FHIR IG analytics| Package | fhir.nwgenomics.nhs.uk |
| Resource Type | Questionnaire |
| Id | Questionnaire-ChimerismResultPanel.json |
| FHIR Version | R4 |
| Source | https://build.fhir.org/ig/nw-gmsa/nw-gmsa.github.com/Questionnaire-ChimerismResultPanel.html |
| URL | https://fhir.nwgenomics.nhs.uk/Questionnaire/ChimerismResultPanel |
| Version | 2.2.0 |
| Status | draft |
| Date | 2026-09-27T08:17:18+00:00 |
| Title | Chimerism Testing Result Panel |
| Realm | us |
| Authority | hl7 |
| Description | Result panel for STR-based chimerism testing (Clatterbridge post-transplant monitoring) - see [Histocompatibility and Immunogenetics - Chimerism Testing Result Panel (Future?)](HistocompatibilityAndImmunogenetics.html#chimerism-testing-result-panel-future) for the source data table this Questionnaire structures. The payload described there is currently unstructured `NTE`/`OBX` text, with no FHIR mapping yet - `item.definition` values here are the same candidate mappings recorded in that table's "FHIR Genomic Report Field" column, most inferred by analogy with [HL7's Genomics Reporting IG - Histocompatibility and Immunogenetic Reporting](http://hl7.org/fhir/uv/genomics-reporting/histocompatibility.html) (a dependency of this IG, though it profiles HLA allele genotyping, not STR chimerism) rather than confirmed against a real example, unlike [BCRABLResultPanel](Questionnaire-BCRABLResultPanel.html) which is inferred from real `Observation` examples. Several rows have no direct FHIR fit and are marked as such rather than forced onto one. |
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Note: links and images are rebased to the (stated) source
Generated Narrative: Questionnaire ChimerismResultPanel
Profile: Questionnaire
| LinkID | Text | Cardinality | Type | Description & Constraints |
|---|---|---|---|---|
  | Result panel for STR-based chimerism testing (Clatterbridge post-transplant monitoring) - see [Histocompatibility and Immunogenetics - Chimerism Testing Result Panel (Future?)](HistocompatibilityAndImmunogenetics.html#chimerism-testing-result-panel-future) for the source data table this Questionnaire structures. The payload described there is currently unstructured `NTE`/`OBX` text, with no FHIR mapping yet - `item.definition` values here are the same candidate mappings recorded in that table's "FHIR Genomic Report Field" column, most inferred by analogy with [HL7's Genomics Reporting IG - Histocompatibility and Immunogenetic Reporting](http://hl7.org/fhir/uv/genomics-reporting/histocompatibility.html) (a dependency of this IG, though it profiles HLA allele genotyping, not STR chimerism) rather than confirmed against a real example, unlike [BCRABLResultPanel](Questionnaire-BCRABLResultPanel.html) which is inferred from real `Observation` examples. Several rows have no direct FHIR fit and are marked as such rather than forced onto one. | Questionnaire | https://fhir.nwgenomics.nhs.uk/Questionnaire/ChimerismResultPanel#2.2.0 | |
  Report | Chimerism Report | 0..1 | group | Definition: DiagnosticReport |
   Chimerism/TestMethod | Test Method | 0..1 | string | Definition: DiagnosticReport.method |
  Chimerism/TestMethod-designNote | e.g. "Chimerism analysis by STR technique." No local code (NTE, unstructured) - candidate mapping only, DiagnosticReport.method is not otherwise used in this IG. | 0..1 | display | |
| Chimerism/Device | Device | 0..1 | string | Definition: Device |
| Chimerism/Device-designNote | e.g. "Test performed using Promega GenePrint 24 kit." No local code (NTE, unstructured) - candidate mapping only, referenced from DiagnosticReport or Observation.device. | 0..1 | display | |
| Result | Chimerism Result | 0..1 | group | Definition: DiagnosticReport.result |
 Chimerism/AverageChimerism | Average % Chimerism | 0..1 | decimal | Definition: Observation.valueQuantity |
| Chimerism/InformativeMarkers | Informative Markers | 0..1 | string | Definition: MolecularSequence |
| Chimerism/InformativeMarkers-designNote | e.g. "D13S317 PENTA E CSF1PO PENTA D D21S11 D8S1179 D12S391" - the STR loci examined. Candidate mapping: the same role a Haplotype Observation's MolecularSequence evidence plays for HLA alleles, but for STR loci. | 0..1 | display | |
| Chimerism/Range | Range | 0..1 | string | Definition: Observation.referenceRange |
| Chimerism/CV | CV | 0..1 | string | Definition: Observation.component |
| Chimerism/CV-designNote | Coefficient of variation - a QC metric, not profiled by the Histocompatibility Reporting page. | 0..1 | display | |
| Specimen | Specimen | 0..1 | group | Definition: Specimen |
| Chimerism/ExtractionMethod | Extraction Method | 0..1 | string | Definition: Specimen.collection.method |
| Chimerism/ExtractionMethod-designNote | e.g. "DNA extracted from peripheral blood leukocyte" - the same field dWGS's dna_extraction_protocol uses, see dWGS field mapping. | 0..1 | display | |
| Chimerism/Purity | % Purity | 0..1 | decimal | |
| Chimerism/Purity-designNote | Specimen quality metric - not profiled by the Histocompatibility Reporting page. No definition mapping - low confidence, free text/number only. | 0..1 | display | |
| ClinicalContext | Clinical Context | 0..1 | group | |
| Chimerism/TimePostTransplant | Time Post Transplant | 0..1 | string | Definition: Observation.valueString |
| Chimerism/TimePostTransplant-designNote | e.g. "2YR 7 MONTHS" - carried as an Observation referenced from ServiceRequest.supportingInfo, the same Ask at Order Entry pattern used elsewhere in this IG (dWGS's Family Structure/Participant Type). | 0..1 | display | |
 Chimerism/DateOfTransplant | Date of Transplant | 0..1 | date | Definition: Procedure.performedDateTime |
| Chimerism/DateOfTransplant-designNote | The transplant event itself - outside the Histocompatibility Reporting page's scope, which starts from the genotyping result, not the clinical transplant history. | 0..1 | display | |
| Chimerism/DonorID | Donor ID | 0..1 | string | Definition: Specimen.identifier |
| Chimerism/DonorID-designNote | e.g. "6939 DKM0 0096 2141 100" - the same identifier-on-Specimen pattern dWGS uses for its PLAC/FILL identifiers; could alternatively be a reference to the donor's own Patient resource. | 0..1 | display | |
| Documentation for this format | ||||
FHIR
FHIRsmith{
"resourceType": "Questionnaire",
"id": "ChimerismResultPanel",
"meta": {
"profile": [
"https://fhir.nwgenomics.nhs.uk/StructureDefinition/NWQuestionnaire"
]
},
"text": {
"status": "extensions",
"div": "<!-- snip (see above) -->"
},
"extension": [
{
"url": "http://hl7.org/fhir/StructureDefinition/artifact-versionAlgorithm",
"valueCoding": {
"system": "http://hl7.org/fhir/version-algorithm",
"code": "semver"
}
}
],
"url": "https://fhir.nwgenomics.nhs.uk/Questionnaire/ChimerismResultPanel",
"version": "2.2.0",
"title": "Chimerism Testing Result Panel",
"status": "draft",
"date": "2026-09-27T08:17:18+00:00",
"publisher": "NHS North West Genomics",
"contact": [
{
"telecom": [
{
"system": "url",
"value": "https://www.nwgenomics.nhs.uk/contact-us"
}
]
}
],
"description": "Result panel for STR-based chimerism testing (Clatterbridge post-transplant\nmonitoring) - see [Histocompatibility and Immunogenetics - Chimerism Testing\nResult Panel (Future?)](HistocompatibilityAndImmunogenetics.html#chimerism-testing-result-panel-future)\nfor the source data table this Questionnaire structures.\n\nThe payload described there is currently unstructured `NTE`/`OBX` text, with no\nFHIR mapping yet - `item.definition` values here are the same candidate\nmappings recorded in that table's \"FHIR Genomic Report Field\" column, most\ninferred by analogy with [HL7's Genomics Reporting IG - Histocompatibility and\nImmunogenetic Reporting](http://hl7.org/fhir/uv/genomics-reporting/histocompatibility.html)\n(a dependency of this IG, though it profiles HLA allele genotyping, not STR\nchimerism) rather than confirmed against a real example, unlike\n[BCRABLResultPanel](Questionnaire-BCRABLResultPanel.html) which is inferred\nfrom real `Observation` examples. Several rows have no direct FHIR fit and are\nmarked as such rather than forced onto one.",
"jurisdiction": [
{
"coding": [
{
"system": "urn:iso:std:iso:3166",
"code": "GB",
"display": "United Kingdom of Great Britain and Northern Ireland"
}
]
}
],
"item": [
{
"linkId": "Report",
"definition": "http://hl7.org/fhir/StructureDefinition/DiagnosticReport#DiagnosticReport",
"text": "Chimerism Report",
"type": "group",
"item": [
{
"linkId": "Chimerism/TestMethod",
"definition": "http://hl7.org/fhir/StructureDefinition/DiagnosticReport#DiagnosticReport.method",
"text": "Test Method",
"type": "string",
"item": [
{
"extension": [
{
"url": "http://hl7.org/fhir/StructureDefinition/questionnaire-itemControl",
"valueCodeableConcept": {
"coding": [
{
"system": "http://hl7.org/fhir/questionnaire-item-control",
"code": "help"
}
]
}
}
],
"linkId": "Chimerism/TestMethod-designNote",
"text": "e.g. \"Chimerism analysis by STR technique.\" No local code (NTE, unstructured) - candidate mapping only, DiagnosticReport.method is not otherwise used in this IG.",
"type": "display"
}
]
},
{
"linkId": "Chimerism/Device",
"definition": "http://hl7.org/fhir/StructureDefinition/Device#Device",
"text": "Device",
"type": "string",
"item": [
{
"extension": [
{
"url": "http://hl7.org/fhir/StructureDefinition/questionnaire-itemControl",
"valueCodeableConcept": {
"coding": [
{
"system": "http://hl7.org/fhir/questionnaire-item-control",
"code": "help"
}
]
}
}
],
"linkId": "Chimerism/Device-designNote",
"text": "e.g. \"Test performed using Promega GenePrint 24 kit.\" No local code (NTE, unstructured) - candidate mapping only, referenced from DiagnosticReport or Observation.device.",
"type": "display"
}
]
},
{
"linkId": "Result",
"definition": "http://hl7.org/fhir/StructureDefinition/DiagnosticReport#DiagnosticReport.result",
"text": "Chimerism Result",
"type": "group",
"item": [
{
"linkId": "Chimerism/AverageChimerism",
"definition": "http://hl7.org/fhir/StructureDefinition/Observation#Observation.valueQuantity",
"code": [
{
"system": "https://fhir.nwgenomics.nhs.uk/CodeSystem/Chimerism",
"code": "STR"
}
],
"text": "Average % Chimerism",
"type": "decimal"
},
{
"linkId": "Chimerism/InformativeMarkers",
"definition": "http://hl7.org/fhir/StructureDefinition/MolecularSequence#MolecularSequence",
"code": [
{
"system": "https://fhir.nwgenomics.nhs.uk/CodeSystem/Chimerism",
"code": "IM"
}
],
"text": "Informative Markers",
"type": "string",
"item": [
{
"extension": [
{
"url": "http://hl7.org/fhir/StructureDefinition/questionnaire-itemControl",
"valueCodeableConcept": {
"coding": [
{
"system": "http://hl7.org/fhir/questionnaire-item-control",
"code": "help"
}
]
}
}
],
"linkId": "Chimerism/InformativeMarkers-designNote",
"text": "e.g. \"D13S317 PENTA E CSF1PO PENTA D D21S11 D8S1179 D12S391\" - the STR loci examined. Candidate mapping: the same role a Haplotype Observation's MolecularSequence evidence plays for HLA alleles, but for STR loci.",
"type": "display"
}
]
},
{
"linkId": "Chimerism/Range",
"definition": "http://hl7.org/fhir/StructureDefinition/Observation#Observation.referenceRange",
"code": [
{
"system": "https://fhir.nwgenomics.nhs.uk/CodeSystem/Chimerism",
"code": "RANGE"
}
],
"text": "Range",
"type": "string"
},
{
"linkId": "Chimerism/CV",
"definition": "http://hl7.org/fhir/StructureDefinition/Observation#Observation.component",
"code": [
{
"system": "https://fhir.nwgenomics.nhs.uk/CodeSystem/Chimerism",
"code": "CV"
}
],
"text": "CV",
"type": "string",
"item": [
{
"extension": [
{
"url": "http://hl7.org/fhir/StructureDefinition/questionnaire-itemControl",
"valueCodeableConcept": {
"coding": [
{
"system": "http://hl7.org/fhir/questionnaire-item-control",
"code": "help"
}
]
}
}
],
"linkId": "Chimerism/CV-designNote",
"text": "Coefficient of variation - a QC metric, not profiled by the Histocompatibility Reporting page.",
"type": "display"
}
]
}
]
},
{
"linkId": "Specimen",
"definition": "http://hl7.org/fhir/StructureDefinition/Specimen#Specimen",
"text": "Specimen",
"type": "group",
"item": [
{
"linkId": "Chimerism/ExtractionMethod",
"definition": "http://hl7.org/fhir/StructureDefinition/Specimen#Specimen.collection.method",
"code": [
{
"system": "https://fhir.nwgenomics.nhs.uk/CodeSystem/Chimerism",
"code": "EXT"
}
],
"text": "Extraction Method",
"type": "string",
"item": [
{
"extension": [
{
"url": "http://hl7.org/fhir/StructureDefinition/questionnaire-itemControl",
"valueCodeableConcept": {
"coding": [
{
"system": "http://hl7.org/fhir/questionnaire-item-control",
"code": "help"
}
]
}
}
],
"linkId": "Chimerism/ExtractionMethod-designNote",
"text": "e.g. \"DNA extracted from peripheral blood leukocyte\" - the same field dWGS's dna_extraction_protocol uses, see dWGS field mapping.",
"type": "display"
}
]
},
{
"linkId": "Chimerism/Purity",
"code": [
{
"system": "https://fhir.nwgenomics.nhs.uk/CodeSystem/Chimerism",
"code": "PURE"
}
],
"text": "% Purity",
"type": "decimal",
"item": [
{
"extension": [
{
"url": "http://hl7.org/fhir/StructureDefinition/questionnaire-itemControl",
"valueCodeableConcept": {
"coding": [
{
"system": "http://hl7.org/fhir/questionnaire-item-control",
"code": "help"
}
]
}
}
],
"linkId": "Chimerism/Purity-designNote",
"text": "Specimen quality metric - not profiled by the Histocompatibility Reporting page. No definition mapping - low confidence, free text/number only.",
"type": "display"
}
]
}
]
},
{
"linkId": "ClinicalContext",
"text": "Clinical Context",
"type": "group",
"item": [
{
"linkId": "Chimerism/TimePostTransplant",
"definition": "http://hl7.org/fhir/StructureDefinition/Observation#Observation.valueString",
"code": [
{
"system": "https://fhir.nwgenomics.nhs.uk/CodeSystem/Chimerism",
"code": "POST"
}
],
"text": "Time Post Transplant",
"type": "string",
"item": [
{
"extension": [
{
"url": "http://hl7.org/fhir/StructureDefinition/questionnaire-itemControl",
"valueCodeableConcept": {
"coding": [
{
"system": "http://hl7.org/fhir/questionnaire-item-control",
"code": "help"
}
]
}
}
],
"linkId": "Chimerism/TimePostTransplant-designNote",
"text": "e.g. \"2YR 7 MONTHS\" - carried as an Observation referenced from ServiceRequest.supportingInfo, the same Ask at Order Entry pattern used elsewhere in this IG (dWGS's Family Structure/Participant Type).",
"type": "display"
}
]
},
{
"linkId": "Chimerism/DateOfTransplant",
"definition": "http://hl7.org/fhir/StructureDefinition/Procedure#Procedure.performedDateTime",
"code": [
{
"system": "https://fhir.nwgenomics.nhs.uk/CodeSystem/Chimerism",
"code": "DTP"
}
],
"text": "Date of Transplant",
"type": "date",
"item": [
{
"extension": [
{
"url": "http://hl7.org/fhir/StructureDefinition/questionnaire-itemControl",
"valueCodeableConcept": {
"coding": [
{
"system": "http://hl7.org/fhir/questionnaire-item-control",
"code": "help"
}
]
}
}
],
"linkId": "Chimerism/DateOfTransplant-designNote",
"text": "The transplant event itself - outside the Histocompatibility Reporting page's scope, which starts from the genotyping result, not the clinical transplant history.",
"type": "display"
}
]
},
{
"linkId": "Chimerism/DonorID",
"definition": "http://hl7.org/fhir/StructureDefinition/Specimen#Specimen.identifier",
"code": [
{
"system": "https://fhir.nwgenomics.nhs.uk/CodeSystem/Chimerism",
"code": "DID"
}
],
"text": "Donor ID",
"type": "string",
"item": [
{
"extension": [
{
"url": "http://hl7.org/fhir/StructureDefinition/questionnaire-itemControl",
"valueCodeableConcept": {
"coding": [
{
"system": "http://hl7.org/fhir/questionnaire-item-control",
"code": "help"
}
]
}
}
],
"linkId": "Chimerism/DonorID-designNote",
"text": "e.g. \"6939 DKM0 0096 2141 100\" - the same identifier-on-Specimen pattern dWGS uses for its PLAC/FILL identifiers; could alternatively be a reference to the donor's own Patient resource.",
"type": "display"
}
]
}
]
}
]
}
]
}