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Packagede.netzwerk-universitaetsmedizin.ebm-cpg
Resource TypeBundle
IdBundle-GuidelineRecommendationExample.json
FHIR VersionR5

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Narrative

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Source1

{
  "resourceType": "Bundle",
  "id": "GuidelineRecommendationExample",
  "meta": {
    "profile": [
      "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/guideline-bundle"
    ]
  },
  "type": "collection",
  "entry": [
    {
      "fullUrl": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/guideline-example",
      "resource": {
        "resourceType": "Composition",
        "id": "GuidelineExample",
        "meta": {
          "profile": [
            "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/guideline"
          ]
        },
        "text": {
          "status": "generated",
          "div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Composition_GuidelineExample\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Composition GuidelineExample</b></p><a name=\"GuidelineExample\"> </a><a name=\"hcGuidelineExample\"> </a><a name=\"GuidelineExample-en-US\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-guideline.html\">Clinical Practice Guideline</a></p></div><p><b>identifier</b>: Resource identifier/guideline example</p><p><b>version</b>: 0.1.0</p><p><b>status</b>: Final</p><p><b>type</b>: <span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system clinical-practice-guideline}, {https://data.cochrane.org/concepts/ e07eN1w1Rwswg4}\">Guidelines</span></p><p><b>category</b>: <span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-guideline-stage-classification S3}\">Evidence- and consensus-based guideline</span></p><p><b>date</b>: 2022-01-28</p><p><b>author</b>: <a href=\"Organization-ExampleOrganization.html\">Organization Example Organization</a></p><p><b>title</b>: Example Guideline</p><h3>RelatesTos</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>ResourceReference</b></td></tr><tr><td style=\"display: none\">*</td><td>Citation</td><td><a href=\"Citation-ExampleGuidelineCitation.html\">Citation ExampleGuidelineCitation</a></td></tr></table></div>"
        },
        "identifier": [
          {
            "type": {
              "coding": [
                {
                  "system": "http://terminology.hl7.org/CodeSystem/v2-0203",
                  "code": "RI",
                  "display": "Resource identifier"
                }
              ]
            },
            "system": "https://www.ceosys.de",
            "value": "guideline example"
          }
        ],
        "version": "0.1.0",
        "status": "final",
        "type": {
          "coding": [
            {
              "system": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system",
              "code": "clinical-practice-guideline"
            },
            {
              "system": "https://data.cochrane.org/concepts/",
              "code": "e07eN1w1Rwswg4",
              "display": "Guidelines"
            }
          ]
        },
        "category": [
          {
            "coding": [
              {
                "system": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-guideline-stage-classification",
                "code": "S3",
                "display": "Evidence- and consensus-based guideline"
              }
            ]
          }
        ],
        "date": "2022-01-28",
        "author": [
          {
            "reference": "Organization/ExampleOrganization"
          }
        ],
        "title": "Example Guideline",
        "relatesTo": [
          {
            "type": "citation",
            "resourceReference": {
              "reference": "Citation/ExampleGuidelineCitation"
            }
          }
        ],
        "section": [
          {
            "title": "Example Guideline Recommendation",
            "code": {
              "coding": [
                {
                  "system": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system",
                  "code": "guideline-recommendation",
                  "display": "Clinical practice guideline recommendation"
                }
              ]
            },
            "focus": {
              "reference": "PlanDefinition/ExampleRecommendation"
            },
            "text": {
              "status": "generated",
              "div": "<div xmlns=\"http://www.w3.org/1999/xhtml\">This is an example guideline recommendation.</div>"
            }
          }
        ]
      }
    },
    {
      "fullUrl": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/guideline-example/citation",
      "resource": {
        "resourceType": "Citation",
        "id": "ExampleGuidelineCitation",
        "meta": {
          "profile": [
            "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/guideline-citation"
          ]
        },
        "text": {
          "status": "generated",
          "div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Citation_ExampleGuidelineCitation\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Citation ExampleGuidelineCitation</b></p><a name=\"ExampleGuidelineCitation\"> </a><a name=\"hcExampleGuidelineCitation\"> </a><a name=\"ExampleGuidelineCitation-en-US\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-guideline-citation.html\">Guideline Citation</a></p></div><p><b>name</b>: ExampleGuidelineCitation</p><p><b>status</b>: Active</p><blockquote><p><b>citedArtifact</b></p><p><b>identifier</b>: ceoysy/exampleIdentifier</p><h3>Versions</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Value</b></td></tr><tr><td style=\"display: none\">*</td><td>1.0-alpha1</td></tr></table><p><b>currentState</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-status-type archived}\">Archived</span></p><h3>Titles</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Text</b></td></tr><tr><td style=\"display: none\">*</td><td><div><p>Example Citation</p>\n</div></td></tr></table><h3>WebLocations</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://example.com/guideline/exampleIdentifier\">https://example.com/guideline/exampleIdentifier</a></td></tr></table><h3>Classifications</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type publication-type}\">Publication Type</span></td><td><span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system clinical-practice-guideline}\">Clinical practice guideline</span></td></tr></table></blockquote></div>"
        },
        "name": "ExampleGuidelineCitation",
        "status": "active",
        "citedArtifact": {
          "identifier": [
            {
              "value": "ceoysy/exampleIdentifier"
            }
          ],
          "version": {
            "value": "1.0-alpha1"
          },
          "currentState": [
            {
              "coding": [
                {
                  "system": "http://hl7.org/fhir/cited-artifact-status-type",
                  "code": "archived",
                  "display": "Archived"
                }
              ]
            }
          ],
          "title": [
            {
              "text": "Example Citation"
            }
          ],
          "webLocation": [
            {
              "url": "https://example.com/guideline/exampleIdentifier"
            }
          ],
          "classification": [
            {
              "type": {
                "coding": [
                  {
                    "system": "http://hl7.org/fhir/cited-artifact-classification-type",
                    "code": "publication-type",
                    "display": "Publication Type"
                  }
                ]
              },
              "classifier": [
                {
                  "coding": [
                    {
                      "system": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system",
                      "code": "clinical-practice-guideline",
                      "display": "Clinical practice guideline"
                    }
                  ]
                }
              ]
            }
          ]
        }
      }
    },
    {
      "fullUrl": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/guideline-example/recommendation",
      "resource": {
        "resourceType": "PlanDefinition",
        "id": "ExampleRecommendation",
        "meta": {
          "profile": [
            "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/recommendation"
          ]
        },
        "text": {
          "status": "extensions",
          "div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"PlanDefinition_ExampleRecommendation\"> </a><p class=\"res-header-id\"><b>Generated Narrative: PlanDefinition ExampleRecommendation</b></p><a name=\"ExampleRecommendation\"> </a><a name=\"hcExampleRecommendation\"> </a><a name=\"ExampleRecommendation-en-US\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-recommendation.html\">Recommendation</a></p></div><p><b>knowledgeCapability</b>: computable</p><p><b>knowledgeRepresentationLevel</b>: structured</p><blockquote><p><b>Action Combination Method</b></p><ul><li>method: <span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-action-combination-method at-least}\">At Least</span></li><li>threshold: 2</li></ul></blockquote><p><b>url</b>: <a href=\"PlanDefinition-ExampleRecommendation.html\">PlanDefinition Recommendation</a></p><p><b>version</b>: 1.0</p><p><b>name</b>: Recommendation</p><p><b>title</b>: Recommendation</p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/plan-definition-type workflow-definition}\">Workflow Definition</span></p><p><b>status</b>: Active</p><p><b>experimental</b>: true</p><p><b>date</b>: 2022-02-14</p><p><b>publisher</b>: CPGonEBMonFHIR</p><p><b>description</b>: </p><div><p>Example Recommendation</p>\n</div><h3>RelatedArtifacts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td><td><b>ResourceReference</b></td></tr><tr><td style=\"display: none\">*</td><td>Justification</td><td><span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system recommendation-rating}\">Recommendation rating</span></td><td><a href=\"ArtifactAssessment-ExampleRecommendationJustification.html\">ArtifactAssessment: extension = 0.1.0,active; date = 2020-01-03; artifact[x] = -&gt;PlanDefinition Recommendation Plan</a></td></tr><tr><td style=\"display: none\">*</td><td>Citation</td><td><span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system guideline-recommendation}\">Clinical practice guideline recommendation</span></td><td><a href=\"Citation-ExampleRecommendationCitation.html\">Citation ExampleRecommendationCitation</a></td></tr><tr><td style=\"display: none\">*</td><td>Citation</td><td><span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system clinical-practice-guideline}\">Clinical practice guideline</span></td><td><a href=\"Citation-ExampleGuidelineCitation.html\">Citation ExampleGuidelineCitation</a></td></tr></table><blockquote><p><b>action</b></p><p><b>title</b>: example recommendation</p><p><b>description</b>: </p><div><p>Example recommendation</p>\n</div><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/cpg/CodeSystem/cpg-common-process guideline-based-care}\">Guideline-based Care</span></p><p><b>definition</b>: <a href=\"PlanDefinition-ExampleRecommendationPlan.html\">Recommendation Plan</a></p></blockquote><blockquote><p><b>action</b></p><p><b>title</b>: example recommendation</p><p><b>description</b>: </p><div><p>Example recommendation</p>\n</div><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/cpg/CodeSystem/cpg-common-process guideline-based-care}\">Guideline-based Care</span></p><p><b>definition</b>: <a href=\"PlanDefinition-ExampleRecommendationPlan.html\">Recommendation Plan</a></p></blockquote></div>"
        },
        "extension": [
          {
            "url": "http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeCapability",
            "valueCode": "computable"
          },
          {
            "url": "http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeRepresentationLevel",
            "valueCode": "structured"
          },
          {
            "extension": [
              {
                "url": "method",
                "valueCodeableConcept": {
                  "coding": [
                    {
                      "system": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-action-combination-method",
                      "code": "at-least"
                    }
                  ]
                }
              },
              {
                "url": "threshold",
                "valuePositiveInt": 2
              }
            ],
            "url": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/ext-action-combination-method"
          }
        ],
        "url": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-plan/example-recommendation",
        "version": "1.0",
        "name": "Recommendation",
        "title": "Recommendation",
        "type": {
          "coding": [
            {
              "system": "http://terminology.hl7.org/CodeSystem/plan-definition-type",
              "code": "workflow-definition"
            }
          ]
        },
        "status": "active",
        "experimental": true,
        "date": "2022-02-14",
        "publisher": "CPGonEBMonFHIR",
        "description": "Example Recommendation",
        "relatedArtifact": [
          {
            "type": "justification",
            "classifier": [
              {
                "coding": [
                  {
                    "system": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system",
                    "code": "recommendation-rating",
                    "display": "Recommendation rating"
                  }
                ]
              }
            ],
            "resourceReference": {
              "reference": "ArtifactAssessment/ExampleRecommendationJustification"
            }
          },
          {
            "type": "citation",
            "classifier": [
              {
                "coding": [
                  {
                    "system": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system",
                    "code": "guideline-recommendation",
                    "display": "Clinical practice guideline recommendation"
                  }
                ]
              }
            ],
            "resourceReference": {
              "reference": "Citation/ExampleRecommendationCitation"
            }
          },
          {
            "type": "citation",
            "classifier": [
              {
                "coding": [
                  {
                    "system": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system",
                    "code": "clinical-practice-guideline",
                    "display": "Clinical practice guideline"
                  }
                ]
              }
            ],
            "resourceReference": {
              "reference": "Citation/ExampleGuidelineCitation"
            }
          }
        ],
        "action": [
          {
            "title": "example recommendation",
            "description": "Example recommendation",
            "code": {
              "coding": [
                {
                  "system": "http://hl7.org/fhir/uv/cpg/CodeSystem/cpg-common-process",
                  "code": "guideline-based-care"
                }
              ]
            },
            "definitionCanonical": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-plan/example-recommendation-plan"
          },
          {
            "title": "example recommendation",
            "description": "Example recommendation",
            "code": {
              "coding": [
                {
                  "system": "http://hl7.org/fhir/uv/cpg/CodeSystem/cpg-common-process",
                  "code": "guideline-based-care"
                }
              ]
            },
            "definitionCanonical": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-plan/example-recommendation-plan"
          }
        ]
      }
    },
    {
      "fullUrl": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/guideline-example/recommendation-plan",
      "resource": {
        "resourceType": "PlanDefinition",
        "id": "ExampleRecommendationPlan",
        "meta": {
          "profile": [
            "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/recommendation-plan"
          ]
        },
        "text": {
          "status": "extensions",
          "div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"PlanDefinition_ExampleRecommendationPlan\"> </a><p class=\"res-header-id\"><b>Generated Narrative: PlanDefinition ExampleRecommendationPlan</b></p><a name=\"ExampleRecommendationPlan\"> </a><a name=\"hcExampleRecommendationPlan\"> </a><a name=\"ExampleRecommendationPlan-en-US\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-recommendation-plan.html\">Recommendation Plan</a></p></div><p><b>knowledgeCapability</b>: computable</p><p><b>knowledgeRepresentationLevel</b>: structured</p><p><b>partOf</b>: <a href=\"PlanDefinition-ExampleRecommendation.html\">Recommendation</a></p><blockquote><p><b>Action Combination Method</b></p><ul><li>method: <span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-action-combination-method exactly}\">Exactly</span></li><li>threshold: 1</li></ul></blockquote><p><b>url</b>: <a href=\"PlanDefinition-ExampleRecommendationPlan.html\">PlanDefinition Recommendation Plan</a></p><p><b>version</b>: 1.0</p><p><b>name</b>: RecommendationPlan</p><p><b>title</b>: Recommendation Plan</p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/plan-definition-type eca-rule}\">ECA Rule</span></p><p><b>status</b>: Active</p><p><b>experimental</b>: true</p><p><b>subject</b>: <a href=\"EvidenceVariable-ExampleRecommendationEligibilityCriteria.html\">PopulationExample</a></p><p><b>date</b>: 2022-02-14</p><p><b>publisher</b>: CPGonEBMonFHIR</p><p><b>description</b>: </p><div><p>Example Recommendation Plan</p>\n</div><blockquote><p><b>goal</b></p><blockquote><p><b>id</b></p>ventilator-management-goal</blockquote><p><b>category</b>: <span title=\"Codes:{http://snomed.info/sct 385857005}\">Ventilator care and adjustment (regime/therapy)</span></p><p><b>description</b>: <span title=\"Codes:\">The ventilator should be set up to provide a breath reate of at least 20 and at most per minute.</span></p><h3>Targets</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Measure</b></td><td><b>Detail[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://loinc.org 33438-3}\">Breath rate mechanical --on ventilator</span></td><td>20-24</td></tr></table></blockquote><blockquote><p><b>goal</b></p><blockquote><p><b>id</b></p>lab-ddimer-concentration-goal</blockquote><p><b>category</b>: <span title=\"Codes:{http://snomed.info/sct 410394004}\">Lab findings surveillance (regime/therapy)</span></p><p><b>description</b>: <span title=\"Codes:\">D-Dimer concentration shall be below 250 ng/mL</span></p><h3>Targets</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Measure</b></td><td><b>Detail[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://loinc.org 48066-5}\">Fibrin D-dimer DDU [Mass/volume] in Platelet poor plasma</span></td><td>?-250</td></tr></table></blockquote><blockquote><p><b>action</b></p><p><b>code</b>: <span title=\"Codes:{http://snomed.info/sct 18629005}\">Administration of drug or medicament (procedure)</span></p><p><b>definition</b>: <a href=\"Bundle-GuidelineRecommendationExample.html\">DrugAdministrationAction</a></p></blockquote><blockquote><p><b>action</b></p><p><b>code</b>: <span title=\"Codes:{http://snomed.info/sct 229824005}\">Positioning patient (procedure)</span></p><p><b>goalId</b>: ventilator-management-goal</p><p><b>definition</b>: <a href=\"ActivityDefinition-ExampleBodyPositioningAction.html\">DrugAdministrationAction</a></p></blockquote><blockquote><p><b>action</b></p><p><b>code</b>: <span title=\"Codes:{http://snomed.info/sct 410210009}\">Ventilator care management (procedure)</span></p><p><b>goalId</b>: ventilator-management-goal</p></blockquote><blockquote><p><b>action</b></p><blockquote><p><b>Action Combination Method</b></p><ul><li>method: <span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-action-combination-method one-or-more}\">One or More</span></li></ul></blockquote><p><b>code</b>: <span title=\"Codes:{http://snomed.info/sct 89780004}\">Combined (qualifier value)</span></p><h3>Actions</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>GoalId</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://snomed.info/sct 410210009}\">Ventilator care management (procedure)</span></td><td>ventilator-management-goal</td></tr></table></blockquote></div>"
        },
        "extension": [
          {
            "url": "http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeCapability",
            "valueCode": "computable"
          },
          {
            "url": "http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeRepresentationLevel",
            "valueCode": "structured"
          },
          {
            "url": "http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-partOf",
            "valueCanonical": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-plan/example-recommendation"
          },
          {
            "extension": [
              {
                "url": "method",
                "valueCodeableConcept": {
                  "coding": [
                    {
                      "system": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-action-combination-method",
                      "code": "exactly"
                    }
                  ]
                }
              },
              {
                "url": "threshold",
                "valuePositiveInt": 1
              }
            ],
            "url": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/ext-action-combination-method"
          }
        ],
        "url": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-plan/example-recommendation-plan",
        "version": "1.0",
        "name": "RecommendationPlan",
        "title": "Recommendation Plan",
        "type": {
          "coding": [
            {
              "system": "http://terminology.hl7.org/CodeSystem/plan-definition-type",
              "code": "eca-rule"
            }
          ]
        },
        "status": "active",
        "experimental": true,
        "subjectCanonical": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-eligibility-criteria",
        "date": "2022-02-14",
        "publisher": "CPGonEBMonFHIR",
        "description": "Example Recommendation Plan",
        "goal": [
          {
            "id": "ventilator-management-goal",
            "category": {
              "coding": [
                {
                  "system": "http://snomed.info/sct",
                  "code": "385857005",
                  "display": "Ventilator care and adjustment (regime/therapy)"
                }
              ]
            },
            "description": {
              "text": "The ventilator should be set up to provide a breath reate of at least 20 and at most per minute."
            },
            "target": [
              {
                "measure": {
                  "coding": [
                    {
                      "system": "http://loinc.org",
                      "code": "33438-3",
                      "display": "Breath rate mechanical --on ventilator"
                    }
                  ]
                },
                "detailRange": {
                  "low": {
                    "value": 20,
                    "system": "http://unitsofmeasure.org",
                    "code": "/min"
                  },
                  "high": {
                    "value": 24,
                    "system": "http://unitsofmeasure.org",
                    "code": "/min"
                  }
                }
              }
            ]
          },
          {
            "id": "lab-ddimer-concentration-goal",
            "category": {
              "coding": [
                {
                  "system": "http://snomed.info/sct",
                  "code": "410394004",
                  "display": "Lab findings surveillance (regime/therapy)"
                }
              ]
            },
            "description": {
              "text": "D-Dimer concentration shall be below 250 ng/mL"
            },
            "target": [
              {
                "measure": {
                  "coding": [
                    {
                      "system": "http://loinc.org",
                      "code": "48066-5",
                      "display": "Fibrin D-dimer DDU [Mass/volume] in Platelet poor plasma"
                    }
                  ]
                },
                "detailRange": {
                  "high": {
                    "value": 250,
                    "system": "http://unitsofmeasure.org",
                    "code": "ng/mL"
                  }
                }
              }
            ]
          }
        ],
        "action": [
          {
            "code": {
              "coding": [
                {
                  "system": "http://snomed.info/sct",
                  "code": "18629005",
                  "display": "Administration of drug or medicament (procedure)"
                }
              ]
            },
            "definitionCanonical": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-action/drug-administration-example"
          },
          {
            "code": {
              "coding": [
                {
                  "system": "http://snomed.info/sct",
                  "code": "229824005",
                  "display": "Positioning patient (procedure)"
                }
              ]
            },
            "goalId": [
              "ventilator-management-goal"
            ],
            "definitionCanonical": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-action/body-positioning-example"
          },
          {
            "code": {
              "coding": [
                {
                  "system": "http://snomed.info/sct",
                  "code": "410210009",
                  "display": "Ventilator care management (procedure)"
                }
              ]
            },
            "goalId": [
              "ventilator-management-goal"
            ]
          },
          {
            "extension": [
              {
                "extension": [
                  {
                    "url": "method",
                    "valueCodeableConcept": {
                      "coding": [
                        {
                          "system": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/cs-action-combination-method",
                          "code": "one-or-more"
                        }
                      ]
                    }
                  }
                ],
                "url": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/ext-action-combination-method"
              }
            ],
            "code": {
              "coding": [
                {
                  "system": "http://snomed.info/sct",
                  "code": "89780004",
                  "display": "Combined (qualifier value)"
                }
              ]
            },
            "action": [
              {
                "code": {
                  "coding": [
                    {
                      "system": "http://snomed.info/sct",
                      "code": "410210009",
                      "display": "Ventilator care management (procedure)"
                    }
                  ]
                },
                "goalId": [
                  "ventilator-management-goal"
                ]
              }
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/guideline-example/recommendation-action",
      "resource": {
        "resourceType": "ActivityDefinition",
        "id": "ExampleDrugAdministrationAction",
        "meta": {
          "profile": [
            "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/drug-administration-action"
          ]
        },
        "text": {
          "status": "extensions",
          "div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"ActivityDefinition_ExampleDrugAdministrationAction\"> </a><p class=\"res-header-id\"><b>Generated Narrative: ActivityDefinition ExampleDrugAdministrationAction</b></p><a name=\"ExampleDrugAdministrationAction\"> </a><a name=\"hcExampleDrugAdministrationAction\"> </a><a name=\"ExampleDrugAdministrationAction-en-US\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-drug-administration-action.html\">Drug Administration Action</a></p></div><p><b>knowledgeCapability</b>: computable</p><p><b>knowledgeRepresentationLevel</b>: structured</p><p><b>url</b>: <a href=\"ActivityDefinition-ExampleDrugAdministrationAction.html\">ActivityDefinition DrugAdministrationAction</a></p><p><b>version</b>: 1.0</p><p><b>name</b>: DrugAdministrationAction</p><p><b>status</b>: Active</p><p><b>experimental</b>: true</p><p><b>subject</b>: <span title=\"Codes:{http://hl7.org/fhir/fhir-types Patient}\">Patient</span></p><p><b>publisher</b>: CPGonEBMonFHIR</p><p><b>description</b>: </p><div><p>A drug administration that should be performed.</p>\n</div><p><b>kind</b>: MedicationRequest</p><p><b>code</b>: <span title=\"Codes:{http://snomed.info/sct 18629005}\">Administration of drug or medicament (procedure)</span></p><p><b>product</b>: <span title=\"Codes:{http://snomed.info/sct 372584003}, {http://fhir.de/CodeSystem/bfarm/atc C05AA09}\">Dexamethasone (substance)</span></p><blockquote><p><b>dosage</b></p><blockquote><p><b>Dosage Condition</b></p><ul><li>type: <span title=\"Codes:{http://loinc.org 29463-7}\">Body weight</span></li><li>value: ?-70</li></ul></blockquote><p><b>timing</b>: Count 10  times, Duration 10days , Once per 1 day</p><p><b>route</b>: <span title=\"Codes:{http://snomed.info/sct 26643006}\">Oral route</span></p><h3>DoseAndRates</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Dose[x]</b></td><td><b>Rate[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>6 mg<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM  codemg = 'mg')</span></td><td>1 /d<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM  code/d = '/d')</span></td></tr></table></blockquote></div>"
        },
        "extension": [
          {
            "url": "http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeCapability",
            "valueCode": "computable"
          },
          {
            "url": "http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeRepresentationLevel",
            "valueCode": "structured"
          }
        ],
        "url": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-action/drug-administration-example",
        "version": "1.0",
        "name": "DrugAdministrationAction",
        "status": "active",
        "experimental": true,
        "subjectCodeableConcept": {
          "coding": [
            {
              "system": "http://hl7.org/fhir/fhir-types",
              "code": "Patient"
            }
          ]
        },
        "publisher": "CPGonEBMonFHIR",
        "description": "A drug administration that should be performed.",
        "kind": "MedicationRequest",
        "code": {
          "coding": [
            {
              "system": "http://snomed.info/sct",
              "code": "18629005",
              "display": "Administration of drug or medicament (procedure)"
            }
          ]
        },
        "productCodeableConcept": {
          "coding": [
            {
              "system": "http://snomed.info/sct",
              "code": "372584003",
              "display": "Dexamethasone (substance)"
            },
            {
              "system": "http://fhir.de/CodeSystem/bfarm/atc",
              "code": "C05AA09",
              "display": "Dexamethason"
            }
          ]
        },
        "dosage": [
          {
            "extension": [
              {
                "extension": [
                  {
                    "url": "type",
                    "valueCodeableConcept": {
                      "coding": [
                        {
                          "system": "http://loinc.org",
                          "code": "29463-7",
                          "display": "Body weight"
                        }
                      ]
                    }
                  },
                  {
                    "url": "value",
                    "valueRange": {
                      "high": {
                        "value": 70,
                        "unit": "kg",
                        "system": "http://unitsofmeasure.org",
                        "code": "kg"
                      }
                    }
                  }
                ],
                "url": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/ext-dosage-condition"
              }
            ],
            "timing": {
              "repeat": {
                "count": 10,
                "duration": 10,
                "durationUnit": "d",
                "frequency": 1,
                "period": 1,
                "periodUnit": "d"
              }
            },
            "route": {
              "coding": [
                {
                  "system": "http://snomed.info/sct",
                  "code": "26643006",
                  "display": "Oral route"
                }
              ]
            },
            "doseAndRate": [
              {
                "doseQuantity": {
                  "value": 6,
                  "unit": "mg",
                  "system": "http://unitsofmeasure.org",
                  "code": "mg"
                },
                "rateQuantity": {
                  "value": 1,
                  "unit": "/d",
                  "system": "http://unitsofmeasure.org",
                  "code": "/d"
                }
              }
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/guideline-example/population",
      "resource": {
        "resourceType": "EvidenceVariable",
        "id": "ExampleRecommendationEligibilityCriteria",
        "meta": {
          "profile": [
            "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/recommendation-eligibility-criteria"
          ]
        },
        "text": {
          "status": "generated",
          "div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"EvidenceVariable_ExampleRecommendationEligibilityCriteria\"> </a><p class=\"res-header-id\"><b>Generated Narrative: EvidenceVariable ExampleRecommendationEligibilityCriteria</b></p><a name=\"ExampleRecommendationEligibilityCriteria\"> </a><a name=\"hcExampleRecommendationEligibilityCriteria\"> </a><a name=\"ExampleRecommendationEligibilityCriteria-en-US\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-recommendation-eligibility-criteria.html\">Recommendation Eligibility Criteria</a></p></div><p><b>url</b>: <a href=\"EvidenceVariable-ExampleRecommendationEligibilityCriteria.html\">EvidenceVariable PopulationExample</a></p><p><b>name</b>: PopulationExample</p><p><b>status</b>: Active</p><blockquote><p><b>characteristic</b></p><h3>DefinitionByTypeAndValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://snomed.info/sct 404684003}\">Clinical finding (finding)</span></td><td><span title=\"Codes:{http://snomed.info/sct 840539006}\">Disease caused by Severe acute respiratory syndrome coronavirus 2 (disorder)</span></td></tr></table></blockquote></div>"
        },
        "url": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/recommendation-eligibility-criteria",
        "name": "PopulationExample",
        "status": "active",
        "characteristic": [
          {
            "definitionByTypeAndValue": {
              "type": {
                "coding": [
                  {
                    "system": "http://snomed.info/sct",
                    "code": "404684003",
                    "display": "Clinical finding (finding)"
                  }
                ]
              },
              "valueCodeableConcept": {
                "coding": [
                  {
                    "system": "http://snomed.info/sct",
                    "code": "840539006",
                    "display": "Disease caused by Severe acute respiratory syndrome coronavirus 2 (disorder)"
                  }
                ]
              }
            }
          }
        ]
      }
    },
    {
      "fullUrl": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/guideline-example/recommendation-justification",
      "resource": {
        "resourceType": "ArtifactAssessment",
        "id": "ExampleRecommendationJustification",
        "meta": {
          "profile": [
            "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/recommendation-justification"
          ]
        },
        "text": {
          "status": "extensions",
          "div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"ArtifactAssessment_ExampleRecommendationJustification\"> </a><p class=\"res-header-id\"><b>Generated Narrative: ArtifactAssessment ExampleRecommendationJustification</b></p><a name=\"ExampleRecommendationJustification\"> </a><a name=\"hcExampleRecommendationJustification\"> </a><a name=\"ExampleRecommendationJustification-en-US\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-recommendation-justification.html\">Recommendation Justification</a></p></div><p><b>ArtifactAssessment Version</b>: 0.1.0</p><p><b>ArtifactAssessment Publication Status</b>: active</p><p><b>date</b>: 2020-01-03</p><p><b>artifact</b>: <a href=\"PlanDefinition-ExampleRecommendationPlan.html\">PlanDefinition Recommendation Plan</a></p><blockquote><p><b>content</b></p><p><b>informationType</b>: Rating</p><p><b>type</b>: <span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system strength}\">Strength of recommendation</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-cs-recommendation-strength strong-for}\">Strong for an intervention</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Rating</p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/certainty-type Overall}\">Overall certainty</span></p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/certainty-rating very-low}\">Very low quality</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Rating</p><p><b>type</b>: <span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system consensus}\">Consensus</span></p><p><b>classifier</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/recommendation-strength strong}\">Strong</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Container</p><p><b>type</b>: <span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system certainty-of-evidence-rating}\">Certainty of evidence rating</span></p><h3>RelatedArtifacts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td><td><b>ResourceReference</b></td></tr><tr><td style=\"display: none\">*</td><td>Justification</td><td><span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system certainty-of-evidence-rating}\">Certainty of evidence rating</span></td><td><a href=\"ArtifactAssessment-ExampleCertaintyOfEvidenceRating.html\">ArtifactAssessment: extension = 0.1.1,active; date = 2022-03-11; artifact[x] = -&gt;Evidence ExampleStudyOutcomeEvidence</a></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Container</p><p><b>type</b>: <span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system net-effect}\">Net effect</span></p><h3>RelatedArtifacts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td><td><b>ResourceReference</b></td></tr><tr><td style=\"display: none\">*</td><td>Supported With</td><td><span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system net-effect}\">Net effect</span></td><td><a href=\"Evidence-ExampleNetEffectEstimate.html\">Evidence NetEffectExample</a></td></tr></table></blockquote></div>"
        },
        "extension": [
          {
            "url": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/ceosys-extension-artifact-assessment-version",
            "valueString": "0.1.0"
          },
          {
            "url": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/ceosys-extension-artifact-assessment-publication-status",
            "valueCode": "active"
          }
        ],
        "date": "2020-01-03",
        "artifactReference": {
          "reference": "PlanDefinition/ExampleRecommendationPlan"
        },
        "content": [
          {
            "informationType": "rating",
            "type": {
              "coding": [
                {
                  "system": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system",
                  "code": "strength",
                  "display": "Strength of recommendation"
                }
              ]
            },
            "classifier": [
              {
                "coding": [
                  {
                    "system": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-cs-recommendation-strength",
                    "code": "strong-for"
                  }
                ]
              }
            ]
          },
          {
            "informationType": "rating",
            "type": {
              "coding": [
                {
                  "system": "http://hl7.org/fhir/certainty-type",
                  "code": "Overall",
                  "display": "Overall certainty"
                }
              ]
            },
            "classifier": [
              {
                "coding": [
                  {
                    "system": "http://hl7.org/fhir/certainty-rating",
                    "code": "very-low",
                    "display": "Very low quality"
                  }
                ]
              }
            ]
          },
          {
            "informationType": "rating",
            "type": {
              "coding": [
                {
                  "system": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system",
                  "code": "consensus",
                  "display": "Consensus"
                }
              ]
            },
            "classifier": [
              {
                "coding": [
                  {
                    "system": "http://terminology.hl7.org/CodeSystem/recommendation-strength",
                    "code": "strong",
                    "display": "Strong"
                  }
                ]
              }
            ]
          },
          {
            "informationType": "container",
            "type": {
              "coding": [
                {
                  "system": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system",
                  "code": "certainty-of-evidence-rating",
                  "display": "Certainty of evidence rating"
                }
              ]
            },
            "relatedArtifact": [
              {
                "type": "justification",
                "classifier": [
                  {
                    "coding": [
                      {
                        "system": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system",
                        "code": "certainty-of-evidence-rating",
                        "display": "Certainty of evidence rating"
                      }
                    ]
                  }
                ],
                "resourceReference": {
                  "reference": "ArtifactAssessment/ExampleCertaintyOfEvidenceRating"
                }
              }
            ]
          },
          {
            "informationType": "container",
            "type": {
              "coding": [
                {
                  "system": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system",
                  "code": "net-effect",
                  "display": "Net effect"
                }
              ]
            },
            "relatedArtifact": [
              {
                "type": "supported-with",
                "classifier": [
                  {
                    "coding": [
                      {
                        "system": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system",
                        "code": "net-effect",
                        "display": "Net effect"
                      }
                    ]
                  }
                ],
                "resourceReference": {
                  "reference": "Evidence/ExampleNetEffectEstimate"
                }
              }
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/guideline-example/certainty-of-evidence-rating",
      "resource": {
        "resourceType": "ArtifactAssessment",
        "id": "ExampleCertaintyOfEvidenceRating",
        "meta": {
          "profile": [
            "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/certainty-of-evidence-rating"
          ]
        },
        "text": {
          "status": "extensions",
          "div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"ArtifactAssessment_ExampleCertaintyOfEvidenceRating\"> </a><p class=\"res-header-id\"><b>Generated Narrative: ArtifactAssessment ExampleCertaintyOfEvidenceRating</b></p><a name=\"ExampleCertaintyOfEvidenceRating\"> </a><a name=\"hcExampleCertaintyOfEvidenceRating\"> </a><a name=\"ExampleCertaintyOfEvidenceRating-en-US\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-certainty-of-evidence-rating.html\">Certainty of Evidence Rating</a></p></div><p><b>ArtifactAssessment Version</b>: 0.1.1</p><p><b>ArtifactAssessment Publication Status</b>: active</p><p><b>date</b>: 2022-03-11</p><p><b>artifact</b>: <a href=\"Evidence-ExampleStudyOutcomeEvidence.html\">Evidence ExampleStudyOutcomeEvidence</a></p><blockquote><p><b>content</b></p><p><b>informationType</b>: Rating</p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/certainty-type Overall}\">Overall certainty</span></p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/certainty-rating moderate}\">Moderate quality</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Rating</p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/certainty-type RiskOfBias}\">Risk of bias</span></p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/certainty-rating serious-concern}\">serious concern</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Rating</p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/certainty-type Imprecision}\">Imprecision</span></p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/certainty-rating serious-concern}\">serious concern</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Rating</p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/certainty-type LargeEffect}\">Large effect</span></p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/certainty-rating upcode2}\">increase rating: +2</span></p></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Rating</p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/certainty-type PlausibleConfounding}\">Plausible confounding</span></p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/certainty-rating upcode1}\">increase rating: +1</span></p></blockquote></div>"
        },
        "extension": [
          {
            "url": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/ceosys-extension-artifact-assessment-version",
            "valueString": "0.1.1"
          },
          {
            "url": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/ceosys-extension-artifact-assessment-publication-status",
            "valueCode": "active"
          }
        ],
        "date": "2022-03-11",
        "artifactReference": {
          "reference": "Evidence/ExampleStudyOutcomeEvidence"
        },
        "content": [
          {
            "informationType": "rating",
            "type": {
              "coding": [
                {
                  "system": "http://hl7.org/fhir/certainty-type",
                  "code": "Overall",
                  "display": "Overall certainty"
                }
              ]
            },
            "classifier": [
              {
                "coding": [
                  {
                    "system": "http://hl7.org/fhir/certainty-rating",
                    "code": "moderate",
                    "display": "Moderate quality"
                  }
                ]
              }
            ]
          },
          {
            "informationType": "rating",
            "type": {
              "coding": [
                {
                  "system": "http://hl7.org/fhir/certainty-type",
                  "code": "RiskOfBias",
                  "display": "Risk of bias"
                }
              ]
            },
            "classifier": [
              {
                "coding": [
                  {
                    "system": "http://hl7.org/fhir/certainty-rating",
                    "code": "serious-concern",
                    "display": "serious concern"
                  }
                ]
              }
            ]
          },
          {
            "informationType": "rating",
            "type": {
              "coding": [
                {
                  "system": "http://hl7.org/fhir/certainty-type",
                  "code": "Imprecision",
                  "display": "Imprecision"
                }
              ]
            },
            "classifier": [
              {
                "coding": [
                  {
                    "system": "http://hl7.org/fhir/certainty-rating",
                    "code": "serious-concern",
                    "display": "serious concern"
                  }
                ]
              }
            ]
          },
          {
            "informationType": "rating",
            "type": {
              "coding": [
                {
                  "system": "http://hl7.org/fhir/certainty-type",
                  "code": "LargeEffect",
                  "display": "Large effect"
                }
              ]
            },
            "classifier": [
              {
                "coding": [
                  {
                    "system": "http://hl7.org/fhir/certainty-rating",
                    "code": "upcode2",
                    "display": "increase rating: +2"
                  }
                ]
              }
            ]
          },
          {
            "informationType": "rating",
            "type": {
              "coding": [
                {
                  "system": "http://hl7.org/fhir/certainty-type",
                  "code": "PlausibleConfounding",
                  "display": "Plausible confounding"
                }
              ]
            },
            "classifier": [
              {
                "coding": [
                  {
                    "system": "http://hl7.org/fhir/certainty-rating",
                    "code": "upcode1",
                    "display": "increase rating: +1"
                  }
                ]
              }
            ]
          }
        ]
      }
    },
    {
      "fullUrl": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/guideline-example/study-outcome-evidence",
      "resource": {
        "resourceType": "Evidence",
        "id": "ExampleStudyOutcomeEvidence",
        "meta": {
          "profile": [
            "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/study-outcome-evidence"
          ]
        },
        "text": {
          "status": "generated",
          "div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Evidence_ExampleStudyOutcomeEvidence\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Evidence ExampleStudyOutcomeEvidence</b></p><a name=\"ExampleStudyOutcomeEvidence\"> </a><a name=\"hcExampleStudyOutcomeEvidence\"> </a><a name=\"ExampleStudyOutcomeEvidence-en-US\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-study-outcome-evidence.html\">Study Outcome Evidence</a></p></div><p><b>name</b>: ExampleStudyOutcomeEvidence</p><p><b>status</b>: Active</p><h3>RelatedArtifacts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>ResourceReference</b></td></tr><tr><td style=\"display: none\">*</td><td>Citation</td><td><a href=\"Citation-ExampleStudyCitation.html\">Citation ExampleCitation</a></td></tr></table><blockquote><p><b>variableDefinition</b></p><p><b>variableRole</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/variable-role population}\">population</span></p><p><b>observed</b>: <a href=\"Group-ExampleStudyCohort.html\">Group: type = person; membership = definitional; quantity = 20</a></p><p><b>intended</b>: <a href=\"EvidenceVariable-ExampleStudyEligibilityCriteria.html\">EvidenceVariable ExampleStudyEligibilityCriteria</a></p></blockquote><blockquote><p><b>variableDefinition</b></p><p><b>variableRole</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/variable-role measuredVariable}\">measured variable</span></p><p><b>observed</b>: <a href=\"EvidenceVariable-ExampleOutcome.html\">EvidenceVariable Mortality</a></p></blockquote><p><b>synthesisType</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/synthesis-type NotApplicable}\">not applicable</span></p></div>"
        },
        "name": "ExampleStudyOutcomeEvidence",
        "status": "active",
        "relatedArtifact": [
          {
            "type": "citation",
            "resourceReference": {
              "reference": "Citation/ExampleStudyCitation"
            }
          }
        ],
        "variableDefinition": [
          {
            "variableRole": {
              "coding": [
                {
                  "system": "http://terminology.hl7.org/CodeSystem/variable-role",
                  "code": "population"
                }
              ]
            },
            "observed": {
              "reference": "Group/ExampleStudyCohort"
            },
            "intended": {
              "reference": "EvidenceVariable/ExampleStudyEligibilityCriteria"
            }
          },
          {
            "variableRole": {
              "coding": [
                {
                  "system": "http://terminology.hl7.org/CodeSystem/variable-role",
                  "code": "measuredVariable"
                }
              ]
            },
            "observed": {
              "reference": "EvidenceVariable/ExampleOutcome"
            }
          }
        ],
        "synthesisType": {
          "coding": [
            {
              "system": "http://terminology.hl7.org/CodeSystem/synthesis-type",
              "code": "NotApplicable"
            }
          ]
        }
      }
    },
    {
      "fullUrl": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/guideline-example/outcome-evidence-synthesis",
      "resource": {
        "resourceType": "Evidence",
        "id": "ExampleOutcomeEvidenceSynthesis",
        "meta": {
          "profile": [
            "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/outcome-evidence-synthesis"
          ]
        },
        "text": {
          "status": "generated",
          "div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Evidence_ExampleOutcomeEvidenceSynthesis\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Evidence ExampleOutcomeEvidenceSynthesis</b></p><a name=\"ExampleOutcomeEvidenceSynthesis\"> </a><a name=\"hcExampleOutcomeEvidenceSynthesis\"> </a><a name=\"ExampleOutcomeEvidenceSynthesis-en-US\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-outcome-evidence-synthesis.html\">Outcome Evidence Synthesis</a></p></div><p><b>name</b>: ExampleOutcomeEvidenceSynthesis</p><p><b>status</b>: Active</p><h3>RelatedArtifacts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>ResourceReference</b></td></tr><tr><td style=\"display: none\">*</td><td>Citation</td><td><a href=\"Citation-ExampleStudyCitation.html\">Citation ExampleCitation</a></td></tr></table><blockquote><p><b>variableDefinition</b></p><p><b>variableRole</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/variable-role population}\">population</span></p><p><b>observed</b>: <a href=\"Group-ExampleEvidenceSynthesisCohorts.html\">Group: type = person; membership = definitional; quantity = 20</a></p><p><b>intended</b>: <a href=\"EvidenceVariable-ExampleStudyEligibilityCriteria.html\">EvidenceVariable ExampleStudyEligibilityCriteria</a></p></blockquote><blockquote><p><b>variableDefinition</b></p><p><b>variableRole</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/variable-role measuredVariable}\">measured variable</span></p><p><b>observed</b>: <a href=\"EvidenceVariable-ExampleOutcome.html\">EvidenceVariable Mortality</a></p></blockquote><p><b>synthesisType</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/synthesis-type NotApplicable}\">not applicable</span></p></div>"
        },
        "name": "ExampleOutcomeEvidenceSynthesis",
        "status": "active",
        "relatedArtifact": [
          {
            "type": "citation",
            "resourceReference": {
              "reference": "Citation/ExampleStudyCitation"
            }
          }
        ],
        "variableDefinition": [
          {
            "variableRole": {
              "coding": [
                {
                  "system": "http://terminology.hl7.org/CodeSystem/variable-role",
                  "code": "population"
                }
              ]
            },
            "observed": {
              "reference": "Group/ExampleEvidenceSynthesisCohorts"
            },
            "intended": {
              "reference": "EvidenceVariable/ExampleStudyEligibilityCriteria"
            }
          },
          {
            "variableRole": {
              "coding": [
                {
                  "system": "http://terminology.hl7.org/CodeSystem/variable-role",
                  "code": "measuredVariable"
                }
              ]
            },
            "observed": {
              "reference": "EvidenceVariable/ExampleOutcome"
            }
          }
        ],
        "synthesisType": {
          "coding": [
            {
              "system": "http://terminology.hl7.org/CodeSystem/synthesis-type",
              "code": "NotApplicable"
            }
          ]
        }
      }
    },
    {
      "fullUrl": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/guideline-example/study-eligbility-criteria",
      "resource": {
        "resourceType": "EvidenceVariable",
        "id": "ExampleStudyEligibilityCriteria",
        "meta": {
          "profile": [
            "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/study-eligibility-criteria"
          ]
        },
        "text": {
          "status": "generated",
          "div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"EvidenceVariable_ExampleStudyEligibilityCriteria\"> </a><p class=\"res-header-id\"><b>Generated Narrative: EvidenceVariable ExampleStudyEligibilityCriteria</b></p><a name=\"ExampleStudyEligibilityCriteria\"> </a><a name=\"hcExampleStudyEligibilityCriteria\"> </a><a name=\"ExampleStudyEligibilityCriteria-en-US\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-study-eligibility-criteria.html\">Study Eligibility Criteria</a></p></div><p><b>name</b>: ExampleStudyEligibilityCriteria</p><p><b>status</b>: Active</p><blockquote><p><b>characteristic</b></p><h3>DefinitionByTypeAndValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://snomed.info/sct 404684003}\">Clinical finding (finding)</span></td><td><span title=\"Codes:{http://snomed.info/sct 840539006}\">Disease caused by Severe acute respiratory syndrome coronavirus 2 (disorder)</span></td></tr></table></blockquote></div>"
        },
        "name": "ExampleStudyEligibilityCriteria",
        "status": "active",
        "characteristic": [
          {
            "definitionByTypeAndValue": {
              "type": {
                "coding": [
                  {
                    "system": "http://snomed.info/sct",
                    "code": "404684003",
                    "display": "Clinical finding (finding)"
                  }
                ]
              },
              "valueCodeableConcept": {
                "coding": [
                  {
                    "system": "http://snomed.info/sct",
                    "code": "840539006",
                    "display": "Disease caused by Severe acute respiratory syndrome coronavirus 2 (disorder)"
                  }
                ]
              }
            }
          }
        ]
      }
    },
    {
      "fullUrl": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/guideline-example/study-citation",
      "resource": {
        "resourceType": "Citation",
        "id": "ExampleStudyCitation",
        "meta": {
          "profile": [
            "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/study-citation"
          ]
        },
        "text": {
          "status": "generated",
          "div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Citation_ExampleStudyCitation\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Citation ExampleStudyCitation</b></p><a name=\"ExampleStudyCitation\"> </a><a name=\"hcExampleStudyCitation\"> </a><a name=\"ExampleStudyCitation-en-US\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-study-citation.html\">Study Citation</a></p></div><p><b>name</b>: ExampleCitation</p><p><b>status</b>: Active</p><blockquote><p><b>citedArtifact</b></p><p><b>identifier</b>: ceoysy/exampleIdentifier</p><h3>Titles</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Text</b></td></tr><tr><td style=\"display: none\">*</td><td><div><p>Example Citation</p>\n</div></td></tr></table><h3>Classifications</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type publication-type}\">Publication Type</span></td><td><span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></td></tr></table></blockquote></div>"
        },
        "name": "ExampleCitation",
        "status": "active",
        "citedArtifact": {
          "identifier": [
            {
              "value": "ceoysy/exampleIdentifier"
            }
          ],
          "title": [
            {
              "text": "Example Citation"
            }
          ],
          "classification": [
            {
              "type": {
                "coding": [
                  {
                    "system": "http://hl7.org/fhir/cited-artifact-classification-type",
                    "code": "publication-type",
                    "display": "Publication Type"
                  }
                ]
              },
              "classifier": [
                {
                  "coding": [
                    {
                      "system": "http://hl7.org/fhir/citation-artifact-classifier",
                      "code": "D016428",
                      "display": "Journal Article"
                    }
                  ]
                }
              ]
            }
          ]
        }
      }
    },
    {
      "fullUrl": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/guideline-example/outcome",
      "resource": {
        "resourceType": "EvidenceVariable",
        "id": "ExampleOutcome",
        "meta": {
          "profile": [
            "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/outcome-definition"
          ]
        },
        "text": {
          "status": "generated",
          "div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"EvidenceVariable_ExampleOutcome\"> </a><p class=\"res-header-id\"><b>Generated Narrative: EvidenceVariable ExampleOutcome</b></p><a name=\"ExampleOutcome\"> </a><a name=\"hcExampleOutcome\"> </a><a name=\"ExampleOutcome-en-US\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-outcome-definition.html\">Outcome Definition</a></p></div><p><b>identifier</b>: <code>https://www.ceosys.de</code>/outcome-example</p><p><b>name</b>: Mortality</p><p><b>status</b>: Active</p><blockquote><p><b>characteristic</b></p><p><b>exclude</b>: false</p><h3>DefinitionByTypeAndValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://snomed.info/sct 409651001}\">Mortality rate (observable entity)</span></td><td> percent<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM  code% = '%')</span></td></tr></table></blockquote><p><b>handling</b>: dichotomous variable</p></div>"
        },
        "identifier": [
          {
            "system": "https://www.ceosys.de",
            "value": "outcome-example"
          }
        ],
        "name": "Mortality",
        "status": "active",
        "characteristic": [
          {
            "exclude": false,
            "definitionByTypeAndValue": {
              "type": {
                "coding": [
                  {
                    "system": "http://snomed.info/sct",
                    "code": "409651001",
                    "display": "Mortality rate (observable entity)"
                  }
                ]
              },
              "valueQuantity": {
                "unit": "percent",
                "system": "http://unitsofmeasure.org",
                "code": "%"
              }
            }
          }
        ],
        "handling": "dichotomous"
      }
    },
    {
      "fullUrl": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/guideline-example/recommendation-citation",
      "resource": {
        "resourceType": "Citation",
        "id": "ExampleRecommendationCitation",
        "meta": {
          "profile": [
            "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/recommendation-citation"
          ]
        },
        "text": {
          "status": "generated",
          "div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Citation_ExampleRecommendationCitation\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Citation ExampleRecommendationCitation</b></p><a name=\"ExampleRecommendationCitation\"> </a><a name=\"hcExampleRecommendationCitation\"> </a><a name=\"ExampleRecommendationCitation-en-US\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-recommendation-citation.html\">Recommendation Citation</a></p></div><p><b>name</b>: ExampleRecommendationCitation</p><p><b>status</b>: Active</p><blockquote><p><b>citedArtifact</b></p><p><b>identifier</b>: ceoysy/exampleIdentifier</p><h3>Versions</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Value</b></td></tr><tr><td style=\"display: none\">*</td><td>1.0-alpha1</td></tr></table><p><b>currentState</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-status-type archived}\">Archived</span></p><h3>Titles</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Text</b></td></tr><tr><td style=\"display: none\">*</td><td><div><p>Example Citation</p>\n</div></td></tr></table><h3>Classifications</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type publication-type}\">Publication Type</span></td><td><span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system guideline-recommendation}\">Clinical practice guideline recommendation</span></td></tr></table></blockquote></div>"
        },
        "name": "ExampleRecommendationCitation",
        "status": "active",
        "citedArtifact": {
          "identifier": [
            {
              "value": "ceoysy/exampleIdentifier"
            }
          ],
          "version": {
            "value": "1.0-alpha1"
          },
          "currentState": [
            {
              "coding": [
                {
                  "system": "http://hl7.org/fhir/cited-artifact-status-type",
                  "code": "archived",
                  "display": "Archived"
                }
              ]
            }
          ],
          "title": [
            {
              "text": "Example Citation"
            }
          ],
          "classification": [
            {
              "type": {
                "coding": [
                  {
                    "system": "http://hl7.org/fhir/cited-artifact-classification-type",
                    "code": "publication-type",
                    "display": "Publication Type"
                  }
                ]
              },
              "classifier": [
                {
                  "coding": [
                    {
                      "system": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system",
                      "code": "guideline-recommendation",
                      "display": "Clinical practice guideline recommendation"
                    }
                  ]
                }
              ]
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          ]
        }
      }
    },
    {
      "fullUrl": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/example/guidelines/guideline-example/net-effect-estimate",
      "resource": {
        "resourceType": "Evidence",
        "id": "ExampleNetEffectEstimate",
        "meta": {
          "profile": [
            "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/net-effect-estimate"
          ]
        },
        "text": {
          "status": "generated",
          "div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Evidence_ExampleNetEffectEstimate\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Evidence ExampleNetEffectEstimate</b></p><a name=\"ExampleNetEffectEstimate\"> </a><a name=\"hcExampleNetEffectEstimate\"> </a><a name=\"ExampleNetEffectEstimate-en-US\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-net-effect-estimate.html\">Net Effect Estimate</a></p></div><p><b>name</b>: NetEffectExample</p><p><b>status</b>: Unknown</p><h3>VariableDefinitions</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>VariableRole</b></td><td><b>Intended</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://terminology.hl7.org/CodeSystem/variable-role measuredVariable}\">measured variable</span></td><td><a href=\"EvidenceVariable-ExampleOutcome.html\">EvidenceVariable Mortality</a></td></tr></table><blockquote><p><b>statistic</b></p><p><b>description</b>: </p><div><p>Net Effect</p>\n</div><p><b>statisticType</b>: <span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system net-effect}\">Net Effect</span></p><p><b>quantity</b>: 1.7 %<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM  code% = '%')</span></p><h3>AttributeEstimates</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Level</b></td><td><b>Range</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://terminology.hl7.org/CodeSystem/attribute-estimate-type C53324}\">Confidence interval</span></td><td>0.95</td><td>1.5-1.9</td></tr></table><blockquote><p><b>modelCharacteristic</b></p><p><b>code</b>: <span title=\"Codes:{https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system relative-importance-weighting}\">Relative importance weighting for use in weighted linear combinations</span></p><p><b>value</b>: 1</p><h3>Variables</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>VariableDefinition</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"EvidenceVariable-ExampleOutcome.html\">EvidenceVariable Mortality</a></td></tr></table></blockquote></blockquote></div>"
        },
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              "coding": [
                {
                  "system": "http://terminology.hl7.org/CodeSystem/variable-role",
                  "code": "measuredVariable"
                }
              ]
            },
            "intended": {
              "reference": "EvidenceVariable/ExampleOutcome"
            }
          }
        ],
        "statistic": [
          {
            "description": "Net Effect",
            "statisticType": {
              "coding": [
                {
                  "system": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system",
                  "code": "net-effect",
                  "display": "Net Effect"
                }
              ]
            },
            "quantity": {
              "value": 1.7,
              "system": "http://unitsofmeasure.org",
              "code": "%"
            },
            "attributeEstimate": [
              {
                "type": {
                  "coding": [
                    {
                      "system": "http://terminology.hl7.org/CodeSystem/attribute-estimate-type",
                      "code": "C53324",
                      "display": "Confidence interval"
                    }
                  ]
                },
                "level": 0.95,
                "range": {
                  "low": {
                    "value": 1.5,
                    "system": "http://unitsofmeasure.org",
                    "code": "%"
                  },
                  "high": {
                    "value": 1.9,
                    "system": "http://unitsofmeasure.org",
                    "code": "%"
                  }
                }
              }
            ],
            "modelCharacteristic": [
              {
                "code": {
                  "coding": [
                    {
                      "system": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/CodeSystem/ceosys-code-system",
                      "code": "relative-importance-weighting"
                    }
                  ]
                },
                "value": {
                  "value": 1
                },
                "variable": [
                  {
                    "variableDefinition": {
                      "reference": "EvidenceVariable/ExampleOutcome"
                    }
                  }
                ]
              }
            ]
          }
        ]
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}