mg/day) plus LHRH agonist (estramustine group) or flutamide (375 mg/day) plus LHRH agonist (flutamide group) with stratification for the degree of performance status, histological differentiation and bone metastasis. RESULTS: Both of the treatment regimens were well tolerated with similar incidences of adverse drug reactions. The overall response rates (complete response plus partial response) at 12 weeks after treatment in the estramustine and flutamide groups were 76 and 55%, respectively. The median time to objective progression for the estramustine group (25.4 months) was longer than that of the flutamide group (14.6 months). The serum levels of follicle stimulating hormone and testosterone were significantly lower in the estramustine group. CONCLUSIONS: Chemohormonal therapy with estramustine phosphate plus LHRH agonist showed longer clinical progression-free survival than the hormonal therapy with flutamide plus LHRH agonist (P = 0.03), although there was no significant difference in the overall survival. A larger-scaled trial with more statistical power is required to clarify that the former regimen is more beneficial than the latter for newly diagnosed patients with advanced prostate cancer.
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identifier: Print ISSN Type/0919-8172, ISOAbbreviation/Int J Urol, ISSN Linking/0919-8172, Medline Title Abbreviation/Int J Urol, NLM Unique ID/9440237
title: International journal of urology : official journal of the Japanese Urological Association
publisherLocation: Australia
citedMedium: Print
volume: 11
issue: 2
articleDate: 2004-02
pageString: 103-9
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affiliation: Department of Urology, Kurume University School of Medicine, Kurume, Japan. noguchi@med.kurume-u.ac.jp
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