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{
  "resourceType": "ConceptMap",
  "id": "mii-cm-onko-atc-transitions-2021",
  "meta": {
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      {
        "extension": [
          {
            "url": "packageId",
            "valueId": "de.medizininformatikinitiative.kerndatensatz.onkologie"
          },
          {
            "url": "version",
            "valueString": "2027.0.0-ballot.1"
          },
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  },
  "text": {
    "status": "generated",
    "div": "<!-- snip (see above) -->"
  },
  "extension": [
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    },
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    },
    {
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      "valueDate": "2026-09-15"
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      "valueContactDetail": {
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    },
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      "valueContactDetail": {
        "name": "Taskforce Core Data Set"
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    },
    {
      "url": "http://hl7.org/fhir/StructureDefinition/artifact-reviewer",
      "valueContactDetail": {
        "name": "Interoperability Working Group",
        "telecom": [
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          }
        ]
      }
    },
    {
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      "valueContactDetail": {
        "name": "National Steering Committee",
        "telecom": [
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            "value": "https://www.medizininformatik-initiative.de/en/collaboration/national-steering-committee"
          }
        ]
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    },
    {
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      "valueContactDetail": {
        "name": "Interoperability Working Group",
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          }
        ]
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    },
    {
      "url": "http://hl7.org/fhir/StructureDefinition/artifact-endorser",
      "valueContactDetail": {
        "name": "National Steering Committee",
        "telecom": [
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            "value": "https://www.medizininformatik-initiative.de/en/collaboration/national-steering-committee"
          }
        ]
      }
    },
    {
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      "valueCoding": {
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        "code": "semver",
        "display": "SemVer"
      }
    },
    {
      "url": "http://hl7.org/fhir/StructureDefinition/resource-effectivePeriod",
      "valuePeriod": {
        "start": "2027"
      }
    }
  ],
  "url": "https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/ConceptMap/mii-cm-onko-atc-transitions-2021",
  "version": "2027.0.0-ballot.1",
  "name": "MII_CM_Onko_ATC_Transitions_2021",
  "title": "MII CM Onko ATC Code Changes 2020 to 2021",
  "status": "active",
  "experimental": false,
  "date": "2024-12-12",
  "publisher": "Medizininformatik Initiative",
  "contact": [
    {
      "name": "Medizininformatik Initiative",
      "telecom": [
        {
          "system": "url",
          "value": "https://www.medizininformatik-initiative.de/"
        }
      ]
    }
  ],
  "description": "Diese ConceptMap dokumentiert ausschließlich die ATC-Code-Änderungen von 2020 zu 2021. Im Jahr 2021 erfolgte eine umfassende Reorganisation der ATC-Klassifikation für onkologische Substanzen mit Umkodierung von über 60 Wirkstoffen.",
  "jurisdiction": [
    {
      "coding": [
        {
          "system": "urn:iso:std:iso:3166",
          "code": "DE",
          "display": "Germany"
        }
      ]
    }
  ],
  "purpose": "Migration von ATC-Codes für Substanzen, die 2021 umkodiert wurden. Enthält nur geänderte Codes, keine neuen oder unveränderten Einträge.",
  "sourceCanonical": "https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/ValueSet/mii-vs-onko-systemische-therapie-substanzen-2020",
  "targetCanonical": "https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/ValueSet/mii-vs-onko-systemische-therapie-substanzen-2021",
  "group": [
    {
      "source": "http://fhir.de/CodeSystem/bfarm/atc",
      "target": "http://fhir.de/CodeSystem/bfarm/atc",
      "element": [
        {
          "code": "L01XE01",
          "display": "Imatinib",
          "target": [
            {
              "code": "L01EA01",
              "display": "Imatinib",
              "equivalence": "equivalent",
              "comment": "Reklassifizierung zu BCR-ABL Tyrosinkinase-Inhibitoren"
            }
          ]
        },
        {
          "code": "L01XE06",
          "display": "Dasatinib",
          "target": [
            {
              "code": "L01EA02",
              "display": "Dasatinib",
              "equivalence": "equivalent"
            }
          ]
        },
        {
          "code": "L01XE08",
          "display": "Nilotinib",
          "target": [
            {
              "code": "L01EA03",
              "display": "Nilotinib",
              "equivalence": "equivalent"
            }
          ]
        },
        {
          "code": "L01XE14",
          "display": "Bosutinib",
          "target": [
            {
              "code": "L01EA04",
              "display": "Bosutinib",
              "equivalence": "equivalent"
            }
          ]
        },
        {
          "code": "L01XE24",
          "display": "Ponatinib",
          "target": [
            {
              "code": "L01EA05",
              "display": "Ponatinib",
              "equivalence": "equivalent"
            }
          ]
        },
        {
          "code": "L01XE02",
          "display": "Gefitinib",
          "target": [
            {
              "code": "L01EB01",
              "display": "Gefitinib",
              "equivalence": "equivalent",
              "comment": "Reklassifizierung zu EGFR Tyrosinkinase-Inhibitoren"
            }
          ]
        },
        {
          "code": "L01XE03",
          "display": "Erlotinib",
          "target": [
            {
              "code": "L01EB02",
              "display": "Erlotinib",
              "equivalence": "equivalent"
            }
          ]
        },
        {
          "code": "L01XE13",
          "display": "Afatinib",
          "target": [
            {
              "code": "L01EB03",
              "display": "Afatinib",
              "equivalence": "equivalent"
            }
          ]
        },
        {
          "code": "L01XE35",
          "display": "Osimertinib",
          "target": [
            {
              "code": "L01EB04",
              "display": "Osimertinib",
              "equivalence": "equivalent"
            }
          ]
        },
        {
          "code": "L01XE15",
          "display": "Vemurafenib",
          "target": [
            {
              "code": "L01EC01",
              "display": "Vemurafenib",
              "equivalence": "equivalent",
              "comment": "Reklassifizierung zu BRAF-Inhibitoren"
            }
          ]
        },
        {
          "code": "L01XE23",
          "display": "Dabrafenib",
          "target": [
            {
              "code": "L01EC02",
              "display": "Dabrafenib",
              "equivalence": "equivalent"
            }
          ]
        },
        {
          "code": "L01XE46",
          "display": "Encorafenib",
          "target": [
            {
              "code": "L01EC03",
              "display": "Encorafenib",
              "equivalence": "equivalent"
            }
          ]
        },
        {
          "code": "L01XE16",
          "display": "Crizotinib",
          "target": [
            {
              "code": "L01ED01",
              "display": "Crizotinib",
              "equivalence": "equivalent",
              "comment": "Reklassifizierung zu ALK-Inhibitoren"
            }
          ]
        },
        {
          "code": "L01XE28",
          "display": "Ceritinib",
          "target": [
            {
              "code": "L01ED02",
              "display": "Ceritinib",
              "equivalence": "equivalent"
            }
          ]
        },
        {
          "code": "L01XE36",
          "display": "Alectinib",
          "target": [
            {
              "code": "L01ED03",
              "display": "Alectinib",
              "equivalence": "equivalent"
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          ]
        },
        {
          "code": "L01XE43",
          "display": "Brigatinib",
          "target": [
            {
              "code": "L01ED04",
              "display": "Brigatinib",
              "equivalence": "equivalent"
            }
          ]
        },
        {
          "code": "L01XE44",
          "display": "Lorlatinib",
          "target": [
            {
              "code": "L01ED05",
              "display": "Lorlatinib",
              "equivalence": "equivalent"
            }
          ]
        },
        {
          "code": "L01XE25",
          "display": "Trametinib",
          "target": [
            {
              "code": "L01EE01",
              "display": "Trametinib",
              "equivalence": "equivalent",
              "comment": "Reklassifizierung zu MEK-Inhibitoren"
            }
          ]
        },
        {
          "code": "L01XE38",
          "display": "Cobimetinib",
          "target": [
            {
              "code": "L01EE02",
              "display": "Cobimetinib",
              "equivalence": "equivalent"
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          ]
        },
        {
          "code": "L01XE41",
          "display": "Binimetinib",
          "target": [
            {
              "code": "L01EE03",
              "display": "Binimetinib",
              "equivalence": "equivalent"
            }
          ]
        },
        {
          "code": "L01XE33",
          "display": "Palbociclib",
          "target": [
            {
              "code": "L01EF01",
              "display": "Palbociclib",
              "equivalence": "equivalent",
              "comment": "Reklassifizierung zu CDK4/6-Inhibitoren"
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          ]
        },
        {
          "code": "L01XE42",
          "display": "Ribociclib",
          "target": [
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              "code": "L01EF02",
              "display": "Ribociclib",
              "equivalence": "equivalent"
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          ]
        },
        {
          "code": "L01XE50",
          "display": "Abemaciclib",
          "target": [
            {
              "code": "L01EF03",
              "display": "Abemaciclib",
              "equivalence": "equivalent"
            }
          ]
        },
        {
          "code": "L01XE09",
          "display": "Temsirolimus",
          "target": [
            {
              "code": "L01EG01",
              "display": "Temsirolimus",
              "equivalence": "equivalent",
              "comment": "Reklassifizierung zu mTOR-Inhibitoren"
            }
          ]
        },
        {
          "code": "L01XE10",
          "display": "Everolimus",
          "target": [
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              "code": "L01EG02",
              "display": "Everolimus",
              "equivalence": "equivalent"
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          ]
        },
        {
          "code": "L01XE07",
          "display": "Lapatinib",
          "target": [
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              "code": "L01EH01",
              "display": "Lapatinib",
              "equivalence": "equivalent",
              "comment": "Reklassifizierung zu HER2-Inhibitoren"
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        },
        {
          "code": "L01XE45",
          "display": "Neratinib",
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              "code": "L01EH02",
              "display": "Neratinib",
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          "display": "Ruxolitinib",
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              "code": "L01EJ01",
              "display": "Ruxolitinib",
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              "comment": "Reklassifizierung zu JAK-Inhibitoren"
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          ]
        },
        {
          "code": "L01XE17",
          "display": "Axitinib",
          "target": [
            {
              "code": "L01EK01",
              "display": "Axitinib",
              "equivalence": "equivalent",
              "comment": "Reklassifizierung zu VEGFR-Inhibitoren"
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          ]
        },
        {
          "code": "L01XE34",
          "display": "Tivozanib",
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              "code": "L01EK03",
              "display": "Tivozanib",
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        {
          "code": "L01XE27",
          "display": "Ibrutinib",
          "target": [
            {
              "code": "L01EL01",
              "display": "Ibrutinib",
              "equivalence": "equivalent",
              "comment": "Reklassifizierung zu BTK-Inhibitoren"
            }
          ]
        },
        {
          "code": "L01XE51",
          "display": "Acalabrutinib",
          "target": [
            {
              "code": "L01EL02",
              "display": "Acalabrutinib",
              "equivalence": "equivalent"
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          ]
        },
        {
          "code": "L01XX47",
          "display": "Idelalisib",
          "target": [
            {
              "code": "L01EM01",
              "display": "Idelalisib",
              "equivalence": "equivalent",
              "comment": "Reklassifizierung zu PI3K-Inhibitoren"
            }
          ]
        },
        {
          "code": "L01XX61",
          "display": "Copanlisib",
          "target": [
            {
              "code": "L01EM02",
              "display": "Copanlisib",
              "equivalence": "equivalent"
            }
          ]
        },
        {
          "code": "L01XE04",
          "display": "Sunitinib",
          "target": [
            {
              "code": "L01EX01",
              "display": "Sunitinib",
              "equivalence": "equivalent",
              "comment": "Reklassifizierung zu andere Proteinkinase-Inhibitoren"
            }
          ]
        },
        {
          "code": "L01XE05",
          "display": "Sorafenib",
          "target": [
            {
              "code": "L01EX02",
              "display": "Sorafenib",
              "equivalence": "equivalent"
            }
          ]
        },
        {
          "code": "L01XE12",
          "display": "Vandetanib",
          "target": [
            {
              "code": "L01EX04",
              "display": "Vandetanib",
              "equivalence": "equivalent"
            }
          ]
        },
        {
          "code": "L01XE21",
          "display": "Regorafenib",
          "target": [
            {
              "code": "L01EX05",
              "display": "Regorafenib",
              "equivalence": "equivalent"
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          ]
        },
        {
          "code": "L01XE26",
          "display": "Cabozantinib",
          "target": [
            {
              "code": "L01EX07",
              "display": "Cabozantinib",
              "equivalence": "equivalent"
            }
          ]
        },
        {
          "code": "L01XE29",
          "display": "Lenvatinib",
          "target": [
            {
              "code": "L01EX08",
              "display": "Lenvatinib",
              "equivalence": "equivalent"
            }
          ]
        },
        {
          "code": "L01XE31",
          "display": "Nintedanib",
          "target": [
            {
              "code": "L01EX09",
              "display": "Nintedanib",
              "equivalence": "equivalent"
            }
          ]
        },
        {
          "code": "L01XE39",
          "display": "Midostaurin",
          "target": [
            {
              "code": "L01EX10",
              "display": "Midostaurin",
              "equivalence": "equivalent"
            }
          ]
        },
        {
          "code": "L01XE52",
          "display": "Quizartinib",
          "target": [
            {
              "code": "L01EX11",
              "display": "Quizartinib",
              "equivalence": "equivalent"
            }
          ]
        },
        {
          "code": "L01XE53",
          "display": "Larotrectinib",
          "target": [
            {
              "code": "L01EX12",
              "display": "Larotrectinib",
              "equivalence": "equivalent"
            }
          ]
        },
        {
          "code": "L01XE54",
          "display": "Gilteritinib",
          "target": [
            {
              "code": "L01EX13",
              "display": "Gilteritinib",
              "equivalence": "equivalent"
            }
          ]
        },
        {
          "code": "L01XX14",
          "display": "Tretinoin",
          "target": [
            {
              "code": "L01XF01",
              "display": "Tretinoin",
              "equivalence": "equivalent",
              "comment": "Reklassifizierung zu Retinoide"
            }
          ]
        },
        {
          "code": "L01XX22",
          "display": "Alitretinoin",
          "target": [
            {
              "code": "L01XF02",
              "display": "Alitretinoin",
              "equivalence": "equivalent"
            }
          ]
        },
        {
          "code": "L01XX25",
          "display": "Bexaroten",
          "target": [
            {
              "code": "L01XF03",
              "display": "Bexaroten",
              "equivalence": "equivalent"
            }
          ]
        },
        {
          "code": "L01XX32",
          "display": "Bortezomib",
          "target": [
            {
              "code": "L01XG01",
              "display": "Bortezomib",
              "equivalence": "equivalent",
              "comment": "Reklassifizierung zu Proteasom-Inhibitoren"
            }
          ]
        },
        {
          "code": "L01XX45",
          "display": "Carfilzomib",
          "target": [
            {
              "code": "L01XG02",
              "display": "Carfilzomib",
              "equivalence": "equivalent"
            }
          ]
        },
        {
          "code": "L01XX50",
          "display": "Ixazomib",
          "target": [
            {
              "code": "L01XG03",
              "display": "Ixazomib",
              "equivalence": "equivalent"
            }
          ]
        },
        {
          "code": "L01XX38",
          "display": "Vorinostat",
          "target": [
            {
              "code": "L01XH01",
              "display": "Vorinostat",
              "equivalence": "equivalent",
              "comment": "Reklassifizierung zu Histon-Deacetylase-Inhibitoren"
            }
          ]
        },
        {
          "code": "L01XX39",
          "display": "Romidepsin",
          "target": [
            {
              "code": "L01XH02",
              "display": "Romidepsin",
              "equivalence": "equivalent"
            }
          ]
        },
        {
          "code": "L01XX42",
          "display": "Panobinostat",
          "target": [
            {
              "code": "L01XH03",
              "display": "Panobinostat",
              "equivalence": "equivalent"
            }
          ]
        },
        {
          "code": "L01XX49",
          "display": "Belinostat",
          "target": [
            {
              "code": "L01XH04",
              "display": "Belinostat",
              "equivalence": "equivalent"
            }
          ]
        },
        {
          "code": "L01XX43",
          "display": "Vismodegib",
          "target": [
            {
              "code": "L01XJ01",
              "display": "Vismodegib",
              "equivalence": "equivalent",
              "comment": "Reklassifizierung zu Hedgehog-Signalweg-Inhibitoren"
            }
          ]
        },
        {
          "code": "L01XX63",
          "display": "Glasdegib",
          "target": [
            {
              "code": "L01XJ03",
              "display": "Glasdegib",
              "equivalence": "equivalent"
            }
          ]
        },
        {
          "code": "L01XX46",
          "display": "Olaparib",
          "target": [
            {
              "code": "L01XK01",
              "display": "Olaparib",
              "equivalence": "equivalent",
              "comment": "Reklassifizierung zu PARP-Inhibitoren"
            }
          ]
        },
        {
          "code": "L01XX54",
          "display": "Niraparib",
          "target": [
            {
              "code": "L01XK02",
              "display": "Niraparib",
              "equivalence": "equivalent"
            }
          ]
        },
        {
          "code": "L01XX60",
          "display": "Talazoparib",
          "target": [
            {
              "code": "L01XK04",
              "display": "Talazoparib",
              "equivalence": "equivalent"
            }
          ]
        },
        {
          "code": "L01XX17",
          "display": "Topotecan",
          "target": [
            {
              "code": "L01CE01",
              "display": "Topotecan",
              "equivalence": "equivalent",
              "comment": "Reklassifizierung zu Topoisomerase-I-Inhibitoren"
            }
          ]
        },
        {
          "code": "L01XX19",
          "display": "Irinotecan",
          "target": [
            {
              "code": "L01CE02",
              "display": "Irinotecan",
              "equivalence": "equivalent"
            }
          ]
        }
      ]
    }
  ]
}