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Source1

{
  "resourceType": "Observation",
  "id": "mii-exa-mtb-kim-musterperson-TherapeutischeImplikation-PIK3R1",
  "meta": {
    "profile": [
      "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-therapeutische-implikation|2026.0.0"
    ]
  },
  "category": [
    {
      "coding": [
        {
          "system": "http://terminology.hl7.org/CodeSystem/observation-category",
          "code": "laboratory",
          "display": "Laboratory"
        }
      ]
    },
    {
      "coding": [
        {
          "system": "http://terminology.hl7.org/CodeSystem/v2-0074",
          "code": "GE"
        }
      ]
    }
  ],
  "derivedFrom": [
    {
      "reference": "Observation/mii-exa-mtb-kim-musterperson-EinfacheVariante-PIK3R1"
    }
  ],
  "component": [
    {
      "code": {
        "coding": [
          {
            "system": "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
            "code": "conclusion-string"
          }
        ]
      },
      "valueString": "Ausweislich praeklinischer Daten liegt ein Ansprechen auf MEK-Inhibition nahe (PMID: 31209687, EL m3)."
    },
    {
      "code": {
        "coding": [
          {
            "system": "http://loinc.org",
            "code": "51963-7",
            "display": "Medication assessed [ID]"
          }
        ]
      },
      "valueCodeableConcept": {
        "coding": [
          {
            "code": "L01EE",
            "system": "http://fhir.de/CodeSystem/bfarm/atc",
            "display": "Mitogen-aktivierte Proteinkinase (MEK)-Inhibitoren"
          }
        ]
      }
    }
  ],
  "extension": [
    {
      "valueCodeableConcept": {
        "coding": [
          {
            "system": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-empfehlung-evidenzgrad",
            "code": "m3"
          }
        ]
      },
      "url": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-evidenzgraduierung"
    }
  ],
  "code": {
    "coding": [
      {
        "system": "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
        "code": "therapeutic-implication",
        "display": "Therapeutic Implication"
      }
    ]
  },
  "status": "final",
  "subject": {
    "reference": "Patient/PatientKimMusterperson"
  }
}