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Source1

{
  "resourceType": "EvidenceVariable",
  "id": "mii-exa-studie-ein-auschluss-kriterium",
  "meta": {
    "profile": [
      "https://www.medizininformatik-initiative.de/fhir/modul-studie/StructureDefinition/mii-pr-studie-ein-auschluss-kriterium"
    ]
  },
  "characteristic": [
    {
      "extension": [
        {
          "url": "http://hl7.org/fhir/5.0/StructureDefinition/extension-EvidenceVariable.characteristic.definitionReference",
          "valueReference": {
            "reference": "EvidenceVariable/mii-exa-studie-evidence-variable-age-restriction"
          }
        }
      ],
      "definitionCodeableConcept": {
        "text": "Altersbeschränkung"
      },
      "description": "Altersbeschränkung"
    },
    {
      "extension": [
        {
          "url": "http://hl7.org/fhir/5.0/StructureDefinition/extension-EvidenceVariable.characteristic.definitionCanonical",
          "valueCanonical": "https://www.medizininformatik-initiative.de/fhir/EvidenceVariable/administrative-gender"
        }
      ],
      "definitionCodeableConcept": {
        "text": "Alle"
      },
      "description": "Geschlecht",
      "exclude": false
    },
    {
      "extension": [
        {
          "url": "http://hl7.org/fhir/5.0/StructureDefinition/extension-EvidenceVariable.characteristic.linkId",
          "valueId": "aa83ebf3-cfe4-4ed6-aa71-0779c28e85a2"
        }
      ],
      "definitionCodeableConcept": {
        "coding": [
          {
            "code": "unknown",
            "system": "http://terminology.hl7.org/CodeSystem/data-absent-reason"
          }
        ]
      },
      "description": "Kognitive Fatigue (WeiMUS kognitive Skala >= 17)",
      "exclude": false
    },
    {
      "extension": [
        {
          "url": "http://hl7.org/fhir/5.0/StructureDefinition/extension-EvidenceVariable.characteristic.linkId",
          "valueId": "8e8f63ff-65f1-40cd-bf79-da83d7fb4e09"
        }
      ],
      "definitionCodeableConcept": {
        "coding": [
          {
            "code": "unknown",
            "system": "http://terminology.hl7.org/CodeSystem/data-absent-reason"
          }
        ]
      },
      "description": "Positiver SARS-CoV-2(COVID-19)-Befund; mind. 3 Monate alt",
      "exclude": false
    },
    {
      "extension": [
        {
          "url": "http://hl7.org/fhir/5.0/StructureDefinition/extension-EvidenceVariable.characteristic.definitionByCombination",
          "extension": [
            {
              "url": "code",
              "valueCode": "any-of"
            },
            {
              "url": "characteristic",
              "valueId": "aa83ebf3-cfe4-4ed6-aa71-0779c28e85a2"
            },
            {
              "url": "characteristic",
              "valueId": "8e8f63ff-65f1-40cd-bf79-da83d7fb4e09"
            }
          ]
        }
      ],
      "definitionCodeableConcept": {
        "coding": [
          {
            "code": "unknown",
            "system": "http://terminology.hl7.org/CodeSystem/data-absent-reason"
          }
        ]
      },
      "description": "Weitere Einschlusskriterien",
      "exclude": false
    },
    {
      "definitionCodeableConcept": {
        "coding": [
          {
            "code": "unknown",
            "system": "http://terminology.hl7.org/CodeSystem/data-absent-reason"
          }
        ]
      },
      "description": "diagnostizierte Depressionen, Angststörungen, andere psychiatrische Erkrankungen",
      "exclude": true
    },
    {
      "definitionCodeableConcept": {
        "coding": [
          {
            "code": "unknown",
            "system": "http://terminology.hl7.org/CodeSystem/data-absent-reason"
          }
        ]
      },
      "description": "Einnahme von Antidepressiva, Opioiden, Antikonvulsiva",
      "exclude": true
    },
    {
      "definitionCodeableConcept": {
        "coding": [
          {
            "code": "unknown",
            "system": "http://terminology.hl7.org/CodeSystem/data-absent-reason"
          }
        ]
      },
      "description": "weitere neurologische Erkrankungen",
      "exclude": true
    },
    {
      "extension": [
        {
          "url": "http://hl7.org/fhir/5.0/StructureDefinition/extension-EvidenceVariable.characteristic.definitionByTypeAndValue",
          "extension": [
            {
              "url": "type",
              "valueCodeableConcept": {
                "coding": [
                  {
                    "system": "http://snomed.info/sct",
                    "code": "424144002",
                    "display": "Current chronological age"
                  }
                ]
              }
            },
            {
              "url": "value",
              "valueQuantity": {
                "value": 18,
                "comparator": ">=",
                "unit": "year",
                "system": "http://unitsofmeasure.org",
                "code": "a"
              }
            }
          ]
        }
      ],
      "definitionCodeableConcept": {
        "text": "Mindestalter"
      },
      "description": "Alter mindestens 18 Jahre",
      "exclude": false
    }
  ],
  "status": "active"
}