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Source1

{
  "resourceType": "ObservationDefinition",
  "id": "mii-obsdef-pro-depression-t-score",
  "meta": {
    "profile": [
      "https://www.medizininformatik-initiative.de/fhir/ext/modul-pro/StructureDefinition/mii-pr-pro-score-blueprint|2026.0.1"
    ]
  },
  "extension": [
    {
      "url": "http://hl7.org/fhir/StructureDefinition/artifact-version",
      "valueString": "2026.0.1"
    },
    {
      "url": "http://hl7.org/fhir/StructureDefinition/cqf-citation",
      "valueString": "Riazy L, Grote M, Liegl G, Rose M, Fischer F. Cross-Sectional Reference Data From 29 European Countries for 6 Frequently Used Depression Measures. JAMA Network Open. 2025;8(6):e2517394"
    }
  ],
  "category": [
    {
      "coding": [
        {
          "system": "http://terminology.hl7.org/CodeSystem/observation-category",
          "code": "survey"
        }
      ]
    }
  ],
  "code": {
    "coding": [
      {
        "system": "http://loinc.org",
        "code": "77861-3",
        "display": "PROMIS emotional distress - depression - version 1.0 Tscore"
      }
    ]
  },
  "permittedDataType": [
    "Quantity"
  ],
  "multipleResultsAllowed": false,
  "method": {
    "text": "PROMIS Depression T-score metric derived from European Health Interview Survey (EHIS) wave 3 cross-cultural validation study"
  },
  "quantitativeDetails": {
    "unit": {
      "coding": [
        {
          "system": "http://unitsofmeasure.org",
          "code": "{score}",
          "display": "{score}"
        }
      ]
    }
  },
  "qualifiedInterval": [
    {
      "category": "reference",
      "range": {
        "extension": [
          {
            "url": "https://www.medizininformatik-initiative.de/fhir/ext/modul-pro/StructureDefinition/mii-ex-pro-score-score-health-correlation",
            "valueCodeableConcept": {
              "coding": [
                {
                  "system": "http://terminology.hl7.org/CodeSystem/measure-improvement-notation",
                  "code": "decrease"
                }
              ],
              "text": "Higher scores indicate worse health (more depression symptoms)"
            }
          }
        ],
        "low": {
          "value": 41.8
        },
        "high": {
          "value": 51.5
        }
      },
      "context": {
        "coding": [
          {
            "system": "http://loinc.org",
            "code": "LA6112-2",
            "display": "General population"
          }
        ],
        "text": "German general population - EHIS wave 3 (n=22,996): Mean 46.5 (SD 7.7), Median 45.5"
      }
    },
    {
      "category": "reference",
      "range": {
        "extension": [
          {
            "url": "https://www.medizininformatik-initiative.de/fhir/ext/modul-pro/StructureDefinition/mii-ex-pro-score-score-health-correlation",
            "valueCodeableConcept": {
              "coding": [
                {
                  "system": "http://terminology.hl7.org/CodeSystem/measure-improvement-notation",
                  "code": "decrease"
                }
              ],
              "text": "Higher scores indicate worse health (more depression symptoms)"
            }
          }
        ],
        "low": {
          "value": 38.06
        },
        "high": {
          "value": 50.4
        }
      },
      "context": {
        "coding": [
          {
            "system": "http://loinc.org",
            "code": "LA6112-2",
            "display": "General population"
          }
        ],
        "text": "European male population - EHIS wave 3 (29 countries): Median 44.11"
      },
      "appliesTo": [
        {
          "coding": [
            {
              "system": "http://terminology.hl7.org/CodeSystem/v3-AdministrativeGender",
              "code": "M",
              "display": "Male"
            }
          ]
        }
      ]
    },
    {
      "category": "reference",
      "range": {
        "extension": [
          {
            "url": "https://www.medizininformatik-initiative.de/fhir/ext/modul-pro/StructureDefinition/mii-ex-pro-score-score-health-correlation",
            "valueCodeableConcept": {
              "coding": [
                {
                  "system": "http://terminology.hl7.org/CodeSystem/measure-improvement-notation",
                  "code": "decrease"
                }
              ],
              "text": "Higher scores indicate worse health (more depression symptoms)"
            }
          }
        ],
        "low": {
          "value": 40
        },
        "high": {
          "value": 52.76
        }
      },
      "context": {
        "coding": [
          {
            "system": "http://loinc.org",
            "code": "LA6112-2",
            "display": "General population"
          }
        ],
        "text": "European female population - EHIS wave 3 (29 countries): Median 46.37"
      },
      "appliesTo": [
        {
          "coding": [
            {
              "system": "http://terminology.hl7.org/CodeSystem/v3-AdministrativeGender",
              "code": "F",
              "display": "Female"
            }
          ]
        }
      ]
    },
    {
      "category": "reference",
      "range": {
        "low": {
          "value": 39.11
        },
        "high": {
          "value": 51.68
        }
      },
      "context": {
        "coding": [
          {
            "system": "http://loinc.org",
            "code": "LA6112-2",
            "display": "General population"
          }
        ],
        "text": "Overall European population median (IQR) - EHIS wave 3, 29 countries (n=287,530)"
      }
    }
  ]
}