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Source1

{
  "resourceType": "CodeSystem",
  "id": "mii-cs-onko-mamma-her2neu-status-leitlinie",
  "meta": {
    "profile": [
      "http://hl7.org/fhir/StructureDefinition/shareablecodesystem"
    ]
  },
  "url": "https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-mamma-her2neu-status-leitlinie",
  "version": "2026.0.0",
  "name": "MII_CS_Onko_Mamma_Her2neu_Status_Leitlinie",
  "title": "MII CS Onkologie Mamma Her2neu Status Leitlinie",
  "status": "active",
  "experimental": false,
  "publisher": "Medizininformatik Initiative",
  "contact": [
    {
      "telecom": [
        {
          "system": "url",
          "value": "https://www.medizininformatik-initiative.de"
        }
      ]
    }
  ],
  "description": "Codesystem für Her2neu Status basierend auf der S3-Leitlinie Mammakarzinom und ASCO/CAP Guidelines mit erweiterten Klassifikationen (HER2-low, HER2-ultralow)",
  "caseSensitive": true,
  "content": "complete",
  "count": 5,
  "concept": [
    {
      "code": "positiv",
      "display": "HER2-positiv",
      "definition": "HER2-positiv: IHC 3+ (Score 3+) oder IHC 2+ (Score 2+) und ISH positiv"
    },
    {
      "code": "low",
      "display": "HER2-low",
      "definition": "HER2-low: IHC 1+ oder IHC 2+ und ISH negativ"
    },
    {
      "code": "ultralow",
      "display": "HER2-ultralow",
      "definition": "HER2-ultralow: IHC 0 mit Membranfärbung"
    },
    {
      "code": "negativ",
      "display": "HER2-negativ",
      "definition": "HER2-negativ: IHC 0 ohne Membranfärbung"
    },
    {
      "code": "equivocal",
      "display": "equivocal",
      "definition": "Equivocal: Grenzwertig/unklarer Befund, weitere Testung erforderlich"
    }
  ]
}