FHIR IG analytics| Package | de.medizininformatikinitiative.kerndatensatz.mtb |
| Resource Type | Bundle |
| Id | Bundle-mii-exa-mtb-kim-musterperson-bundle.json |
| FHIR Version | R4 |
No resources found
No resources found
No narrative content found in resource
FHIR
FHIRsmith{
"resourceType": "Bundle",
"id": "mii-exa-mtb-kim-musterperson-bundle",
"entry": [
{
"request": {
"method": "PUT",
"url": "ClinicalImpression/mii-exa-mtb-kim-musterperson-behandlungsepisode"
},
"resource": {
"resourceType": "ClinicalImpression",
"id": "mii-exa-mtb-kim-musterperson-behandlungsepisode",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-behandlungsepisode|2026.0.0"
]
},
"effectivePeriod": {
"start": "2023-01-20",
"end": "2023-03-28"
},
"problem": [
{
"reference": "Condition/mii-exa-mtb-kim-diagnose"
}
],
"investigation": [
{
"item": [
{
"reference": "DiagnosticReport/mii-exa-mtb-kim-musterperson-ngs-bericht"
}
],
"code": {
"coding": [
{
"code": "106221001",
"system": "http://snomed.info/sct",
"display": "Genetic finding"
}
]
}
},
{
"item": [
{
"reference": "DiagnosticReport/PatientKimMusterperson-MolecularPathologyReport-1"
}
],
"code": {
"coding": [
{
"code": "60568-3",
"system": "http://loinc.org",
"display": "Pathology synoptic report"
}
]
}
},
{
"item": [
{
"reference": "Observation/mii-exa-onko-allgemeiner-leistungszustand-ecog"
}
],
"code": {
"coding": [
{
"code": "424122007",
"system": "http://snomed.info/sct",
"display": "ECOG performance status finding"
}
]
}
},
{
"item": [
{
"reference": "Observation/mii-exa-mtb-kim-musterperson-aufklaerung"
}
],
"code": {
"coding": [
{
"code": "105511-0",
"system": "http://loinc.org",
"display": "Was consent given"
}
]
}
}
],
"supportingInfo": [
{
"reference": "Procedure/PatientKimMusterperson-Procedure-1"
},
{
"reference": "Observation/PatientKimMusterperson-Observation-1"
},
{
"reference": "Observation/PatientKimMusterperson-Observation-2"
},
{
"reference": "Observation/PatientKimMusterperson-Observation-3"
},
{
"reference": "Observation/PatientKimMusterperson-Observation-4"
},
{
"reference": "Procedure/PatientKimMusterperson-Procedure-2"
},
{
"reference": "Observation/PatientKimMusterperson-Observation-5"
},
{
"reference": "Observation/PatientKimMusterperson-Observation-6"
},
{
"reference": "Observation/PatientKimMusterperson-Observation-7"
},
{
"reference": "Observation/PatientKimMusterperson-Observation-8"
},
{
"reference": "Procedure/PatientKimMusterperson-Procedure-3"
},
{
"reference": "Observation/PatientKimMusterperson-Observation-9"
},
{
"reference": "Observation/PatientKimMusterperson-Observation-10"
},
{
"reference": "Observation/PatientKimMusterperson-Observation-11"
},
{
"reference": "Observation/PatientKimMusterperson-Observation-12"
},
{
"reference": "Observation/PatientKimMusterperson-Observation-13"
},
{
"reference": "Observation/PatientKimMusterperson-Observation-14"
},
{
"reference": "Observation/PatientKimMusterperson-Observation-15"
},
{
"reference": "Procedure/PatientKimMusterperson-Procedure-4"
},
{
"reference": "Procedure/PatientKimMusterperson-Procedure-4a"
},
{
"reference": "Procedure/PatientKimMusterperson-Procedure-4b"
},
{
"reference": "Procedure/PatientKimMusterperson-Procedure-4c"
},
{
"reference": "Procedure/PatientKimMusterperson-Procedure-4d"
},
{
"reference": "Observation/PatientKimMusterperson-Observation-16"
},
{
"reference": "Observation/PatientKimMusterperson-Observation-17"
},
{
"reference": "Observation/PatientKimMusterperson-Observation-18"
},
{
"reference": "Observation/PatientKimMusterperson-Observation-19"
},
{
"reference": "Procedure/PatientKimMusterperson-SystemicTherapy-1"
},
{
"reference": "Procedure/PatientKimMusterperson-SystemicTherapy-2"
},
{
"reference": "Procedure/PatientKimMusterperson-SystemicTherapy-3"
},
{
"reference": "Procedure/MTBChemo1Procedure"
},
{
"reference": "Procedure/PatientKimMusterperson-Procedure-5"
},
{
"reference": "Observation/PatientKimMusterperson-Observation-20"
},
{
"reference": "Observation/PatientKimMusterperson-Observation-21"
},
{
"reference": "Observation/PatientKimMusterperson-Observation-22"
},
{
"reference": "Observation/PatientKimMusterperson-Observation-23"
},
{
"reference": "Procedure/MTBChemo2Procedure"
},
{
"reference": "Procedure/PatientKimMusterperson-Procedure-6"
},
{
"reference": "Observation/PatientKimMusterperson-Observation-24"
},
{
"reference": "Observation/PatientKimMusterperson-Observation-25"
},
{
"reference": "Procedure/PatientKimMusterperson-Procedure-7"
},
{
"reference": "Observation/PatientKimMusterperson-Observation-26"
},
{
"reference": "Observation/PatientKimMusterperson-Observation-27"
},
{
"reference": "Observation/PatientKimMusterperson-Observation-28"
},
{
"reference": "Observation/PatientKimMusterperson-Observation-29"
},
{
"reference": "Observation/PatientKimMusterperson-Observation-30"
}
],
"status": "completed",
"subject": {
"reference": "Patient/PatientKimMusterperson"
}
},
"fullUrl": "http://example.org/fhir/ClinicalImpression/mii-exa-mtb-kim-musterperson-behandlungsepisode"
},
{
"request": {
"method": "PUT",
"url": "Observation/mii-exa-mtb-kim-musterperson-aufklaerung"
},
"resource": {
"resourceType": "Observation",
"id": "mii-exa-mtb-kim-musterperson-aufklaerung",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-consent-given|2026.0.0"
]
},
"status": "final",
"code": {
"coding": [
{
"code": "105511-0",
"system": "http://loinc.org",
"display": "Was consent given"
}
]
},
"valueCodeableConcept": {
"coding": [
{
"system": "http://snomed.info/sct",
"code": "373066001",
"display": "Yes (qualifier value)"
}
]
},
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"effectiveDateTime": "2023-01-02"
},
"fullUrl": "http://example.org/fhir/Observation/mii-exa-mtb-kim-musterperson-aufklaerung"
},
{
"request": {
"method": "PUT",
"url": "Patient/PatientKimMusterperson"
},
"resource": {
"resourceType": "Patient",
"id": "PatientKimMusterperson",
"name": [
{
"given": [
"Kim"
],
"family": "Musterperson"
}
],
"birthDate": "1956-03-14"
},
"fullUrl": "http://example.org/fhir/Patient/PatientKimMusterperson"
},
{
"request": {
"method": "PUT",
"url": "Observation/MTBObservationCA125-1"
},
"resource": {
"resourceType": "Observation",
"id": "MTBObservationCA125-1",
"category": [
{
"coding": [
{
"code": "26436-6",
"system": "http://loinc.org",
"display": "Laboratory studies (set)"
}
]
},
{
"coding": [
{
"code": "laboratory",
"system": "http://terminology.hl7.org/CodeSystem/observation-category"
}
]
}
],
"valueQuantity": {
"value": 42.3,
"unit": "IU/ml",
"code": "[iU]/ml",
"system": "http://unitsofmeasure.org"
},
"status": "final",
"code": {
"coding": [
{
"code": "11210-2",
"system": "http://loinc.org",
"display": "Cancer Ag 125 [Units/volume] in Body fluid"
}
]
},
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"effectiveDateTime": "2022-04-22"
},
"fullUrl": "http://example.org/fhir/Observation/MTBObservationCA125-1"
},
{
"request": {
"method": "PUT",
"url": "Observation/MTBObservationCA125-2"
},
"resource": {
"resourceType": "Observation",
"id": "MTBObservationCA125-2",
"category": [
{
"coding": [
{
"code": "26436-6",
"system": "http://loinc.org",
"display": "Laboratory studies (set)"
}
]
},
{
"coding": [
{
"code": "laboratory",
"system": "http://terminology.hl7.org/CodeSystem/observation-category"
}
]
}
],
"valueQuantity": {
"value": 45.8,
"unit": "IU/ml",
"code": "[iU]/ml",
"system": "http://unitsofmeasure.org"
},
"status": "final",
"code": {
"coding": [
{
"code": "11210-2",
"system": "http://loinc.org",
"display": "Cancer Ag 125 [Units/volume] in Body fluid"
}
]
},
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"effectiveDateTime": "2022-07-18"
},
"fullUrl": "http://example.org/fhir/Observation/MTBObservationCA125-2"
},
{
"request": {
"method": "PUT",
"url": "Observation/MTBObservationCA125-3"
},
"resource": {
"resourceType": "Observation",
"id": "MTBObservationCA125-3",
"category": [
{
"coding": [
{
"code": "26436-6",
"system": "http://loinc.org",
"display": "Laboratory studies (set)"
}
]
},
{
"coding": [
{
"code": "laboratory",
"system": "http://terminology.hl7.org/CodeSystem/observation-category"
}
]
}
],
"valueQuantity": {
"value": 49.7,
"unit": "IU/ml",
"code": "[iU]/ml",
"system": "http://unitsofmeasure.org"
},
"status": "final",
"code": {
"coding": [
{
"code": "11210-2",
"system": "http://loinc.org",
"display": "Cancer Ag 125 [Units/volume] in Body fluid"
}
]
},
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"effectiveDateTime": "2022-10-24"
},
"fullUrl": "http://example.org/fhir/Observation/MTBObservationCA125-3"
},
{
"request": {
"method": "PUT",
"url": "Observation/MTBObservationCA125-4"
},
"resource": {
"resourceType": "Observation",
"id": "MTBObservationCA125-4",
"category": [
{
"coding": [
{
"code": "26436-6",
"system": "http://loinc.org",
"display": "Laboratory studies (set)"
}
]
},
{
"coding": [
{
"code": "laboratory",
"system": "http://terminology.hl7.org/CodeSystem/observation-category"
}
]
}
],
"valueQuantity": {
"value": 67.2,
"unit": "IU/ml",
"code": "[iU]/ml",
"system": "http://unitsofmeasure.org"
},
"status": "final",
"code": {
"coding": [
{
"code": "11210-2",
"system": "http://loinc.org",
"display": "Cancer Ag 125 [Units/volume] in Body fluid"
}
]
},
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"effectiveDateTime": "2022-12-27"
},
"fullUrl": "http://example.org/fhir/Observation/MTBObservationCA125-4"
},
{
"request": {
"method": "PUT",
"url": "Observation/MTBObservationCA125-5"
},
"resource": {
"resourceType": "Observation",
"id": "MTBObservationCA125-5",
"category": [
{
"coding": [
{
"code": "26436-6",
"system": "http://loinc.org",
"display": "Laboratory studies (set)"
}
]
},
{
"coding": [
{
"code": "laboratory",
"system": "http://terminology.hl7.org/CodeSystem/observation-category"
}
]
}
],
"valueQuantity": {
"value": 43.7,
"unit": "IU/ml",
"code": "[iU]/ml",
"system": "http://unitsofmeasure.org"
},
"status": "final",
"code": {
"coding": [
{
"code": "11210-2",
"system": "http://loinc.org",
"display": "Cancer Ag 125 [Units/volume] in Body fluid"
}
]
},
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"effectiveDateTime": "2023-03-24"
},
"fullUrl": "http://example.org/fhir/Observation/MTBObservationCA125-5"
},
{
"request": {
"method": "PUT",
"url": "Observation/MTBObservationCA125-6"
},
"resource": {
"resourceType": "Observation",
"id": "MTBObservationCA125-6",
"category": [
{
"coding": [
{
"code": "26436-6",
"system": "http://loinc.org",
"display": "Laboratory studies (set)"
}
]
},
{
"coding": [
{
"code": "laboratory",
"system": "http://terminology.hl7.org/CodeSystem/observation-category"
}
]
}
],
"valueQuantity": {
"value": 78.2,
"unit": "IU/ml",
"code": "[iU]/ml",
"system": "http://unitsofmeasure.org"
},
"status": "final",
"code": {
"coding": [
{
"code": "11210-2",
"system": "http://loinc.org",
"display": "Cancer Ag 125 [Units/volume] in Body fluid"
}
]
},
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"effectiveDateTime": "2023-06-20"
},
"fullUrl": "http://example.org/fhir/Observation/MTBObservationCA125-6"
},
{
"request": {
"method": "PUT",
"url": "DiagnosticReport/PatientKimMusterperson-MolecularPathologyReport-1"
},
"resource": {
"resourceType": "DiagnosticReport",
"id": "PatientKimMusterperson-MolecularPathologyReport-1",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-molecular-pathology-report|2026.0.0"
]
},
"result": [
{
"reference": "Observation/PatientKimMusterperson-MolecularPathologyObservation-0a-Her2neu"
}
],
"status": "final",
"code": {
"coding": [
{
"code": "60568-3",
"system": "http://loinc.org",
"display": "Pathology synoptic report"
}
]
},
"subject": {
"reference": "Patient/PatientKimMusterperson"
}
},
"fullUrl": "http://example.org/fhir/DiagnosticReport/PatientKimMusterperson-MolecularPathologyReport-1"
},
{
"request": {
"method": "PUT",
"url": "Specimen/PatientKimMusterperson-AscitesSpecimen-2"
},
"resource": {
"resourceType": "Specimen",
"id": "PatientKimMusterperson-AscitesSpecimen-2",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-specimen"
]
},
"collection": {
"collectedDateTime": "2023-02-01"
},
"accessionIdentifier": {
"value": "Z230201/23"
},
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"type": {
"coding": [
{
"code": "309201001",
"system": "http://snomed.info/sct",
"display": "Ascitic fluid specimen (specimen)"
}
]
}
},
"fullUrl": "http://example.org/fhir/Specimen/PatientKimMusterperson-AscitesSpecimen-2"
},
{
"request": {
"method": "PUT",
"url": "Observation/PatientKimMusterperson-MolecularPathologyObservation-0a-Her2neu"
},
"resource": {
"resourceType": "Observation",
"id": "PatientKimMusterperson-MolecularPathologyObservation-0a-Her2neu",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-immunohistochemistry|2026.0.0"
]
},
"category": [
{
"coding": [
{
"system": "http://terminology.hl7.org/CodeSystem/observation-category",
"code": "laboratory"
}
]
},
{
"coding": [
{
"system": "http://terminology.hl7.org/CodeSystem/v2-0074",
"code": "GE"
}
]
},
{
"coding": [
{
"system": "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
"code": "biomarker-category"
}
]
}
],
"code": {
"coding": [
{
"code": "18474-7",
"system": "http://loinc.org",
"display": "HER2 Ag [Presence] in Tissue by Immune stain"
},
{
"code": "1234806008",
"system": "http://snomed.info/sct",
"display": "Observation using immunohistochemistry (observable entity)"
}
]
},
"valueCodeableConcept": {
"coding": [
{
"code": "LA11842-4",
"system": "http://loinc.org",
"display": "2+"
}
]
},
"component": [
{
"code": {
"coding": [
{
"code": "48018-6",
"system": "http://loinc.org",
"display": "Gene studied [ID]"
}
]
},
"valueCodeableConcept": {
"coding": [
{
"code": "HGNC:3430",
"system": "http://www.genenames.org/geneId",
"display": "ERBB2"
}
]
}
}
],
"status": "final",
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"specimen": {
"reference": "Specimen/PatientKimMusterperson-AscitesSpecimen-2"
}
},
"fullUrl": "http://example.org/fhir/Observation/PatientKimMusterperson-MolecularPathologyObservation-0a-Her2neu"
},
{
"request": {
"method": "PUT",
"url": "Observation/PatientKimMusterperson-MolecularPathologyInterpret-0a-Her2neu"
},
"resource": {
"resourceType": "Observation",
"id": "PatientKimMusterperson-MolecularPathologyInterpret-0a-Her2neu",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-immunohistochemistry|2026.0.0"
]
},
"code": {
"coding": [
{
"code": "48676-1",
"system": "http://loinc.org",
"display": "HER2 [Interpretation] in Tissue"
},
{
"code": "1234806008",
"system": "http://snomed.info/sct",
"display": "Observation using immunohistochemistry (observable entity)"
}
]
},
"valueCodeableConcept": {
"coding": [
{
"code": "1381317004",
"system": "http://snomed.info/sct",
"display": "Human epidermal growth factor receptor 2 low"
}
],
"text": "HER2-low (IHC 2+/ISH negative)"
},
"component": [
{
"code": {
"coding": [
{
"code": "48018-6",
"system": "http://loinc.org",
"display": "Gene studied [ID]"
}
]
},
"valueCodeableConcept": {
"coding": [
{
"code": "HGNC:3430",
"system": "http://www.genenames.org/geneId",
"display": "ERBB2"
}
]
}
}
],
"category": [
{
"coding": [
{
"system": "http://terminology.hl7.org/CodeSystem/observation-category",
"code": "laboratory"
}
]
},
{
"coding": [
{
"system": "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
"code": "biomarker-category"
}
]
}
],
"status": "final",
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"specimen": {
"reference": "Specimen/PatientKimMusterperson-AscitesSpecimen-2"
}
},
"fullUrl": "http://example.org/fhir/Observation/PatientKimMusterperson-MolecularPathologyInterpret-0a-Her2neu"
},
{
"request": {
"method": "PUT",
"url": "Observation/PatientKimMusterperson-MolecularPathologyObservation-0b-Folat-Ra"
},
"resource": {
"resourceType": "Observation",
"id": "PatientKimMusterperson-MolecularPathologyObservation-0b-Folat-Ra",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-immunohistochemistry|2026.0.0"
]
},
"code": {
"coding": [
{
"code": "55229-9",
"system": "http://loinc.org",
"display": "Immune stain study"
},
{
"code": "1234806008",
"system": "http://snomed.info/sct",
"display": "Observation using immunohistochemistry (observable entity)"
}
]
},
"valueQuantity": {
"code": "{/100}",
"value": 70,
"unit": "%",
"system": "http://unitsofmeasure.org"
},
"component": [
{
"code": {
"coding": [
{
"code": "48018-6",
"system": "http://loinc.org",
"display": "Gene studied [ID]"
}
]
},
"valueCodeableConcept": {
"coding": [
{
"code": "HGNC:3791",
"system": "http://www.genenames.org/geneId",
"display": "FOLR1"
},
{
"code": "LP440974-6",
"system": "http://loinc.org",
"display": "Folate receptor alpha"
}
]
}
}
],
"category": [
{
"coding": [
{
"system": "http://terminology.hl7.org/CodeSystem/observation-category",
"code": "laboratory"
}
]
},
{
"coding": [
{
"system": "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
"code": "biomarker-category"
}
]
}
],
"status": "final",
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"specimen": {
"reference": "Specimen/PatientKimMusterperson-AscitesSpecimen-2"
}
},
"fullUrl": "http://example.org/fhir/Observation/PatientKimMusterperson-MolecularPathologyObservation-0b-Folat-Ra"
},
{
"request": {
"method": "PUT",
"url": "Observation/PatientKimMusterperson-MolecularPathologyObservation-0c-Trop2"
},
"resource": {
"resourceType": "Observation",
"id": "PatientKimMusterperson-MolecularPathologyObservation-0c-Trop2",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-immunohistochemistry|2026.0.0"
]
},
"code": {
"coding": [
{
"code": "55229-9",
"system": "http://loinc.org",
"display": "Immune stain study"
},
{
"code": "1234806008",
"system": "http://snomed.info/sct",
"display": "Observation using immunohistochemistry (observable entity)"
}
]
},
"valueCodeableConcept": {
"coding": [
{
"code": "LA6576-8",
"system": "http://loinc.org",
"display": "Positive"
}
]
},
"component": [
{
"code": {
"coding": [
{
"code": "48018-6",
"system": "http://loinc.org",
"display": "Gene studied [ID]"
}
]
},
"valueCodeableConcept": {
"coding": [
{
"code": "HGNC:11530",
"system": "http://www.genenames.org/geneId",
"display": "TACSTD2"
},
{
"code": "P09758",
"system": "http://www.uniprot.org",
"display": "Tumor-associated calcium signal transducer 2"
}
]
}
}
],
"category": [
{
"coding": [
{
"system": "http://terminology.hl7.org/CodeSystem/observation-category",
"code": "laboratory"
}
]
},
{
"coding": [
{
"system": "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
"code": "biomarker-category"
}
]
}
],
"status": "final",
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"specimen": {
"reference": "Specimen/PatientKimMusterperson-AscitesSpecimen-2"
}
},
"fullUrl": "http://example.org/fhir/Observation/PatientKimMusterperson-MolecularPathologyObservation-0c-Trop2"
},
{
"request": {
"method": "PUT",
"url": "Observation/PatientKimMusterperson-MolecularPathologyObservation-1-CA125"
},
"resource": {
"resourceType": "Observation",
"id": "PatientKimMusterperson-MolecularPathologyObservation-1-CA125",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-immunohistochemistry|2026.0.0"
]
},
"code": {
"coding": [
{
"code": "48677-9",
"system": "http://loinc.org",
"display": "Cancer Ag 125 [Presence] in Tissue by Immune stain"
},
{
"code": "1234806008",
"system": "http://snomed.info/sct",
"display": "Observation using immunohistochemistry (observable entity)"
}
]
},
"valueCodeableConcept": {
"coding": [
{
"code": "LA6576-8",
"system": "http://loinc.org",
"display": "Positive"
}
],
"text": "Die Tumorzellen sind partiell positiv für CA125,..."
},
"component": [
{
"code": {
"coding": [
{
"code": "48018-6",
"system": "http://loinc.org",
"display": "Gene studied [ID]"
}
]
},
"valueCodeableConcept": {
"coding": [
{
"code": "HGNC:11530",
"system": "http://www.genenames.org/geneId",
"display": "TACSTD2"
},
{
"code": "P09758",
"system": "http://www.uniprot.org",
"display": "Tumor-associated calcium signal transducer 2"
}
]
}
}
],
"category": [
{
"coding": [
{
"system": "http://terminology.hl7.org/CodeSystem/observation-category",
"code": "laboratory"
}
]
},
{
"coding": [
{
"system": "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
"code": "biomarker-category"
}
]
}
],
"status": "final",
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"specimen": {
"reference": "Specimen/PatientKimMusterperson-AscitesSpecimen-2"
}
},
"fullUrl": "http://example.org/fhir/Observation/PatientKimMusterperson-MolecularPathologyObservation-1-CA125"
},
{
"request": {
"method": "PUT",
"url": "Observation/PatientKimMusterperson-MolecularPathologyObservation-2-Pax8"
},
"resource": {
"resourceType": "Observation",
"id": "PatientKimMusterperson-MolecularPathologyObservation-2-Pax8",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-immunohistochemistry|2026.0.0"
]
},
"code": {
"coding": [
{
"code": "73910-2",
"system": "http://loinc.org",
"display": "PAX8 Ag [Presence] in Tissue by Immune stain"
},
{
"code": "1234806008",
"system": "http://snomed.info/sct",
"display": "Observation using immunohistochemistry (observable entity)"
}
]
},
"valueCodeableConcept": {
"coding": [
{
"code": "LA6576-8",
"system": "http://loinc.org",
"display": "Positive"
}
],
"text": "Tumorzellen durchgehend nukleär für Pax 8"
},
"category": [
{
"coding": [
{
"system": "http://terminology.hl7.org/CodeSystem/observation-category",
"code": "laboratory"
}
]
},
{
"coding": [
{
"system": "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
"code": "biomarker-category"
}
]
}
],
"status": "final",
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"specimen": {
"reference": "Specimen/PatientKimMusterperson-AscitesSpecimen-2"
}
},
"fullUrl": "http://example.org/fhir/Observation/PatientKimMusterperson-MolecularPathologyObservation-2-Pax8"
},
{
"request": {
"method": "PUT",
"url": "Observation/PatientKimMusterperson-MolecularPathologyObservation-3-WT1"
},
"resource": {
"resourceType": "Observation",
"id": "PatientKimMusterperson-MolecularPathologyObservation-3-WT1",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-immunohistochemistry|2026.0.0"
]
},
"valueCodeableConcept": {
"coding": [
{
"code": "LA6576-8",
"system": "http://loinc.org",
"display": "Positive"
}
],
"text": "Tumorzellen durchgehend nukleär für WT1"
},
"component": [
{
"code": {
"coding": [
{
"system": "http://loinc.org",
"code": "48018-6",
"display": "Gene studied [ID]"
}
]
},
"valueCodeableConcept": {
"coding": [
{
"code": "HGNC:12796",
"system": "http://www.genenames.org/geneId",
"display": "WT1"
},
{
"code": "LP65352-4",
"system": "http://loinc.org",
"display": "WT-1 Ag"
}
]
}
}
],
"bodySite": {
"coding": [
{
"code": "84640000",
"system": "http://snomed.info/sct",
"display": "Nucleus (cell structure)"
}
],
"text": "Nukleär"
},
"category": [
{
"coding": [
{
"system": "http://terminology.hl7.org/CodeSystem/observation-category",
"code": "laboratory"
}
]
},
{
"coding": [
{
"system": "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
"code": "biomarker-category"
}
]
}
],
"code": {
"coding": [
{
"code": "1234806008",
"system": "http://snomed.info/sct",
"display": "Observation using immunohistochemistry (observable entity)"
}
]
},
"status": "final",
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"specimen": {
"reference": "Specimen/PatientKimMusterperson-AscitesSpecimen-2"
}
},
"fullUrl": "http://example.org/fhir/Observation/PatientKimMusterperson-MolecularPathologyObservation-3-WT1"
},
{
"request": {
"method": "PUT",
"url": "Observation/PatientKimMusterperson-MolecularPathologyObservation-4-ER"
},
"resource": {
"resourceType": "Observation",
"id": "PatientKimMusterperson-MolecularPathologyObservation-4-ER",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-immunohistochemistry|2026.0.0"
]
},
"code": {
"coding": [
{
"code": "14228-1",
"system": "http://loinc.org",
"display": "Cells.estrogen receptor/cells in Tissue by Immune stain"
},
{
"code": "1234806008",
"system": "http://snomed.info/sct",
"display": "Observation using immunohistochemistry (observable entity)"
}
]
},
"valueQuantity": {
"code": "/100",
"value": 70,
"unit": "%",
"system": "http://unitsofmeasure.org"
},
"category": [
{
"coding": [
{
"system": "http://terminology.hl7.org/CodeSystem/observation-category",
"code": "laboratory"
}
]
},
{
"coding": [
{
"system": "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
"code": "biomarker-category"
}
]
}
],
"status": "final",
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"specimen": {
"reference": "Specimen/PatientKimMusterperson-AscitesSpecimen-2"
}
},
"fullUrl": "http://example.org/fhir/Observation/PatientKimMusterperson-MolecularPathologyObservation-4-ER"
},
{
"request": {
"method": "PUT",
"url": "Observation/PatientKimMusterperson-MolecularPathologyObservation-5-PR"
},
"resource": {
"resourceType": "Observation",
"id": "PatientKimMusterperson-MolecularPathologyObservation-5-PR",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-immunohistochemistry|2026.0.0"
]
},
"code": {
"coding": [
{
"code": "14230-7",
"system": "http://loinc.org",
"display": "Cells.progesterone receptor/cells in Tissue by Immune stain"
},
{
"code": "1234806008",
"system": "http://snomed.info/sct",
"display": "Observation using immunohistochemistry (observable entity)"
}
]
},
"valueQuantity": {
"code": "/100",
"value": 30,
"unit": "%",
"system": "http://unitsofmeasure.org"
},
"category": [
{
"coding": [
{
"system": "http://terminology.hl7.org/CodeSystem/observation-category",
"code": "laboratory"
}
]
},
{
"coding": [
{
"system": "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
"code": "biomarker-category"
}
]
}
],
"status": "final",
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"specimen": {
"reference": "Specimen/PatientKimMusterperson-AscitesSpecimen-2"
}
},
"fullUrl": "http://example.org/fhir/Observation/PatientKimMusterperson-MolecularPathologyObservation-5-PR"
},
{
"request": {
"method": "PUT",
"url": "Observation/PatientKimMusterperson-MolecularPathologyObservation-6-p53"
},
"resource": {
"resourceType": "Observation",
"id": "PatientKimMusterperson-MolecularPathologyObservation-6-p53",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-immunohistochemistry|2026.0.0"
]
},
"code": {
"coding": [
{
"code": "14229-9",
"system": "http://loinc.org",
"display": "P53 protein Ag [Presence] in Tissue by Immune stain"
},
{
"code": "1234806008",
"system": "http://snomed.info/sct",
"display": "Observation using immunohistochemistry (observable entity)"
}
]
},
"valueCodeableConcept": {
"coding": [
{
"code": "LA6576-8",
"system": "http://loinc.org",
"display": "Positive"
}
],
"text": "Kräftige nukleäre Überexpression von p53"
},
"category": [
{
"coding": [
{
"system": "http://terminology.hl7.org/CodeSystem/observation-category",
"code": "laboratory"
}
]
},
{
"coding": [
{
"system": "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
"code": "biomarker-category"
}
]
}
],
"status": "final",
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"specimen": {
"reference": "Specimen/PatientKimMusterperson-AscitesSpecimen-2"
}
},
"fullUrl": "http://example.org/fhir/Observation/PatientKimMusterperson-MolecularPathologyObservation-6-p53"
},
{
"request": {
"method": "PUT",
"url": "Observation/PatientKimMusterperson-MolecularPathologyObservation-7-p53"
},
"resource": {
"resourceType": "Observation",
"id": "PatientKimMusterperson-MolecularPathologyObservation-7-p53",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-immunohistochemistry|2026.0.0"
]
},
"code": {
"coding": [
{
"code": "14229-9",
"system": "http://loinc.org",
"display": "P53 protein Ag [Presence] in Tissue by Immune stain"
},
{
"code": "1234806008",
"system": "http://snomed.info/sct",
"display": "Observation using immunohistochemistry (observable entity)"
}
]
},
"valueCodeableConcept": {
"coding": [
{
"code": "LA6576-8",
"system": "http://loinc.org",
"display": "Positive"
}
],
"text": "Kräftige nukleäre Überexpression von p53"
},
"category": [
{
"coding": [
{
"system": "http://terminology.hl7.org/CodeSystem/observation-category",
"code": "laboratory"
}
]
},
{
"coding": [
{
"system": "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
"code": "biomarker-category"
}
]
}
],
"status": "final",
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"specimen": {
"reference": "Specimen/PatientKimMusterperson-AscitesSpecimen-2"
}
},
"fullUrl": "http://example.org/fhir/Observation/PatientKimMusterperson-MolecularPathologyObservation-7-p53"
},
{
"request": {
"method": "PUT",
"url": "Procedure/PatientKimMusterperson-Procedure-1"
},
"resource": {
"resourceType": "Procedure",
"id": "PatientKimMusterperson-Procedure-1",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/core/modul-prozedur/StructureDefinition/Procedure"
]
},
"category": {
"coding": [
{
"system": "http://snomed.info/sct",
"code": "363680008",
"display": "Radiographic imaging procedure"
}
]
},
"code": {
"coding": [
{
"code": "3-20",
"system": "http://fhir.de/CodeSystem/bfarm/ops",
"display": "Computertomographie [CT], nativ",
"version": "2025"
}
]
},
"bodySite": [
{
"coding": [
{
"code": "818983003",
"system": "http://snomed.info/sct",
"display": "Abdomen"
}
]
},
{
"coding": [
{
"code": "51185008",
"system": "http://snomed.info/sct",
"display": "Thoracic structure"
}
]
}
],
"status": "completed",
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"performedDateTime": "2022-04-20"
},
"fullUrl": "http://example.org/fhir/Procedure/PatientKimMusterperson-Procedure-1"
},
{
"request": {
"method": "PUT",
"url": "Procedure/PatientKimMusterperson-Procedure-2"
},
"resource": {
"resourceType": "Procedure",
"id": "PatientKimMusterperson-Procedure-2",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/core/modul-prozedur/StructureDefinition/Procedure"
]
},
"category": {
"coding": [
{
"system": "http://snomed.info/sct",
"code": "363680008",
"display": "Radiographic imaging procedure"
}
]
},
"code": {
"coding": [
{
"code": "3-20",
"system": "http://fhir.de/CodeSystem/bfarm/ops",
"display": "Computertomographie [CT], nativ",
"version": "2025"
}
]
},
"bodySite": [
{
"coding": [
{
"code": "818983003",
"system": "http://snomed.info/sct",
"display": "Abdomen"
}
]
},
{
"coding": [
{
"code": "51185008",
"system": "http://snomed.info/sct",
"display": "Thoracic structure"
}
]
}
],
"status": "completed",
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"performedDateTime": "2022-07-15"
},
"fullUrl": "http://example.org/fhir/Procedure/PatientKimMusterperson-Procedure-2"
},
{
"request": {
"method": "PUT",
"url": "Procedure/PatientKimMusterperson-Procedure-3"
},
"resource": {
"resourceType": "Procedure",
"id": "PatientKimMusterperson-Procedure-3",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/core/modul-prozedur/StructureDefinition/Procedure"
]
},
"category": {
"coding": [
{
"system": "http://snomed.info/sct",
"code": "363680008",
"display": "Radiographic imaging procedure"
}
]
},
"code": {
"coding": [
{
"code": "3-20",
"system": "http://fhir.de/CodeSystem/bfarm/ops",
"display": "Computertomographie [CT], nativ",
"version": "2025"
}
]
},
"bodySite": [
{
"coding": [
{
"code": "818983003",
"system": "http://snomed.info/sct",
"display": "Abdomen"
}
]
},
{
"coding": [
{
"code": "51185008",
"system": "http://snomed.info/sct",
"display": "Thoracic structure"
}
]
}
],
"status": "completed",
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"performedDateTime": "2022-10-22"
},
"fullUrl": "http://example.org/fhir/Procedure/PatientKimMusterperson-Procedure-3"
},
{
"request": {
"method": "PUT",
"url": "Procedure/PatientKimMusterperson-Procedure-4"
},
"resource": {
"resourceType": "Procedure",
"id": "PatientKimMusterperson-Procedure-4",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/core/modul-prozedur/StructureDefinition/Procedure"
]
},
"category": {
"coding": [
{
"system": "http://snomed.info/sct",
"code": "363680008",
"display": "Radiographic imaging procedure"
}
]
},
"code": {
"coding": [
{
"code": "3-20",
"system": "http://fhir.de/CodeSystem/bfarm/ops",
"display": "Computertomographie [CT], nativ",
"version": "2025"
}
]
},
"bodySite": [
{
"coding": [
{
"code": "818983003",
"system": "http://snomed.info/sct",
"display": "Abdomen"
}
]
},
{
"coding": [
{
"code": "51185008",
"system": "http://snomed.info/sct",
"display": "Thoracic structure"
}
]
}
],
"status": "completed",
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"performedDateTime": "2022-12-19"
},
"fullUrl": "http://example.org/fhir/Procedure/PatientKimMusterperson-Procedure-4"
},
{
"request": {
"method": "PUT",
"url": "Procedure/PatientKimMusterperson-Procedure-5"
},
"resource": {
"resourceType": "Procedure",
"id": "PatientKimMusterperson-Procedure-5",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/core/modul-prozedur/StructureDefinition/Procedure"
]
},
"category": {
"coding": [
{
"system": "http://snomed.info/sct",
"code": "363680008",
"display": "Radiographic imaging procedure"
}
]
},
"code": {
"coding": [
{
"code": "3-20",
"system": "http://fhir.de/CodeSystem/bfarm/ops",
"display": "Computertomographie [CT], nativ",
"version": "2025"
}
]
},
"bodySite": [
{
"coding": [
{
"code": "818983003",
"system": "http://snomed.info/sct",
"display": "Abdomen"
}
]
},
{
"coding": [
{
"code": "51185008",
"system": "http://snomed.info/sct",
"display": "Thoracic structure"
}
]
}
],
"status": "completed",
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"performedDateTime": "2023-03-20"
},
"fullUrl": "http://example.org/fhir/Procedure/PatientKimMusterperson-Procedure-5"
},
{
"request": {
"method": "PUT",
"url": "Procedure/PatientKimMusterperson-Procedure-6"
},
"resource": {
"resourceType": "Procedure",
"id": "PatientKimMusterperson-Procedure-6",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/core/modul-prozedur/StructureDefinition/Procedure"
]
},
"category": {
"coding": [
{
"system": "http://snomed.info/sct",
"code": "363680008",
"display": "Radiographic imaging procedure"
}
]
},
"code": {
"coding": [
{
"code": "3-20",
"system": "http://fhir.de/CodeSystem/bfarm/ops",
"display": "Computertomographie [CT], nativ",
"version": "2025"
}
]
},
"bodySite": [
{
"coding": [
{
"code": "818983003",
"system": "http://snomed.info/sct",
"display": "Abdomen"
}
]
},
{
"coding": [
{
"code": "51185008",
"system": "http://snomed.info/sct",
"display": "Thoracic structure"
}
]
}
],
"status": "completed",
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"performedDateTime": "2023-08-20"
},
"fullUrl": "http://example.org/fhir/Procedure/PatientKimMusterperson-Procedure-6"
},
{
"request": {
"method": "PUT",
"url": "Procedure/PatientKimMusterperson-Procedure-7"
},
"resource": {
"resourceType": "Procedure",
"id": "PatientKimMusterperson-Procedure-7",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/core/modul-prozedur/StructureDefinition/Procedure"
]
},
"category": {
"coding": [
{
"system": "http://snomed.info/sct",
"code": "363680008",
"display": "Radiographic imaging procedure"
}
]
},
"code": {
"coding": [
{
"code": "3-20",
"system": "http://fhir.de/CodeSystem/bfarm/ops",
"display": "Computertomographie [CT], nativ",
"version": "2025"
}
]
},
"bodySite": [
{
"coding": [
{
"code": "818983003",
"system": "http://snomed.info/sct",
"display": "Abdomen"
}
]
},
{
"coding": [
{
"code": "51185008",
"system": "http://snomed.info/sct",
"display": "Thoracic structure"
}
]
}
],
"status": "completed",
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"performedDateTime": "2023-10-22"
},
"fullUrl": "http://example.org/fhir/Procedure/PatientKimMusterperson-Procedure-7"
},
{
"request": {
"method": "PUT",
"url": "Observation/PatientKimMusterperson-Observation-1"
},
"resource": {
"resourceType": "Observation",
"id": "PatientKimMusterperson-Observation-1",
"partOf": [
{
"reference": "Procedure/PatientKimMusterperson-Procedure-1"
}
],
"code": {
"coding": [
{
"code": "128462008",
"system": "http://snomed.info/sct",
"display": "Metastatic malignant neoplasm (disorder)"
}
]
},
"valueCodeableConcept": {
"coding": [
{
"code": "41647002",
"system": "http://snomed.info/sct",
"display": "No evidence of (contextual qualifier) (qualifier value)"
}
],
"text": "kein Hinweis auf thorakale Metastasierung"
},
"status": "final"
},
"fullUrl": "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-1"
},
{
"request": {
"method": "PUT",
"url": "Observation/PatientKimMusterperson-Observation-2"
},
"resource": {
"resourceType": "Observation",
"id": "PatientKimMusterperson-Observation-2",
"partOf": [
{
"reference": "Procedure/PatientKimMusterperson-Procedure-1"
}
],
"code": {
"coding": [
{
"code": "255227004",
"system": "http://snomed.info/sct",
"display": "Recurrent"
}
]
},
"valueCodeableConcept": {
"coding": [
{
"code": "41647002",
"system": "http://snomed.info/sct",
"display": "No evidence of (contextual qualifier) (qualifier value)"
}
],
"text": "kein Hinweis auf Lokalrezidiv"
},
"status": "final"
},
"fullUrl": "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-2"
},
{
"request": {
"method": "PUT",
"url": "Observation/PatientKimMusterperson-Observation-3"
},
"resource": {
"resourceType": "Observation",
"id": "PatientKimMusterperson-Observation-3",
"partOf": [
{
"reference": "Procedure/PatientKimMusterperson-Procedure-1"
}
],
"code": {
"coding": [
{
"code": "389026000",
"system": "http://snomed.info/sct",
"display": "Ascites"
}
]
},
"valueCodeableConcept": {
"coding": [
{
"code": "860638000",
"system": "http://snomed.info/sct",
"display": "No ascites"
}
],
"text": "kein Aszites"
},
"status": "final"
},
"fullUrl": "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-3"
},
{
"request": {
"method": "PUT",
"url": "Observation/PatientKimMusterperson-Observation-4"
},
"resource": {
"resourceType": "Observation",
"id": "PatientKimMusterperson-Observation-4",
"partOf": [
{
"reference": "Procedure/PatientKimMusterperson-Procedure-1"
}
],
"code": {
"coding": [
{
"code": "237679004",
"system": "http://snomed.info/sct",
"display": "Status post (contextual qualifier) (qualifier value)"
},
{
"code": "112231000",
"system": "http://snomed.info/sct",
"display": "Atypical (qualifier value)"
},
{
"code": "174430004",
"system": "http://snomed.info/sct",
"display": "Resection of segment of liver (procedure)"
}
]
},
"valueCodeableConcept": {
"coding": [
{
"code": "309201001",
"system": "http://snomed.info/sct",
"display": "Ascitic fluid specimen"
},
{
"code": "262061000",
"system": "http://snomed.info/sct",
"display": "After surgery"
}
],
"text": "Flüssigkeitskollektion angrenzend DD postoperativ"
},
"status": "final",
"bodySite": {
"coding": [
{
"code": "181247007",
"system": "http://snomed.info/sct",
"display": "Entire duodenum"
}
]
}
},
"fullUrl": "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-4"
},
{
"request": {
"method": "PUT",
"url": "Observation/PatientKimMusterperson-Observation-5"
},
"resource": {
"resourceType": "Observation",
"id": "PatientKimMusterperson-Observation-5",
"partOf": [
{
"reference": "Procedure/PatientKimMusterperson-Procedure-2"
}
],
"code": {
"coding": [
{
"code": "237679004",
"system": "http://snomed.info/sct",
"display": "Status post (contextual qualifier) (qualifier value)"
},
{
"code": "112231000",
"system": "http://snomed.info/sct",
"display": "Atypical"
},
{
"code": "174430004",
"system": "http://snomed.info/sct",
"display": "Resection of segment of liver (procedure)"
}
]
},
"valueCodeableConcept": {
"coding": [
{
"code": "420341009",
"system": "http://snomed.info/sct",
"display": "Constant"
},
{
"code": "309201001",
"system": "http://snomed.info/sct",
"display": "Ascitic fluid specimen"
}
],
"text": "konstante Flüssigkeitskollektion angrenzend"
},
"status": "final",
"bodySite": {
"coding": [
{
"code": "181247007",
"system": "http://snomed.info/sct",
"display": "Entire duodenum"
}
]
}
},
"fullUrl": "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-5"
},
{
"request": {
"method": "PUT",
"url": "Observation/PatientKimMusterperson-Observation-6"
},
"resource": {
"resourceType": "Observation",
"id": "PatientKimMusterperson-Observation-6",
"partOf": [
{
"reference": "Procedure/PatientKimMusterperson-Procedure-2"
}
],
"code": {
"coding": [
{
"code": "389026000",
"system": "http://snomed.info/sct",
"display": "Ascites"
}
]
},
"valueCodeableConcept": {
"coding": [
{
"code": "860638000",
"system": "http://snomed.info/sct",
"display": "No ascites"
}
],
"text": "kein Aszites"
},
"status": "final"
},
"fullUrl": "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-6"
},
{
"request": {
"method": "PUT",
"url": "Observation/PatientKimMusterperson-Observation-7"
},
"resource": {
"resourceType": "Observation",
"id": "PatientKimMusterperson-Observation-7",
"partOf": [
{
"reference": "Procedure/PatientKimMusterperson-Procedure-2"
}
],
"code": {
"coding": [
{
"code": "255227004",
"system": "http://snomed.info/sct",
"display": "Recurrent"
}
]
},
"valueCodeableConcept": {
"coding": [
{
"code": "41647002",
"system": "http://snomed.info/sct",
"display": "No evidence of (contextual qualifier) (qualifier value)"
}
],
"text": "kein Hinweis auf Lokalrezidiv"
},
"status": "final"
},
"fullUrl": "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-7"
},
{
"request": {
"method": "PUT",
"url": "Observation/PatientKimMusterperson-Observation-8"
},
"resource": {
"resourceType": "Observation",
"id": "PatientKimMusterperson-Observation-8",
"partOf": [
{
"reference": "Procedure/PatientKimMusterperson-Procedure-2"
}
],
"code": {
"coding": [
{
"code": "112231000",
"system": "http://snomed.info/sct",
"display": "Atypical"
},
{
"code": "1217294009",
"system": "http://snomed.info/sct",
"display": "Ground glass opacity"
},
{
"code": "44714003",
"system": "http://snomed.info/sct",
"display": "Structure of upper lobe of left lung"
}
],
"text": "im linken Oberlappen der Lunge diskrete milchglasartige Trübung"
},
"valueCodeableConcept": {
"coding": [
{
"code": "41647002",
"system": "http://snomed.info/sct",
"display": "No evidence of (contextual qualifier) (qualifier value)"
},
{
"code": "255058005",
"system": "http://snomed.info/sct",
"display": "Neoplasm of thorax"
}
],
"text": "kein Hinweis auf thorakale Filiae"
},
"status": "final"
},
"fullUrl": "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-8"
},
{
"request": {
"method": "PUT",
"url": "Observation/PatientKimMusterperson-Observation-9"
},
"resource": {
"resourceType": "Observation",
"id": "PatientKimMusterperson-Observation-9",
"partOf": [
{
"reference": "Procedure/PatientKimMusterperson-Procedure-3"
}
],
"code": {
"coding": [
{
"code": "237679004",
"system": "http://snomed.info/sct",
"display": "Status post (contextual qualifier) (qualifier value)"
},
{
"code": "112231000",
"system": "http://snomed.info/sct",
"display": "Atypical"
},
{
"code": "174430004",
"system": "http://snomed.info/sct",
"display": "Resection of segment of liver (procedure)"
}
]
},
"valueCodeableConcept": {
"coding": [
{
"code": "309201001",
"system": "http://snomed.info/sct",
"display": "Ascitic fluid specimen"
},
{
"code": "249567002",
"system": "http://snomed.info/sct",
"display": "Liver edge (finding)"
}
],
"text": "regrediente Flüssigkeitskollektion am Leberrand"
},
"status": "final",
"bodySite": {
"coding": [
{
"code": "181268008",
"system": "http://snomed.info/sct",
"display": "Entire liver"
}
]
}
},
"fullUrl": "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-9"
},
{
"request": {
"method": "PUT",
"url": "Observation/PatientKimMusterperson-Observation-10"
},
"resource": {
"resourceType": "Observation",
"id": "PatientKimMusterperson-Observation-10",
"partOf": [
{
"reference": "Procedure/PatientKimMusterperson-Procedure-3"
}
],
"code": {
"coding": [
{
"code": "237679004",
"system": "http://snomed.info/sct",
"display": "Status post (contextual qualifier) (qualifier value)"
},
{
"code": "112231000",
"system": "http://snomed.info/sct",
"display": "Atypical"
},
{
"code": "174430004",
"system": "http://snomed.info/sct",
"display": "Resection of segment of liver (procedure)"
}
]
},
"valueCodeableConcept": {
"coding": [
{
"code": "94381002",
"system": "http://snomed.info/sct",
"display": "Metastatic malignant neoplasm to liver (disorder)"
},
{
"code": "41647002",
"system": "http://snomed.info/sct",
"display": "No evidence of (contextual qualifier) (qualifier value)"
}
],
"text": "Darüberhinaus kein Hinweis auf Leberfilialisierung."
},
"status": "final",
"bodySite": {
"coding": [
{
"code": "181268008",
"system": "http://snomed.info/sct",
"display": "Entire liver"
}
]
}
},
"fullUrl": "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-10"
},
{
"request": {
"method": "PUT",
"url": "Observation/PatientKimMusterperson-Observation-11"
},
"resource": {
"resourceType": "Observation",
"id": "PatientKimMusterperson-Observation-11",
"partOf": [
{
"reference": "Procedure/PatientKimMusterperson-Procedure-3"
}
],
"code": {
"coding": [
{
"code": "389026000",
"system": "http://snomed.info/sct",
"display": "Ascites"
}
]
},
"valueCodeableConcept": {
"coding": [
{
"code": "860638000",
"system": "http://snomed.info/sct",
"display": "No ascites"
}
],
"text": "kein Aszites"
},
"status": "final"
},
"fullUrl": "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-11"
},
{
"request": {
"method": "PUT",
"url": "Observation/PatientKimMusterperson-Observation-12"
},
"resource": {
"resourceType": "Observation",
"id": "PatientKimMusterperson-Observation-12",
"partOf": [
{
"reference": "Procedure/PatientKimMusterperson-Procedure-3"
}
],
"code": {
"coding": [
{
"code": "255227004",
"system": "http://snomed.info/sct",
"display": "Recurrent"
}
]
},
"valueCodeableConcept": {
"coding": [
{
"code": "41647002",
"system": "http://snomed.info/sct",
"display": "No evidence of (contextual qualifier) (qualifier value)"
}
],
"text": "kein Hinweis auf Lokalrezidiv"
},
"status": "final"
},
"fullUrl": "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-12"
},
{
"request": {
"method": "PUT",
"url": "Observation/PatientKimMusterperson-Observation-13"
},
"resource": {
"resourceType": "Observation",
"id": "PatientKimMusterperson-Observation-13",
"partOf": [
{
"reference": "Procedure/PatientKimMusterperson-Procedure-3"
}
],
"code": {
"coding": [
{
"code": "255227004",
"system": "http://snomed.info/sct",
"display": "Recurrent"
},
{
"code": "1217294009",
"system": "http://snomed.info/sct",
"display": "Ground glass opacity"
},
{
"code": "44714003",
"system": "http://snomed.info/sct",
"display": "Structure of upper lobe of left lung"
}
],
"text": "regrediente Milchglasinfiltrate im linken Oberlappen"
},
"valueCodeableConcept": {
"coding": [
{
"code": "112231000",
"system": "http://snomed.info/sct",
"display": "Atypical"
},
{
"code": "257552002",
"system": "http://snomed.info/sct",
"display": "Inflammation"
}
],
"text": "a.e. atypisch entzündlich"
},
"status": "final"
},
"fullUrl": "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-13"
},
{
"request": {
"method": "PUT",
"url": "Observation/PatientKimMusterperson-Observation-14"
},
"resource": {
"resourceType": "Observation",
"id": "PatientKimMusterperson-Observation-14",
"partOf": [
{
"reference": "Procedure/PatientKimMusterperson-Procedure-3"
}
],
"code": {
"coding": [
{
"code": "245276004",
"system": "http://snomed.info/sct",
"display": "Mediastinal lymph node group"
}
],
"text": "mediastinaler Lymphknoten"
},
"valueCodeableConcept": {
"coding": [
{
"code": "258283002",
"system": "http://snomed.info/sct",
"display": "Lymphomatous nodal involvement"
},
{
"code": "373067005",
"system": "http://snomed.info/sct",
"display": "No"
},
{
"code": "385420005",
"system": "http://snomed.info/sct",
"display": "Contrast media"
},
{
"code": "151174005",
"system": "http://snomed.info/sct",
"display": "Drug intake observed"
}
],
"text": "vermehrter mediastinaler Lymphknotenbesatz ohne Kontrastmittelaufnahme"
},
"status": "final"
},
"fullUrl": "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-14"
},
{
"request": {
"method": "PUT",
"url": "Observation/PatientKimMusterperson-Observation-15"
},
"resource": {
"resourceType": "Observation",
"id": "PatientKimMusterperson-Observation-15",
"partOf": [
{
"reference": "Procedure/PatientKimMusterperson-Procedure-3"
}
],
"code": {
"coding": [
{
"code": "245276004",
"system": "http://snomed.info/sct",
"display": "Mediastinal lymph node group"
}
],
"text": "mediastinaler Lymphknoten"
},
"valueCodeableConcept": {
"coding": [
{
"code": "373067005",
"system": "http://snomed.info/sct",
"display": "No"
},
{
"code": "15454001",
"system": "http://snomed.info/sct",
"display": "Increased size"
}
],
"text": "ohne pathologische Vergrößerung"
},
"status": "final"
},
"fullUrl": "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-15"
},
{
"request": {
"method": "PUT",
"url": "Observation/PatientKimMusterperson-Observation-16"
},
"resource": {
"resourceType": "Observation",
"id": "PatientKimMusterperson-Observation-16",
"partOf": [
{
"reference": "Procedure/PatientKimMusterperson-Procedure-4"
}
],
"code": {
"coding": [
{
"code": "255314001",
"system": "http://snomed.info/sct",
"display": "Progressive"
}
],
"text": "Progredienter Aszites"
},
"valueQuantity": {
"value": 700,
"unit": "ml",
"system": "http://unitsofmeasure.org",
"code": "mL"
},
"status": "final"
},
"fullUrl": "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-16"
},
{
"request": {
"method": "PUT",
"url": "Observation/PatientKimMusterperson-Observation-17"
},
"resource": {
"resourceType": "Observation",
"id": "PatientKimMusterperson-Observation-17",
"partOf": [
{
"reference": "Procedure/PatientKimMusterperson-Procedure-4"
}
],
"code": {
"coding": [
{
"code": "362700006",
"system": "http://snomed.info/sct",
"display": "Entire peritoneal serous membrane of peritoneum"
}
],
"text": "Peritonealblatt"
},
"valueCodeableConcept": {
"coding": [
{
"code": "385420005",
"system": "http://snomed.info/sct",
"display": "Contrast media"
},
{
"code": "49608001",
"system": "http://snomed.info/sct",
"display": "Irregular"
},
{
"code": "260366006",
"system": "http://snomed.info/sct",
"display": "Increase"
},
{
"code": "151174005",
"system": "http://snomed.info/sct",
"display": "Drug intake observed"
}
],
"text": "Peritonealblatt mit zunehmender, unregelmäßiger KM-Aufnahme"
},
"status": "final"
},
"fullUrl": "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-17"
},
{
"request": {
"method": "PUT",
"url": "Observation/PatientKimMusterperson-Observation-18"
},
"resource": {
"resourceType": "Observation",
"id": "PatientKimMusterperson-Observation-18",
"partOf": [
{
"reference": "Procedure/PatientKimMusterperson-Procedure-4"
}
],
"code": {
"coding": [
{
"code": "836274002",
"system": "http://snomed.info/sct",
"display": "Carcinomatosis of peritoneum"
}
],
"text": "Peritonealkarzinose"
},
"valueCodeableConcept": {
"coding": [
{
"code": "255314001",
"system": "http://snomed.info/sct",
"display": "Progressive"
}
],
"text": "Progress"
},
"status": "final"
},
"fullUrl": "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-18"
},
{
"request": {
"method": "PUT",
"url": "Observation/PatientKimMusterperson-Observation-19"
},
"resource": {
"resourceType": "Observation",
"id": "PatientKimMusterperson-Observation-19",
"partOf": [
{
"reference": "Procedure/PatientKimMusterperson-Procedure-4"
}
],
"code": {
"coding": [
{
"code": "80266002",
"system": "http://snomed.info/sct",
"display": "True pelvis"
}
],
"text": "kleinen Becken"
},
"valueCodeableConcept": {
"coding": [
{
"code": "255227004",
"system": "http://snomed.info/sct",
"display": "Recurrent"
}
],
"text": "Lokalrezidiv bei kontrastmittelaufnehmender Raumforderung"
},
"status": "final"
},
"fullUrl": "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-19"
},
{
"request": {
"method": "PUT",
"url": "Observation/PatientKimMusterperson-Observation-20"
},
"resource": {
"resourceType": "Observation",
"id": "PatientKimMusterperson-Observation-20",
"partOf": [
{
"reference": "Procedure/PatientKimMusterperson-Procedure-5"
}
],
"code": {
"coding": [
{
"code": "389026000",
"system": "http://snomed.info/sct",
"display": "Ascites"
}
],
"text": "Aszites"
},
"valueCodeableConcept": {
"coding": [
{
"code": "37865006",
"system": "http://snomed.info/sct",
"display": "Regressive"
}
],
"text": "Regredient"
},
"status": "final"
},
"fullUrl": "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-20"
},
{
"request": {
"method": "PUT",
"url": "Observation/PatientKimMusterperson-Observation-21"
},
"resource": {
"resourceType": "Observation",
"id": "PatientKimMusterperson-Observation-21",
"partOf": [
{
"reference": "Procedure/PatientKimMusterperson-Procedure-5"
}
],
"code": {
"coding": [
{
"code": "80266002",
"system": "http://snomed.info/sct",
"display": "True pelvis"
}
],
"text": "im kleinen Becken"
},
"valueCodeableConcept": {
"coding": [
{
"code": "37865006",
"system": "http://snomed.info/sct",
"display": "Regressive"
},
{
"code": "385420005",
"system": "http://snomed.info/sct",
"display": "Contrast media"
}
],
"text": "rückläufige KM-Aufnahme der lokalrezidivsuspekten Raumforderung"
},
"status": "final"
},
"fullUrl": "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-21"
},
{
"request": {
"method": "PUT",
"url": "Observation/PatientKimMusterperson-Observation-22"
},
"resource": {
"resourceType": "Observation",
"id": "PatientKimMusterperson-Observation-22",
"partOf": [
{
"reference": "Procedure/PatientKimMusterperson-Procedure-5"
}
],
"code": {
"coding": [
{
"code": "274744005",
"system": "http://snomed.info/sct",
"display": "Localized enlarged lymph nodes"
}
],
"text": "zahlenmäßig vermehrten LK im Mediastinum"
},
"valueCodeableConcept": {
"coding": [
{
"code": "37865006",
"system": "http://snomed.info/sct",
"display": "Regressive"
},
{
"code": "385420005",
"system": "http://snomed.info/sct",
"display": "Contrast media"
}
],
"text": "noch flaue, aber insgesamt regrediente KM-Aufnhame"
},
"status": "final"
},
"fullUrl": "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-22"
},
{
"request": {
"method": "PUT",
"url": "Observation/PatientKimMusterperson-Observation-23"
},
"resource": {
"resourceType": "Observation",
"id": "PatientKimMusterperson-Observation-23",
"partOf": [
{
"reference": "Procedure/PatientKimMusterperson-Procedure-5"
}
],
"code": {
"coding": [
{
"code": "52988006",
"system": "http://snomed.info/sct",
"display": "Lesion"
}
],
"text": "Läsion"
},
"valueCodeableConcept": {
"coding": [
{
"code": "373067005",
"system": "http://snomed.info/sct",
"display": "No"
}
],
"text": "keine neue"
},
"status": "final"
},
"fullUrl": "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-23"
},
{
"request": {
"method": "PUT",
"url": "Observation/PatientKimMusterperson-Observation-24"
},
"resource": {
"resourceType": "Observation",
"id": "PatientKimMusterperson-Observation-24",
"partOf": [
{
"reference": "Procedure/PatientKimMusterperson-Procedure-6"
}
],
"code": {
"coding": [
{
"code": "389026000",
"system": "http://snomed.info/sct",
"display": "Ascites"
}
]
},
"valueCodeableConcept": {
"coding": [
{
"code": "860638000",
"system": "http://snomed.info/sct",
"display": "No ascites"
}
],
"text": "kein Aszites"
},
"status": "final"
},
"fullUrl": "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-24"
},
{
"request": {
"method": "PUT",
"url": "Observation/PatientKimMusterperson-Observation-25"
},
"resource": {
"resourceType": "Observation",
"id": "PatientKimMusterperson-Observation-25",
"partOf": [
{
"reference": "Procedure/PatientKimMusterperson-Procedure-6"
}
],
"code": {
"coding": [
{
"code": "255227004",
"system": "http://snomed.info/sct",
"display": "Recurrent"
}
],
"text": "Lokalrezidiv"
},
"valueCodeableConcept": {
"coding": [
{
"code": "37865006",
"system": "http://snomed.info/sct",
"display": "Regressive"
},
{
"code": "373067005",
"system": "http://snomed.info/sct",
"display": "No"
},
{
"code": "385420005",
"system": "http://snomed.info/sct",
"display": "Contrast media"
},
{
"code": "151174005",
"system": "http://snomed.info/sct",
"display": "Drug intake observed"
}
],
"text": "regredientes Lokalrezidiv ohne KM-Aufnahme im kleinen Becken"
},
"status": "final"
},
"fullUrl": "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-25"
},
{
"request": {
"method": "PUT",
"url": "Observation/PatientKimMusterperson-Observation-26"
},
"resource": {
"resourceType": "Observation",
"id": "PatientKimMusterperson-Observation-26",
"partOf": [
{
"reference": "Procedure/PatientKimMusterperson-Procedure-7"
}
],
"code": {
"coding": [
{
"code": "80266002",
"system": "http://snomed.info/sct",
"display": "True pelvis"
}
],
"text": "kleinen Becken"
},
"valueCodeableConcept": {
"coding": [
{
"code": "255606000",
"system": "http://snomed.info/sct",
"display": "Minor"
},
{
"code": "389026000",
"system": "http://snomed.info/sct",
"display": "Ascites"
}
],
"text": "geringer Aszites"
},
"status": "final"
},
"fullUrl": "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-26"
},
{
"request": {
"method": "PUT",
"url": "Observation/PatientKimMusterperson-Observation-27"
},
"resource": {
"resourceType": "Observation",
"id": "PatientKimMusterperson-Observation-27",
"partOf": [
{
"reference": "Procedure/PatientKimMusterperson-Procedure-7"
}
],
"code": {
"coding": [
{
"code": "237679004",
"system": "http://snomed.info/sct",
"display": "Status post (contextual qualifier) (qualifier value)"
},
{
"code": "246455001",
"system": "http://snomed.info/sct",
"display": "Recurrence"
}
],
"text": "vormals KM-aufnehmendes Lokalrezidiv im kleinen Becken"
},
"valueCodeableConcept": {
"coding": [
{
"code": "246455001",
"system": "http://snomed.info/sct",
"display": "Recurrence"
},
{
"code": "263920009",
"system": "http://snomed.info/sct",
"display": "Unrecordable"
}
],
"text": "aktuell metrisch nur noch schwer fassbar"
},
"bodySite": {
"coding": [
{
"code": "80266002",
"system": "http://snomed.info/sct",
"display": "True pelvis"
}
]
},
"status": "final"
},
"fullUrl": "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-27"
},
{
"request": {
"method": "PUT",
"url": "Observation/PatientKimMusterperson-Observation-29"
},
"resource": {
"resourceType": "Observation",
"id": "PatientKimMusterperson-Observation-29",
"partOf": [
{
"reference": "Procedure/PatientKimMusterperson-Procedure-7"
}
],
"code": {
"coding": [
{
"code": "245276004",
"system": "http://snomed.info/sct",
"display": "Mediastinal lymph node group"
}
],
"text": "mediastinale Lymphknoten"
},
"valueCodeableConcept": {
"coding": [
{
"code": "35105006",
"system": "http://snomed.info/sct",
"display": "Increased"
}
],
"text": "formal noch vermehrte"
},
"status": "final"
},
"fullUrl": "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-29"
},
{
"request": {
"method": "PUT",
"url": "Observation/PatientKimMusterperson-Observation-30"
},
"resource": {
"resourceType": "Observation",
"id": "PatientKimMusterperson-Observation-30",
"partOf": [
{
"reference": "Procedure/PatientKimMusterperson-Procedure-7"
}
],
"code": {
"coding": [
{
"code": "245276004",
"system": "http://snomed.info/sct",
"display": "Mediastinal lymph node group"
}
],
"text": "mediastinale Lymphknoten"
},
"valueCodeableConcept": {
"coding": [
{
"code": "373067005",
"system": "http://snomed.info/sct",
"display": "No"
},
{
"code": "385420005",
"system": "http://snomed.info/sct",
"display": "Contrast media"
},
{
"code": "151174005",
"system": "http://snomed.info/sct",
"display": "Drug intake observed"
}
],
"text": "nicht mehr KM-aufnehmende"
},
"status": "final"
},
"fullUrl": "http://example.org/fhir/Observation/PatientKimMusterperson-Observation-30"
},
{
"request": {
"method": "PUT",
"url": "ClinicalImpression/MII-EXA-MTB-Follow-Up-ClinicalImpression-1"
},
"resource": {
"resourceType": "ClinicalImpression",
"id": "MII-EXA-MTB-Follow-Up-ClinicalImpression-1",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-follow-up-clinicalimpression|2026.0.0"
]
},
"code": {
"coding": [
{
"code": "390906007",
"system": "http://snomed.info/sct",
"display": "Follow-up encounter (procedure)"
}
]
},
"investigation": [
{
"code": {
"coding": [
{
"code": "completed",
"system": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-follow-up-status"
}
]
}
}
],
"supportingInfo": [
{
"reference": "Procedure/MII-EXA-MTB-Systemische-Therapie-1"
},
{
"reference": "Claim/MII-EXA-MTB-Antrag-Kostenuebernahme-1"
},
{
"reference": "ClaimResponse/MII-EXA-MTB-Antwort-Kostenuebernahme-1"
}
],
"status": "completed",
"effectiveDateTime": "2023-10-22",
"previous": {
"reference": "ClinicalImpression/mii-exa-mtb-kim-musterperson-behandlungsepisode"
},
"subject": {
"reference": "Patient/PatientKimMusterperson"
}
},
"fullUrl": "http://example.org/fhir/ClinicalImpression/MII-EXA-MTB-Follow-Up-ClinicalImpression-1"
},
{
"request": {
"method": "PUT",
"url": "Procedure/MII-EXA-MTB-Systemische-Therapie-1"
},
"resource": {
"resourceType": "Procedure",
"id": "MII-EXA-MTB-Systemische-Therapie-1",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-systemische-therapie|2026.0.0"
]
},
"extension": [
{
"valueCodeableConcept": {
"coding": [
{
"system": "https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-intention",
"code": "K"
}
]
},
"url": "https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-ex-onko-systemische-therapie-intention"
}
],
"code": {
"coding": [
{
"code": "CH",
"system": "https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-therapie-typ"
},
{
"system": "http://fhir.de/CodeSystem/bfarm/ops",
"code": "8-54",
"display": "Zytostatische Chemotherapie, Immuntherapie und antiretrovirale Therapie",
"version": "2023"
}
]
},
"performedPeriod": {
"start": "2023-06-24",
"end": "2023-10-12"
},
"basedOn": [
{
"reference": "CarePlan/mii-exa-mtb-kim-musterperson-therapieplan"
}
],
"status": "completed",
"statusReason": {
"coding": [
{
"code": "regular-completion"
}
]
},
"category": {
"coding": [
{
"code": "367336001",
"system": "http://snomed.info/sct",
"display": "Chemotherapy (procedure)"
}
]
},
"subject": {
"reference": "Patient/PatientKimMusterperson"
}
},
"fullUrl": "http://example.org/fhir/Procedure/MII-EXA-MTB-Systemische-Therapie-1"
},
{
"request": {
"method": "PUT",
"url": "MedicationStatement/MII-EXA-MTB-Systemische-Therapie-Medication-1"
},
"resource": {
"resourceType": "MedicationStatement",
"id": "MII-EXA-MTB-Systemische-Therapie-Medication-1",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-systemtherapie-medication-statement",
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-systemische-therapie-medication-statement|2026.0.0"
]
},
"basedOn": [
{
"reference": "MedicationRequest/mii-exa-mtb-medication-request-mirvetuximab"
}
],
"partOf": [
{
"reference": "Procedure/MII-EXA-MTB-Systemische-Therapie-1"
}
],
"medicationCodeableConcept": {
"coding": [
{
"code": "98DE7VN88D",
"system": "http://fdasis.nlm.nih.gov",
"display": "MIRVETUXIMAB SORAVTANSINE"
},
{
"system": "http://fhir.de/CodeSystem/bfarm/atc",
"code": "L01FX26",
"display": "Mirvetuximab soravtansin",
"version": "2025"
}
]
},
"effectivePeriod": {
"start": "2023-06-24",
"end": "2023-06-24"
},
"note": [
{
"text": "24.06.2023 Z1 Mirvetuximab soravtansine 6mg/kg KG, Wdh d22"
}
],
"dosage": [
{
"doseAndRate": [
{
"doseQuantity": {
"value": 6,
"unit": "mg/kg KG",
"code": "mg/kg{KG}",
"system": "http://unitsofmeasure.org"
}
}
]
}
],
"status": "completed",
"subject": {
"reference": "Patient/PatientKimMusterperson"
}
},
"fullUrl": "http://example.org/fhir/MedicationStatement/MII-EXA-MTB-Systemische-Therapie-Medication-1"
},
{
"request": {
"method": "PUT",
"url": "MedicationStatement/MII-EXA-MTB-Systemische-Therapie-Medication-2"
},
"resource": {
"resourceType": "MedicationStatement",
"id": "MII-EXA-MTB-Systemische-Therapie-Medication-2",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-systemtherapie-medication-statement",
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-systemische-therapie-medication-statement|2026.0.0"
]
},
"basedOn": [
{
"reference": "MedicationRequest/mii-exa-mtb-medication-request-mirvetuximab"
}
],
"partOf": [
{
"reference": "Procedure/MII-EXA-MTB-Systemische-Therapie-1"
}
],
"medicationCodeableConcept": {
"coding": [
{
"code": "98DE7VN88D",
"system": "http://fdasis.nlm.nih.gov",
"display": "MIRVETUXIMAB SORAVTANSINE"
},
{
"system": "http://fhir.de/CodeSystem/bfarm/atc",
"code": "L01FX26",
"display": "Mirvetuximab soravtansin",
"version": "2025"
}
]
},
"effectivePeriod": {
"start": "2023-07-16",
"end": "2023-07-16"
},
"note": [
{
"text": "16.07.2023 Z2 Mirvetuximab soravtansine 6mg/kg KG, Wdh d22"
}
],
"statusReason": [
{
"coding": [
{
"code": "E"
}
]
}
],
"dosage": [
{
"doseAndRate": [
{
"doseQuantity": {
"value": 6,
"unit": "mg/kg KG",
"code": "mg/kg{KG}",
"system": "http://unitsofmeasure.org"
}
}
]
}
],
"status": "completed",
"subject": {
"reference": "Patient/PatientKimMusterperson"
}
},
"fullUrl": "http://example.org/fhir/MedicationStatement/MII-EXA-MTB-Systemische-Therapie-Medication-2"
},
{
"request": {
"method": "PUT",
"url": "MedicationStatement/MII-EXA-MTB-Systemische-Therapie-Medication-3"
},
"resource": {
"resourceType": "MedicationStatement",
"id": "MII-EXA-MTB-Systemische-Therapie-Medication-3",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-systemtherapie-medication-statement",
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-systemische-therapie-medication-statement|2026.0.0"
]
},
"basedOn": [
{
"reference": "MedicationRequest/mii-exa-mtb-medication-request-mirvetuximab"
}
],
"partOf": [
{
"reference": "Procedure/MII-EXA-MTB-Systemische-Therapie-1"
}
],
"medicationCodeableConcept": {
"coding": [
{
"code": "98DE7VN88D",
"system": "http://fdasis.nlm.nih.gov",
"display": "MIRVETUXIMAB SORAVTANSINE"
},
{
"system": "http://fhir.de/CodeSystem/bfarm/atc",
"code": "L01FX26",
"display": "Mirvetuximab soravtansin",
"version": "2025"
}
]
},
"effectivePeriod": {
"start": "2023-08-07",
"end": "2023-08-07"
},
"note": [
{
"text": "07.08.2023 Z3 Mirvetuximab soravtansine 6mg/kg KG, Wdh d22"
}
],
"statusReason": [
{
"coding": [
{
"code": "E"
}
]
}
],
"dosage": [
{
"doseAndRate": [
{
"doseQuantity": {
"value": 6,
"unit": "mg/kg KG",
"code": "mg/kg{KG}",
"system": "http://unitsofmeasure.org"
}
}
]
}
],
"status": "completed",
"subject": {
"reference": "Patient/PatientKimMusterperson"
}
},
"fullUrl": "http://example.org/fhir/MedicationStatement/MII-EXA-MTB-Systemische-Therapie-Medication-3"
},
{
"request": {
"method": "PUT",
"url": "MedicationStatement/MII-EXA-MTB-Systemische-Therapie-Medication-4"
},
"resource": {
"resourceType": "MedicationStatement",
"id": "MII-EXA-MTB-Systemische-Therapie-Medication-4",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-systemtherapie-medication-statement",
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-systemische-therapie-medication-statement|2026.0.0"
]
},
"basedOn": [
{
"reference": "MedicationRequest/mii-exa-mtb-medication-request-mirvetuximab"
}
],
"partOf": [
{
"reference": "Procedure/MII-EXA-MTB-Systemische-Therapie-1"
}
],
"medicationCodeableConcept": {
"coding": [
{
"code": "98DE7VN88D",
"system": "http://fdasis.nlm.nih.gov",
"display": "MIRVETUXIMAB SORAVTANSINE"
},
{
"system": "http://fhir.de/CodeSystem/bfarm/atc",
"code": "L01FX26",
"display": "Mirvetuximab soravtansin",
"version": "2025"
}
]
},
"effectivePeriod": {
"start": "2023-08-29",
"end": "2023-08-29"
},
"note": [
{
"text": "29.08.2023 Z4 Mirvetuximab soravtansine 6mg/kg KG, Wdh d22"
}
],
"dosage": [
{
"doseAndRate": [
{
"doseQuantity": {
"value": 6,
"unit": "mg/kg KG",
"code": "mg/kg{KG}",
"system": "http://unitsofmeasure.org"
}
}
]
}
],
"status": "completed",
"subject": {
"reference": "Patient/PatientKimMusterperson"
}
},
"fullUrl": "http://example.org/fhir/MedicationStatement/MII-EXA-MTB-Systemische-Therapie-Medication-4"
},
{
"request": {
"method": "PUT",
"url": "MedicationStatement/MII-EXA-MTB-Systemische-Therapie-Medication-5"
},
"resource": {
"resourceType": "MedicationStatement",
"id": "MII-EXA-MTB-Systemische-Therapie-Medication-5",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-systemtherapie-medication-statement",
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-systemische-therapie-medication-statement|2026.0.0"
]
},
"basedOn": [
{
"reference": "MedicationRequest/mii-exa-mtb-medication-request-mirvetuximab"
}
],
"partOf": [
{
"reference": "Procedure/MII-EXA-MTB-Systemische-Therapie-1"
}
],
"medicationCodeableConcept": {
"coding": [
{
"code": "98DE7VN88D",
"system": "http://fdasis.nlm.nih.gov",
"display": "MIRVETUXIMAB SORAVTANSINE"
},
{
"system": "http://fhir.de/CodeSystem/bfarm/atc",
"code": "L01FX26",
"display": "Mirvetuximab soravtansin",
"version": "2025"
}
]
},
"effectivePeriod": {
"start": "2023-09-20",
"end": "2023-09-20"
},
"note": [
{
"text": "20.09.2023 Z2 Mirvetuximab soravtansine 6mg/kg KG, Wdh d22"
}
],
"statusReason": [
{
"coding": [
{
"code": "E"
}
]
}
],
"dosage": [
{
"doseAndRate": [
{
"doseQuantity": {
"value": 6,
"unit": "mg/kg KG",
"code": "mg/kg{KG}",
"system": "http://unitsofmeasure.org"
}
}
]
}
],
"status": "completed",
"subject": {
"reference": "Patient/PatientKimMusterperson"
}
},
"fullUrl": "http://example.org/fhir/MedicationStatement/MII-EXA-MTB-Systemische-Therapie-Medication-5"
},
{
"request": {
"method": "PUT",
"url": "MedicationStatement/MII-EXA-MTB-Systemische-Therapie-Medication-6"
},
"resource": {
"resourceType": "MedicationStatement",
"id": "MII-EXA-MTB-Systemische-Therapie-Medication-6",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-systemtherapie-medication-statement",
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-systemische-therapie-medication-statement|2026.0.0"
]
},
"basedOn": [
{
"reference": "MedicationRequest/mii-exa-mtb-medication-request-mirvetuximab"
}
],
"partOf": [
{
"reference": "Procedure/MII-EXA-MTB-Systemische-Therapie-1"
}
],
"medicationCodeableConcept": {
"coding": [
{
"code": "98DE7VN88D",
"system": "http://fdasis.nlm.nih.gov",
"display": "MIRVETUXIMAB SORAVTANSINE"
},
{
"system": "http://fhir.de/CodeSystem/bfarm/atc",
"code": "L01FX26",
"display": "Mirvetuximab soravtansin",
"version": "2025"
}
]
},
"effectivePeriod": {
"start": "2023-10-12",
"end": "2023-10-12"
},
"note": [
{
"text": "12.10.2023 Z3 Mirvetuximab soravtansine 6mg/kg KG, Wdh d22"
}
],
"dosage": [
{
"doseAndRate": [
{
"doseQuantity": {
"value": 6,
"unit": "mg/kg KG",
"code": "mg/kg{KG}",
"system": "http://unitsofmeasure.org"
}
}
]
}
],
"status": "completed",
"subject": {
"reference": "Patient/PatientKimMusterperson"
}
},
"fullUrl": "http://example.org/fhir/MedicationStatement/MII-EXA-MTB-Systemische-Therapie-Medication-6"
},
{
"request": {
"method": "PUT",
"url": "Observation/MII-EXA-MTB-Response-Befund-1"
},
"resource": {
"resourceType": "Observation",
"id": "MII-EXA-MTB-Response-Befund-1",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-response-befund|2026.0.0"
]
},
"focus": [
{
"reference": "Condition/PatientKimMusterperson-PrimaryDiagnosis-2"
}
],
"partOf": [
{
"reference": "Procedure/MII-EXA-MTB-Systemische-Therapie-1"
}
],
"valueCodeableConcept": {
"coding": [
{
"code": "CR",
"system": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-response-befund-beurteilung",
"display": "Complete Response"
}
]
},
"component": [
{
"code": {
"coding": [
{
"system": "http://snomed.info/sct",
"code": "399656008",
"display": "Presence of metastatic neoplasm in regional lymph node (observable entity)"
}
]
},
"valueCodeableConcept": {
"coding": [
{
"code": "K",
"system": "https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-verlauf-lymphknoten",
"display": "kein Lymphknotenbefall nachweisbar"
}
]
}
}
],
"status": "final",
"code": {
"coding": [
{
"code": "396432002",
"system": "http://snomed.info/sct",
"display": "Status of regression of tumor (observable entity)"
}
]
},
"method": {
"coding": [
{
"code": "RECIST",
"system": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-response-befund-beurteilungsmethode",
"display": "RECIST"
}
]
},
"effectiveDateTime": "2023-08-20",
"subject": {
"reference": "Patient/PatientKimMusterperson"
}
},
"fullUrl": "http://example.org/fhir/Observation/MII-EXA-MTB-Response-Befund-1"
},
{
"request": {
"method": "PUT",
"url": "Observation/MII-EXA-MTB-Response-Befund-2"
},
"resource": {
"resourceType": "Observation",
"id": "MII-EXA-MTB-Response-Befund-2",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-response-befund|2026.0.0"
]
},
"focus": [
{
"reference": "Condition/PatientKimMusterperson-PrimaryDiagnosis-2"
}
],
"partOf": [
{
"reference": "Procedure/MII-EXA-MTB-Systemische-Therapie-1"
}
],
"valueCodeableConcept": {
"coding": [
{
"code": "PR",
"system": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-response-befund-beurteilung",
"display": "Partial Response"
}
]
},
"component": [
{
"code": {
"coding": [
{
"system": "http://snomed.info/sct",
"code": "399656008",
"display": "Presence of metastatic neoplasm in regional lymph node (observable entity)"
}
]
},
"valueCodeableConcept": {
"coding": [
{
"code": "K",
"system": "https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-verlauf-lymphknoten",
"display": "kein Lymphknotenbefall nachweisbar"
}
]
}
}
],
"status": "final",
"code": {
"coding": [
{
"code": "396432002",
"system": "http://snomed.info/sct",
"display": "Status of regression of tumor (observable entity)"
}
]
},
"method": {
"coding": [
{
"code": "RECIST",
"system": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-response-befund-beurteilungsmethode",
"display": "RECIST"
}
]
},
"effectiveDateTime": "2023-10-22",
"subject": {
"reference": "Patient/PatientKimMusterperson"
}
},
"fullUrl": "http://example.org/fhir/Observation/MII-EXA-MTB-Response-Befund-2"
},
{
"request": {
"method": "PUT",
"url": "Claim/MII-EXA-MTB-Antrag-Kostenuebernahme-1"
},
"resource": {
"resourceType": "Claim",
"id": "MII-EXA-MTB-Antrag-Kostenuebernahme-1",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-antrag-kostenuebernahme|2026.0.0"
]
},
"insurance": [
{
"focal": true,
"sequence": 1,
"coverage": {
"reference": "Coverage/MyCoverage"
},
"claimResponse": {
"reference": "ClaimResponse/MII-EXA-MTB-Antwort-Kostenuebernahme-1"
}
}
],
"careTeam": [
{
"sequence": 1,
"provider": {
"reference": "Organization/MyInsurer"
},
"responsible": true
}
],
"related": [
{
"relationship": {
"coding": [
{
"code": "initial-claim"
}
]
}
}
],
"status": "active",
"priority": {
"coding": [
{
"code": "normal",
"system": "http://terminology.hl7.org/CodeSystem/processpriority"
}
]
},
"type": {
"coding": [
{
"code": "institutional"
}
]
},
"use": "claim",
"patient": {
"reference": "Patient/PatientKimMusterperson"
},
"created": "2023-03-10",
"provider": {
"reference": "Organization/MyHospital"
},
"prescription": {
"reference": "MedicationRequest/mii-exa-mtb-medication-request-mirvetuximab"
}
},
"fullUrl": "http://example.org/fhir/Claim/MII-EXA-MTB-Antrag-Kostenuebernahme-1"
},
{
"request": {
"method": "PUT",
"url": "ClaimResponse/MII-EXA-MTB-Antwort-Kostenuebernahme-1"
},
"resource": {
"resourceType": "ClaimResponse",
"id": "MII-EXA-MTB-Antwort-Kostenuebernahme-1",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-antwort-kostenuebernahme|2026.0.0"
]
},
"status": "active",
"outcome": "complete",
"type": {
"coding": [
{
"code": "institutional"
}
]
},
"use": "claim",
"patient": {
"reference": "Patient/PatientKimMusterperson"
},
"created": "2023-05-01",
"insurer": {
"reference": "Organization/MyHospital"
},
"request": {
"reference": "Claim/MII-EXA-MTB-Antrag-Kostenuebernahme-1"
}
},
"fullUrl": "http://example.org/fhir/ClaimResponse/MII-EXA-MTB-Antwort-Kostenuebernahme-1"
},
{
"request": {
"method": "PUT",
"url": "Specimen/PatientKimMusterperson-Specimen-1"
},
"resource": {
"resourceType": "Specimen",
"id": "PatientKimMusterperson-Specimen-1",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen"
]
},
"identifier": [
{
"value": "Z 230201/23"
}
],
"accessionIdentifier": {
"value": "Z 230201/23"
},
"type": {
"coding": [
{
"system": "http://snomed.info/sct",
"code": "309201001",
"display": "Ascitic fluid specimen"
}
]
},
"collection": {
"quantity": {
"system": "http://unitsofmeasure.org",
"value": 20,
"unit": "mL",
"code": "mL"
},
"collectedDateTime": "2023-01-02",
"method": {
"coding": [
{
"code": "178012008",
"system": "http://snomed.info/sct"
}
]
}
},
"status": "available",
"subject": {
"reference": "Patient/PatientKimMusterperson"
}
},
"fullUrl": "http://example.org/fhir/Specimen/PatientKimMusterperson-Specimen-1"
},
{
"request": {
"method": "PUT",
"url": "Procedure/MTBChemo1Procedure"
},
"resource": {
"resourceType": "Procedure",
"id": "MTBChemo1Procedure",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-systemische-vortherapie|2026.0.0"
]
},
"extension": [
{
"valueCodeableConcept": {
"coding": [
{
"system": "https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-intention",
"code": "K"
}
]
},
"url": "https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-ex-onko-systemische-therapie-intention"
}
],
"category": {
"coding": [
{
"system": "http://snomed.info/sct",
"code": "277132007"
}
]
},
"code": {
"coding": [
{
"system": "http://snomed.info/sct",
"code": "367336001"
},
{
"code": "CH",
"system": "https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-therapie-typ"
}
]
},
"performedPeriod": {
"start": "2023-01-04",
"end": "2023-05-24"
},
"outcome": {
"coding": [
{
"code": "W",
"system": "https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-therapie-ende-grund"
}
],
"text": "Reguläres Ende mit Substanzwechsel"
},
"status": "completed",
"subject": {
"reference": "Patient/PatientKimMusterperson"
}
},
"fullUrl": "http://example.org/fhir/Procedure/MTBChemo1Procedure"
},
{
"request": {
"method": "PUT",
"url": "MedicationStatement/MTBChemo1MedicationStatement1"
},
"resource": {
"resourceType": "MedicationStatement",
"id": "MTBChemo1MedicationStatement1",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/MedicationStatement"
]
},
"partOf": [
{
"reference": "Procedure/MTBChemo1Procedure"
}
],
"medicationCodeableConcept": {
"text": "Z1 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2, d1"
},
"status": "completed",
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"effectiveDateTime": "2023-01-04"
},
"fullUrl": "http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement1"
},
{
"request": {
"method": "PUT",
"url": "MedicationStatement/MTBChemo1MedicationStatement1-1"
},
"resource": {
"resourceType": "MedicationStatement",
"id": "MTBChemo1MedicationStatement1-1",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-systemische-therapie-medikation"
]
},
"partOf": [
{
"reference": "Procedure/MTBChemo1Procedure"
},
{
"reference": "MedicationStatement/MTBChemo1MedicationStatement1"
}
],
"medicationCodeableConcept": {
"coding": [
{
"system": "http://fhir.de/CodeSystem/bfarm/atc",
"code": "L01XA02"
}
]
},
"note": [
{
"text": "Z1 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2 d1"
}
],
"dosage": [
{
"doseAndRate": [
{
"doseQuantity": {
"value": 5,
"unit": "AUC",
"code": "mg.min/ml",
"system": "http://unitsofmeasure.org"
}
}
]
}
],
"status": "completed",
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"effectiveDateTime": "2023-01-04"
},
"fullUrl": "http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement1-1"
},
{
"request": {
"method": "PUT",
"url": "MedicationStatement/MTBChemo1MedicationStatement1-2"
},
"resource": {
"resourceType": "MedicationStatement",
"id": "MTBChemo1MedicationStatement1-2",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-systemische-therapie-medikation"
]
},
"partOf": [
{
"reference": "Procedure/MTBChemo1Procedure"
},
{
"reference": "MedicationStatement/MTBChemo1MedicationStatement1"
}
],
"medicationCodeableConcept": {
"coding": [
{
"system": "http://fhir.de/CodeSystem/bfarm/atc",
"code": "L01DB01"
}
]
},
"note": [
{
"text": "Z1 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2 d1"
}
],
"dosage": [
{
"doseAndRate": [
{
"doseQuantity": {
"value": 30,
"unit": "mg/m2",
"code": "mg/m2",
"system": "http://unitsofmeasure.org"
}
}
]
}
],
"status": "completed",
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"effectiveDateTime": "2023-01-04"
},
"fullUrl": "http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement1-2"
},
{
"request": {
"method": "PUT",
"url": "MedicationStatement/MTBChemo1MedicationStatement2"
},
"resource": {
"resourceType": "MedicationStatement",
"id": "MTBChemo1MedicationStatement2",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/MedicationStatement"
]
},
"partOf": [
{
"reference": "Procedure/MTBChemo1Procedure"
}
],
"medicationCodeableConcept": {
"text": "Z2 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2, d1"
},
"status": "completed",
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"effectiveDateTime": "2023-02-01"
},
"fullUrl": "http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement2"
},
{
"request": {
"method": "PUT",
"url": "MedicationStatement/MTBChemo1MedicationStatement2-1"
},
"resource": {
"resourceType": "MedicationStatement",
"id": "MTBChemo1MedicationStatement2-1",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-systemische-therapie-medikation"
]
},
"partOf": [
{
"reference": "Procedure/MTBChemo1Procedure"
},
{
"reference": "MedicationStatement/MTBChemo1MedicationStatement2"
}
],
"medicationCodeableConcept": {
"coding": [
{
"system": "http://fhir.de/CodeSystem/bfarm/atc",
"code": "L01XA02"
}
]
},
"note": [
{
"text": "Z2 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2 d1"
}
],
"dosage": [
{
"doseAndRate": [
{
"doseQuantity": {
"value": 5,
"unit": "AUC",
"code": "mg.min/ml",
"system": "http://unitsofmeasure.org"
}
}
]
}
],
"status": "completed",
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"effectiveDateTime": "2023-02-01"
},
"fullUrl": "http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement2-1"
},
{
"request": {
"method": "PUT",
"url": "MedicationStatement/MTBChemo1MedicationStatement2-2"
},
"resource": {
"resourceType": "MedicationStatement",
"id": "MTBChemo1MedicationStatement2-2",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-systemische-therapie-medikation"
]
},
"partOf": [
{
"reference": "Procedure/MTBChemo1Procedure"
},
{
"reference": "MedicationStatement/MTBChemo1MedicationStatement2"
}
],
"medicationCodeableConcept": {
"coding": [
{
"system": "http://fhir.de/CodeSystem/bfarm/atc",
"code": "L01DB01"
}
]
},
"note": [
{
"text": "Z2 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2 d1"
}
],
"dosage": [
{
"doseAndRate": [
{
"doseQuantity": {
"value": 30,
"unit": "mg/m2",
"code": "mg/m2",
"system": "http://unitsofmeasure.org"
}
}
]
}
],
"status": "completed",
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"effectiveDateTime": "2023-02-01"
},
"fullUrl": "http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement2-2"
},
{
"request": {
"method": "PUT",
"url": "MedicationStatement/MTBChemo1MedicationStatement3"
},
"resource": {
"resourceType": "MedicationStatement",
"id": "MTBChemo1MedicationStatement3",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/MedicationStatement"
]
},
"partOf": [
{
"reference": "Procedure/MTBChemo1Procedure"
}
],
"medicationCodeableConcept": {
"text": "Z3 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2, d1"
},
"status": "completed",
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"effectiveDateTime": "2023-03-01"
},
"fullUrl": "http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement3"
},
{
"request": {
"method": "PUT",
"url": "MedicationStatement/MTBChemo1MedicationStatement3-1"
},
"resource": {
"resourceType": "MedicationStatement",
"id": "MTBChemo1MedicationStatement3-1",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-systemische-therapie-medikation"
]
},
"partOf": [
{
"reference": "Procedure/MTBChemo1Procedure"
},
{
"reference": "MedicationStatement/MTBChemo1MedicationStatement3"
}
],
"medicationCodeableConcept": {
"coding": [
{
"system": "http://fhir.de/CodeSystem/bfarm/atc",
"code": "L01XA02"
}
]
},
"note": [
{
"text": "Z3 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2 d1"
}
],
"dosage": [
{
"doseAndRate": [
{
"doseQuantity": {
"value": 5,
"unit": "AUC",
"code": "mg.min/ml",
"system": "http://unitsofmeasure.org"
}
}
]
}
],
"status": "completed",
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"effectiveDateTime": "2023-03-01"
},
"fullUrl": "http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement3-1"
},
{
"request": {
"method": "PUT",
"url": "MedicationStatement/MTBChemo1MedicationStatement3-2"
},
"resource": {
"resourceType": "MedicationStatement",
"id": "MTBChemo1MedicationStatement3-2",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-systemische-therapie-medikation"
]
},
"partOf": [
{
"reference": "Procedure/MTBChemo1Procedure"
},
{
"reference": "MedicationStatement/MTBChemo1MedicationStatement3"
}
],
"medicationCodeableConcept": {
"coding": [
{
"system": "http://fhir.de/CodeSystem/bfarm/atc",
"code": "L01DB01"
}
]
},
"note": [
{
"text": "Z3 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2 d1"
}
],
"dosage": [
{
"doseAndRate": [
{
"doseQuantity": {
"value": 30,
"unit": "mg/m2",
"code": "mg/m2",
"system": "http://unitsofmeasure.org"
}
}
]
}
],
"status": "completed",
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"effectiveDateTime": "2023-03-01"
},
"fullUrl": "http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement3-2"
},
{
"request": {
"method": "PUT",
"url": "MedicationStatement/MTBChemo1MedicationStatement4"
},
"resource": {
"resourceType": "MedicationStatement",
"id": "MTBChemo1MedicationStatement4",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/MedicationStatement"
]
},
"partOf": [
{
"reference": "Procedure/MTBChemo1Procedure"
}
],
"medicationCodeableConcept": {
"text": "Z4 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2, d1"
},
"status": "completed",
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"effectiveDateTime": "2023-03-29"
},
"fullUrl": "http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement4"
},
{
"request": {
"method": "PUT",
"url": "MedicationStatement/MTBChemo1MedicationStatement4-1"
},
"resource": {
"resourceType": "MedicationStatement",
"id": "MTBChemo1MedicationStatement4-1",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-systemische-therapie-medikation"
]
},
"partOf": [
{
"reference": "Procedure/MTBChemo1Procedure"
},
{
"reference": "MedicationStatement/MTBChemo1MedicationStatement4"
}
],
"medicationCodeableConcept": {
"coding": [
{
"system": "http://fhir.de/CodeSystem/bfarm/atc",
"code": "L01XA02"
}
]
},
"note": [
{
"text": "Z4 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2 d1"
}
],
"dosage": [
{
"doseAndRate": [
{
"doseQuantity": {
"value": 5,
"unit": "AUC",
"code": "mg.min/ml",
"system": "http://unitsofmeasure.org"
}
}
]
}
],
"status": "completed",
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"effectiveDateTime": "2023-03-29"
},
"fullUrl": "http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement4-1"
},
{
"request": {
"method": "PUT",
"url": "MedicationStatement/MTBChemo1MedicationStatement4-2"
},
"resource": {
"resourceType": "MedicationStatement",
"id": "MTBChemo1MedicationStatement4-2",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-systemische-therapie-medikation"
]
},
"partOf": [
{
"reference": "Procedure/MTBChemo1Procedure"
},
{
"reference": "MedicationStatement/MTBChemo1MedicationStatement4"
}
],
"medicationCodeableConcept": {
"coding": [
{
"system": "http://fhir.de/CodeSystem/bfarm/atc",
"code": "L01DB01"
}
]
},
"note": [
{
"text": "Z4 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2 d1"
}
],
"dosage": [
{
"doseAndRate": [
{
"doseQuantity": {
"value": 30,
"unit": "mg/m2",
"code": "mg/m2",
"system": "http://unitsofmeasure.org"
}
}
]
}
],
"status": "completed",
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"effectiveDateTime": "2023-03-29"
},
"fullUrl": "http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement4-2"
},
{
"request": {
"method": "PUT",
"url": "MedicationStatement/MTBChemo1MedicationStatement5"
},
"resource": {
"resourceType": "MedicationStatement",
"id": "MTBChemo1MedicationStatement5",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/MedicationStatement"
]
},
"partOf": [
{
"reference": "Procedure/MTBChemo1Procedure"
}
],
"medicationCodeableConcept": {
"text": "Z5 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2, d1"
},
"status": "completed",
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"effectiveDateTime": "2023-04-26"
},
"fullUrl": "http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement5"
},
{
"request": {
"method": "PUT",
"url": "MedicationStatement/MTBChemo1MedicationStatement5-1"
},
"resource": {
"resourceType": "MedicationStatement",
"id": "MTBChemo1MedicationStatement5-1",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-systemische-therapie-medikation"
]
},
"partOf": [
{
"reference": "Procedure/MTBChemo1Procedure"
},
{
"reference": "MedicationStatement/MTBChemo1MedicationStatement5"
}
],
"medicationCodeableConcept": {
"coding": [
{
"system": "http://fhir.de/CodeSystem/bfarm/atc",
"code": "L01XA02"
}
]
},
"note": [
{
"text": "Z5 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2 d1"
}
],
"dosage": [
{
"doseAndRate": [
{
"doseQuantity": {
"value": 5,
"unit": "AUC",
"code": "mg.min/ml",
"system": "http://unitsofmeasure.org"
}
}
]
}
],
"status": "completed",
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"effectiveDateTime": "2023-04-26"
},
"fullUrl": "http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement5-1"
},
{
"request": {
"method": "PUT",
"url": "MedicationStatement/MTBChemo1MedicationStatement5-2"
},
"resource": {
"resourceType": "MedicationStatement",
"id": "MTBChemo1MedicationStatement5-2",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-systemische-therapie-medikation"
]
},
"partOf": [
{
"reference": "Procedure/MTBChemo1Procedure"
},
{
"reference": "MedicationStatement/MTBChemo1MedicationStatement5"
}
],
"medicationCodeableConcept": {
"coding": [
{
"system": "http://fhir.de/CodeSystem/bfarm/atc",
"code": "L01DB01"
}
]
},
"note": [
{
"text": "Z5 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2 d1"
}
],
"dosage": [
{
"doseAndRate": [
{
"doseQuantity": {
"value": 30,
"unit": "mg/m2",
"code": "mg/m2",
"system": "http://unitsofmeasure.org"
}
}
]
}
],
"status": "completed",
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"effectiveDateTime": "2023-04-26"
},
"fullUrl": "http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement5-2"
},
{
"request": {
"method": "PUT",
"url": "MedicationStatement/MTBChemo1MedicationStatement6"
},
"resource": {
"resourceType": "MedicationStatement",
"id": "MTBChemo1MedicationStatement6",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/MedicationStatement"
]
},
"partOf": [
{
"reference": "Procedure/MTBChemo1Procedure"
}
],
"medicationCodeableConcept": {
"text": "Z6 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2, d1"
},
"status": "completed",
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"effectiveDateTime": "2023-05-24"
},
"fullUrl": "http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement6"
},
{
"request": {
"method": "PUT",
"url": "MedicationStatement/MTBChemo1MedicationStatement6-1"
},
"resource": {
"resourceType": "MedicationStatement",
"id": "MTBChemo1MedicationStatement6-1",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-systemische-therapie-medikation"
]
},
"partOf": [
{
"reference": "Procedure/MTBChemo1Procedure"
},
{
"reference": "MedicationStatement/MTBChemo1MedicationStatement6"
}
],
"medicationCodeableConcept": {
"coding": [
{
"system": "http://fhir.de/CodeSystem/bfarm/atc",
"code": "L01XA02"
}
]
},
"note": [
{
"text": "Z6 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2 d1"
}
],
"dosage": [
{
"doseAndRate": [
{
"doseQuantity": {
"value": 5,
"unit": "AUC",
"code": "mg.min/ml",
"system": "http://unitsofmeasure.org"
}
}
]
}
],
"status": "completed",
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"effectiveDateTime": "2023-05-24"
},
"fullUrl": "http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement6-1"
},
{
"request": {
"method": "PUT",
"url": "MedicationStatement/MTBChemo1MedicationStatement6-2"
},
"resource": {
"resourceType": "MedicationStatement",
"id": "MTBChemo1MedicationStatement6-2",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-systemische-therapie-medikation"
]
},
"partOf": [
{
"reference": "Procedure/MTBChemo1Procedure"
},
{
"reference": "MedicationStatement/MTBChemo1MedicationStatement6"
}
],
"medicationCodeableConcept": {
"coding": [
{
"system": "http://fhir.de/CodeSystem/bfarm/atc",
"code": "L01DB01"
}
]
},
"note": [
{
"text": "Z6 Carboplatin AUC5 d1, pegliposomales Doxorubicin 30 mg/m2 d1"
}
],
"dosage": [
{
"doseAndRate": [
{
"doseQuantity": {
"value": 30,
"unit": "mg/m2",
"code": "mg/m2",
"system": "http://unitsofmeasure.org"
}
}
]
}
],
"status": "completed",
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"effectiveDateTime": "2023-05-24"
},
"fullUrl": "http://example.org/fhir/MedicationStatement/MTBChemo1MedicationStatement6-2"
},
{
"request": {
"method": "PUT",
"url": "Procedure/MTBChemo2Procedure"
},
"resource": {
"resourceType": "Procedure",
"id": "MTBChemo2Procedure",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-systemische-vortherapie|2026.0.0"
]
},
"extension": [
{
"valueCodeableConcept": {
"coding": [
{
"system": "https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-intention",
"code": "K"
}
]
},
"url": "https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-ex-onko-systemische-therapie-intention"
}
],
"basedOn": [
{
"reference": "CarePlan/mii-exa-mtb-kim-musterperson-therapieplan"
}
],
"category": {
"coding": [
{
"system": "http://snomed.info/sct",
"code": "277132007"
}
]
},
"code": {
"coding": [
{
"system": "http://snomed.info/sct",
"code": "367336001"
},
{
"code": "CH",
"system": "https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-therapie-typ"
}
]
},
"performedPeriod": {
"start": "2023-06-24",
"end": "2023-10-12"
},
"outcome": {
"coding": [
{
"code": "E",
"system": "https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-therapie-ende-grund"
}
],
"text": "Reguläres Ende"
},
"status": "completed",
"subject": {
"reference": "Patient/PatientKimMusterperson"
}
},
"fullUrl": "http://example.org/fhir/Procedure/MTBChemo2Procedure"
},
{
"request": {
"method": "PUT",
"url": "MedicationStatement/MTBChemo2MedicationStatement1"
},
"resource": {
"resourceType": "MedicationStatement",
"id": "MTBChemo2MedicationStatement1",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/MedicationStatement"
]
},
"partOf": [
{
"reference": "Procedure/MTBChemo2Procedure"
}
],
"basedOn": [
{
"reference": "MedicationRequest/mii-exa-mtb-medication-request-mirvetuximab"
}
],
"medicationCodeableConcept": {
"coding": [
{
"code": "98DE7VN88D",
"system": "http://fdasis.nlm.nih.gov",
"display": "MIRVETUXIMAB SORAVTANSINE"
},
{
"system": "http://fhir.de/CodeSystem/bfarm/atc",
"code": "L01FX26",
"display": "Mirvetuximab soravtansin",
"version": "2025"
}
]
},
"note": [
{
"text": "Z1 Mirvetuximab soravtansine 6mg/kg KG, Wdh d22"
}
],
"dosage": [
{
"doseAndRate": [
{
"doseQuantity": {
"value": 6,
"unit": "mg/kg KG",
"code": "mg/kg{KG}",
"system": "http://unitsofmeasure.org"
}
}
]
}
],
"status": "completed",
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"effectiveDateTime": "2023-06-24"
},
"fullUrl": "http://example.org/fhir/MedicationStatement/MTBChemo2MedicationStatement1"
},
{
"request": {
"method": "PUT",
"url": "MedicationStatement/MTBChemo2MedicationStatement2"
},
"resource": {
"resourceType": "MedicationStatement",
"id": "MTBChemo2MedicationStatement2",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/MedicationStatement"
]
},
"partOf": [
{
"reference": "Procedure/MTBChemo2Procedure"
}
],
"basedOn": [
{
"reference": "MedicationRequest/mii-exa-mtb-medication-request-mirvetuximab"
}
],
"medicationCodeableConcept": {
"coding": [
{
"code": "98DE7VN88D",
"system": "http://fdasis.nlm.nih.gov",
"display": "MIRVETUXIMAB SORAVTANSINE"
},
{
"system": "http://fhir.de/CodeSystem/bfarm/atc",
"code": "L01FX26",
"display": "Mirvetuximab soravtansin",
"version": "2025"
}
]
},
"note": [
{
"text": "Z2 Mirvetuximab soravtansine 6mg/kg KG, Wdh d22"
}
],
"dosage": [
{
"doseAndRate": [
{
"doseQuantity": {
"value": 6,
"unit": "mg/kg KG",
"code": "mg/kg{KG}",
"system": "http://unitsofmeasure.org"
}
}
]
}
],
"status": "completed",
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"effectiveDateTime": "2023-07-16"
},
"fullUrl": "http://example.org/fhir/MedicationStatement/MTBChemo2MedicationStatement2"
},
{
"request": {
"method": "PUT",
"url": "MedicationStatement/MTBChemo2MedicationStatement3"
},
"resource": {
"resourceType": "MedicationStatement",
"id": "MTBChemo2MedicationStatement3",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/MedicationStatement"
]
},
"partOf": [
{
"reference": "Procedure/MTBChemo2Procedure"
}
],
"basedOn": [
{
"reference": "MedicationRequest/mii-exa-mtb-medication-request-mirvetuximab"
}
],
"medicationCodeableConcept": {
"coding": [
{
"code": "98DE7VN88D",
"system": "http://fdasis.nlm.nih.gov",
"display": "MIRVETUXIMAB SORAVTANSINE"
},
{
"system": "http://fhir.de/CodeSystem/bfarm/atc",
"code": "L01FX26",
"display": "Mirvetuximab soravtansin",
"version": "2025"
}
]
},
"note": [
{
"text": "Z3 Mirvetuximab soravtansine 6mg/kg KG, Wdh d22"
}
],
"dosage": [
{
"doseAndRate": [
{
"doseQuantity": {
"value": 6,
"unit": "mg/kg KG",
"code": "mg/kg{KG}",
"system": "http://unitsofmeasure.org"
}
}
]
}
],
"status": "completed",
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"effectiveDateTime": "2023-08-07"
},
"fullUrl": "http://example.org/fhir/MedicationStatement/MTBChemo2MedicationStatement3"
},
{
"request": {
"method": "PUT",
"url": "MedicationStatement/MTBChemo2MedicationStatement4"
},
"resource": {
"resourceType": "MedicationStatement",
"id": "MTBChemo2MedicationStatement4",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/MedicationStatement"
]
},
"partOf": [
{
"reference": "Procedure/MTBChemo2Procedure"
}
],
"basedOn": [
{
"reference": "MedicationRequest/mii-exa-mtb-medication-request-mirvetuximab"
}
],
"medicationCodeableConcept": {
"coding": [
{
"code": "98DE7VN88D",
"system": "http://fdasis.nlm.nih.gov",
"display": "MIRVETUXIMAB SORAVTANSINE"
},
{
"system": "http://fhir.de/CodeSystem/bfarm/atc",
"code": "L01FX26",
"display": "Mirvetuximab soravtansin",
"version": "2025"
}
]
},
"note": [
{
"text": "Z4 Mirvetuximab soravtansine 6mg/kg KG, Wdh d22"
}
],
"dosage": [
{
"doseAndRate": [
{
"doseQuantity": {
"value": 6,
"unit": "mg/kg KG",
"code": "mg/kg{KG}",
"system": "http://unitsofmeasure.org"
}
}
]
}
],
"status": "completed",
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"effectiveDateTime": "2023-08-29"
},
"fullUrl": "http://example.org/fhir/MedicationStatement/MTBChemo2MedicationStatement4"
},
{
"request": {
"method": "PUT",
"url": "MedicationStatement/MTBChemo2MedicationStatement5"
},
"resource": {
"resourceType": "MedicationStatement",
"id": "MTBChemo2MedicationStatement5",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/MedicationStatement"
]
},
"partOf": [
{
"reference": "Procedure/MTBChemo2Procedure"
}
],
"basedOn": [
{
"reference": "MedicationRequest/mii-exa-mtb-medication-request-mirvetuximab"
}
],
"medicationCodeableConcept": {
"coding": [
{
"code": "98DE7VN88D",
"system": "http://fdasis.nlm.nih.gov",
"display": "MIRVETUXIMAB SORAVTANSINE"
},
{
"system": "http://fhir.de/CodeSystem/bfarm/atc",
"code": "L01FX26",
"display": "Mirvetuximab soravtansin",
"version": "2025"
}
]
},
"note": [
{
"text": "Z5 Mirvetuximab soravtansine 6mg/kg KG, Wdh d22"
}
],
"dosage": [
{
"doseAndRate": [
{
"doseQuantity": {
"value": 6,
"unit": "mg/kg KG",
"code": "mg/kg{KG}",
"system": "http://unitsofmeasure.org"
}
}
]
}
],
"status": "completed",
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"effectiveDateTime": "2023-09-20"
},
"fullUrl": "http://example.org/fhir/MedicationStatement/MTBChemo2MedicationStatement5"
},
{
"request": {
"method": "PUT",
"url": "MedicationStatement/MTBChemo2MedicationStatement6"
},
"resource": {
"resourceType": "MedicationStatement",
"id": "MTBChemo2MedicationStatement6",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/MedicationStatement"
]
},
"partOf": [
{
"reference": "Procedure/MTBChemo2Procedure"
}
],
"basedOn": [
{
"reference": "MedicationRequest/mii-exa-mtb-medication-request-mirvetuximab"
}
],
"medicationCodeableConcept": {
"coding": [
{
"code": "98DE7VN88D",
"system": "http://fdasis.nlm.nih.gov",
"display": "MIRVETUXIMAB SORAVTANSINE"
},
{
"system": "http://fhir.de/CodeSystem/bfarm/atc",
"code": "L01FX26",
"display": "Mirvetuximab soravtansin",
"version": "2025"
}
]
},
"note": [
{
"text": "Z6 Mirvetuximab soravtansine 6mg/kg KG, Wdh d22"
}
],
"dosage": [
{
"doseAndRate": [
{
"doseQuantity": {
"value": 6,
"unit": "mg/kg KG",
"code": "mg/kg{KG}",
"system": "http://unitsofmeasure.org"
}
}
]
}
],
"status": "completed",
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"effectiveDateTime": "2023-10-12"
},
"fullUrl": "http://example.org/fhir/MedicationStatement/MTBChemo2MedicationStatement6"
},
{
"request": {
"method": "PUT",
"url": "DiagnosticReport/mii-exa-mtb-kim-musterperson-ngs-bericht"
},
"resource": {
"resourceType": "DiagnosticReport",
"id": "mii-exa-mtb-kim-musterperson-ngs-bericht",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-ngs-bericht|2026.0.0"
]
},
"category": [
{
"coding": [
{
"code": "GE",
"system": "http://terminology.hl7.org/CodeSystem/v2-0074",
"display": "Genetics"
}
]
}
],
"specimen": [
{
"reference": "Specimen/PatientKimMusterperson-AscitesSpecimen-2"
}
],
"result": [
{
"reference": "Observation/mii-exa-mtb-kim-musterperson-EinfacheVariante-TP53"
},
{
"reference": "Observation/mii-exa-mtb-kim-musterperson-EinfacheVariante-PIK3R1"
},
{
"reference": "Observation/mii-exa-mtb-kim-musterperson-CNVariante-CCNE1"
}
],
"status": "final",
"code": {
"coding": [
{
"code": "51969-4",
"system": "http://loinc.org",
"display": "Genetic analysis report"
}
]
},
"issued": "2023-03-28T00:00:00.000Z",
"subject": {
"reference": "Patient/PatientKimMusterperson"
}
},
"fullUrl": "http://example.org/fhir/DiagnosticReport/mii-exa-mtb-kim-musterperson-ngs-bericht"
},
{
"request": {
"method": "PUT",
"url": "Procedure/mii-exa-mtb-kim-musterperson-genomic-study"
},
"resource": {
"resourceType": "Procedure",
"id": "mii-exa-mtb-kim-musterperson-genomic-study",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-genomic-study|2026.0.0"
]
},
"extension": [
{
"url": "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-study-analysis-ext",
"valueReference": {
"reference": "Procedure/mii-exa-mtb-kim-musterperson-genomic-study-analysis-1"
}
},
{
"url": "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-study-analysis-ext",
"valueReference": {
"reference": "Procedure/mii-exa-mtb-kim-musterperson-genomic-study-analysis-2"
}
},
{
"url": "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-study-analysis-ext",
"valueReference": {
"reference": "Procedure/mii-exa-mtb-kim-musterperson-genomic-study-analysis-3"
}
}
],
"category": {
"coding": [
{
"system": "http://terminology.hl7.org/CodeSystem/observation-category",
"code": "laboratory"
}
]
},
"status": "completed",
"subject": {
"reference": "Patient/PatientKimMusterperson"
}
},
"fullUrl": "http://example.org/fhir/Procedure/mii-exa-mtb-kim-musterperson-genomic-study"
},
{
"request": {
"method": "PUT",
"url": "Procedure/mii-exa-mtb-kim-musterperson-genomic-study-analysis-1"
},
"resource": {
"resourceType": "Procedure",
"id": "mii-exa-mtb-kim-musterperson-genomic-study-analysis-1",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-genomic-study-analysis|2026.0.0"
]
},
"category": {
"coding": [
{
"system": "http://terminology.hl7.org/CodeSystem/observation-category",
"code": "laboratory"
}
]
},
"extension": [
{
"url": "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-study-analysis-method-type",
"valueCodeableConcept": {
"coding": [
{
"code": "ngs-mps",
"system": "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/genomic-study-method-type-cs",
"display": "Next-Generation (NGS)/Massively parallel sequencing (MPS)"
}
]
}
},
{
"url": "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-study-analysis-change-type",
"valueCodeableConcept": {
"coding": [
{
"code": "SO:0001483",
"system": "http://www.sequenceontology.org",
"display": "SNV"
}
]
}
},
{
"url": "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-study-analysis-genome-build",
"valueCodeableConcept": {
"coding": [
{
"code": "LA26806-2",
"system": "http://loinc.org",
"display": "GRCh38"
}
]
}
}
],
"status": "completed",
"subject": {
"reference": "Patient/PatientKimMusterperson"
}
},
"fullUrl": "http://example.org/fhir/Procedure/mii-exa-mtb-kim-musterperson-genomic-study-analysis-1"
},
{
"request": {
"method": "PUT",
"url": "Procedure/mii-exa-mtb-kim-musterperson-genomic-study-analysis-2"
},
"resource": {
"resourceType": "Procedure",
"id": "mii-exa-mtb-kim-musterperson-genomic-study-analysis-2",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-genomic-study-analysis|2026.0.0"
]
},
"category": {
"coding": [
{
"system": "http://terminology.hl7.org/CodeSystem/observation-category",
"code": "laboratory"
}
]
},
"status": "completed",
"subject": {
"reference": "Patient/PatientKimMusterperson"
}
},
"fullUrl": "http://example.org/fhir/Procedure/mii-exa-mtb-kim-musterperson-genomic-study-analysis-2"
},
{
"request": {
"method": "PUT",
"url": "Procedure/mii-exa-mtb-kim-musterperson-genomic-study-analysis-3"
},
"resource": {
"resourceType": "Procedure",
"id": "mii-exa-mtb-kim-musterperson-genomic-study-analysis-3",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-genomic-study-analysis|2026.0.0"
]
},
"category": {
"coding": [
{
"system": "http://terminology.hl7.org/CodeSystem/observation-category",
"code": "laboratory"
}
]
},
"extension": [
{
"url": "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-study-analysis-method-type",
"valueCodeableConcept": {
"coding": [
{
"code": "immunohistochemistry",
"system": "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/genomic-study-method-type-cs",
"display": "Immunohistochemistry"
}
]
}
}
],
"status": "completed",
"subject": {
"reference": "Patient/PatientKimMusterperson"
}
},
"fullUrl": "http://example.org/fhir/Procedure/mii-exa-mtb-kim-musterperson-genomic-study-analysis-3"
},
{
"request": {
"method": "PUT",
"url": "Observation/mii-exa-mtb-kim-musterperson-EinfacheVariante-TP53"
},
"resource": {
"resourceType": "Observation",
"id": "mii-exa-mtb-kim-musterperson-EinfacheVariante-TP53",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-einfache-variante|2026.0.0"
]
},
"category": [
{
"coding": [
{
"system": "http://terminology.hl7.org/CodeSystem/observation-category",
"code": "laboratory",
"display": "Laboratory"
}
]
},
{
"coding": [
{
"system": "http://terminology.hl7.org/CodeSystem/v2-0074",
"code": "GE"
}
]
}
],
"component": [
{
"code": {
"coding": [
{
"system": "http://loinc.org",
"code": "48018-6",
"display": "Gene studied [ID]"
}
]
},
"valueCodeableConcept": {
"coding": [
{
"code": "HGNC:11998",
"system": "http://www.genenames.org/geneId",
"display": "TP53"
}
]
}
},
{
"code": {
"coding": [
{
"system": "http://loinc.org",
"code": "48005-3",
"display": "Amino acid change (pHGVS)"
}
]
},
"valueCodeableConcept": {
"coding": [
{
"code": "NP_000537.3:p.Arg213Ter",
"system": "http://varnomen.hgvs.org"
}
]
}
}
],
"code": {
"coding": [
{
"system": "http://loinc.org",
"code": "69548-6",
"display": "Genetic variant assessment"
}
]
},
"status": "final",
"valueCodeableConcept": {
"coding": [
{
"code": "LA9633-4",
"system": "http://loinc.org",
"display": "Present"
}
]
},
"subject": {
"reference": "Patient/PatientKimMusterperson"
}
},
"fullUrl": "http://example.org/fhir/Observation/mii-exa-mtb-kim-musterperson-EinfacheVariante-TP53"
},
{
"request": {
"method": "PUT",
"url": "Observation/mii-exa-mtb-kim-musterperson-DiagnostischeImplikation-TP53"
},
"resource": {
"resourceType": "Observation",
"id": "mii-exa-mtb-kim-musterperson-DiagnostischeImplikation-TP53",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-diagnostische-implikation|2026.0.0"
]
},
"category": [
{
"coding": [
{
"system": "http://terminology.hl7.org/CodeSystem/observation-category",
"code": "laboratory",
"display": "Laboratory"
}
]
},
{
"coding": [
{
"system": "http://terminology.hl7.org/CodeSystem/v2-0074",
"code": "GE"
}
]
}
],
"derivedFrom": [
{
"reference": "Observation/mii-exa-mtb-kim-musterperson-EinfacheVariante-TP53"
}
],
"component": [
{
"code": {
"coding": [
{
"system": "http://loinc.org",
"code": "53037-8"
}
]
},
"valueCodeableConcept": {
"coding": [
{
"code": "LA6668-3",
"system": "http://loinc.org",
"display": "Pathogenic"
}
]
}
}
],
"code": {
"coding": [
{
"system": "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
"code": "diagnostic-implication",
"display": "Diagnostic Implication"
}
]
},
"status": "final",
"subject": {
"reference": "Patient/PatientKimMusterperson"
}
},
"fullUrl": "http://example.org/fhir/Observation/mii-exa-mtb-kim-musterperson-DiagnostischeImplikation-TP53"
},
{
"request": {
"method": "PUT",
"url": "Observation/mii-exa-mtb-kim-musterperson-EinfacheVariante-PIK3R1"
},
"resource": {
"resourceType": "Observation",
"id": "mii-exa-mtb-kim-musterperson-EinfacheVariante-PIK3R1",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-einfache-variante|2026.0.0"
]
},
"category": [
{
"coding": [
{
"system": "http://terminology.hl7.org/CodeSystem/observation-category",
"code": "laboratory",
"display": "Laboratory"
}
]
},
{
"coding": [
{
"system": "http://terminology.hl7.org/CodeSystem/v2-0074",
"code": "GE"
}
]
}
],
"component": [
{
"code": {
"coding": [
{
"system": "http://loinc.org",
"code": "48018-6",
"display": "Gene studied [ID]"
}
]
},
"valueCodeableConcept": {
"coding": [
{
"code": "HGNC:8979",
"system": "http://www.genenames.org/geneId",
"display": "PIK3R1"
}
]
}
},
{
"code": {
"coding": [
{
"system": "http://loinc.org",
"code": "48005-3",
"display": "Amino acid change (pHGVS)"
}
]
},
"valueCodeableConcept": {
"coding": [
{
"code": "NM_181523.2:p.E160*",
"system": "http://varnomen.hgvs.org"
}
]
}
}
],
"code": {
"coding": [
{
"system": "http://loinc.org",
"code": "69548-6",
"display": "Genetic variant assessment"
}
]
},
"status": "final",
"valueCodeableConcept": {
"coding": [
{
"code": "LA9633-4",
"system": "http://loinc.org",
"display": "Present"
}
]
},
"subject": {
"reference": "Patient/PatientKimMusterperson"
}
},
"fullUrl": "http://example.org/fhir/Observation/mii-exa-mtb-kim-musterperson-EinfacheVariante-PIK3R1"
},
{
"request": {
"method": "PUT",
"url": "Observation/mii-exa-mtb-kim-musterperson-TherapeutischeImplikation-PIK3R1"
},
"resource": {
"resourceType": "Observation",
"id": "mii-exa-mtb-kim-musterperson-TherapeutischeImplikation-PIK3R1",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-therapeutische-implikation|2026.0.0"
]
},
"category": [
{
"coding": [
{
"system": "http://terminology.hl7.org/CodeSystem/observation-category",
"code": "laboratory",
"display": "Laboratory"
}
]
},
{
"coding": [
{
"system": "http://terminology.hl7.org/CodeSystem/v2-0074",
"code": "GE"
}
]
}
],
"derivedFrom": [
{
"reference": "Observation/mii-exa-mtb-kim-musterperson-EinfacheVariante-PIK3R1"
}
],
"component": [
{
"code": {
"coding": [
{
"system": "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
"code": "conclusion-string"
}
]
},
"valueString": "Ausweislich praeklinischer Daten liegt ein Ansprechen auf MEK-Inhibition nahe (PMID: 31209687, EL m3)."
},
{
"code": {
"coding": [
{
"system": "http://loinc.org",
"code": "51963-7",
"display": "Medication assessed [ID]"
}
]
},
"valueCodeableConcept": {
"coding": [
{
"code": "L01EE",
"system": "http://fhir.de/CodeSystem/bfarm/atc",
"display": "Mitogen-aktivierte Proteinkinase (MEK)-Inhibitoren"
}
]
}
}
],
"extension": [
{
"valueCodeableConcept": {
"coding": [
{
"system": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-empfehlung-evidenzgrad",
"code": "m3"
}
]
},
"url": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-evidenzgraduierung"
}
],
"code": {
"coding": [
{
"system": "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
"code": "therapeutic-implication",
"display": "Therapeutic Implication"
}
]
},
"status": "final",
"subject": {
"reference": "Patient/PatientKimMusterperson"
}
},
"fullUrl": "http://example.org/fhir/Observation/mii-exa-mtb-kim-musterperson-TherapeutischeImplikation-PIK3R1"
},
{
"request": {
"method": "PUT",
"url": "Observation/mii-exa-mtb-kim-musterperson-CNVariante-CCNE1"
},
"resource": {
"resourceType": "Observation",
"id": "mii-exa-mtb-kim-musterperson-CNVariante-CCNE1",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-copy-number-variant|2026.0.0"
]
},
"category": [
{
"coding": [
{
"system": "http://terminology.hl7.org/CodeSystem/observation-category",
"code": "laboratory",
"display": "Laboratory"
}
]
},
{
"coding": [
{
"system": "http://terminology.hl7.org/CodeSystem/v2-0074",
"code": "GE"
}
]
}
],
"component": [
{
"code": {
"coding": [
{
"system": "http://loinc.org",
"code": "48018-6",
"display": "Gene studied [ID]"
}
]
},
"valueCodeableConcept": {
"coding": [
{
"code": "HGNC:1589",
"system": "http://www.genenames.org/geneId",
"display": "CCNE1"
}
]
}
},
{
"code": {
"coding": [
{
"code": "type",
"system": "http://bwhc.de/mtb/genetics-copy-number-variant"
}
]
},
"valueCodeableConcept": {
"coding": [
{
"code": "high-level-gain",
"system": "http://bwhc.de/mtb/genetics-copy-number-variant",
"display": "high-level-gain"
}
]
}
},
{
"valueQuantity": {
"value": 7,
"system": "http://unitsofmeasure.org",
"code": "1"
},
"code": {
"coding": [
{
"system": "http://loinc.org",
"code": "82155-3",
"display": "Genomic structural variant copy number"
}
]
}
}
],
"code": {
"coding": [
{
"system": "http://loinc.org",
"code": "69548-6",
"display": "Genetic variant assessment"
}
]
},
"status": "final",
"valueCodeableConcept": {
"coding": [
{
"code": "LA9633-4",
"system": "http://loinc.org",
"display": "Present"
}
]
},
"subject": {
"reference": "Patient/PatientKimMusterperson"
}
},
"fullUrl": "http://example.org/fhir/Observation/mii-exa-mtb-kim-musterperson-CNVariante-CCNE1"
},
{
"request": {
"method": "PUT",
"url": "ServiceRequest/mii-exa-mtb-study-request-cldn6"
},
"resource": {
"resourceType": "ServiceRequest",
"id": "mii-exa-mtb-study-request-cldn6",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-studieneinschluss-anfrage|2026.0.0"
]
},
"supportingInfo": [
{
"reference": "ResearchStudy/mii-exa-mtb-study-cldn6"
}
],
"extension": [
{
"url": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-prioritaet",
"valueDecimal": 2.1
},
{
"valueIdentifier": {
"system": "http://www.ncbi.nlm.nih.gov/pubmed",
"value": "37872225"
},
"url": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-publikation"
}
],
"intent": "proposal",
"category": [
{
"coding": [
{
"code": "110465008",
"system": "http://snomed.info/sct",
"display": "Clinical trial (procedure)"
}
]
}
],
"code": {
"coding": [
{
"code": "702475000",
"system": "http://snomed.info/sct",
"display": "Referral to clinical trial (procedure)"
}
]
},
"status": "draft",
"subject": {
"reference": "Patient/PatientKimMusterperson"
}
},
"fullUrl": "http://example.org/fhir/ServiceRequest/mii-exa-mtb-study-request-cldn6"
},
{
"request": {
"method": "PUT",
"url": "ResearchStudy/mii-exa-mtb-study-cldn6"
},
"resource": {
"resourceType": "ResearchStudy",
"id": "mii-exa-mtb-study-cldn6",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-studie|2026.0.0"
]
},
"identifier": [
{
"system": "https://www.medizininformatik-initiative.de/fhir/modul-mtb/sid/nct",
"value": "04503278"
}
],
"condition": [
{
"coding": [
{
"code": "369757002",
"system": "http://snomed.info/sct",
"display": "Solid tumor configuration"
}
]
}
],
"keyword": [
{
"text": "Non-small cell lung cancer (NSCLC)"
}
],
"enrollment": [
{
"reference": "Group/mii-exa-mtb-study-cldn6-eligibility-criteria"
}
],
"period": {
"start": "2020-09-16",
"end": "2040-01"
},
"site": [
{
"reference": "Location/mii-exa-mtb-study-cldn6-location-11"
}
],
"arm": [
{
"name": "Part 1 - CLDN6 CAR-T: Dose escalation in lymphodepleted patients until the MTD and/or RP2D"
},
{
"name": "Part 2 Vaccine-modulated - CLDN6 uRNA-LPX/CLDN6 modRNA-LPX: Dose escalation until the MTD and/or RP2D"
}
],
"objective": [
{
"type": {
"coding": [
{
"code": "primary"
}
]
},
"name": "Occurrence of treatment-emergent adverse events (TEAEs) including ≥ Grade 3, serious, fatal TEAEs by relationship"
},
{
"type": {
"coding": [
{
"code": "primary"
}
]
},
"name": "Occurrence of dose reduction and discontinuation of investigational medicinal product (IMP) due to TEAEs"
},
{
"type": {
"coding": [
{
"code": "primary"
}
]
},
"name": "Occurrence of dose-limiting toxicity (DLT) during the DLT evaluation period"
},
{
"type": {
"coding": [
{
"code": "secondary"
}
]
},
"name": "Change from baseline in the levels and kinetics of soluble immune factors measured by cytokine multiplex assay"
},
{
"type": {
"coding": [
{
"code": "secondary"
}
]
},
"name": "Objective response rate (ORR) defined as the proportion of patients in whom a complete response (CR) or partial response (PR) (per response evaluation criteria in solid tumors [RECIST 1.1]) is observed as best overall response"
},
{
"type": {
"coding": [
{
"code": "secondary"
}
]
},
"name": "Disease control rate (DCR) defined as the proportion of patients in whom a CR or PR or stable disease (SD) (per RECIST 1.1, SD assessed at least 6 weeks after the first dose) is observed as best overall response"
},
{
"type": {
"coding": [
{
"code": "secondary"
}
]
},
"name": "Duration of response (DOR) defined as the time from first objective response (CR or PR per RECIST 1.1) to first occurrence of objective progressive disease (PD) per RECIST 1.1/recurrence or death from any cause, whichever occurs first"
}
],
"status": "active",
"primaryPurposeType": {
"coding": [
{
"code": "treatment"
}
]
},
"phase": {
"coding": [
{
"code": "phase-1"
}
]
},
"sponsor": {
"reference": "Organization/mii-exa-mtb-study-sponsor-biontech"
},
"principalInvestigator": {
"reference": "PractitionerRole/mii-exa-mtb-study-investigator-biontech"
}
},
"fullUrl": "http://example.org/fhir/ResearchStudy/mii-exa-mtb-study-cldn6"
},
{
"request": {
"method": "PUT",
"url": "Group/mii-exa-mtb-study-cldn6-eligibility-criteria"
},
"resource": {
"resourceType": "Group",
"id": "mii-exa-mtb-study-cldn6-eligibility-criteria",
"characteristic": [
{
"code": {
"text": "Eligibility Criteria"
},
"valueReference": {
"display": "Inclusion Criteria:\n\n* Each patient enrolled in the trial must have CLDN6-positive tumor regardless of tumor histology defined as ≥ 50% of tumor cells expressing ≥ 2+ CLDN6 protein using a semi-quantitative immunohistochemistry (IHC) assay in a central laboratory for specific detection of CLDN6 protein expression in formalin-fixed, paraffin-embedded (FFPE) neoplastic tissues.\n* Availability of a FFPE tumor tissue sample. FFPE can be from an archival tumor tissue sample, and it should be from the most recent tumor tissue obtained. If this is not available, patient must be biopsied for CLDN6 staining.\n* Must have histological documentation of the original primary tumor via a pathology report.\n* Must have measurable disease per RECIST 1.1 (except for germ cell tumors, where patients can be evaluated according to Cancer-Antigen (CA)-125, Alpha-fetoprotein or human chorionic gonadotropin \\[as applicable\\] or ovarian cancer, where patients can be evaluated according to CA-125. The pre-treatment sample must be at least twice the upper limit of normal).\n* Must have a histologically confirmed solid tumor that is metastatic or unresectable and for which there is no available standard therapy likely to confer clinical benefit, or patient who is not a candidate for such available therapy.\n* Must be ≥ 18 years of age at the time the pre-screening informed consent is signed.\n* Must sign an informed consent form (ICF) indicating that he or she understands the purpose of and procedures required for the trial and are willing to participate in the trial prior to any trial-related assessments or procedures.\n* Must have an Eastern Cooperative Oncology Group performance status of 0 to 1.\n* Must have adequate coagulation function at screening as defined in the protocol.\n* Must have adequate hematologic function at screening as defined in the protocol.\n* Must have adequate hepatic function at screening as defined in the protocol.\n* Must have adequate renal function at screening as defined in the protocol.\n* Must be able to attend trial visits as required by the protocol.\n* Women of childbearing potential (WOCBP) must have a negative serum (beta-human chorionic gonadotropin) test/value at screening. Patients who are post-menopausal or permanently sterilized can be considered as not having reproductive potential.\n* WOCBP must agree not to donate eggs (ova, oocytes) for the purposes of assisted reproduction during the entire trial and thereafter.\n* WOCBP and men that are sexually active with a WOCBP and have not had a vasectomy must agree to use highly effective birth control method(s), as defined in the protocol. True abstinence is an acceptable alternative to the use of contraception.\n* Men must agree not to father a child or donate sperm, and WOCBP must agree not to become pregnant during the trial and for at least 12 months after the CLDN6 CAR-T infusion or CLDN6 RNA-LPX treatment.\n\nFor Part 2 only:\n\n* Histologically or cytologically confirmed solid tumor fulfilling inclusion criteria 1-4 that is metastatic or unresectable, and for whom there is no available standard therapy likely to confer clinical benefit, or patient who is not a candidate for such available therapy.\n\nExclusion Criteria:\n\n* Has received prior CAR-T therapy, except CLDN6 CAR-T therapy.\n* Has received vaccination with live virus vaccines within 6 weeks prior to the start of lymphodepletion (LD).\n* Receives concurrent systemic (oral or i.v.) steroid therapy \\> 10 mg prednisolone daily, or its equivalent, for an underlying condition.\n* Has side effects of any prior therapy or procedures for any medical condition not recovered to national cancer institute common terminology criteria for adverse events (CTCAE v.5) Grade ≤ 1.\n\nMedical conditions:\n\n* Current evidence of new or growing brain or spinal metastases during screening. Patients with known brain or spinal metastases may be eligible if they:\n\n 1. Have had radiotherapy or another appropriate therapy for the brain or spinal metastases,\n 2. Have no neurological symptoms,\n 3. Have stable brain or spinal disease on the computer tomography or magnetic resonance imaging scan within 4 weeks before signing of the ICF,\n 4. Are not undergoing acute corticosteroid therapy or steroid taper. Chronic steroid therapy is acceptable provided that the dose is stable for the last 14 days prior to screening (≤ 10 mg prednisolone daily or equivalent),\n 5. Do not require steroid therapy within 7 days before the first dose of CLDN6 CAR-T,\n 6. Do not have anticipated imminent fracture or cord compression due to spinal bone metastases.\n* Has history of epilepsy. Isolated seizures in the past or febrile seizures in childhood are permitted; has a history of a cerebrovascular accident or transient ischemic attack less than 6 months ago.\n* Pericardial effusion requiring any drainage is excluded.\n* Has an active autoimmune disease including but not limited to inflammatory bowel disease, systemic lupus erythematosus, ankylosing spondylitis, scleroderma, or multiple sclerosis. Has any active immunologic disorder requiring immunosuppression with steroids or other immunosuppressive agents with the exception of patients with isolated vitiligo, resolved childhood asthma or atopic dermatitis, controlled hypoadrenalism or hypopituitarism, and euthyroid patients with a history of Grave's disease. Patients with controlled hyperthyroidism must be negative for thyroglobulin, thyroid peroxidase antibodies, and thyroid-stimulating immunoglobulin prior to trial drug administration.\n* Seropositivity for human immunodeficiency virus.\n* Known history/positive serology for hepatitis B requiring active antiviral therapy (unless immune due to vaccination or resolved natural infection or unless passive immunization due to immunoglobulin therapy). Patients with positive serology must have hepatitis B virus viral load below the limit of quantification.\n* Active hepatitis C virus (HCV) infection; patients who have completed curative antiviral treatment with HCV viral load below the limit of quantification are allowed.\n* Has a known hypersensitivity to a component of CLDN6 CAR-T or CLDN6 RNA-LPX cancer vaccine drug product, or another similar compound.\n* Only for patients recruited for Part 2 with LD chemotherapy (CLDN6 CAR-T + CLDN6 RNA-LPX with LD chemotherapy): history of severe immediate hypersensitivity reaction to LD chemotherapy consisting of cyclophosphamide or fludarabine.\n* Has a history of another primary cancer within the 2 years prior to enrollment except for the following: Non-melanoma skin cancer, cervical carcinoma in situ, superficial bladder cancer, prostate cancer with currently undetectable prostate specific antigen, or other non-metastatic carcinoma that has been in complete remission without treatment for more than 2 years.\n* Receipt of allogenic stem cell transplantation in the 5 years prior to enrollment into the trial.\n* Patients with acute or chronic graft versus host disease.\n\nOther comorbidities:\n\n* Has abnormal electrocardiograms that are clinically significant, such as QT prolongation.\n* In the opinion of the Investigator, has any concurrent conditions that could pose an undue medical hazard or interfere with the interpretation of the trial results; these conditions include, but are not limited to:\n\n 1. Ongoing or active infection requiring antibiotic/antiviral/antifungal therapy\n 2. Concurrent congestive heart failure (New York Heart Association Functional Classification Class III or IV)\n 3. Concurrent unstable angina\n 4. Concurrent cardiac arrhythmia requiring treatment (excluding asymptomatic atrial fibrillation)\n 5. Acute coronary syndrome within the previous 6 months\n 6. Significant pulmonary disease (shortness of breath at rest or on mild exertion) for example due concurrent severe obstructive pulmonary disease.\n* Has a cognitive, psychological or psychosocial impediment that would impair the ability of the patient to receive therapy according to the protocol or adversely affect the ability of the patient to comply with the informed consent process, protocol, or protocol-required visits and procedures.\n* Is pregnant or breastfeeding"
},
"exclude": false
},
{
"code": {
"text": "Accepts Healthy Volunteers"
},
"valueBoolean": false,
"exclude": false
},
{
"code": {
"text": "Age"
},
"valueRange": {
"low": {
"value": 18,
"code": "a",
"system": "http://unitsofmeasure.org",
"unit": "year"
}
},
"exclude": false
},
{
"code": {
"text": "Age Group"
},
"valueReference": {
"reference": "Group/mii-exa-mtb-study-cldn6-eligibility-criteria-age-groups"
},
"exclude": false
}
],
"type": "person",
"actual": false,
"quantity": 145
},
"fullUrl": "http://example.org/fhir/Group/mii-exa-mtb-study-cldn6-eligibility-criteria"
},
{
"request": {
"method": "PUT",
"url": "Group/mii-exa-mtb-study-cldn6-eligibility-criteria-age-groups"
},
"resource": {
"resourceType": "Group",
"id": "mii-exa-mtb-study-cldn6-eligibility-criteria-age-groups",
"characteristic": [
{
"code": {
"text": "Age Group (Adult)"
},
"valueCodeableConcept": {
"coding": [
{
"code": "41847000",
"system": "http://snomed.info/sct",
"display": "Adulthood (qualifier value)"
}
]
},
"exclude": false
},
{
"code": {
"text": "Age Group (Older Adult)"
},
"valueCodeableConcept": {
"coding": [
{
"code": "271872005",
"system": "http://snomed.info/sct",
"display": "Old age (qualifier value)"
}
]
},
"exclude": false
}
],
"type": "person",
"actual": false
},
"fullUrl": "http://example.org/fhir/Group/mii-exa-mtb-study-cldn6-eligibility-criteria-age-groups"
},
{
"request": {
"method": "PUT",
"url": "Group/mii-exa-mtb-study-cldn6-comparison-group-0"
},
"resource": {
"resourceType": "Group",
"id": "mii-exa-mtb-study-cldn6-comparison-group-0",
"characteristic": [
{
"code": {
"text": "Exposed to"
},
"valueReference": {
"reference": "EvidenceVariable/mii-exa-mtb-study-cldn6-evidence-variable-0",
"display": "Biological: CLDN6 CAR-T"
},
"exclude": false
}
],
"type": "person",
"actual": false
},
"fullUrl": "http://example.org/fhir/Group/mii-exa-mtb-study-cldn6-comparison-group-0"
},
{
"request": {
"method": "PUT",
"url": "EvidenceVariable/mii-exa-mtb-study-cldn6-evidence-variable-0"
},
"resource": {
"resourceType": "EvidenceVariable",
"id": "mii-exa-mtb-study-cldn6-evidence-variable-0",
"useContext": [
{
"valueCodeableConcept": {
"coding": [
{
"code": "12893009",
"system": "http://snomed.info/sct",
"display": "Biological"
}
]
},
"code": {
"code": "362956003",
"system": "http://snomed.info/sct",
"display": "Procedure/intervention (navigational concept)"
}
}
],
"characteristic": [
{
"definitionReference": {
"reference": "Group/mii-exa-mtb-study-cldn6-eligibility-criteria"
}
}
],
"status": "active"
},
"fullUrl": "http://example.org/fhir/EvidenceVariable/mii-exa-mtb-study-cldn6-evidence-variable-0"
},
{
"request": {
"method": "PUT",
"url": "Group/mii-exa-mtb-study-cldn6-comparison-group-1"
},
"resource": {
"resourceType": "Group",
"id": "mii-exa-mtb-study-cldn6-comparison-group-1",
"characteristic": [
{
"code": {
"text": "Exposed to"
},
"valueReference": {
"reference": "EvidenceVariable/mii-exa-mtb-study-cldn6-evidence-variable-1",
"display": "Biological: CLDN6 uRNA-LPX/CLDN6 modRNA-LPX"
},
"exclude": false
}
],
"type": "person",
"actual": false
},
"fullUrl": "http://example.org/fhir/Group/mii-exa-mtb-study-cldn6-comparison-group-1"
},
{
"request": {
"method": "PUT",
"url": "EvidenceVariable/mii-exa-mtb-study-cldn6-evidence-variable-1"
},
"resource": {
"resourceType": "EvidenceVariable",
"id": "mii-exa-mtb-study-cldn6-evidence-variable-1",
"useContext": [
{
"valueCodeableConcept": {
"coding": [
{
"code": "12893009",
"system": "http://snomed.info/sct",
"display": "Biological"
}
]
},
"code": {
"code": "362956003",
"system": "http://snomed.info/sct",
"display": "Procedure/intervention (navigational concept)"
}
}
],
"characteristic": [
{
"definitionReference": {
"reference": "Group/mii-exa-mtb-study-cldn6-eligibility-criteria"
}
}
],
"status": "active"
},
"fullUrl": "http://example.org/fhir/EvidenceVariable/mii-exa-mtb-study-cldn6-evidence-variable-1"
},
{
"request": {
"method": "PUT",
"url": "Organization/mii-exa-mtb-study-sponsor-biontech"
},
"resource": {
"resourceType": "Organization",
"id": "mii-exa-mtb-study-sponsor-biontech",
"type": [
{
"coding": [
{
"code": "crs",
"system": "http://terminology.hl7.org/CodeSystem/organization-type",
"display": "Clinical Research Sponsor"
}
]
}
],
"name": "BioNTech Cell & Gene Therapies GmbH"
},
"fullUrl": "http://example.org/fhir/Organization/mii-exa-mtb-study-sponsor-biontech"
},
{
"request": {
"method": "PUT",
"url": "PractitionerRole/mii-exa-mtb-study-investigator-biontech"
},
"resource": {
"resourceType": "PractitionerRole",
"id": "mii-exa-mtb-study-investigator-biontech",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/modul-studie/StructureDefinition/mii-pr-studie-beteiligte-person"
]
},
"code": [
{
"coding": [
{
"code": "768734005",
"system": "http://snomed.info/sct",
"display": "Study coordinator"
}
]
}
]
},
"fullUrl": "http://example.org/fhir/PractitionerRole/mii-exa-mtb-study-investigator-biontech"
},
{
"request": {
"method": "PUT",
"url": "Location/mii-exa-mtb-study-cldn6-location-0"
},
"resource": {
"resourceType": "Location",
"id": "mii-exa-mtb-study-cldn6-location-0",
"address": {
"city": "Melbourne",
"state": "Victoria",
"postalCode": "3000",
"country": "Australia"
},
"position": {
"longitude": 144.96332,
"latitude": -37.814
},
"name": "Peter MacCallum Cancer Centre"
},
"fullUrl": "http://example.org/fhir/Location/mii-exa-mtb-study-cldn6-location-0"
},
{
"request": {
"method": "PUT",
"url": "Location/mii-exa-mtb-study-cldn6-location-1"
},
"resource": {
"resourceType": "Location",
"id": "mii-exa-mtb-study-cldn6-location-1",
"address": {
"city": "Berlin",
"postalCode": "12200",
"country": "Germany"
},
"position": {
"longitude": 13.41053,
"latitude": 52.52437
},
"name": "Charité - Universitätsmedizin Berlin - Campus Benjamin Franklin"
},
"fullUrl": "http://example.org/fhir/Location/mii-exa-mtb-study-cldn6-location-1"
},
{
"request": {
"method": "PUT",
"url": "Location/mii-exa-mtb-study-cldn6-location-2"
},
"resource": {
"resourceType": "Location",
"id": "mii-exa-mtb-study-cldn6-location-2",
"address": {
"city": "Erlangen",
"postalCode": "91054",
"country": "Germany"
},
"position": {
"longitude": 11.00783,
"latitude": 49.59099
},
"name": "Universitätsklinikum Erlangen - Hämatologie & Intrinsische Onkologie - Medizinische Klinik 5"
},
"fullUrl": "http://example.org/fhir/Location/mii-exa-mtb-study-cldn6-location-2"
},
{
"request": {
"method": "PUT",
"url": "Location/mii-exa-mtb-study-cldn6-location-3"
},
"resource": {
"resourceType": "Location",
"id": "mii-exa-mtb-study-cldn6-location-3",
"address": {
"city": "Hamburg",
"postalCode": "20246",
"country": "Germany"
},
"position": {
"longitude": 10.01534,
"latitude": 53.57532
},
"name": "Universitätsklinikum Hamburg Eppendorf - II Medizinische Klinik und Poliklinik"
},
"fullUrl": "http://example.org/fhir/Location/mii-exa-mtb-study-cldn6-location-3"
},
{
"request": {
"method": "PUT",
"url": "Location/mii-exa-mtb-study-cldn6-location-4"
},
"resource": {
"resourceType": "Location",
"id": "mii-exa-mtb-study-cldn6-location-4",
"address": {
"city": "Hannover",
"postalCode": "30625",
"country": "Germany"
},
"position": {
"longitude": 9.73322,
"latitude": 52.37052
},
"name": "Medizinische Hochschule Hannover - Klinik für Hämatologie, Hämostaseologie, Onkologie und Stammzelltransplantation"
},
"fullUrl": "http://example.org/fhir/Location/mii-exa-mtb-study-cldn6-location-4"
},
{
"request": {
"method": "PUT",
"url": "Location/mii-exa-mtb-study-cldn6-location-5"
},
"resource": {
"resourceType": "Location",
"id": "mii-exa-mtb-study-cldn6-location-5",
"address": {
"city": "Heidelberg",
"postalCode": "69120",
"country": "Germany"
},
"position": {
"longitude": 8.69079,
"latitude": 49.40768
},
"name": "Nationales Centrum für Tumorerkrankungen (NCT) Heidelberg"
},
"fullUrl": "http://example.org/fhir/Location/mii-exa-mtb-study-cldn6-location-5"
},
{
"request": {
"method": "PUT",
"url": "Location/mii-exa-mtb-study-cldn6-location-6"
},
"resource": {
"resourceType": "Location",
"id": "mii-exa-mtb-study-cldn6-location-6",
"address": {
"city": "Köln",
"postalCode": "50937",
"country": "Germany"
},
"position": {
"longitude": 6.95,
"latitude": 50.93333
},
"name": "Universitätsklinikum Köln AÖR-Centrum für Integrierte Onkologie (CIO)-Studienzentrum der Klinik I für Innere Medizin (CTU Cologne)"
},
"fullUrl": "http://example.org/fhir/Location/mii-exa-mtb-study-cldn6-location-6"
},
{
"request": {
"method": "PUT",
"url": "Location/mii-exa-mtb-study-cldn6-location-7"
},
"resource": {
"resourceType": "Location",
"id": "mii-exa-mtb-study-cldn6-location-7",
"address": {
"city": "Mainz",
"postalCode": "55131",
"country": "Germany"
},
"position": {
"longitude": 8.2791,
"latitude": 49.98419
},
"name": "Universitätsmedizin Mainz - III Medizinische Klinik und Poliklinik"
},
"fullUrl": "http://example.org/fhir/Location/mii-exa-mtb-study-cldn6-location-7"
},
{
"request": {
"method": "PUT",
"url": "Location/mii-exa-mtb-study-cldn6-location-8"
},
"resource": {
"resourceType": "Location",
"id": "mii-exa-mtb-study-cldn6-location-8",
"address": {
"city": "Regensburg",
"postalCode": "93053",
"country": "Germany"
},
"position": {
"longitude": 12.10161,
"latitude": 49.01513
},
"name": "Universitätsklinikum Regensburg - Klinik und Poliklinik für Innere Medizin III"
},
"fullUrl": "http://example.org/fhir/Location/mii-exa-mtb-study-cldn6-location-8"
},
{
"request": {
"method": "PUT",
"url": "Location/mii-exa-mtb-study-cldn6-location-9"
},
"resource": {
"resourceType": "Location",
"id": "mii-exa-mtb-study-cldn6-location-9",
"address": {
"city": "Amsterdam",
"postalCode": "1066",
"country": "Netherlands"
},
"position": {
"longitude": 4.88969,
"latitude": 52.37403
},
"name": "He Nederlands Kanker Instituut (The Netherlands Cancer Institute) - Antoni van Leeuwenhoek Ziekenhuis (NKI-AVL)"
},
"fullUrl": "http://example.org/fhir/Location/mii-exa-mtb-study-cldn6-location-9"
},
{
"request": {
"method": "PUT",
"url": "Location/mii-exa-mtb-study-cldn6-location-10"
},
"resource": {
"resourceType": "Location",
"id": "mii-exa-mtb-study-cldn6-location-10",
"address": {
"city": "Rotterdam",
"postalCode": "3015",
"country": "Netherlands"
},
"position": {
"longitude": 4.47917,
"latitude": 51.9225
},
"name": "Erasmus MC - Universitair Medisch Centrum - Medical oncology"
},
"fullUrl": "http://example.org/fhir/Location/mii-exa-mtb-study-cldn6-location-10"
},
{
"request": {
"method": "PUT",
"url": "Location/mii-exa-mtb-study-cldn6-location-11"
},
"resource": {
"resourceType": "Location",
"id": "mii-exa-mtb-study-cldn6-location-11",
"address": {
"city": "Stockholm",
"postalCode": "14186",
"country": "Sweden"
},
"position": {
"longitude": 18.0649,
"latitude": 59.33258
},
"name": "Karolinska Comprehensive Cancer Center Cancerstudieenheten Huddinge Karolinska Universitetssjukhuset"
},
"fullUrl": "http://example.org/fhir/Location/mii-exa-mtb-study-cldn6-location-11"
},
{
"request": {
"method": "PUT",
"url": "ResearchStudy/mii-exa-mtb-study-tedova"
},
"resource": {
"resourceType": "ResearchStudy",
"id": "mii-exa-mtb-study-tedova",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-studie|2026.0.0"
]
},
"identifier": [
{
"system": "https://www.medizininformatik-initiative.de/fhir/modul-mtb/sid/nct",
"value": "04713514"
}
],
"status": "active"
},
"fullUrl": "http://example.org/fhir/ResearchStudy/mii-exa-mtb-study-tedova"
},
{
"request": {
"method": "PUT",
"url": "ServiceRequest/mii-exa-mtb-study-request-tedova"
},
"resource": {
"resourceType": "ServiceRequest",
"id": "mii-exa-mtb-study-request-tedova",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-studieneinschluss-anfrage|2026.0.0"
]
},
"supportingInfo": [
{
"reference": "ResearchStudy/mii-exa-mtb-study-tedova"
}
],
"extension": [
{
"url": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-prioritaet",
"valueDecimal": 2.2
}
],
"intent": "proposal",
"category": [
{
"coding": [
{
"code": "110465008",
"system": "http://snomed.info/sct",
"display": "Clinical trial (procedure)"
}
]
}
],
"code": {
"coding": [
{
"code": "702475000",
"system": "http://snomed.info/sct",
"display": "Referral to clinical trial (procedure)"
}
]
},
"status": "draft",
"subject": {
"reference": "Patient/PatientKimMusterperson"
}
},
"fullUrl": "http://example.org/fhir/ServiceRequest/mii-exa-mtb-study-request-tedova"
},
{
"request": {
"method": "PUT",
"url": "ResearchStudy/mii-exa-mtb-study-ccne1"
},
"resource": {
"resourceType": "ResearchStudy",
"id": "mii-exa-mtb-study-ccne1",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-studie|2026.0.0"
]
},
"status": "active"
},
"fullUrl": "http://example.org/fhir/ResearchStudy/mii-exa-mtb-study-ccne1"
},
{
"request": {
"method": "PUT",
"url": "ServiceRequest/mii-exa-mtb-study-request-ccne1"
},
"resource": {
"resourceType": "ServiceRequest",
"id": "mii-exa-mtb-study-request-ccne1",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-studieneinschluss-anfrage|2026.0.0"
]
},
"supportingInfo": [
{
"reference": "ResearchStudy/mii-exa-mtb-study-ccne1"
}
],
"extension": [
{
"url": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-prioritaet",
"valueDecimal": 2.3
}
],
"intent": "proposal",
"category": [
{
"coding": [
{
"code": "110465008",
"system": "http://snomed.info/sct",
"display": "Clinical trial (procedure)"
}
]
}
],
"code": {
"coding": [
{
"code": "702475000",
"system": "http://snomed.info/sct",
"display": "Referral to clinical trial (procedure)"
}
]
},
"status": "draft",
"subject": {
"reference": "Patient/PatientKimMusterperson"
}
},
"fullUrl": "http://example.org/fhir/ServiceRequest/mii-exa-mtb-study-request-ccne1"
},
{
"request": {
"method": "PUT",
"url": "MedicationRequest/mii-exa-mtb-medication-request-mirvetuximab"
},
"resource": {
"resourceType": "MedicationRequest",
"id": "mii-exa-mtb-medication-request-mirvetuximab",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-therapieempfehlung|2026.0.0"
]
},
"basedOn": [
{
"reference": "CarePlan/mii-exa-mtb-kim-musterperson-therapieplan"
}
],
"medicationCodeableConcept": {
"coding": [
{
"code": "98DE7VN88D",
"system": "http://fdasis.nlm.nih.gov",
"display": "MIRVETUXIMAB SORAVTANSINE"
},
{
"code": "L01FX26",
"system": "http://fhir.de/CodeSystem/bfarm/atc",
"display": "Mirvetuximab soravtansin",
"version": "2025"
},
{
"code": "L01FX",
"system": "http://fhir.de/CodeSystem/bfarm/atc",
"display": "Andere monoklonale Antikörper und Antikörper-Wirkstoff-Konjugate",
"version": "2025"
}
]
},
"reasonReference": [
{
"reference": "Condition/PatientKimMusterperson-PrimaryDiagnosis-2"
}
],
"extension": [
{
"url": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-prioritaet",
"valuePositiveInt": 1
},
{
"valueCodeableConcept": {
"coding": [
{
"system": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-empfehlung-evidenzgrad",
"code": "m1A"
}
]
},
"url": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-evidenzgraduierung"
},
{
"valueIdentifier": {
"system": "http://doi.org",
"value": "10.1200/JCO.2022.40.16_suppl.5512"
},
"url": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-publikation"
},
{
"valueIdentifier": {
"system": "http://www.ncbi.nlm.nih.gov/pubmed",
"value": "38055253"
},
"url": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-publikation"
}
],
"status": "completed",
"intent": "proposal",
"authoredOn": "2023-03-28",
"subject": {
"reference": "Patient/PatientKimMusterperson"
}
},
"fullUrl": "http://example.org/fhir/MedicationRequest/mii-exa-mtb-medication-request-mirvetuximab"
},
{
"request": {
"method": "PUT",
"url": "MedicationRequest/mii-exa-mtb-medication-request-trastuzumab-deruxtecan"
},
"resource": {
"resourceType": "MedicationRequest",
"id": "mii-exa-mtb-medication-request-trastuzumab-deruxtecan",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-therapieempfehlung|2026.0.0"
]
},
"medicationCodeableConcept": {
"coding": [
{
"code": "L01FD04",
"system": "http://fhir.de/CodeSystem/bfarm/atc",
"display": "Trastuzumab deruxtecan",
"version": "2025"
}
]
},
"reasonReference": [
{
"reference": "Condition/PatientKimMusterperson-PrimaryDiagnosis-2"
}
],
"extension": [
{
"url": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-prioritaet",
"valuePositiveInt": 3
},
{
"valueCodeableConcept": {
"coding": [
{
"system": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-empfehlung-evidenzgrad",
"code": "m1B"
}
]
},
"url": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-evidenzgraduierung"
},
{
"valueIdentifier": {
"system": "http://www.ncbi.nlm.nih.gov/pubmed",
"value": "35665782"
},
"url": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-publikation"
},
{
"valueIdentifier": {
"system": "http://www.ncbi.nlm.nih.gov/pubmed",
"value": "37870536"
},
"url": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-publikation"
},
{
"valueIdentifier": {
"system": "http://doi.org",
"value": "10.1200/JCO.2023.41.17_suppl.LBA3000"
},
"url": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-publikation"
}
],
"status": "draft",
"intent": "proposal",
"authoredOn": "2023-03-28",
"subject": {
"reference": "Patient/PatientKimMusterperson"
}
},
"fullUrl": "http://example.org/fhir/MedicationRequest/mii-exa-mtb-medication-request-trastuzumab-deruxtecan"
},
{
"request": {
"method": "PUT",
"url": "MedicationRequest/mii-exa-mtb-medication-request-adavosertib"
},
"resource": {
"resourceType": "MedicationRequest",
"id": "mii-exa-mtb-medication-request-adavosertib",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-therapieempfehlung|2026.0.0"
]
},
"medicationCodeableConcept": {
"coding": [
{
"code": "K2T6HJX3I3",
"system": "http://fdasis.nlm.nih.gov",
"display": "ADAVOSERTIB"
}
]
},
"reasonReference": [
{
"reference": "Condition/PatientKimMusterperson-PrimaryDiagnosis-2"
}
],
"status": "draft",
"intent": "option",
"authoredOn": "2023-03-28",
"subject": {
"reference": "Patient/PatientKimMusterperson"
}
},
"fullUrl": "http://example.org/fhir/MedicationRequest/mii-exa-mtb-medication-request-adavosertib"
},
{
"request": {
"method": "PUT",
"url": "MedicationRequest/mii-exa-mtb-medication-request-carboplatin"
},
"resource": {
"resourceType": "MedicationRequest",
"id": "mii-exa-mtb-medication-request-carboplatin",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-therapieempfehlung|2026.0.0"
]
},
"medicationCodeableConcept": {
"coding": [
{
"code": "L01XA02",
"system": "http://fhir.de/CodeSystem/bfarm/atc",
"display": "Carboplatin",
"version": "2025"
}
]
},
"reasonReference": [
{
"reference": "Condition/PatientKimMusterperson-PrimaryDiagnosis-2"
}
],
"status": "draft",
"intent": "option",
"authoredOn": "2023-03-28",
"subject": {
"reference": "Patient/PatientKimMusterperson"
}
},
"fullUrl": "http://example.org/fhir/MedicationRequest/mii-exa-mtb-medication-request-carboplatin"
},
{
"request": {
"method": "PUT",
"url": "RequestGroup/mii-exa-mtb-request-group-adavosertib-carboplatin"
},
"resource": {
"resourceType": "RequestGroup",
"id": "mii-exa-mtb-request-group-adavosertib-carboplatin",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-therapieempfehlung-kombination|2026.0.0"
]
},
"action": [
{
"resource": {
"reference": "MedicationRequest/mii-exa-mtb-medication-request-carboplatin"
}
}
],
"extension": [
{
"url": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-prioritaet",
"valuePositiveInt": 4
},
{
"valueCodeableConcept": {
"coding": [
{
"system": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-empfehlung-evidenzgrad",
"code": "m1B"
}
]
},
"url": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-evidenzgraduierung"
},
{
"valueIdentifier": {
"system": "http://www.ncbi.nlm.nih.gov/pubmed",
"value": "37236033"
},
"url": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-publikation"
}
],
"intent": "proposal",
"status": "draft",
"authoredOn": "2023-03-28",
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"code": {
"coding": [
{
"code": "CZ",
"system": "https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-therapie-typ",
"display": "Chemotherapie + zielgerichtete Substanzen"
}
]
}
},
"fullUrl": "http://example.org/fhir/RequestGroup/mii-exa-mtb-request-group-adavosertib-carboplatin"
},
{
"request": {
"method": "PUT",
"url": "MedicationRequest/mii-exa-mtb-medication-request-lunresertib"
},
"resource": {
"resourceType": "MedicationRequest",
"id": "mii-exa-mtb-medication-request-lunresertib",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-therapieempfehlung|2026.0.0"
]
},
"medicationCodeableConcept": {
"coding": [
{
"code": "N95U3A7N57",
"system": "http://fdasis.nlm.nih.gov",
"display": "LUNRESERTIB"
}
]
},
"reasonReference": [
{
"reference": "Condition/PatientKimMusterperson-PrimaryDiagnosis-2"
}
],
"status": "draft",
"intent": "option",
"authoredOn": "2023-03-28",
"subject": {
"reference": "Patient/PatientKimMusterperson"
}
},
"fullUrl": "http://example.org/fhir/MedicationRequest/mii-exa-mtb-medication-request-lunresertib"
},
{
"request": {
"method": "PUT",
"url": "MedicationRequest/mii-exa-mtb-medication-request-camonsertib"
},
"resource": {
"resourceType": "MedicationRequest",
"id": "mii-exa-mtb-medication-request-camonsertib",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-therapieempfehlung|2026.0.0"
]
},
"medicationCodeableConcept": {
"coding": [
{
"code": "S1Z7Y5G56T",
"system": "http://fdasis.nlm.nih.gov",
"display": "CAMONSERTIB"
}
]
},
"reasonReference": [
{
"reference": "Condition/PatientKimMusterperson-PrimaryDiagnosis-2"
}
],
"status": "draft",
"intent": "option",
"authoredOn": "2023-03-28",
"subject": {
"reference": "Patient/PatientKimMusterperson"
}
},
"fullUrl": "http://example.org/fhir/MedicationRequest/mii-exa-mtb-medication-request-camonsertib"
},
{
"request": {
"method": "PUT",
"url": "RequestGroup/mii-exa-mtb-request-group-lunresertib-camonsertib"
},
"resource": {
"resourceType": "RequestGroup",
"id": "mii-exa-mtb-request-group-lunresertib-camonsertib",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-therapieempfehlung-kombination|2026.0.0"
]
},
"action": [
{
"resource": {
"reference": "MedicationRequest/mii-exa-mtb-medication-request-camonsertib"
}
}
],
"extension": [
{
"url": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-prioritaet",
"valuePositiveInt": 5
},
{
"valueCodeableConcept": {
"coding": [
{
"system": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-empfehlung-evidenzgrad",
"code": "m1B"
}
]
},
"url": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-evidenzgraduierung"
},
{
"valueIdentifier": {
"system": "http://doi.org",
"value": "10.1158/1535-7163.TARG-23-PR008"
},
"url": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-publikation"
}
],
"intent": "proposal",
"status": "draft",
"authoredOn": "2023-03-28",
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"code": {
"coding": [
{
"code": "ZS",
"system": "https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-therapie-typ",
"display": "zielgerichtete Substanzen"
}
]
}
},
"fullUrl": "http://example.org/fhir/RequestGroup/mii-exa-mtb-request-group-lunresertib-camonsertib"
},
{
"request": {
"method": "PUT",
"url": "MedicationRequest/mii-exa-mtb-medication-request-cobimetinib"
},
"resource": {
"resourceType": "MedicationRequest",
"id": "mii-exa-mtb-medication-request-cobimetinib",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-therapieempfehlung|2026.0.0"
]
},
"medicationCodeableConcept": {
"coding": [
{
"code": "ER29L26N1X",
"system": "http://fdasis.nlm.nih.gov",
"display": "COBIMETINIB"
}
]
},
"reasonReference": [
{
"reference": "Condition/PatientKimMusterperson-PrimaryDiagnosis-2"
}
],
"extension": [
{
"url": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-prioritaet",
"valuePositiveInt": 6
},
{
"valueCodeableConcept": {
"coding": [
{
"system": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-empfehlung-evidenzgrad",
"code": "m3"
}
]
},
"url": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-evidenzgraduierung"
},
{
"valueIdentifier": {
"system": "http://www.ncbi.nlm.nih.gov/pubmed",
"value": "31209687"
},
"url": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-publikation"
}
],
"status": "draft",
"intent": "option",
"authoredOn": "2023-03-28",
"subject": {
"reference": "Patient/PatientKimMusterperson"
}
},
"fullUrl": "http://example.org/fhir/MedicationRequest/mii-exa-mtb-medication-request-cobimetinib"
},
{
"request": {
"method": "PUT",
"url": "CarePlan/mii-exa-mtb-kim-musterperson-therapieplan"
},
"resource": {
"resourceType": "CarePlan",
"id": "mii-exa-mtb-kim-musterperson-therapieplan",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-therapieplan|2026.0.0"
]
},
"category": [
{
"coding": [
{
"system": "https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-therapieplanung-typ",
"code": "praeth"
}
]
}
],
"addresses": [
{
"reference": "Condition/PatientKimMusterperson-PrimaryDiagnosis-2"
}
],
"supportingInfo": [
{
"reference": "ClinicalImpression/mii-exa-mtb-kim-musterperson-behandlungsepisode"
}
],
"activity": [
{
"outcomeReference": [
{
"reference": "Procedure/MTBChemo2Procedure"
}
],
"reference": {
"reference": "MedicationRequest/mii-exa-mtb-medication-request-mirvetuximab"
}
},
{
"reference": {
"reference": "ServiceRequest/mii-exa-mtb-study-request-cldn6"
}
},
{
"reference": {
"reference": "ServiceRequest/mii-exa-mtb-study-request-tedova"
}
},
{
"reference": {
"reference": "ServiceRequest/mii-exa-mtb-study-request-ccne1"
}
},
{
"reference": {
"reference": "MedicationRequest/mii-exa-mtb-medication-request-trastuzumab-deruxtecan"
}
},
{
"reference": {
"reference": "RequestGroup/mii-exa-mtb-request-group-adavosertib-carboplatin"
}
},
{
"reference": {
"reference": "RequestGroup/mii-exa-mtb-request-group-lunresertib-camonsertib"
}
},
{
"reference": {
"reference": "MedicationRequest/mii-exa-mtb-medication-request-cobimetinib"
}
},
{
"reference": {
"reference": "ServiceRequest/mii-exa-mtb-kim-humangenetische-beratung-aszites"
}
},
{
"reference": {
"reference": "ServiceRequest/mii-exa-mtb-kim-histologie-evaluation-aszites"
}
},
{
"reference": {
"reference": "ServiceRequest/mii-exa-mtb-kim-rebiopsie-aszites"
}
}
],
"intent": "plan",
"status": "active",
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"created": "2023-03-28"
},
"fullUrl": "http://example.org/fhir/CarePlan/mii-exa-mtb-kim-musterperson-therapieplan"
},
{
"request": {
"method": "PUT",
"url": "Observation/mii-exa-mtb-kim-tumorzellgehalt-aszites"
},
"resource": {
"resourceType": "Observation",
"id": "mii-exa-mtb-kim-tumorzellgehalt-aszites",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-tumorzellgehalt|2026.0.0"
]
},
"valueQuantity": {
"system": "http://unitsofmeasure.org",
"value": 0.028,
"code": "%"
},
"code": {
"coding": [
{
"code": "93356-4",
"system": "http://loinc.org",
"display": "Cells with cytogenetic abnormality [#] in Blood or Tissue by Molecular genetics method"
}
]
},
"status": "final",
"method": {
"coding": [
{
"code": "histologic",
"system": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-bestimmungsmethode-tumorzellgehalt"
}
]
}
},
"fullUrl": "http://example.org/fhir/Observation/mii-exa-mtb-kim-tumorzellgehalt-aszites"
},
{
"request": {
"method": "PUT",
"url": "ServiceRequest/mii-exa-mtb-kim-humangenetische-beratung-aszites"
},
"resource": {
"resourceType": "ServiceRequest",
"id": "mii-exa-mtb-kim-humangenetische-beratung-aszites",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-humangenetische-beratung-auftrag|2026.0.0"
]
},
"code": {
"coding": [
{
"code": "788339009",
"system": "http://snomed.info/sct",
"display": "Genetic consultation (procedure)"
}
]
},
"reasonCode": [
{
"coding": [
{
"code": "secondary-tumor",
"system": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-auftrag-begruendung"
}
]
}
],
"specimen": [
{
"reference": "Specimen/PatientKimMusterperson-AscitesSpecimen-2"
}
],
"intent": "proposal",
"status": "completed",
"subject": {
"reference": "Patient/PatientKimMusterperson"
}
},
"fullUrl": "http://example.org/fhir/ServiceRequest/mii-exa-mtb-kim-humangenetische-beratung-aszites"
},
{
"request": {
"method": "PUT",
"url": "ServiceRequest/mii-exa-mtb-kim-histologie-evaluation-aszites"
},
"resource": {
"resourceType": "ServiceRequest",
"id": "mii-exa-mtb-kim-histologie-evaluation-aszites",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-histologie-evaluation-auftrag|2026.0.0"
]
},
"code": {
"coding": [
{
"code": "183825009",
"system": "http://snomed.info/sct",
"display": "Refer for histology (procedure)"
}
]
},
"reasonReference": [
{
"reference": "Observation/mii-exa-mtb-kim-tumorzellgehalt-aszites"
}
],
"specimen": [
{
"reference": "Specimen/PatientKimMusterperson-AscitesSpecimen-2"
}
],
"intent": "proposal",
"status": "draft",
"subject": {
"reference": "Patient/PatientKimMusterperson"
}
},
"fullUrl": "http://example.org/fhir/ServiceRequest/mii-exa-mtb-kim-histologie-evaluation-aszites"
},
{
"request": {
"method": "PUT",
"url": "ServiceRequest/mii-exa-mtb-kim-rebiopsie-aszites"
},
"resource": {
"resourceType": "ServiceRequest",
"id": "mii-exa-mtb-kim-rebiopsie-aszites",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-biopsie-auftrag|2026.0.0"
]
},
"code": {
"coding": [
{
"code": "86273004",
"system": "http://snomed.info/sct",
"display": "Biopsy (procedure)"
}
]
},
"reasonReference": [
{
"reference": "Observation/mii-exa-mtb-kim-tumorzellgehalt-aszites"
}
],
"specimen": [
{
"reference": "Specimen/PatientKimMusterperson-AscitesSpecimen-2"
}
],
"intent": "proposal",
"status": "completed",
"subject": {
"reference": "Patient/PatientKimMusterperson"
}
},
"fullUrl": "http://example.org/fhir/ServiceRequest/mii-exa-mtb-kim-rebiopsie-aszites"
},
{
"request": {
"method": "PUT",
"url": "Condition/mii-exa-mtb-kim-diagnose"
},
"resource": {
"resourceType": "Condition",
"id": "mii-exa-mtb-kim-diagnose",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-diagnose-primaertumor|2026.0.0"
]
},
"extension": [
{
"url": "http://hl7.org/fhir/StructureDefinition/condition-assertedDate",
"valueDateTime": "2021-06-10"
}
],
"clinicalStatus": {
"coding": [
{
"code": "active",
"system": "http://terminology.hl7.org/CodeSystem/condition-clinical"
}
]
},
"verificationStatus": {
"coding": [
{
"system": "http://terminology.hl7.org/CodeSystem/condition-ver-status",
"code": "unconfirmed"
},
{
"system": "https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-primaertumor-diagnosesicherung",
"code": "2"
}
]
},
"code": {
"coding": [
{
"code": "C48.2",
"system": "http://fhir.de/CodeSystem/bfarm/icd-10-gm",
"display": "Bösartige Neubildung: Peritoneum, nicht näher bezeichnet",
"version": "2023"
}
]
},
"bodySite": [
{
"coding": [
{
"code": "C56.9",
"system": "http://terminology.hl7.org/CodeSystem/icd-o-3",
"display": "Ovar"
}
]
}
],
"stage": [
{
"assessment": [
{
"reference": "Observation/mii-exa-mtb-kim-tumorausbreitung"
}
],
"type": {
"coding": [
{
"code": "C19251",
"system": "https://nih-ncpi.github.io/ncpi-fhir-ig/CodeSystem-ncit.html",
"display": "Stage at Diagnosis"
}
]
}
},
{
"type": {
"coding": [
{
"code": "371441004",
"system": "http://snomed.info/sct",
"display": "Histologic type of proliferative mass"
}
]
},
"assessment": [
{
"reference": "Observation/mii-exa-mtb-kim-oncotree"
}
]
}
],
"recordedDate": "2021-06-10",
"subject": {
"reference": "Patient/PatientKimMusterperson"
}
},
"fullUrl": "http://example.org/fhir/Condition/mii-exa-mtb-kim-diagnose"
},
{
"request": {
"method": "PUT",
"url": "Observation/mii-exa-mtb-kim-tumorausbreitung"
},
"resource": {
"resourceType": "Observation",
"id": "mii-exa-mtb-kim-tumorausbreitung",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-tumorausbreitung|2026.0.0"
]
},
"category": [
{
"coding": [
{
"code": "473302008",
"system": "http://snomed.info/sct",
"display": "Aware of diagnosis"
}
]
}
],
"code": {
"coding": [
{
"code": "371508000",
"system": "http://snomed.info/sct",
"display": "Tumor stage"
}
]
},
"valueCodeableConcept": {
"coding": [
{
"system": "http://snomed.info/sct",
"code": "255127006"
}
]
},
"status": "final",
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"effectiveDateTime": "2021-06-10"
},
"fullUrl": "http://example.org/fhir/Observation/mii-exa-mtb-kim-tumorausbreitung"
},
{
"request": {
"method": "PUT",
"url": "Observation/mii-exa-mtb-kim-oncotree"
},
"resource": {
"resourceType": "Observation",
"id": "mii-exa-mtb-kim-oncotree",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-oncotree|2026.0.0"
]
},
"code": {
"coding": [
{
"code": "371469007",
"system": "http://snomed.info/sct",
"display": "Histologic grade of neoplasm (observable entity)"
}
]
},
"valueCodeableConcept": {
"coding": [
{
"system": "http://data.mskcc.org/ontologies/oncotree",
"code": "HGONEC"
}
]
},
"status": "final",
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"effectiveDateTime": "2021-06-10"
},
"fullUrl": "http://example.org/fhir/Observation/mii-exa-mtb-kim-oncotree"
},
{
"request": {
"method": "PUT",
"url": "Condition/PatientKimMusterperson-PrimaryDiagnosis-2"
},
"resource": {
"resourceType": "Condition",
"id": "PatientKimMusterperson-PrimaryDiagnosis-2",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-diagnose-primaertumor"
]
},
"extension": [
{
"url": "http://hl7.org/fhir/StructureDefinition/condition-assertedDate",
"valueDateTime": "2021-06-10"
}
],
"verificationStatus": {
"coding": [
{
"system": "http://terminology.hl7.org/CodeSystem/condition-ver-status",
"code": "unconfirmed"
},
{
"system": "https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-primaertumor-diagnosesicherung",
"code": "2"
}
]
},
"code": {
"coding": [
{
"code": "C48.2",
"system": "http://fhir.de/CodeSystem/bfarm/icd-10-gm",
"version": "2020",
"display": "Bösartige Neubildung: Peritoneum, nicht näher bezeichnet"
}
]
},
"bodySite": [
{
"coding": [
{
"code": "C56.9",
"system": "http://terminology.hl7.org/CodeSystem/icd-o-3",
"display": "Ovar"
}
]
}
],
"recordedDate": "2021-06-10",
"subject": {
"reference": "Patient/PatientKimMusterperson"
},
"clinicalStatus": {
"coding": [
{
"code": "active",
"system": "http://terminology.hl7.org/CodeSystem/condition-clinical"
}
]
}
},
"fullUrl": "http://example.org/fhir/Condition/PatientKimMusterperson-PrimaryDiagnosis-2"
},
{
"request": {
"method": "PUT",
"url": "Observation/mii-exa-onko-allgemeiner-leistungszustand-ecog"
},
"resource": {
"resourceType": "Observation",
"id": "mii-exa-onko-allgemeiner-leistungszustand-ecog",
"meta": {
"profile": [
"https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-allgemeiner-leistungszustand-ecog"
]
},
"valueCodeableConcept": {
"coding": [
{
"system": "https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-allgemeiner-leistungszustand-ecog",
"code": "2",
"display": "Gehfähig, Selbstversorgung möglich, aber nicht arbeitsfähig; kann mehr als 50 % der Wachzeit aufstehen (50 - 60 % nach Karnofsky)"
}
]
},
"code": {
"coding": [
{
"system": "http://snomed.info/sct",
"code": "423740007"
}
]
},
"status": "final",
"subject": {
"reference": "Patient/PatientKimMusterperson"
}
},
"fullUrl": "http://example.org/fhir/Observation/mii-exa-onko-allgemeiner-leistungszustand-ecog"
},
{
"request": {
"method": "PUT",
"url": "Organization/MyHospital"
},
"resource": {
"resourceType": "Organization",
"id": "MyHospital",
"type": [
{
"coding": [
{
"system": "http://terminology.hl7.org/CodeSystem/organization-type",
"code": "prov",
"display": "Healthcare Provider"
}
]
}
],
"address": [
{
"line": [
"1234 Health St"
],
"city": "Medicity",
"state": "CareState",
"postalCode": "12345",
"country": "DE"
}
],
"name": "Example General Hospital"
},
"fullUrl": "http://example.org/fhir/Organization/MyHospital"
},
{
"request": {
"method": "PUT",
"url": "Organization/MyInsurer"
},
"resource": {
"resourceType": "Organization",
"id": "MyInsurer",
"type": [
{
"coding": [
{
"system": "http://terminology.hl7.org/CodeSystem/organization-type",
"code": "ins",
"display": "Insurance Company"
}
]
}
],
"address": [
{
"line": [
"789 Insurance Blvd"
],
"city": "Policytown",
"state": "InsureState",
"postalCode": "98765",
"country": "DE"
}
],
"name": "Example Health Insurance Co."
},
"fullUrl": "http://example.org/fhir/Organization/MyInsurer"
},
{
"request": {
"method": "PUT",
"url": "Coverage/MyCoverage"
},
"resource": {
"resourceType": "Coverage",
"id": "MyCoverage",
"type": {
"coding": [
{
"system": "http://terminology.hl7.org/CodeSystem/v3-ActCode",
"code": "EHCPOL",
"display": "extended healthcare"
}
]
},
"payor": [
{
"reference": "Organization/MyInsurer"
}
],
"period": {
"start": "2023-01-01",
"end": "2025-12-31"
},
"status": "active",
"beneficiary": {
"reference": "Patient/PatientKimMusterperson"
}
},
"fullUrl": "http://example.org/fhir/Coverage/MyCoverage"
}
],
"type": "transaction"
}