FHIR IG Statistics: StructureDefinition/SystemicTreatment
Resources that use this resource
Resources that this resource uses
Narrative
Note: links and images are rebased to the (stated) source
Source
{
"resourceType": "StructureDefinition",
"id": "SystemicTreatment",
"text": {
"status": "extensions",
"div": "<!-- snip (see above) -->"
},
"url": "http://hl7.eu/fhir/ig/idea4rc/StructureDefinition/SystemicTreatment",
"version": "0.1.0",
"name": "SystemicTreatmentI4RC",
"title": "Systemic Treatment",
"status": "draft",
"date": "2025-07-25T13:48:09+00:00",
"publisher": "IDEA4RC Project",
"contact": [
{
"name": "IDEA4RC Project",
"telecom": [
{
"system": "url",
"value": "https://www.idea4rc.eu/"
}
]
},
{
"name": "IDEA4RC Project",
"telecom": [
{
"system": "url",
"value": "https://www.idea4rc.eu/"
}
]
}
],
"description": "Systemic Treatment\nMaturity Level: 0 Draft",
"jurisdiction": [
{
"coding": [
{
"system": "http://unstats.un.org/unsd/methods/m49/m49.htm",
"code": "150",
"display": "Europe"
}
]
}
],
"fhirVersion": "4.0.1",
"kind": "logical",
"abstract": false,
"type": "http://hl7.eu/fhir/ig/idea4rc/StructureDefinition/SystemicTreatment",
"baseDefinition": "http://hl7.org/fhir/StructureDefinition/Base",
"derivation": "specialization",
"snapshot": {
"extension": [
{
"url": "http://hl7.org/fhir/tools/StructureDefinition/snapshot-base-version",
"valueString": "4.0.1"
}
],
"element": [
{
"id": "SystemicTreatment",
"path": "SystemicTreatment",
"short": "Systemic Treatment",
"definition": "Systemic Treatment\nMaturity Level: 0 Draft",
"min": 0,
"max": "*",
"base": {
"path": "Base",
"min": 0,
"max": "*"
},
"isModifier": false
},
{
"id": "SystemicTreatment.diagnosisReference",
"extension": [
{
"extension": [
{
"url": "code",
"valueCode": "SHALL:handle"
},
{
"url": "actor",
"valueCanonical": "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
},
{
"url": "http://hl7.org/fhir/tools/StructureDefinition/snapshot-source",
"valueUri": "http://hl7.eu/fhir/ig/idea4rc/StructureDefinition/SystemicTreatment|0.1.0"
}
],
"url": "http://hl7.org/fhir/StructureDefinition/obligation"
},
{
"extension": [
{
"url": "code",
"valueCode": "SHALL:handle"
},
{
"url": "actor",
"valueCanonical": "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"
},
{
"url": "http://hl7.org/fhir/tools/StructureDefinition/snapshot-source",
"valueUri": "http://hl7.eu/fhir/ig/idea4rc/StructureDefinition/SystemicTreatment|0.1.0"
}
],
"url": "http://hl7.org/fhir/StructureDefinition/obligation"
}
],
"path": "SystemicTreatment.diagnosisReference",
"short": "Diagnosis reference (M)",
"definition": "Diagnosis reference in case the treatment was done for baseline",
"min": 1,
"max": "*",
"base": {
"path": "SystemicTreatment.diagnosisReference",
"min": 1,
"max": "*"
},
"type": [
{
"code": "http://hl7.eu/fhir/ig/idea4rc/StructureDefinition/Diagnosis"
}
]
},
{
"id": "SystemicTreatment.episodeEvent",
"extension": [
{
"extension": [
{
"url": "code",
"valueCode": "SHALL:handle"
},
{
"url": "actor",
"valueCanonical": "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
},
{
"url": "http://hl7.org/fhir/tools/StructureDefinition/snapshot-source",
"valueUri": "http://hl7.eu/fhir/ig/idea4rc/StructureDefinition/SystemicTreatment|0.1.0"
}
],
"url": "http://hl7.org/fhir/StructureDefinition/obligation"
},
{
"extension": [
{
"url": "code",
"valueCode": "SHALL:handle"
},
{
"url": "actor",
"valueCanonical": "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"
},
{
"url": "http://hl7.org/fhir/tools/StructureDefinition/snapshot-source",
"valueUri": "http://hl7.eu/fhir/ig/idea4rc/StructureDefinition/SystemicTreatment|0.1.0"
}
],
"url": "http://hl7.org/fhir/StructureDefinition/obligation"
}
],
"path": "SystemicTreatment.episodeEvent",
"short": "Episode Event reference (M)",
"definition": "EpisodeEvent element containing the data regarding the patient's cancer",
"min": 1,
"max": "*",
"base": {
"path": "SystemicTreatment.episodeEvent",
"min": 1,
"max": "*"
},
"type": [
{
"code": "http://hl7.eu/fhir/ig/idea4rc/StructureDefinition/EpisodeEvent"
}
]
},
{
"id": "SystemicTreatment.systemicTreatmentHospital",
"extension": [
{
"extension": [
{
"url": "code",
"valueCode": "SHALL:handle"
},
{
"url": "actor",
"valueCanonical": "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
},
{
"url": "http://hl7.org/fhir/tools/StructureDefinition/snapshot-source",
"valueUri": "http://hl7.eu/fhir/ig/idea4rc/StructureDefinition/SystemicTreatment|0.1.0"
}
],
"url": "http://hl7.org/fhir/StructureDefinition/obligation"
},
{
"extension": [
{
"url": "code",
"valueCode": "SHALL:handle"
},
{
"url": "actor",
"valueCanonical": "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"
},
{
"url": "http://hl7.org/fhir/tools/StructureDefinition/snapshot-source",
"valueUri": "http://hl7.eu/fhir/ig/idea4rc/StructureDefinition/SystemicTreatment|0.1.0"
}
],
"url": "http://hl7.org/fhir/StructureDefinition/obligation"
}
],
"path": "SystemicTreatment.systemicTreatmentHospital",
"short": "SystemicTreatment Hospital (M)",
"definition": "In which hospital was the SystemicTreatment performed",
"min": 1,
"max": "*",
"base": {
"path": "SystemicTreatment.systemicTreatmentHospital",
"min": 1,
"max": "*"
},
"type": [
{
"code": "string"
}
]
},
{
"id": "SystemicTreatment.typeOfSystemicTreatment",
"extension": [
{
"extension": [
{
"url": "code",
"valueCode": "SHALL:handle"
},
{
"url": "actor",
"valueCanonical": "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
},
{
"url": "http://hl7.org/fhir/tools/StructureDefinition/snapshot-source",
"valueUri": "http://hl7.eu/fhir/ig/idea4rc/StructureDefinition/SystemicTreatment|0.1.0"
}
],
"url": "http://hl7.org/fhir/StructureDefinition/obligation"
},
{
"extension": [
{
"url": "code",
"valueCode": "SHALL:handle"
},
{
"url": "actor",
"valueCanonical": "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"
},
{
"url": "http://hl7.org/fhir/tools/StructureDefinition/snapshot-source",
"valueUri": "http://hl7.eu/fhir/ig/idea4rc/StructureDefinition/SystemicTreatment|0.1.0"
}
],
"url": "http://hl7.org/fhir/StructureDefinition/obligation"
}
],
"path": "SystemicTreatment.typeOfSystemicTreatment",
"short": "type of systemic treatment (M)",
"definition": "Select the type of systemic treatment administered. It is possible to directly select the single treatment as appropriate.",
"comment": "Chemotherapy - 4273629\nImmunotherapy - 40310107\nTargeted therapy - 912065",
"min": 1,
"max": "*",
"base": {
"path": "SystemicTreatment.typeOfSystemicTreatment",
"min": 1,
"max": "*"
},
"type": [
{
"code": "CodeableConcept"
}
]
},
{
"id": "SystemicTreatment.intent",
"extension": [
{
"extension": [
{
"url": "code",
"valueCode": "SHALL:handle"
},
{
"url": "actor",
"valueCanonical": "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
},
{
"url": "http://hl7.org/fhir/tools/StructureDefinition/snapshot-source",
"valueUri": "http://hl7.eu/fhir/ig/idea4rc/StructureDefinition/SystemicTreatment|0.1.0"
}
],
"url": "http://hl7.org/fhir/StructureDefinition/obligation"
}
],
"path": "SystemicTreatment.intent",
"short": "Intent (O)",
"definition": "Clarifies the reasons why systemic therapy is administered\n• Curative chemotherapy is chemotherapy administered with the goal of achieving a complete remission and preventing the recurrence of cancer. \n• Palliative chemotherapy refers to any chemotherapy administration that is not curative but administered simply to decrease tumor load and increase life expectancy. It has been defined also as “…treatment in circumstances where the impact of intervention is insufficient to result in major survival advantage, but does affect improvement in terms of tumor‐related symptoms…”",
"comment": "Palliative - 4179711\nCurative procedure intent - 4162591",
"min": 0,
"max": "*",
"base": {
"path": "SystemicTreatment.intent",
"min": 0,
"max": "*"
},
"type": [
{
"code": "CodeableConcept"
}
]
},
{
"id": "SystemicTreatment.setting",
"extension": [
{
"extension": [
{
"url": "code",
"valueCode": "SHALL:handle"
},
{
"url": "actor",
"valueCanonical": "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
},
{
"url": "http://hl7.org/fhir/tools/StructureDefinition/snapshot-source",
"valueUri": "http://hl7.eu/fhir/ig/idea4rc/StructureDefinition/SystemicTreatment|0.1.0"
}
],
"url": "http://hl7.org/fhir/StructureDefinition/obligation"
}
],
"path": "SystemicTreatment.setting",
"short": "Setting (O)",
"definition": "Clarifies the context / how the therapy was administered alone or in conjunction with other treatments\n• Neoadjuvant: treatment given as a first step to shrink a tumor before the main treatment, which is usually surgery, is given. Examples of neoadjuvant therapy include chemotherapy, radiation therapy, and hormone therapy. It is a type of induction therapy.\n• Adjuvant: additional cancer treatment given after the primary treatment to lower the risk that the cancer will come back. Adjuvant therapy may include chemotherapy, radiation therapy, hormone therapy, targeted therapy, or biological therapy.\n• Concomitant/concurrent: A treatment that is given at the same time as another (es. Chemotherapy and radiotherapy).",
"comment": "Neo-adjuvant - 44808409\nConcomitant - 2000100028\n Adjuvant - 44804498\nSystemic treatment alone - 2000100029",
"min": 0,
"max": "*",
"base": {
"path": "SystemicTreatment.setting",
"min": 0,
"max": "*"
},
"type": [
{
"code": "CodeableConcept"
}
]
},
{
"id": "SystemicTreatment.chemotherapyInfo",
"extension": [
{
"extension": [
{
"url": "code",
"valueCode": "SHALL:handle"
},
{
"url": "actor",
"valueCanonical": "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"
},
{
"url": "http://hl7.org/fhir/tools/StructureDefinition/snapshot-source",
"valueUri": "http://hl7.eu/fhir/ig/idea4rc/StructureDefinition/SystemicTreatment|0.1.0"
}
],
"url": "http://hl7.org/fhir/StructureDefinition/obligation"
}
],
"path": "SystemicTreatment.chemotherapyInfo",
"short": "Chemotherapy info (O)",
"definition": "Information for chemotherapy",
"comment": "Preoperative - 4119031\nPostoperative period - 4118656\nHyperthermic intraperitoneal chemotherapy - 3184898\nTherapeutic - 4133895",
"min": 0,
"max": "*",
"base": {
"path": "SystemicTreatment.chemotherapyInfo",
"min": 0,
"max": "*"
},
"type": [
{
"code": "CodeableConcept"
}
]
},
{
"id": "SystemicTreatment.startDateSystemicTreatment",
"extension": [
{
"extension": [
{
"url": "code",
"valueCode": "SHALL:handle"
},
{
"url": "actor",
"valueCanonical": "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
},
{
"url": "http://hl7.org/fhir/tools/StructureDefinition/snapshot-source",
"valueUri": "http://hl7.eu/fhir/ig/idea4rc/StructureDefinition/SystemicTreatment|0.1.0"
}
],
"url": "http://hl7.org/fhir/StructureDefinition/obligation"
},
{
"extension": [
{
"url": "code",
"valueCode": "SHALL:handle"
},
{
"url": "actor",
"valueCanonical": "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"
},
{
"url": "http://hl7.org/fhir/tools/StructureDefinition/snapshot-source",
"valueUri": "http://hl7.eu/fhir/ig/idea4rc/StructureDefinition/SystemicTreatment|0.1.0"
}
],
"url": "http://hl7.org/fhir/StructureDefinition/obligation"
}
],
"path": "SystemicTreatment.startDateSystemicTreatment",
"short": "Start date systemic treatment (M)",
"definition": "Specifies when systemic treatment begins",
"min": 1,
"max": "*",
"base": {
"path": "SystemicTreatment.startDateSystemicTreatment",
"min": 1,
"max": "*"
},
"type": [
{
"code": "date"
}
]
},
{
"id": "SystemicTreatment.endDateSystemicTreatment",
"extension": [
{
"extension": [
{
"url": "code",
"valueCode": "SHALL:handle"
},
{
"url": "actor",
"valueCanonical": "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
},
{
"url": "http://hl7.org/fhir/tools/StructureDefinition/snapshot-source",
"valueUri": "http://hl7.eu/fhir/ig/idea4rc/StructureDefinition/SystemicTreatment|0.1.0"
}
],
"url": "http://hl7.org/fhir/StructureDefinition/obligation"
},
{
"extension": [
{
"url": "code",
"valueCode": "SHALL:handle"
},
{
"url": "actor",
"valueCanonical": "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"
},
{
"url": "http://hl7.org/fhir/tools/StructureDefinition/snapshot-source",
"valueUri": "http://hl7.eu/fhir/ig/idea4rc/StructureDefinition/SystemicTreatment|0.1.0"
}
],
"url": "http://hl7.org/fhir/StructureDefinition/obligation"
}
],
"path": "SystemicTreatment.endDateSystemicTreatment",
"short": "End date systemic treatment (M)",
"definition": "Specifies when systemic treatment ends",
"min": 1,
"max": "*",
"base": {
"path": "SystemicTreatment.endDateSystemicTreatment",
"min": 1,
"max": "*"
},
"type": [
{
"code": "date"
}
]
},
{
"id": "SystemicTreatment.numberOfCycles",
"extension": [
{
"extension": [
{
"url": "code",
"valueCode": "SHALL:handle"
},
{
"url": "actor",
"valueCanonical": "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
},
{
"url": "http://hl7.org/fhir/tools/StructureDefinition/snapshot-source",
"valueUri": "http://hl7.eu/fhir/ig/idea4rc/StructureDefinition/SystemicTreatment|0.1.0"
}
],
"url": "http://hl7.org/fhir/StructureDefinition/obligation"
},
{
"extension": [
{
"url": "code",
"valueCode": "SHALL:handle"
},
{
"url": "actor",
"valueCanonical": "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"
},
{
"url": "http://hl7.org/fhir/tools/StructureDefinition/snapshot-source",
"valueUri": "http://hl7.eu/fhir/ig/idea4rc/StructureDefinition/SystemicTreatment|0.1.0"
}
],
"url": "http://hl7.org/fhir/StructureDefinition/obligation"
}
],
"path": "SystemicTreatment.numberOfCycles",
"short": "Number of cycles/ administrations (O)",
"definition": "Clarifies how many times the treatment was administered. A cycle of treatment is a period of treatment followed by a period of rest (no treatment). For example, treatment given for one week followed by three weeks of rest is one cycle of treatment. A cycle can be repeated multiple times.",
"min": 0,
"max": "*",
"base": {
"path": "SystemicTreatment.numberOfCycles",
"min": 0,
"max": "*"
},
"type": [
{
"code": "Quantity"
}
]
},
{
"id": "SystemicTreatment.regimen",
"extension": [
{
"extension": [
{
"url": "code",
"valueCode": "SHALL:handle"
},
{
"url": "actor",
"valueCanonical": "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
},
{
"url": "http://hl7.org/fhir/tools/StructureDefinition/snapshot-source",
"valueUri": "http://hl7.eu/fhir/ig/idea4rc/StructureDefinition/SystemicTreatment|0.1.0"
}
],
"url": "http://hl7.org/fhir/StructureDefinition/obligation"
},
{
"extension": [
{
"url": "code",
"valueCode": "SHALL:handle"
},
{
"url": "actor",
"valueCanonical": "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"
},
{
"url": "http://hl7.org/fhir/tools/StructureDefinition/snapshot-source",
"valueUri": "http://hl7.eu/fhir/ig/idea4rc/StructureDefinition/SystemicTreatment|0.1.0"
}
],
"url": "http://hl7.org/fhir/StructureDefinition/obligation"
}
],
"path": "SystemicTreatment.regimen",
"short": "Regimen (O)",
"definition": "The regimen applied to the patient. If this is not present, or the specific regimen is not listed here, use the DrugsForTreatments entity.",
"comment": "Doxorubicin and Ifosfamide - 35806965\nIfosfamide and Paclitaxel - 35805248\ndoxorubicin and vincristine - 2000100054\nEpirubicin monotherapy - 35804228\nEtoposide monotherapy - 35803691\nGemcitabine monotherapy - 35804135\nIfosfamide and Gemcitabine - 35806435\ngemcitabine and vincristine - 2000100055\nhigh dose cisplatin - 2000100056\nIfosfamide monotherapy - 35804542\nifosfamide and etoposide - 2000100057\nIrinotecan liposomal monotherapy - 35805368\nLenvatinib monotherapy - 35805795\nMethotrexate monotherapy - 35804095\nNivolumab monotherapy - 35803677\nADT (other androgen deprivation therapy) - 35806821\nOxaliplatin monotherapy - 35805078\nPaclitaxel monotherapy - 35804166\nGemcitabine and Paclitaxel - 35804158\nIfosfamide and Paclitaxel - 35805248\nPaclitaxel and Trastuzumab (TH) - 35804201\nPaclitaxel and Vinorelbine - 35101452\n Pembrolizumab monotherapy - 35803678\nSorafenib monotherapy - 35803487\nTrastuzumab emtansine monotherapy (TDM1) - 35805230\nTrastuzumab monotherapy - 35804222\nVinorelbine monotherapy - 35804241\nweekly carboplatin - 2000100058\nweekly cisplatin - 2000100059\n\nEpirubicin and Ifosfamide - 35806948\nVincristine and Doxorubicin and Ifosfamide - 2000100060\nVincristine, Actinomycin D, Ifosfamide (\nVAI) - 35805452\nDocetaxel and Gemcitabine - 35803577\nDacarbazine and Doxorubicin - 35806964\nMethotrexate and Doxorubicin and Cisplatin - 2000100061\nMethotrexate and Doxorubicin and Ifosfamide - 2000100062\nDoxorubicin and Cisplatin and Ifosfamide - 2000100063\nCisplatin and Doxorubicin - 35804819\nMethotrexate and Vinorelbine - 2000100064\nIfosfamide and Etoposide (IE) - 35805454\nVincristine and Doxorubicin and Cyclophosphamide - 2000100065\nCyclophosphamide and Etoposide - 35806476\nDoxorubicin and Ifosfamide and Dacarbazine - 2000100066\nDacarbazine and Gemcitabine - 35806969\nCyclophosphamide and Topotecan - 35805453\nIrinotecan and Vincristine - 2000100067\nIrinotecan and Temozolomide - 35805455\nBusulfan and Melphalan - 35804000\nTNF and Melphalan - 2000100068\nCyclophosphamide and Vinorelbine - 2000100069\nVincristine, Ifosfamide, Doxorubicin, Etoposide (VIDE) - 35805451\nPazopanib monotherapy - 35805690\nRegorafenib monotherapy - 35804569\nhigh dose Ifosfamide - 2000100070",
"min": 0,
"max": "*",
"base": {
"path": "SystemicTreatment.regimen",
"min": 0,
"max": "*"
},
"type": [
{
"code": "CodeableConcept"
}
]
},
{
"id": "SystemicTreatment.startDateRegimenChanged",
"extension": [
{
"extension": [
{
"url": "code",
"valueCode": "SHALL:handle"
},
{
"url": "actor",
"valueCanonical": "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
},
{
"url": "http://hl7.org/fhir/tools/StructureDefinition/snapshot-source",
"valueUri": "http://hl7.eu/fhir/ig/idea4rc/StructureDefinition/SystemicTreatment|0.1.0"
}
],
"url": "http://hl7.org/fhir/StructureDefinition/obligation"
}
],
"path": "SystemicTreatment.startDateRegimenChanged",
"short": "Start date regimen changed (M)",
"definition": "Specifies when the new systemic treatment begins, if a combination please specify the start of the first drug",
"min": 1,
"max": "*",
"base": {
"path": "SystemicTreatment.startDateRegimenChanged",
"min": 1,
"max": "*"
},
"type": [
{
"code": "date"
}
]
},
{
"id": "SystemicTreatment.endDateRegimenChanged",
"extension": [
{
"extension": [
{
"url": "code",
"valueCode": "SHALL:handle"
},
{
"url": "actor",
"valueCanonical": "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
},
{
"url": "http://hl7.org/fhir/tools/StructureDefinition/snapshot-source",
"valueUri": "http://hl7.eu/fhir/ig/idea4rc/StructureDefinition/SystemicTreatment|0.1.0"
}
],
"url": "http://hl7.org/fhir/StructureDefinition/obligation"
}
],
"path": "SystemicTreatment.endDateRegimenChanged",
"short": "End date regimen changed (M)",
"definition": "Specifies when the new systemic treatment ends,if a combination please specify the end of the last drug",
"min": 1,
"max": "*",
"base": {
"path": "SystemicTreatment.endDateRegimenChanged",
"min": 1,
"max": "*"
},
"type": [
{
"code": "date"
}
]
},
{
"id": "SystemicTreatment.reasonForEndOfTreatment",
"extension": [
{
"extension": [
{
"url": "code",
"valueCode": "SHALL:handle"
},
{
"url": "actor",
"valueCanonical": "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
},
{
"url": "http://hl7.org/fhir/tools/StructureDefinition/snapshot-source",
"valueUri": "http://hl7.eu/fhir/ig/idea4rc/StructureDefinition/SystemicTreatment|0.1.0"
}
],
"url": "http://hl7.org/fhir/StructureDefinition/obligation"
},
{
"extension": [
{
"url": "code",
"valueCode": "SHALL:handle"
},
{
"url": "actor",
"valueCanonical": "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"
},
{
"url": "http://hl7.org/fhir/tools/StructureDefinition/snapshot-source",
"valueUri": "http://hl7.eu/fhir/ig/idea4rc/StructureDefinition/SystemicTreatment|0.1.0"
}
],
"url": "http://hl7.org/fhir/StructureDefinition/obligation"
}
],
"path": "SystemicTreatment.reasonForEndOfTreatment",
"short": "Reason for end of treatment (M)",
"definition": "Clarifies the reasons why the treatment ended or was interrupted",
"comment": "Completed successfully - 44788181\nChemotherapy changed acute chemotherapy toxicity - 4162594 \nTreatment ended due to comorbidity - 2000100030\nIntolerance to drug - 4240582\nProcedure discontinued by patient - 37017062\nDeath - 4306655",
"min": 1,
"max": "*",
"base": {
"path": "SystemicTreatment.reasonForEndOfTreatment",
"min": 1,
"max": "*"
},
"type": [
{
"code": "CodeableConcept"
}
]
},
{
"id": "SystemicTreatment.treatmentResponse",
"extension": [
{
"extension": [
{
"url": "code",
"valueCode": "SHALL:handle"
},
{
"url": "actor",
"valueCanonical": "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
},
{
"url": "http://hl7.org/fhir/tools/StructureDefinition/snapshot-source",
"valueUri": "http://hl7.eu/fhir/ig/idea4rc/StructureDefinition/SystemicTreatment|0.1.0"
}
],
"url": "http://hl7.org/fhir/StructureDefinition/obligation"
},
{
"extension": [
{
"url": "code",
"valueCode": "SHALL:handle"
},
{
"url": "actor",
"valueCanonical": "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"
},
{
"url": "http://hl7.org/fhir/tools/StructureDefinition/snapshot-source",
"valueUri": "http://hl7.eu/fhir/ig/idea4rc/StructureDefinition/SystemicTreatment|0.1.0"
}
],
"url": "http://hl7.org/fhir/StructureDefinition/obligation"
}
],
"path": "SystemicTreatment.treatmentResponse",
"short": "Treatment response (based on imaging alone; no recist or other criteria) (M)",
"definition": "Measures how well a cancer patient responds to treatment. RECIST criteria should not be applied. The definition of Complete response; Partial response; Stable disease; Progression, should be based on the clinical judgement based on imaging. Only when setting=neoadiuvant or palliative",
"comment": "Complete Remission - 32946\nPartial Remission - 32947\nStable Disease - 32948\nProgression - 32949\nNot applicable - 4294169 (Not usable in OMOP)",
"min": 1,
"max": "*",
"base": {
"path": "SystemicTreatment.treatmentResponse",
"min": 1,
"max": "*"
},
"type": [
{
"code": "CodeableConcept"
}
]
}
]
},
"differential": {
"element": [
{
"id": "SystemicTreatment",
"path": "SystemicTreatment",
"short": "Systemic Treatment",
"definition": "Systemic Treatment\nMaturity Level: 0 Draft"
},
{
"id": "SystemicTreatment.diagnosisReference",
"extension": [
{
"extension": [
{
"url": "code",
"valueCode": "SHALL:handle"
},
{
"url": "actor",
"valueCanonical": "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
}
],
"url": "http://hl7.org/fhir/StructureDefinition/obligation"
},
{
"extension": [
{
"url": "code",
"valueCode": "SHALL:handle"
},
{
"url": "actor",
"valueCanonical": "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"
}
],
"url": "http://hl7.org/fhir/StructureDefinition/obligation"
}
],
"path": "SystemicTreatment.diagnosisReference",
"short": "Diagnosis reference (M)",
"definition": "Diagnosis reference in case the treatment was done for baseline",
"min": 1,
"max": "*",
"type": [
{
"code": "http://hl7.eu/fhir/ig/idea4rc/StructureDefinition/Diagnosis"
}
]
},
{
"id": "SystemicTreatment.episodeEvent",
"extension": [
{
"extension": [
{
"url": "code",
"valueCode": "SHALL:handle"
},
{
"url": "actor",
"valueCanonical": "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
}
],
"url": "http://hl7.org/fhir/StructureDefinition/obligation"
},
{
"extension": [
{
"url": "code",
"valueCode": "SHALL:handle"
},
{
"url": "actor",
"valueCanonical": "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"
}
],
"url": "http://hl7.org/fhir/StructureDefinition/obligation"
}
],
"path": "SystemicTreatment.episodeEvent",
"short": "Episode Event reference (M)",
"definition": "EpisodeEvent element containing the data regarding the patient's cancer",
"min": 1,
"max": "*",
"type": [
{
"code": "http://hl7.eu/fhir/ig/idea4rc/StructureDefinition/EpisodeEvent"
}
]
},
{
"id": "SystemicTreatment.systemicTreatmentHospital",
"extension": [
{
"extension": [
{
"url": "code",
"valueCode": "SHALL:handle"
},
{
"url": "actor",
"valueCanonical": "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
}
],
"url": "http://hl7.org/fhir/StructureDefinition/obligation"
},
{
"extension": [
{
"url": "code",
"valueCode": "SHALL:handle"
},
{
"url": "actor",
"valueCanonical": "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"
}
],
"url": "http://hl7.org/fhir/StructureDefinition/obligation"
}
],
"path": "SystemicTreatment.systemicTreatmentHospital",
"short": "SystemicTreatment Hospital (M)",
"definition": "In which hospital was the SystemicTreatment performed",
"min": 1,
"max": "*",
"type": [
{
"code": "string"
}
]
},
{
"id": "SystemicTreatment.typeOfSystemicTreatment",
"extension": [
{
"extension": [
{
"url": "code",
"valueCode": "SHALL:handle"
},
{
"url": "actor",
"valueCanonical": "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
}
],
"url": "http://hl7.org/fhir/StructureDefinition/obligation"
},
{
"extension": [
{
"url": "code",
"valueCode": "SHALL:handle"
},
{
"url": "actor",
"valueCanonical": "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"
}
],
"url": "http://hl7.org/fhir/StructureDefinition/obligation"
}
],
"path": "SystemicTreatment.typeOfSystemicTreatment",
"short": "type of systemic treatment (M)",
"definition": "Select the type of systemic treatment administered. It is possible to directly select the single treatment as appropriate.",
"comment": "Chemotherapy - 4273629\nImmunotherapy - 40310107\nTargeted therapy - 912065",
"min": 1,
"max": "*",
"type": [
{
"code": "CodeableConcept"
}
]
},
{
"id": "SystemicTreatment.intent",
"extension": [
{
"extension": [
{
"url": "code",
"valueCode": "SHALL:handle"
},
{
"url": "actor",
"valueCanonical": "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
}
],
"url": "http://hl7.org/fhir/StructureDefinition/obligation"
}
],
"path": "SystemicTreatment.intent",
"short": "Intent (O)",
"definition": "Clarifies the reasons why systemic therapy is administered\n• Curative chemotherapy is chemotherapy administered with the goal of achieving a complete remission and preventing the recurrence of cancer. \n• Palliative chemotherapy refers to any chemotherapy administration that is not curative but administered simply to decrease tumor load and increase life expectancy. It has been defined also as “…treatment in circumstances where the impact of intervention is insufficient to result in major survival advantage, but does affect improvement in terms of tumor‐related symptoms…”",
"comment": "Palliative - 4179711\nCurative procedure intent - 4162591",
"min": 0,
"max": "*",
"type": [
{
"code": "CodeableConcept"
}
]
},
{
"id": "SystemicTreatment.setting",
"extension": [
{
"extension": [
{
"url": "code",
"valueCode": "SHALL:handle"
},
{
"url": "actor",
"valueCanonical": "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
}
],
"url": "http://hl7.org/fhir/StructureDefinition/obligation"
}
],
"path": "SystemicTreatment.setting",
"short": "Setting (O)",
"definition": "Clarifies the context / how the therapy was administered alone or in conjunction with other treatments\n• Neoadjuvant: treatment given as a first step to shrink a tumor before the main treatment, which is usually surgery, is given. Examples of neoadjuvant therapy include chemotherapy, radiation therapy, and hormone therapy. It is a type of induction therapy.\n• Adjuvant: additional cancer treatment given after the primary treatment to lower the risk that the cancer will come back. Adjuvant therapy may include chemotherapy, radiation therapy, hormone therapy, targeted therapy, or biological therapy.\n• Concomitant/concurrent: A treatment that is given at the same time as another (es. Chemotherapy and radiotherapy).",
"comment": "Neo-adjuvant - 44808409\nConcomitant - 2000100028\n Adjuvant - 44804498\nSystemic treatment alone - 2000100029",
"min": 0,
"max": "*",
"type": [
{
"code": "CodeableConcept"
}
]
},
{
"id": "SystemicTreatment.chemotherapyInfo",
"extension": [
{
"extension": [
{
"url": "code",
"valueCode": "SHALL:handle"
},
{
"url": "actor",
"valueCanonical": "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"
}
],
"url": "http://hl7.org/fhir/StructureDefinition/obligation"
}
],
"path": "SystemicTreatment.chemotherapyInfo",
"short": "Chemotherapy info (O)",
"definition": "Information for chemotherapy",
"comment": "Preoperative - 4119031\nPostoperative period - 4118656\nHyperthermic intraperitoneal chemotherapy - 3184898\nTherapeutic - 4133895",
"min": 0,
"max": "*",
"type": [
{
"code": "CodeableConcept"
}
]
},
{
"id": "SystemicTreatment.startDateSystemicTreatment",
"extension": [
{
"extension": [
{
"url": "code",
"valueCode": "SHALL:handle"
},
{
"url": "actor",
"valueCanonical": "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
}
],
"url": "http://hl7.org/fhir/StructureDefinition/obligation"
},
{
"extension": [
{
"url": "code",
"valueCode": "SHALL:handle"
},
{
"url": "actor",
"valueCanonical": "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"
}
],
"url": "http://hl7.org/fhir/StructureDefinition/obligation"
}
],
"path": "SystemicTreatment.startDateSystemicTreatment",
"short": "Start date systemic treatment (M)",
"definition": "Specifies when systemic treatment begins",
"min": 1,
"max": "*",
"type": [
{
"code": "date"
}
]
},
{
"id": "SystemicTreatment.endDateSystemicTreatment",
"extension": [
{
"extension": [
{
"url": "code",
"valueCode": "SHALL:handle"
},
{
"url": "actor",
"valueCanonical": "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
}
],
"url": "http://hl7.org/fhir/StructureDefinition/obligation"
},
{
"extension": [
{
"url": "code",
"valueCode": "SHALL:handle"
},
{
"url": "actor",
"valueCanonical": "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"
}
],
"url": "http://hl7.org/fhir/StructureDefinition/obligation"
}
],
"path": "SystemicTreatment.endDateSystemicTreatment",
"short": "End date systemic treatment (M)",
"definition": "Specifies when systemic treatment ends",
"min": 1,
"max": "*",
"type": [
{
"code": "date"
}
]
},
{
"id": "SystemicTreatment.numberOfCycles",
"extension": [
{
"extension": [
{
"url": "code",
"valueCode": "SHALL:handle"
},
{
"url": "actor",
"valueCanonical": "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
}
],
"url": "http://hl7.org/fhir/StructureDefinition/obligation"
},
{
"extension": [
{
"url": "code",
"valueCode": "SHALL:handle"
},
{
"url": "actor",
"valueCanonical": "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"
}
],
"url": "http://hl7.org/fhir/StructureDefinition/obligation"
}
],
"path": "SystemicTreatment.numberOfCycles",
"short": "Number of cycles/ administrations (O)",
"definition": "Clarifies how many times the treatment was administered. A cycle of treatment is a period of treatment followed by a period of rest (no treatment). For example, treatment given for one week followed by three weeks of rest is one cycle of treatment. A cycle can be repeated multiple times.",
"min": 0,
"max": "*",
"type": [
{
"code": "Quantity"
}
]
},
{
"id": "SystemicTreatment.regimen",
"extension": [
{
"extension": [
{
"url": "code",
"valueCode": "SHALL:handle"
},
{
"url": "actor",
"valueCanonical": "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
}
],
"url": "http://hl7.org/fhir/StructureDefinition/obligation"
},
{
"extension": [
{
"url": "code",
"valueCode": "SHALL:handle"
},
{
"url": "actor",
"valueCanonical": "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"
}
],
"url": "http://hl7.org/fhir/StructureDefinition/obligation"
}
],
"path": "SystemicTreatment.regimen",
"short": "Regimen (O)",
"definition": "The regimen applied to the patient. If this is not present, or the specific regimen is not listed here, use the DrugsForTreatments entity.",
"comment": "Doxorubicin and Ifosfamide - 35806965\nIfosfamide and Paclitaxel - 35805248\ndoxorubicin and vincristine - 2000100054\nEpirubicin monotherapy - 35804228\nEtoposide monotherapy - 35803691\nGemcitabine monotherapy - 35804135\nIfosfamide and Gemcitabine - 35806435\ngemcitabine and vincristine - 2000100055\nhigh dose cisplatin - 2000100056\nIfosfamide monotherapy - 35804542\nifosfamide and etoposide - 2000100057\nIrinotecan liposomal monotherapy - 35805368\nLenvatinib monotherapy - 35805795\nMethotrexate monotherapy - 35804095\nNivolumab monotherapy - 35803677\nADT (other androgen deprivation therapy) - 35806821\nOxaliplatin monotherapy - 35805078\nPaclitaxel monotherapy - 35804166\nGemcitabine and Paclitaxel - 35804158\nIfosfamide and Paclitaxel - 35805248\nPaclitaxel and Trastuzumab (TH) - 35804201\nPaclitaxel and Vinorelbine - 35101452\n Pembrolizumab monotherapy - 35803678\nSorafenib monotherapy - 35803487\nTrastuzumab emtansine monotherapy (TDM1) - 35805230\nTrastuzumab monotherapy - 35804222\nVinorelbine monotherapy - 35804241\nweekly carboplatin - 2000100058\nweekly cisplatin - 2000100059\n\nEpirubicin and Ifosfamide - 35806948\nVincristine and Doxorubicin and Ifosfamide - 2000100060\nVincristine, Actinomycin D, Ifosfamide (\nVAI) - 35805452\nDocetaxel and Gemcitabine - 35803577\nDacarbazine and Doxorubicin - 35806964\nMethotrexate and Doxorubicin and Cisplatin - 2000100061\nMethotrexate and Doxorubicin and Ifosfamide - 2000100062\nDoxorubicin and Cisplatin and Ifosfamide - 2000100063\nCisplatin and Doxorubicin - 35804819\nMethotrexate and Vinorelbine - 2000100064\nIfosfamide and Etoposide (IE) - 35805454\nVincristine and Doxorubicin and Cyclophosphamide - 2000100065\nCyclophosphamide and Etoposide - 35806476\nDoxorubicin and Ifosfamide and Dacarbazine - 2000100066\nDacarbazine and Gemcitabine - 35806969\nCyclophosphamide and Topotecan - 35805453\nIrinotecan and Vincristine - 2000100067\nIrinotecan and Temozolomide - 35805455\nBusulfan and Melphalan - 35804000\nTNF and Melphalan - 2000100068\nCyclophosphamide and Vinorelbine - 2000100069\nVincristine, Ifosfamide, Doxorubicin, Etoposide (VIDE) - 35805451\nPazopanib monotherapy - 35805690\nRegorafenib monotherapy - 35804569\nhigh dose Ifosfamide - 2000100070",
"min": 0,
"max": "*",
"type": [
{
"code": "CodeableConcept"
}
]
},
{
"id": "SystemicTreatment.startDateRegimenChanged",
"extension": [
{
"extension": [
{
"url": "code",
"valueCode": "SHALL:handle"
},
{
"url": "actor",
"valueCanonical": "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
}
],
"url": "http://hl7.org/fhir/StructureDefinition/obligation"
}
],
"path": "SystemicTreatment.startDateRegimenChanged",
"short": "Start date regimen changed (M)",
"definition": "Specifies when the new systemic treatment begins, if a combination please specify the start of the first drug",
"min": 1,
"max": "*",
"type": [
{
"code": "date"
}
]
},
{
"id": "SystemicTreatment.endDateRegimenChanged",
"extension": [
{
"extension": [
{
"url": "code",
"valueCode": "SHALL:handle"
},
{
"url": "actor",
"valueCanonical": "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
}
],
"url": "http://hl7.org/fhir/StructureDefinition/obligation"
}
],
"path": "SystemicTreatment.endDateRegimenChanged",
"short": "End date regimen changed (M)",
"definition": "Specifies when the new systemic treatment ends,if a combination please specify the end of the last drug",
"min": 1,
"max": "*",
"type": [
{
"code": "date"
}
]
},
{
"id": "SystemicTreatment.reasonForEndOfTreatment",
"extension": [
{
"extension": [
{
"url": "code",
"valueCode": "SHALL:handle"
},
{
"url": "actor",
"valueCanonical": "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
}
],
"url": "http://hl7.org/fhir/StructureDefinition/obligation"
},
{
"extension": [
{
"url": "code",
"valueCode": "SHALL:handle"
},
{
"url": "actor",
"valueCanonical": "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"
}
],
"url": "http://hl7.org/fhir/StructureDefinition/obligation"
}
],
"path": "SystemicTreatment.reasonForEndOfTreatment",
"short": "Reason for end of treatment (M)",
"definition": "Clarifies the reasons why the treatment ended or was interrupted",
"comment": "Completed successfully - 44788181\nChemotherapy changed acute chemotherapy toxicity - 4162594 \nTreatment ended due to comorbidity - 2000100030\nIntolerance to drug - 4240582\nProcedure discontinued by patient - 37017062\nDeath - 4306655",
"min": 1,
"max": "*",
"type": [
{
"code": "CodeableConcept"
}
]
},
{
"id": "SystemicTreatment.treatmentResponse",
"extension": [
{
"extension": [
{
"url": "code",
"valueCode": "SHALL:handle"
},
{
"url": "actor",
"valueCanonical": "http://hl7.eu/fhir/ig/idea4rc/actor-headneck-i4rc"
}
],
"url": "http://hl7.org/fhir/StructureDefinition/obligation"
},
{
"extension": [
{
"url": "code",
"valueCode": "SHALL:handle"
},
{
"url": "actor",
"valueCanonical": "http://hl7.eu/fhir/ig/idea4rc/actor-sarcoma-i4rc"
}
],
"url": "http://hl7.org/fhir/StructureDefinition/obligation"
}
],
"path": "SystemicTreatment.treatmentResponse",
"short": "Treatment response (based on imaging alone; no recist or other criteria) (M)",
"definition": "Measures how well a cancer patient responds to treatment. RECIST criteria should not be applied. The definition of Complete response; Partial response; Stable disease; Progression, should be based on the clinical judgement based on imaging. Only when setting=neoadiuvant or palliative",
"comment": "Complete Remission - 32946\nPartial Remission - 32947\nStable Disease - 32948\nProgression - 32949\nNot applicable - 4294169 (Not usable in OMOP)",
"min": 1,
"max": "*",
"type": [
{
"code": "CodeableConcept"
}
]
}
]
}
}
SystemicTreatment 
diagnosisReference 
systemicTreatmentHospital 
typeOfSystemicTreatment 
FHIR