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Source1

{
  "resourceType": "CodeSystem",
  "id": "mii-cs-onko-mamma-her2neu-status-leitlinie",
  "meta": {
    "extension": [
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        "url": "http://hl7.org/fhir/uv/crmi/StructureDefinition/crmi-license",
        "valueCode": "CC-BY-4.0"
      },
      {
        "extension": [
          {
            "url": "packageId",
            "valueId": "de.medizininformatikinitiative.kerndatensatz.onkologie"
          },
          {
            "url": "version",
            "valueString": "2027.0.0-ballot.1"
          },
          {
            "url": "uri",
            "valueUri": "https://www.medizininformatik-initiative.de/fhir/ext/modul-onko"
          }
        ],
        "url": "http://hl7.org/fhir/StructureDefinition/package-source"
      }
    ],
    "profile": [
      "http://hl7.org/fhir/StructureDefinition/shareablecodesystem",
      "http://hl7.org/fhir/uv/crmi/StructureDefinition/crmi-shareablecodesystem",
      "http://hl7.org/fhir/uv/crmi/StructureDefinition/crmi-publishablecodesystem"
    ]
  },
  "text": {
    "status": "generated",
    "div": "<!-- snip (see above) -->"
  },
  "extension": [
    {
      "url": "http://hl7.org/fhir/StructureDefinition/cqf-knowledgeCapability",
      "valueCode": "shareable"
    },
    {
      "url": "http://hl7.org/fhir/StructureDefinition/cqf-knowledgeCapability",
      "valueCode": "publishable"
    },
    {
      "url": "http://hl7.org/fhir/StructureDefinition/artifact-versionPolicy",
      "valueCodeableConcept": {
        "coding": [
          {
            "system": "http://terminology.hl7.org/CodeSystem/artifact-version-policy-codes",
            "code": "package",
            "display": "Package"
          }
        ]
      }
    },
    {
      "url": "http://hl7.org/fhir/StructureDefinition/resource-approvalDate",
      "valueDate": "2026-09-15"
    },
    {
      "url": "http://hl7.org/fhir/StructureDefinition/artifact-topic",
      "valueCodeableConcept": {
        "coding": [
          {
            "system": "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl",
            "code": "C3262"
          }
        ]
      }
    },
    {
      "url": "http://hl7.org/fhir/StructureDefinition/artifact-author",
      "valueContactDetail": {
        "telecom": [
          {
            "system": "email",
            "value": "thomas.debertshaeuser@charite.de"
          }
        ]
      }
    },
    {
      "url": "http://hl7.org/fhir/StructureDefinition/artifact-editor",
      "valueContactDetail": {
        "name": "Taskforce Core Data Set"
      }
    },
    {
      "url": "http://hl7.org/fhir/StructureDefinition/artifact-reviewer",
      "valueContactDetail": {
        "name": "Interoperability Working Group",
        "telecom": [
          {
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            "value": "https://www.medizininformatik-initiative.de/en/collaboration/interoperability-working-group"
          }
        ]
      }
    },
    {
      "url": "http://hl7.org/fhir/StructureDefinition/artifact-reviewer",
      "valueContactDetail": {
        "name": "National Steering Committee",
        "telecom": [
          {
            "system": "url",
            "value": "https://www.medizininformatik-initiative.de/en/collaboration/national-steering-committee"
          }
        ]
      }
    },
    {
      "url": "http://hl7.org/fhir/StructureDefinition/artifact-endorser",
      "valueContactDetail": {
        "name": "Interoperability Working Group",
        "telecom": [
          {
            "system": "url",
            "value": "https://www.medizininformatik-initiative.de/en/collaboration/interoperability-working-group"
          }
        ]
      }
    },
    {
      "url": "http://hl7.org/fhir/StructureDefinition/artifact-endorser",
      "valueContactDetail": {
        "name": "National Steering Committee",
        "telecom": [
          {
            "system": "url",
            "value": "https://www.medizininformatik-initiative.de/en/collaboration/national-steering-committee"
          }
        ]
      }
    },
    {
      "url": "http://hl7.org/fhir/StructureDefinition/artifact-versionAlgorithm",
      "valueCoding": {
        "system": "http://hl7.org/fhir/version-algorithm",
        "code": "semver",
        "display": "SemVer"
      }
    },
    {
      "url": "http://hl7.org/fhir/StructureDefinition/resource-effectivePeriod",
      "valuePeriod": {
        "start": "2027"
      }
    }
  ],
  "url": "https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-mamma-her2neu-status-leitlinie",
  "version": "2027.0.0-ballot.1",
  "name": "MII_CS_Onko_Mamma_Her2neu_Status_Leitlinie",
  "title": "MII CS Onkologie Mamma Her2neu Status Leitlinie",
  "status": "active",
  "experimental": false,
  "date": "2026-09-15T06:26:59+00:00",
  "publisher": "Medizininformatik Initiative",
  "contact": [
    {
      "name": "Medizininformatik Initiative",
      "telecom": [
        {
          "system": "url",
          "value": "https://www.medizininformatik-initiative.de/"
        }
      ]
    }
  ],
  "description": "Codesystem für Her2neu Status basierend auf der S3-Leitlinie Mammakarzinom und ASCO/CAP Guidelines mit erweiterten Klassifikationen (HER2-low, HER2-ultralow)",
  "jurisdiction": [
    {
      "coding": [
        {
          "system": "urn:iso:std:iso:3166",
          "code": "DE",
          "display": "Germany"
        }
      ]
    }
  ],
  "caseSensitive": true,
  "content": "complete",
  "count": 5,
  "concept": [
    {
      "code": "positiv",
      "display": "HER2-positiv",
      "definition": "HER2-positiv: IHC 3+ (Score 3+) oder IHC 2+ (Score 2+) und ISH positiv"
    },
    {
      "code": "low",
      "display": "HER2-low",
      "definition": "HER2-low: IHC 1+ oder IHC 2+ und ISH negativ"
    },
    {
      "code": "ultralow",
      "display": "HER2-ultralow",
      "definition": "HER2-ultralow: IHC 0 mit Membranfärbung"
    },
    {
      "code": "negativ",
      "display": "HER2-negativ",
      "definition": "HER2-negativ: IHC 0 ohne Membranfärbung"
    },
    {
      "code": "equivocal",
      "display": "equivocal",
      "definition": "Equivocal: Grenzwertig/unklarer Befund, weitere Testung erforderlich"
    }
  ]
}