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Packagede.dktk.oncology
Resource TypeBundle
IdBundle-Bundle-example-1_a.json
FHIR VersionR4

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Source1

{
  "resourceType": "Bundle",
  "id": "Bundle-Bundle-example-2",
  "meta": {
    "lastUpdated": "2024-07-12T11:33:30+00:00"
  },
  "type": "transaction",
  "entry": [
    {
      "fullUrl": "http://example.com/ClinicalImpression/ClinicalImpression-Verlauf-example-1",
      "resource": {
        "resourceType": "ClinicalImpression",
        "id": "ClinicalImpression-Verlauf-example-1",
        "meta": {
          "profile": [
            "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-ClinicalImpression-Verlauf"
          ]
        },
        "status": "completed",
        "subject": {
          "reference": "Patient/Patient-Patient-example-1"
        },
        "effectiveDateTime": "2018-01-01",
        "problem": [
          {
            "reference": "Condition/Condition-Primaerdiagnose-example-1"
          }
        ],
        "finding": [
          {
            "itemReference": {
              "reference": "Observation/Observation-Vitalstatus-example-1"
            }
          },
          {
            "itemReference": {
              "reference": "Observation/Observation-TumorstatusLymphknoten-example-1"
            }
          },
          {
            "itemReference": {
              "reference": "Observation/Observation-LokalerTumorstatus-example-1"
            }
          },
          {
            "itemReference": {
              "reference": "Observation/Observation-TumorstatusFernmetastasen-example-1"
            }
          },
          {
            "itemReference": {
              "reference": "Observation/Observation-GesamtbeurteilungTumorstatus-example-1"
            }
          },
          {
            "itemReference": {
              "reference": "Observation/Observation-Fernmetastasen-example-1"
            }
          }
        ]
      },
      "request": {
        "method": "PUT",
        "url": "ClinicalImpression/ClinicalImpression-Verlauf-example-1"
      }
    },
    {
      "fullUrl": "http://example.com/Condition/Condition-Primaerdiagnose-example-1",
      "resource": {
        "resourceType": "Condition",
        "id": "Condition-Primaerdiagnose-example-1",
        "meta": {
          "profile": [
            "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Condition-Primaerdiagnose"
          ]
        },
        "extension": [
          {
            "url": "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Extension-Specimen",
            "valueReference": {
              "reference": "Specimen/Specimen-Specimen-example-1"
            }
          },
          {
            "url": "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Extension-Fernmetastasen",
            "valueReference": {
              "reference": "Observation/Observation-Fernmetastasen-example-1"
            }
          }
        ],
        "code": {
          "coding": [
            {
              "system": "http://fhir.de/CodeSystem/bfarm/icd-10-gm",
              "version": "2019",
              "code": "C61.9",
              "display": "Prostata o.n.A."
            }
          ]
        },
        "bodySite": [
          {
            "coding": [
              {
                "system": "urn:oid:2.16.840.1.113883.6.43.1",
                "version": "31",
                "code": "C61.9"
              },
              {
                "system": "urn:oid:2.16.840.1.113883.2.6.60.7.1.1",
                "code": "L"
              }
            ]
          }
        ],
        "subject": {
          "reference": "Patient/Patient-Patient-example-1"
        },
        "encounter": {
          "reference": "Encounter/Encounter-Fall-example-1"
        },
        "onsetDateTime": "2016-02-01",
        "stage": [
          {
            "assessment": [
              {
                "reference": "Observation/Observation-TNMc-example-1"
              }
            ]
          }
        ],
        "evidence": [
          {
            "code": [
              {
                "coding": [
                  {
                    "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/DiagnosesicherungCS",
                    "code": "4"
                  }
                ]
              }
            ],
            "detail": [
              {
                "reference": "Observation/Observation-Histologie-example-1"
              }
            ]
          }
        ]
      },
      "request": {
        "method": "PUT",
        "url": "Condition/Condition-Primaerdiagnose-example-1"
      }
    },
    {
      "fullUrl": "http://example.com/Encounter/Encounter-Fall-example-1",
      "resource": {
        "resourceType": "Encounter",
        "id": "Encounter-Fall-example-1",
        "meta": {
          "profile": [
            "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Encounter-Fall"
          ]
        },
        "status": "finished",
        "class": {
          "system": "http://terminology.hl7.org/CodeSystem/v3-ActCode",
          "code": "VR",
          "display": "virtual"
        },
        "subject": {
          "reference": "Patient/Patient-Patient-example-1"
        },
        "diagnosis": [
          {
            "condition": {
              "reference": "Condition/Condition-Primaerdiagnose-example-1"
            }
          }
        ]
      },
      "request": {
        "method": "PUT",
        "url": "Encounter/Encounter-Fall-example-1"
      }
    },
    {
      "fullUrl": "http://example.com/MedicationStatement/MedicationStatement-Systemtherapie-example-1",
      "resource": {
        "resourceType": "MedicationStatement",
        "id": "MedicationStatement-Systemtherapie-example-1",
        "meta": {
          "profile": [
            "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-MedicationStatement-Systemtherapie"
          ]
        },
        "extension": [
          {
            "url": "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Extension-StellungZurOp",
            "valueCodeableConcept": {
              "coding": [
                {
                  "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/SYSTStellungOPCS",
                  "code": "A",
                  "display": "adjuvant"
                }
              ]
            }
          },
          {
            "url": "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Extension-SYSTIntention",
            "valueCodeableConcept": {
              "coding": [
                {
                  "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/SYSTIntentionCS",
                  "code": "P",
                  "display": "palliativ"
                }
              ]
            }
          },
          {
            "url": "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Extension-LokaleResidualstatus",
            "valueReference": {
              "reference": "Observation/Observation-LokaleBeurteilungResidualstatus-example-1"
            }
          },
          {
            "url": "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Extension-GesamtbeurteilungResidualstatus",
            "valueReference": {
              "reference": "Observation/Observation-GesamtbeurteilungResidualstatus-example-1"
            }
          },
          {
            "url": "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Extension-SystemischeTherapieProtokoll",
            "valueCodeableConcept": {
              "coding": [
                {
                  "system": "https://standards.digital.health.nz/ns/sact-regimen-code",
                  "display": "ABVD"
                }
              ]
            }
          }
        ],
        "status": "active",
        "category": {
          "coding": [
            {
              "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/SYSTTherapieartCS",
              "code": "CH",
              "display": "Chemotherapie"
            }
          ]
        },
        "medicationCodeableConcept": {
          "coding": [
            {
              "system": "http://fhir.de/CodeSystem/bfarm/atc",
              "version": "2024",
              "code": "L01BC05",
              "display": "Gemcitabin"
            },
            {
              "system": "http://fhir.de/CodeSystem/bfarm/atc",
              "version": "2023",
              "code": "L01XA02",
              "display": "Carboplatin"
            }
          ],
          "text": "Carboplatin-Text Gemcitabin-Text"
        },
        "subject": {
          "reference": "Patient/Patient-Patient-example-1"
        },
        "context": {
          "reference": "Encounter/Encounter-Fall-example-1"
        },
        "effectivePeriod": {
          "start": "2021-02-17",
          "end": "2023-03-27"
        }
      },
      "request": {
        "method": "PUT",
        "url": "MedicationStatement/MedicationStatement-Systemtherapie-example-1"
      }
    },
    {
      "fullUrl": "http://example.com/Observation/Observation-Fernmetastasen-example-1",
      "resource": {
        "resourceType": "Observation",
        "id": "Observation-Fernmetastasen-example-1",
        "meta": {
          "profile": [
            "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Observation-Fernmetastasen"
          ]
        },
        "status": "final",
        "code": {
          "coding": [
            {
              "system": "http://loinc.org",
              "code": "21907-1"
            }
          ]
        },
        "subject": {
          "reference": "Patient/Patient-Patient-example-1"
        },
        "encounter": {
          "reference": "Encounter/Encounter-Fall-example-1"
        },
        "effectiveDateTime": "2018-01-01",
        "valueCodeableConcept": {
          "coding": [
            {
              "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/JNUCS",
              "code": "J"
            }
          ]
        },
        "bodySite": {
          "coding": [
            {
              "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/FMLokalisationCS",
              "code": "PUL",
              "display": "Lunge"
            }
          ]
        }
      },
      "request": {
        "method": "PUT",
        "url": "Observation/Observation-Fernmetastasen-example-1"
      }
    },
    {
      "fullUrl": "http://example.com/Observation/Observation-GesamtbeurteilungResidualstatus-example-1",
      "resource": {
        "resourceType": "Observation",
        "id": "Observation-GesamtbeurteilungResidualstatus-example-1",
        "meta": {
          "profile": [
            "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Observation-GesamtbeurteilungResidualstatus"
          ]
        },
        "status": "final",
        "code": {
          "coding": [
            {
              "system": "http://loinc.org",
              "code": "81169-5"
            }
          ]
        },
        "subject": {
          "reference": "Patient/Patient-Patient-example-1"
        },
        "encounter": {
          "reference": "Encounter/Encounter-Fall-example-1"
        },
        "effectiveDateTime": "2018-01-01",
        "valueCodeableConcept": {
          "coding": [
            {
              "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/GesamtbeurteilungResidualstatusCS",
              "code": "RX",
              "display": "Vorhandensein von Residualtumor kann nicht beurteilt werden"
            }
          ]
        }
      },
      "request": {
        "method": "PUT",
        "url": "Observation/Observation-GesamtbeurteilungResidualstatus-example-1"
      }
    },
    {
      "fullUrl": "http://example.com/Observation/Observation-GesamtbeurteilungTumorstatus-example-1",
      "resource": {
        "resourceType": "Observation",
        "id": "Observation-GesamtbeurteilungTumorstatus-example-1",
        "meta": {
          "profile": [
            "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Observation-GesamtbeurteilungTumorstatus"
          ]
        },
        "status": "final",
        "code": {
          "coding": [
            {
              "system": "http://loinc.org",
              "code": "21976-6"
            }
          ]
        },
        "subject": {
          "reference": "Patient/Patient-Patient-example-1"
        },
        "encounter": {
          "reference": "Encounter/Encounter-Fall-example-1"
        },
        "effectiveDateTime": "2018-01-01",
        "valueCodeableConcept": {
          "coding": [
            {
              "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/GesamtbeurteilungTumorstatusCS",
              "code": "V",
              "display": "Vollremission (complete remission, CR)"
            }
          ]
        }
      },
      "request": {
        "method": "PUT",
        "url": "Observation/Observation-GesamtbeurteilungTumorstatus-example-1"
      }
    },
    {
      "fullUrl": "http://example.com/Observation/Observation-Grading-example-1",
      "resource": {
        "resourceType": "Observation",
        "id": "Observation-Grading-example-1",
        "meta": {
          "profile": [
            "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Observation-Grading"
          ]
        },
        "status": "final",
        "code": {
          "coding": [
            {
              "system": "http://loinc.org",
              "code": "59542-1"
            }
          ]
        },
        "subject": {
          "reference": "Patient/Patient-Patient-example-1"
        },
        "encounter": {
          "reference": "Encounter/Encounter-Fall-example-1"
        },
        "effectiveDateTime": "2018-01-01",
        "valueCodeableConcept": {
          "coding": [
            {
              "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/GradingCS",
              "code": "0",
              "display": "malignes Melanom der Konjunktiva"
            }
          ]
        },
        "specimen": {
          "reference": "Specimen/Specimen-Specimen-example-1"
        }
      },
      "request": {
        "method": "PUT",
        "url": "Observation/Observation-Grading-example-1"
      }
    },
    {
      "fullUrl": "http://example.com/Observation/Observation-Histologie-example-1",
      "resource": {
        "resourceType": "Observation",
        "id": "Observation-Histologie-example-1",
        "meta": {
          "profile": [
            "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Observation-Histologie"
          ]
        },
        "status": "final",
        "code": {
          "coding": [
            {
              "system": "http://loinc.org",
              "code": "59847-4"
            }
          ]
        },
        "subject": {
          "reference": "Patient/Patient-Patient-example-1"
        },
        "encounter": {
          "reference": "Encounter/Encounter-Fall-example-1"
        },
        "effectiveDateTime": "2018-01-01",
        "valueCodeableConcept": {
          "coding": [
            {
              "system": "urn:oid:2.16.840.1.113883.6.43.1",
              "version": "32",
              "code": "8140/3",
              "display": "Adenokarzinom"
            }
          ],
          "text": "Gewöhnliches Adenokarzinom"
        },
        "specimen": {
          "reference": "Specimen/Specimen-Specimen-example-1"
        },
        "hasMember": [
          {
            "reference": "Observation/Observation-Grading-example-1"
          }
        ]
      },
      "request": {
        "method": "PUT",
        "url": "Observation/Observation-Histologie-example-1"
      }
    },
    {
      "fullUrl": "http://example.com/Observation/Observation-TodUrsache-example-1",
      "resource": {
        "resourceType": "Observation",
        "id": "Observation-TodUrsache-example-1",
        "meta": {
          "profile": [
            "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Observation-TodUrsache"
          ]
        },
        "status": "final",
        "code": {
          "coding": [
            {
              "system": "http://loinc.org",
              "code": "68343-3"
            }
          ]
        },
        "subject": {
          "reference": "Patient/Patient-Patient-example-1"
        },
        "encounter": {
          "reference": "Encounter/Encounter-Fall-example-1"
        },
        "effectiveDateTime": "2018-01-01",
        "valueCodeableConcept": {
          "coding": [
            {
              "system": "http://fhir.de/CodeSystem/bfarm/icd-10-gm",
              "code": "C61"
            }
          ]
        }
      },
      "request": {
        "method": "PUT",
        "url": "Observation/Observation-TodUrsache-example-1"
      }
    },
    {
      "fullUrl": "http://example.com/Observation/Observation-LokaleBeurteilungResidualstatus-example-1",
      "resource": {
        "resourceType": "Observation",
        "id": "Observation-LokaleBeurteilungResidualstatus-example-1",
        "meta": {
          "profile": [
            "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Observation-LokaleBeurteilungResidualstatus"
          ]
        },
        "status": "final",
        "code": {
          "coding": [
            {
              "system": "http://loinc.org",
              "code": "84892-9"
            }
          ]
        },
        "subject": {
          "reference": "Patient/Patient-Patient-example-1"
        },
        "encounter": {
          "reference": "Encounter/Encounter-Fall-example-1"
        },
        "effectiveDateTime": "2018-01-01",
        "valueCodeableConcept": {
          "coding": [
            {
              "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/LokaleBeurteilungResidualstatusCS",
              "code": "RX",
              "display": "Vorhandensein von Residualtumor kann nicht beurteilt werden"
            }
          ]
        }
      },
      "request": {
        "method": "PUT",
        "url": "Observation/Observation-LokaleBeurteilungResidualstatus-example-1"
      }
    },
    {
      "fullUrl": "http://example.com/Observation/Observation-LokalerTumorstatus-example-1",
      "resource": {
        "resourceType": "Observation",
        "id": "Observation-LokalerTumorstatus-example-1",
        "meta": {
          "profile": [
            "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Observation-LokalerTumorstatus"
          ]
        },
        "status": "final",
        "code": {
          "coding": [
            {
              "system": "http://loinc.org",
              "code": "LA4583-6"
            }
          ]
        },
        "subject": {
          "reference": "Patient/Patient-Patient-example-1"
        },
        "encounter": {
          "reference": "Encounter/Encounter-Fall-example-1"
        },
        "effectiveDateTime": "2018-01-01",
        "valueCodeableConcept": {
          "coding": [
            {
              "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/VerlaufLokalerTumorstatusCS",
              "code": "T",
              "display": "Tumorreste (Residualtumor)"
            }
          ]
        }
      },
      "request": {
        "method": "PUT",
        "url": "Observation/Observation-LokalerTumorstatus-example-1"
      }
    },
    {
      "fullUrl": "http://example.com/Observation/Observation-TumorstatusFernmetastasen-example-1",
      "resource": {
        "resourceType": "Observation",
        "id": "Observation-TumorstatusFernmetastasen-example-1",
        "meta": {
          "profile": [
            "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Observation-TumorstatusFernmetastasen"
          ]
        },
        "status": "final",
        "code": {
          "coding": [
            {
              "system": "http://loinc.org",
              "code": "LA4226-2"
            }
          ]
        },
        "subject": {
          "reference": "Patient/Patient-Patient-example-1"
        },
        "encounter": {
          "reference": "Encounter/Encounter-Fall-example-1"
        },
        "effectiveDateTime": "2018-01-01",
        "valueCodeableConcept": {
          "coding": [
            {
              "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/VerlaufTumorstatusFernmetastasenCS",
              "code": "M",
              "display": "Verbliebene Fernmetastase(n)"
            }
          ]
        }
      },
      "request": {
        "method": "PUT",
        "url": "Observation/Observation-TumorstatusFernmetastasen-example-1"
      }
    },
    {
      "fullUrl": "http://example.com/Observation/Observation-TumorstatusLymphknoten-example-1",
      "resource": {
        "resourceType": "Observation",
        "id": "Observation-TumorstatusLymphknoten-example-1",
        "meta": {
          "profile": [
            "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Observation-TumorstatusLymphknoten"
          ]
        },
        "status": "final",
        "code": {
          "coding": [
            {
              "system": "http://loinc.org",
              "code": "LA4370-8"
            }
          ]
        },
        "subject": {
          "reference": "Patient/Patient-Patient-example-1"
        },
        "encounter": {
          "reference": "Encounter/Encounter-Fall-example-1"
        },
        "effectiveDateTime": "2018-01-01",
        "valueCodeableConcept": {
          "coding": [
            {
              "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/VerlaufTumorstatusLymphknotenCS",
              "code": "R",
              "display": "Neu aufgetretenes Lymphknotenrezidiv"
            }
          ]
        }
      },
      "request": {
        "method": "PUT",
        "url": "Observation/Observation-TumorstatusLymphknoten-example-1"
      }
    },
    {
      "fullUrl": "http://example.com/Observation/Observation-TNMc-example-1",
      "resource": {
        "resourceType": "Observation",
        "id": "Observation-TNMc-example-1",
        "meta": {
          "profile": [
            "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Observation-TNMc"
          ]
        },
        "status": "final",
        "code": {
          "coding": [
            {
              "system": "http://loinc.org",
              "code": "21908-9"
            }
          ]
        },
        "subject": {
          "reference": "Patient/Patient-Patient-example-1"
        },
        "encounter": {
          "reference": "Encounter/Encounter-Fall-example-1"
        },
        "effectiveDateTime": "2018-01-01",
        "valueCodeableConcept": {
          "coding": [
            {
              "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/UiccstadiumCS",
              "version": "8",
              "code": "IIIA"
            }
          ]
        },
        "component": [
          {
            "extension": [
              {
                "url": "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Extension-TNMcpuPraefix",
                "valueCodeableConcept": {
                  "coding": [
                    {
                      "code": "c"
                    }
                  ]
                }
              }
            ],
            "code": {
              "coding": [
                {
                  "system": "http://loinc.org",
                  "code": "21905-5"
                }
              ]
            },
            "valueCodeableConcept": {
              "coding": [
                {
                  "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/TNMTCS",
                  "code": "1b2"
                }
              ]
            }
          },
          {
            "extension": [
              {
                "url": "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Extension-TNMcpuPraefix",
                "valueCodeableConcept": {
                  "coding": [
                    {
                      "code": "c"
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                  ]
                }
              }
            ],
            "code": {
              "coding": [
                {
                  "system": "http://loinc.org",
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            "valueCodeableConcept": {
              "coding": [
                {
                  "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/TNMNCS",
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              ]
            }
          },
          {
            "extension": [
              {
                "url": "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Extension-TNMcpuPraefix",
                "valueCodeableConcept": {
                  "coding": [
                    {
                      "code": "c"
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                }
              }
            ],
            "code": {
              "coding": [
                {
                  "system": "http://loinc.org",
                  "code": "21907-1"
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              ]
            },
            "valueCodeableConcept": {
              "coding": [
                {
                  "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/TNMMCS",
                  "code": "1b"
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              ]
            }
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          {
            "code": {
              "coding": [
                {
                  "system": "http://loinc.org",
                  "code": "59479-6"
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              ]
            },
            "valueCodeableConcept": {
              "coding": [
                {
                  "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/TNMySymbolCS",
                  "code": "y"
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              ]
            }
          },
          {
            "code": {
              "coding": [
                {
                  "system": "http://loinc.org",
                  "code": "21983-2"
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            },
            "valueCodeableConcept": {
              "coding": [
                {
                  "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/TNMrSymbolCS",
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              ]
            }
          },
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            "code": {
              "coding": [
                {
                  "system": "http://loinc.org",
                  "code": "42030-7"
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              ]
            },
            "valueCodeableConcept": {
              "coding": [
                {
                  "code": "m"
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              ]
            }
          }
        ]
      },
      "request": {
        "method": "PUT",
        "url": "Observation/Observation-TNMc-example-1"
      }
    },
    {
      "fullUrl": "http://example.com/Observation/Observation-TNMp-example-1",
      "resource": {
        "resourceType": "Observation",
        "id": "Observation-TNMp-example-1",
        "meta": {
          "profile": [
            "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Observation-TNMp"
          ]
        },
        "status": "final",
        "code": {
          "coding": [
            {
              "system": "http://loinc.org",
              "code": "21902-2"
            }
          ]
        },
        "subject": {
          "reference": "Patient/Patient-Patient-example-1"
        },
        "encounter": {
          "reference": "Encounter/Encounter-Fall-example-1"
        },
        "effectiveDateTime": "2018-01-01",
        "valueCodeableConcept": {
          "coding": [
            {
              "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/UiccstadiumCS",
              "version": "8",
              "code": "IIIA"
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          ]
        },
        "component": [
          {
            "extension": [
              {
                "url": "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Extension-TNMcpuPraefix",
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                  "coding": [
                    {
                      "code": "c"
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                  ]
                }
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            ],
            "code": {
              "coding": [
                {
                  "system": "http://loinc.org",
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            },
            "valueCodeableConcept": {
              "coding": [
                {
                  "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/TNMTCS",
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              ]
            }
          },
          {
            "extension": [
              {
                "url": "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Extension-TNMcpuPraefix",
                "valueCodeableConcept": {
                  "coding": [
                    {
                      "code": "c"
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                }
              }
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            "code": {
              "coding": [
                {
                  "system": "http://loinc.org",
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            "valueCodeableConcept": {
              "coding": [
                {
                  "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/TNMNCS",
                  "code": "0(i+)"
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            }
          },
          {
            "extension": [
              {
                "url": "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Extension-TNMcpuPraefix",
                "valueCodeableConcept": {
                  "coding": [
                    {
                      "code": "c"
                    }
                  ]
                }
              }
            ],
            "code": {
              "coding": [
                {
                  "system": "http://loinc.org",
                  "code": "21901-4"
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              ]
            },
            "valueCodeableConcept": {
              "coding": [
                {
                  "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/TNMMCS",
                  "code": "1b"
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            }
          },
          {
            "code": {
              "coding": [
                {
                  "system": "http://loinc.org",
                  "code": "59479-6"
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            },
            "valueCodeableConcept": {
              "coding": [
                {
                  "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/TNMySymbolCS",
                  "code": "y"
                }
              ]
            }
          },
          {
            "code": {
              "coding": [
                {
                  "system": "http://loinc.org",
                  "code": "21983-2"
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              ]
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            "valueCodeableConcept": {
              "coding": [
                {
                  "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/TNMrSymbolCS",
                  "code": "r"
                }
              ]
            }
          },
          {
            "code": {
              "coding": [
                {
                  "system": "http://loinc.org",
                  "code": "42030-7"
                }
              ]
            },
            "valueCodeableConcept": {
              "coding": [
                {
                  "code": "m"
                }
              ]
            }
          }
        ]
      },
      "request": {
        "method": "PUT",
        "url": "Observation/Observation-TNMp-example-1"
      }
    },
    {
      "fullUrl": "http://example.com/Observation/Observation-TNMp-example-3",
      "resource": {
        "resourceType": "Observation",
        "id": "Observation-TNMp-example-3",
        "meta": {
          "profile": [
            "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Observation-TNMp"
          ]
        },
        "status": "final",
        "code": {
          "coding": [
            {
              "system": "http://loinc.org",
              "code": "21902-2"
            }
          ]
        },
        "subject": {
          "reference": "Patient/Patient-Patient-example-3"
        },
        "encounter": {
          "reference": "Encounter/Encounter-Fall-example-1"
        },
        "effectiveDateTime": "2018-01-01",
        "valueCodeableConcept": {
          "coding": [
            {
              "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/UiccstadiumCS",
              "version": "8",
              "code": "IIIA"
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          ]
        },
        "component": [
          {
            "extension": [
              {
                "url": "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Extension-TNMcpuPraefix",
                "valueCodeableConcept": {
                  "coding": [
                    {
                      "code": "c"
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                }
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            "code": {
              "coding": [
                {
                  "system": "http://loinc.org",
                  "code": "21899-0"
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            "valueCodeableConcept": {
              "coding": [
                {
                  "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/TNMTCS",
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              ]
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          },
          {
            "extension": [
              {
                "url": "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Extension-TNMcpuPraefix",
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                  "coding": [
                    {
                      "code": "c"
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            "code": {
              "coding": [
                {
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            "valueCodeableConcept": {
              "coding": [
                {
                  "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/TNMNCS",
                  "code": "0(i+)"
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          },
          {
            "extension": [
              {
                "url": "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Extension-TNMcpuPraefix",
                "valueCodeableConcept": {
                  "coding": [
                    {
                      "code": "c"
                    }
                  ]
                }
              }
            ],
            "code": {
              "coding": [
                {
                  "system": "http://loinc.org",
                  "code": "21901-4"
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            },
            "valueCodeableConcept": {
              "coding": [
                {
                  "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/TNMMCS",
                  "code": "1b"
                }
              ]
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          },
          {
            "code": {
              "coding": [
                {
                  "system": "http://loinc.org",
                  "code": "59479-6"
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            },
            "valueCodeableConcept": {
              "coding": [
                {
                  "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/TNMySymbolCS",
                  "code": "y"
                }
              ]
            }
          },
          {
            "code": {
              "coding": [
                {
                  "system": "http://loinc.org",
                  "code": "21983-2"
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              ]
            },
            "valueCodeableConcept": {
              "coding": [
                {
                  "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/TNMrSymbolCS",
                  "code": "r"
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              ]
            }
          },
          {
            "code": {
              "coding": [
                {
                  "system": "http://loinc.org",
                  "code": "42030-7"
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              ]
            },
            "valueCodeableConcept": {
              "coding": [
                {
                  "code": "m"
                }
              ]
            }
          }
        ]
      },
      "request": {
        "method": "PUT",
        "url": "Observation/Observation-TNMp-example-3"
      }
    },
    {
      "fullUrl": "http://example.com/Observation/Observation-TNMp-example-4",
      "resource": {
        "resourceType": "Observation",
        "id": "Observation-TNMp-example-4",
        "meta": {
          "profile": [
            "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Observation-TNMp"
          ]
        },
        "status": "final",
        "code": {
          "coding": [
            {
              "system": "http://loinc.org",
              "code": "21902-2"
            }
          ]
        },
        "subject": {
          "reference": "Patient/Patient-Patient-example-4"
        },
        "encounter": {
          "reference": "Encounter/Encounter-Fall-example-1"
        },
        "effectiveDateTime": "2018-01-01",
        "valueCodeableConcept": {
          "coding": [
            {
              "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/UiccstadiumCS",
              "version": "8",
              "code": "IIIA"
            }
          ]
        },
        "component": [
          {
            "extension": [
              {
                "url": "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Extension-TNMcpuPraefix",
                "valueCodeableConcept": {
                  "coding": [
                    {
                      "code": "c"
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            "code": {
              "coding": [
                {
                  "system": "http://loinc.org",
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            "valueCodeableConcept": {
              "coding": [
                {
                  "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/TNMTCS",
                  "code": "1b2"
                }
              ]
            }
          },
          {
            "extension": [
              {
                "url": "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Extension-TNMcpuPraefix",
                "valueCodeableConcept": {
                  "coding": [
                    {
                      "code": "c"
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            ],
            "code": {
              "coding": [
                {
                  "system": "http://loinc.org",
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            "valueCodeableConcept": {
              "coding": [
                {
                  "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/TNMNCS",
                  "code": "0(i+)"
                }
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          },
          {
            "extension": [
              {
                "url": "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Extension-TNMcpuPraefix",
                "valueCodeableConcept": {
                  "coding": [
                    {
                      "code": "c"
                    }
                  ]
                }
              }
            ],
            "code": {
              "coding": [
                {
                  "system": "http://loinc.org",
                  "code": "21901-4"
                }
              ]
            },
            "valueCodeableConcept": {
              "coding": [
                {
                  "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/TNMMCS",
                  "code": "1b"
                }
              ]
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          },
          {
            "code": {
              "coding": [
                {
                  "system": "http://loinc.org",
                  "code": "59479-6"
                }
              ]
            },
            "valueCodeableConcept": {
              "coding": [
                {
                  "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/TNMySymbolCS",
                  "code": "y"
                }
              ]
            }
          },
          {
            "code": {
              "coding": [
                {
                  "system": "http://loinc.org",
                  "code": "21983-2"
                }
              ]
            },
            "valueCodeableConcept": {
              "coding": [
                {
                  "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/TNMrSymbolCS",
                  "code": "r"
                }
              ]
            }
          },
          {
            "code": {
              "coding": [
                {
                  "system": "http://loinc.org",
                  "code": "42030-7"
                }
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            "valueCodeableConcept": {
              "coding": [
                {
                  "code": "m"
                }
              ]
            }
          }
        ]
      },
      "request": {
        "method": "PUT",
        "url": "Observation/Observation-TNMp-example-4"
      }
    },
    {
      "fullUrl": "http://example.com/Observation/Observation-TNMc-example-2",
      "resource": {
        "resourceType": "Observation",
        "id": "Observation-TNMc-example-2",
        "meta": {
          "profile": [
            "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Observation-TNMc"
          ]
        },
        "status": "final",
        "code": {
          "coding": [
            {
              "system": "http://loinc.org",
              "code": "21908-9"
            }
          ]
        },
        "subject": {
          "reference": "Patient/Patient-Patient-example-2"
        },
        "encounter": {
          "reference": "Encounter/Encounter-Fall-example-1"
        },
        "effectiveDateTime": "2018-01-01",
        "valueCodeableConcept": {
          "coding": [
            {
              "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/UiccstadiumCS",
              "version": "8",
              "code": "IIIA"
            }
          ]
        },
        "component": [
          {
            "extension": [
              {
                "url": "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Extension-TNMcpuPraefix",
                "valueCodeableConcept": {
                  "coding": [
                    {
                      "code": "c"
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            "code": {
              "coding": [
                {
                  "system": "http://loinc.org",
                  "code": "21905-5"
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            "valueCodeableConcept": {
              "coding": [
                {
                  "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/TNMTCS",
                  "code": "1b2"
                }
              ]
            }
          },
          {
            "extension": [
              {
                "url": "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Extension-TNMcpuPraefix",
                "valueCodeableConcept": {
                  "coding": [
                    {
                      "code": "c"
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              }
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            "code": {
              "coding": [
                {
                  "system": "http://loinc.org",
                  "code": "201906-3"
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            "valueCodeableConcept": {
              "coding": [
                {
                  "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/TNMNCS",
                  "code": "0(i+)"
                }
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          },
          {
            "extension": [
              {
                "url": "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Extension-TNMcpuPraefix",
                "valueCodeableConcept": {
                  "coding": [
                    {
                      "code": "c"
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                  ]
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              }
            ],
            "code": {
              "coding": [
                {
                  "system": "http://loinc.org",
                  "code": "21907-1"
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            "valueCodeableConcept": {
              "coding": [
                {
                  "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/TNMMCS",
                  "code": "1b"
                }
              ]
            }
          },
          {
            "code": {
              "coding": [
                {
                  "system": "http://loinc.org",
                  "code": "59479-6"
                }
              ]
            },
            "valueCodeableConcept": {
              "coding": [
                {
                  "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/TNMySymbolCS",
                  "code": "y"
                }
              ]
            }
          },
          {
            "code": {
              "coding": [
                {
                  "system": "http://loinc.org",
                  "code": "21983-2"
                }
              ]
            },
            "valueCodeableConcept": {
              "coding": [
                {
                  "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/TNMrSymbolCS",
                  "code": "r"
                }
              ]
            }
          },
          {
            "code": {
              "coding": [
                {
                  "system": "http://loinc.org",
                  "code": "42030-7"
                }
              ]
            },
            "valueCodeableConcept": {
              "coding": [
                {
                  "code": "m"
                }
              ]
            }
          }
        ]
      },
      "request": {
        "method": "PUT",
        "url": "Observation/Observation-TNMc-example-2"
      }
    },
    {
      "fullUrl": "http://example.com/Observation/Observation-Vitalstatus-example-1",
      "resource": {
        "resourceType": "Observation",
        "id": "Observation-Vitalstatus-example-1",
        "meta": {
          "profile": [
            "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Observation-Vitalstatus"
          ]
        },
        "status": "final",
        "code": {
          "coding": [
            {
              "system": "http://loinc.org",
              "code": "75186-7"
            }
          ]
        },
        "subject": {
          "reference": "Patient/Patient-Patient-example-1"
        },
        "encounter": {
          "reference": "Encounter/Encounter-Fall-example-1"
        },
        "effectiveDateTime": "2018-01-01",
        "valueCodeableConcept": {
          "coding": [
            {
              "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/VitalstatusCS",
              "code": "lebend"
            }
          ]
        }
      },
      "request": {
        "method": "PUT",
        "url": "Observation/Observation-Vitalstatus-example-1"
      }
    },
    {
      "fullUrl": "http://example.com/Organization/Organization-Organisation-example-1",
      "resource": {
        "resourceType": "Organization",
        "id": "Organization-Organisation-example-1",
        "meta": {
          "profile": [
            "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Organization-Organisation"
          ]
        },
        "name": "Musterkrankenhaus"
      },
      "request": {
        "method": "PUT",
        "url": "Organization/Organization-Organisation-example-1"
      }
    },
    {
      "fullUrl": "http://example.com/Patient/Patient-Patient-example-1",
      "resource": {
        "resourceType": "Patient",
        "id": "Patient-Patient-example-1",
        "meta": {
          "profile": [
            "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Patient-Patient"
          ]
        },
        "name": [
          {
            "family": "Mustername",
            "given": [
              "Mustervorname"
            ]
          }
        ],
        "gender": "female",
        "birthDate": "2000-01-01",
        "deceasedDateTime": "2020-10-10",
        "address": [
          {
            "city": "Musterstadt",
            "postalCode": "37073"
          }
        ]
      },
      "request": {
        "method": "PUT",
        "url": "Patient/Patient-Patient-example-1"
      }
    },
    {
      "fullUrl": "http://example.com/Patient/Patient-Patient-example-4",
      "resource": {
        "resourceType": "Patient",
        "id": "Patient-Patient-example-4",
        "meta": {
          "profile": [
            "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Patient-Patient"
          ]
        },
        "name": [
          {
            "family": "Mustername",
            "given": [
              "Mustervorname"
            ]
          }
        ],
        "gender": "female",
        "birthDate": "2000-01-01",
        "deceasedDateTime": "2020-10-10",
        "address": [
          {
            "city": "Musterstadt",
            "postalCode": "37073"
          }
        ]
      },
      "request": {
        "method": "PUT",
        "url": "Patient/Patient-Patient-example-4"
      }
    },
    {
      "fullUrl": "http://example.com/Patient/Patient-Patient-example-2",
      "resource": {
        "resourceType": "Patient",
        "id": "Patient-Patient-example-2",
        "meta": {
          "profile": [
            "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Patient-Patient"
          ]
        },
        "name": [
          {
            "family": "Mustername",
            "given": [
              "Mustervorname"
            ]
          }
        ],
        "gender": "male",
        "birthDate": "2002-01-01",
        "deceasedDateTime": "2020-10-10",
        "address": [
          {
            "city": "Musterstadt",
            "postalCode": "37073"
          }
        ]
      },
      "request": {
        "method": "PUT",
        "url": "Patient/Patient-Patient-example-2"
      }
    },
    {
      "fullUrl": "http://example.com/Patient/Patient-Patient-example-3",
      "resource": {
        "resourceType": "Patient",
        "id": "Patient-Patient-example-3",
        "meta": {
          "profile": [
            "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Patient-Patient"
          ]
        },
        "name": [
          {
            "family": "Mustername",
            "given": [
              "Mustervorname"
            ]
          }
        ],
        "gender": "other",
        "birthDate": "2004-01-01",
        "deceasedDateTime": "2020-10-10",
        "address": [
          {
            "city": "Musterstadt",
            "postalCode": "37073"
          }
        ]
      },
      "request": {
        "method": "PUT",
        "url": "Patient/Patient-Patient-example-3"
      }
    },
    {
      "fullUrl": "http://example.com/Patient/Patient-Pseudonym-example-1",
      "resource": {
        "resourceType": "Patient",
        "id": "Patient-Pseudonym-example-1",
        "meta": {
          "profile": [
            "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Patient-Pseudonym"
          ]
        },
        "identifier": [
          {
            "type": {
              "coding": [
                {
                  "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/PseudonymArtCS",
                  "code": "Global"
                }
              ]
            },
            "value": "pseudonym1",
            "assigner": {
              "reference": "Organization/Organization-Organisation-example-1"
            }
          }
        ],
        "gender": "female",
        "birthDate": "2000-01-01",
        "deceasedDateTime": "2020-10-10",
        "managingOrganization": {
          "reference": "Organization/Organization-Organisation-example-1"
        }
      },
      "request": {
        "method": "PUT",
        "url": "Patient/Patient-Pseudonym-example-1"
      }
    },
    {
      "fullUrl": "http://example.com/Procedure/Procedure-Operation-example-1",
      "resource": {
        "resourceType": "Procedure",
        "id": "Procedure-Operation-example-1",
        "meta": {
          "profile": [
            "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Procedure-Operation"
          ]
        },
        "extension": [
          {
            "url": "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Extension-OPIntention",
            "valueCodeableConcept": {
              "coding": [
                {
                  "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/OPIntentionCS",
                  "code": "P",
                  "display": "palliativ"
                }
              ]
            }
          }
        ],
        "status": "completed",
        "category": {
          "coding": [
            {
              "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/SYSTTherapieartCS",
              "code": "OP",
              "display": "Operation"
            }
          ]
        },
        "code": {
          "coding": [
            {
              "system": "http://fhir.de/CodeSystem/bfarm/ops",
              "version": "2019",
              "code": "5-604.41"
            }
          ]
        },
        "subject": {
          "reference": "Patient/Patient-Patient-example-1"
        },
        "encounter": {
          "reference": "Encounter/Encounter-Fall-example-1"
        },
        "performedDateTime": "2022-11-11",
        "outcome": {
          "coding": [
            {
              "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/LokaleBeurteilungResidualstatusCS",
              "code": "R0"
            },
            {
              "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/GesamtbeurteilungResidualstatusCS",
              "code": "R0"
            }
          ]
        },
        "complication": [
          {
            "coding": [
              {
                "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/OPKomplikationenCS",
                "code": "HNK",
                "display": "Hautnekrose im Operationsbereich"
              }
            ]
          },
          {
            "coding": [
              {
                "system": "http://fhir.de/CodeSystem/bfarm/icd-10-gm",
                "code": "C34.1"
              }
            ]
          }
        ]
      },
      "request": {
        "method": "PUT",
        "url": "Procedure/Procedure-Operation-example-1"
      }
    },
    {
      "fullUrl": "http://example.com/Procedure/Procedure-Strahlentherapie-example-1",
      "resource": {
        "resourceType": "Procedure",
        "id": "Procedure-Strahlentherapie-example-1",
        "meta": {
          "profile": [
            "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Procedure-Strahlentherapie"
          ]
        },
        "extension": [
          {
            "url": "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Extension-StellungZurOp",
            "valueCodeableConcept": {
              "coding": [
                {
                  "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/SYSTStellungOPCS",
                  "code": "A",
                  "display": "adjuvant"
                }
              ]
            }
          },
          {
            "url": "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Extension-SYSTIntention",
            "valueCodeableConcept": {
              "coding": [
                {
                  "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/SYSTIntentionCS",
                  "code": "P",
                  "display": "palliativ"
                }
              ]
            }
          },
          {
            "extension": [
              {
                "url": "Applikationsart",
                "valueCodeableConcept": {
                  "coding": [
                    {
                      "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/ApplikationsartCS",
                      "code": "P-ST"
                    }
                  ]
                }
              },
              {
                "url": "Strahlenart",
                "valueCodeableConcept": {
                  "coding": [
                    {
                      "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/StrahlenartCS",
                      "code": "UH"
                    }
                  ]
                }
              },
              {
                "url": "Zielgebiet",
                "valueCodeableConcept": {
                  "coding": [
                    {
                      "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/ZielgebietCS",
                      "code": "3.4"
                    }
                  ]
                }
              },
              {
                "url": "SeiteZielgebiet",
                "valueCodeableConcept": {
                  "coding": [
                    {
                      "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/SeitenlokalisationCS",
                      "code": "L"
                    }
                  ]
                }
              },
              {
                "url": "Gesamtdosis",
                "valueQuantity": {
                  "value": 60,
                  "unit": "Gy"
                }
              },
              {
                "url": "Einzeldosis",
                "valueQuantity": {
                  "value": 12,
                  "unit": "Gy"
                }
              },
              {
                "url": "Boost",
                "valueCodeableConcept": {
                  "coding": [
                    {
                      "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/BoostCS",
                      "code": "SIB"
                    }
                  ]
                }
              }
            ],
            "url": "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Extension-Bestrahlung"
          }
        ],
        "status": "completed",
        "category": {
          "coding": [
            {
              "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/SYSTTherapieartCS",
              "code": "ST",
              "display": "Strahlentherapie"
            }
          ]
        },
        "subject": {
          "reference": "Patient/Patient-Patient-example-1"
        },
        "encounter": {
          "reference": "Encounter/Encounter-Fall-example-1"
        },
        "performedPeriod": {
          "start": "2022-08-09",
          "end": "2023-08-05"
        },
        "outcome": {
          "coding": [
            {
              "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/LokaleBeurteilungResidualstatusCS",
              "code": "R0"
            },
            {
              "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/GesamtbeurteilungResidualstatusCS",
              "code": "R0"
            }
          ]
        }
      },
      "request": {
        "method": "PUT",
        "url": "Procedure/Procedure-Strahlentherapie-example-1"
      }
    },
    {
      "fullUrl": "http://example.com/ServiceRequest/ServiceRequest-ServiceRequest-example-1",
      "resource": {
        "resourceType": "ServiceRequest",
        "id": "ServiceRequest-ServiceRequest-example-1",
        "meta": {
          "profile": [
            "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-ServiceRequest-ServiceRequest-ServiceRequest"
          ]
        },
        "status": "completed",
        "intent": "plan",
        "subject": {
          "reference": "Patient/Patient-Patient-example-1"
        },
        "encounter": {
          "reference": "Encounter/Encounter-Fall-example-1"
        },
        "specimen": [
          {
            "reference": "Specimen/Specimen-Specimen-example-1"
          }
        ]
      },
      "request": {
        "method": "PUT",
        "url": "ServiceRequest/ServiceRequest-ServiceRequest-example-1"
      }
    },
    {
      "fullUrl": "http://example.com/Specimen/Specimen-Specimen-example-1",
      "resource": {
        "resourceType": "Specimen",
        "id": "Specimen-Specimen-example-1",
        "meta": {
          "profile": [
            "https://fhir.bbmri.de/StructureDefinition/Specimen"
          ]
        },
        "extension": [
          {
            "url": "https://fhir.bbmri.de/StructureDefinition/SampleDiagnosis",
            "valueCodeableConcept": {
              "coding": [
                {
                  "system": "https://fhir.bbmri.de/CodeSystem/OtherSampleDiagnosis",
                  "code": "unknown"
                }
              ]
            }
          }
        ],
        "identifier": [
          {
            "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/Projects",
            "value": "http://dktk.dkfz.de/fhir/sid/exliquid-specimen"
          }
        ],
        "type": {
          "coding": [
            {
              "system": "https://fhir.bbmri.de/CodeSystem/SampleMaterialType",
              "code": "whole-blood"
            }
          ]
        },
        "subject": {
          "reference": "Patient/Patient-Patient-example-1"
        },
        "collection": {
          "collectedDateTime": "2005-06-17",
          "bodySite": {
            "coding": [
              {
                "system": "urn:oid:1.3.6.1.4.1.19376.1.3.11.36",
                "code": "C26.8"
              }
            ]
          }
        },
        "container": [
          {
            "specimenQuantity": {
              "value": 12,
              "unit": "mg",
              "system": "http://unitsofmeasure.org"
            }
          }
        ]
      },
      "request": {
        "method": "PUT",
        "url": "Specimen/Specimen-Specimen-example-1"
      }
    },
    {
      "fullUrl": "http://example.com/Observation/Observation-GenetischeVariante-example-1",
      "resource": {
        "resourceType": "Observation",
        "id": "Observation-GenetischeVariante-example-1",
        "meta": {
          "profile": [
            "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Observation-GenetischeVariante"
          ]
        },
        "status": "final",
        "code": {
          "coding": [
            {
              "system": "http://loinc.org",
              "code": "69548-6"
            }
          ]
        },
        "subject": {
          "reference": "Patient/Patient-Patient-example-1"
        },
        "effectiveDateTime": "2018-01-01",
        "valueCodeableConcept": {
          "coding": [
            {
              "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/GenetischeVarianteCS",
              "code": "M"
            }
          ],
          "text": "M-Text"
        },
        "component": [
          {
            "code": {
              "coding": [
                {
                  "system": "http://loinc.org",
                  "code": "48018-6"
                }
              ]
            },
            "valueCodeableConcept": {
              "coding": [
                {
                  "system": "http://www.genenames.org",
                  "code": "PLAAT4"
                }
              ]
            }
          },
          {
            "code": {
              "coding": [
                {
                  "system": "http://loinc.org",
                  "code": "48005-3"
                }
              ]
            },
            "valueString": "p.V600E"
          },
          {
            "code": {
              "coding": [
                {
                  "system": "http://loinc.org",
                  "code": "81290-9"
                }
              ]
            },
            "valueString": "c.1799 T > A"
          },
          {
            "code": {
              "coding": [
                {
                  "system": "http://loinc.org",
                  "code": "81248-7"
                }
              ]
            },
            "valueString": "NM_004333.6"
          },
          {
            "code": {
              "coding": [
                {
                  "system": "http://loinc.org",
                  "code": "81249-5"
                }
              ]
            },
            "valueString": "ENSG00000157764"
          }
        ]
      },
      "request": {
        "method": "PUT",
        "url": "Observation/Observation-GenetischeVariante-example-1"
      }
    },
    {
      "fullUrl": "http://example.com/AdverseEvent/AdverseEvent-Nebenwirkung-example-1",
      "resource": {
        "resourceType": "AdverseEvent",
        "id": "AdverseEvent-Nebenwirkung-example-1",
        "meta": {
          "profile": [
            "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-AdverseEvent-Nebenwirkung"
          ]
        },
        "actuality": "actual",
        "event": {
          "coding": [
            {
              "system": "https://www.meddra.org",
              "version": "4.03",
              "code": "10015667",
              "display": "Exhaustion"
            }
          ]
        },
        "subject": {
          "reference": "Patient/Patient-Patient-example-1"
        },
        "severity": {
          "coding": [
            {
              "system": "http://hl7.org/fhir/us/ctcae/CodeSystem/ctcae-grade-code-system",
              "code": "2",
              "display": "moderat"
            }
          ]
        },
        "suspectEntity": [
          {
            "instance": {
              "reference": "Procedure/Procedure-Strahlentherapie-example-1"
            }
          }
        ]
      },
      "request": {
        "method": "PUT",
        "url": "AdverseEvent/AdverseEvent-Nebenwirkung-example-1"
      }
    },
    {
      "fullUrl": "http://example.com/AdverseEvent/AdverseEvent-Nebenwirkung-example-2",
      "resource": {
        "resourceType": "AdverseEvent",
        "id": "AdverseEvent-Nebenwirkung-example-2",
        "meta": {
          "profile": [
            "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-AdverseEvent-Nebenwirkung"
          ]
        },
        "actuality": "actual",
        "event": {
          "coding": [
            {
              "system": "https://www.meddra.org",
              "version": "4.03",
              "code": "10015667",
              "display": "Exhaustion"
            }
          ]
        },
        "subject": {
          "reference": "Patient/Patient-Patient-example-1"
        },
        "severity": {
          "coding": [
            {
              "system": "http://hl7.org/fhir/us/ctcae/CodeSystem/ctcae-grade-code-system",
              "code": "1",
              "display": "mild"
            }
          ]
        },
        "suspectEntity": [
          {
            "instance": {
              "reference": "MedicationStatement/MedicationStatement-Systemtherapie-example-1"
            }
          }
        ]
      },
      "request": {
        "method": "PUT",
        "url": "AdverseEvent/AdverseEvent-Nebenwirkung-example-2"
      }
    },
    {
      "fullUrl": "http://example.com/CarePlan/CarePlan-Therapieempfehlung-example-1",
      "resource": {
        "resourceType": "CarePlan",
        "id": "CarePlan-Therapieempfehlung-example-1",
        "meta": {
          "profile": [
            "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-CarePlan-Therapieempfehlung"
          ]
        },
        "status": "unknown",
        "intent": "proposal",
        "subject": {
          "reference": "Patient/Patient-Patient-example-1"
        },
        "created": "2024-03-02",
        "addresses": [
          {
            "reference": "Condition/Condition-Primaerdiagnose-example-1"
          }
        ],
        "activity": [
          {
            "detail": {
              "code": {
                "coding": [
                  {
                    "system": "http://dktk.dkfz.de/fhir/onco/core/ValueSet/TherapieempfehlungCS",
                    "code": "CZ"
                  }
                ]
              },
              "status": "unknown",
              "statusReason": {
                "coding": [
                  {
                    "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/JNUCS",
                    "code": "N"
                  }
                ]
              }
            }
          },
          {
            "detail": {
              "code": {
                "coding": [
                  {
                    "system": "http://dktk.dkfz.de/fhir/onco/core/ValueSet/TherapieempfehlungCS",
                    "code": "HO"
                  }
                ]
              },
              "status": "unknown",
              "statusReason": {
                "coding": [
                  {
                    "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/JNUCS",
                    "code": "N"
                  }
                ]
              }
            }
          }
        ]
      },
      "request": {
        "method": "PUT",
        "url": "CarePlan/CarePlan-Therapieempfehlung-example-1"
      }
    },
    {
      "fullUrl": "http://example.com/Observation/Observation-WeitereKlassifikation-example-1",
      "resource": {
        "resourceType": "Observation",
        "id": "Observation-WeitereKlassifikation-example-1",
        "meta": {
          "profile": [
            "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Observation-WeitereKlassifikation"
          ]
        },
        "status": "final",
        "code": {
          "coding": [
            {
              "system": "http://loinc.org",
              "code": "LP248771-0"
            }
          ]
        },
        "subject": {
          "reference": "Patient/Patient-Patient-example-1"
        },
        "encounter": {
          "reference": "Encounter/Encounter-Fall-example-1"
        },
        "effectiveDateTime": "2018-01-01",
        "valueCodeableConcept": {
          "coding": [
            {
              "system": "http://snomed.info/sct",
              "code": "254386003"
            }
          ]
        }
      },
      "request": {
        "method": "PUT",
        "url": "Observation/Observation-WeitereKlassifikation-example-1"
      }
    },
    {
      "fullUrl": "http://example.com/Observation/Observation-Ecog-example-1",
      "resource": {
        "resourceType": "Observation",
        "id": "Observation-Ecog-example-1",
        "meta": {
          "profile": [
            "http://dktk.dkfz.de/fhir/StructureDefinition/onco-core-Observation-Ecog"
          ]
        },
        "status": "final",
        "code": {
          "coding": [
            {
              "system": "http://loinc.org",
              "code": "89247-1"
            }
          ]
        },
        "subject": {
          "reference": "Patient/Patient-Patient-example-1"
        },
        "encounter": {
          "reference": "Encounter/Encounter-Fall-example-1"
        },
        "effectiveDateTime": "2018-01-01",
        "valueCodeableConcept": {
          "coding": [
            {
              "system": "http://dktk.dkfz.de/fhir/onco/core/CodeSystem/EcogCS",
              "code": "3"
            }
          ]
        }
      },
      "request": {
        "method": "PUT",
        "url": "Observation/Observation-Ecog-example-1"
      }
    }
  ]
}