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Source1

{
  "resourceType": "CodeSystem",
  "id": "clinical-event-type-cs",
  "text": {
    "status": "generated",
    "div": "<!-- snip (see above) -->"
  },
  "url": "https://hl7.eu/fhir/ig/hl7.eu.fhir.protect-child/CodeSystem/clinical-event-type-cs",
  "version": "0.1.0-ci-build",
  "name": "ClinicalEventTypeCS",
  "title": "Clinical Event Type CodeSystem",
  "status": "draft",
  "experimental": true,
  "date": "2026-08-11T12:50:29+00:00",
  "publisher": "Protect Child",
  "contact": [
    {
      "name": "Protect Child",
      "telecom": [
        {
          "system": "url",
          "value": "https://protect-child.eu/"
        }
      ]
    }
  ],
  "description": "Types of clinical events in the PROTECT-CHILD study (DMv1.2), replacing outcome_type and post_event_type.",
  "caseSensitive": false,
  "content": "complete",
  "count": 26,
  "concept": [
    {
      "code": "alloimmunization",
      "display": "Alloimmunization",
      "definition": "Development of antibodies against alloantigens (e.g. HLA) following transplantation or transfusion."
    },
    {
      "code": "biliary-complications",
      "display": "Biliary Complications",
      "definition": "Post-transplant complications of the biliary tract (e.g. stricture, leak, stones)."
    },
    {
      "code": "bk-virus-infection",
      "display": "BK Virus Infection",
      "definition": "Infection or reactivation of BK polyomavirus."
    },
    {
      "code": "chronic-liver-failure",
      "display": "Chronic Liver Failure",
      "definition": "Progressive, long-standing loss of liver function."
    },
    {
      "code": "chronic-liver-rejection",
      "display": "Chronic Liver Rejection",
      "definition": "Chronic rejection of the liver allograft (e.g. ductopenia / vanishing bile duct syndrome)."
    },
    {
      "code": "chronic-renal-failure-after-pltx",
      "display": "Chronic Renal Failure After pLTx",
      "definition": "Chronic kidney disease developing after paediatric liver transplantation."
    },
    {
      "code": "cmv-infection",
      "display": "Cytomegalovirus Infection",
      "definition": "Infection or reactivation of cytomegalovirus."
    },
    {
      "code": "delayed-kidney-graft-function",
      "display": "Delayed Kidney Graft Function",
      "definition": "Delayed function of the kidney allograft requiring dialysis in the first post-transplant week."
    },
    {
      "code": "diabetes",
      "display": "Diabetes",
      "definition": "Diabetes mellitus, including new-onset diabetes after transplantation."
    },
    {
      "code": "graft-failure",
      "display": "Graft Failure",
      "definition": "Loss of function of the transplanted organ."
    },
    {
      "code": "high-blood-pressure",
      "display": "High Blood Pressure",
      "definition": "Arterial hypertension."
    },
    {
      "code": "kidney-primary-non-function",
      "display": "Kidney Primary Non-Function",
      "definition": "Kidney allograft that never achieves function after transplantation."
    },
    {
      "code": "kidney-rejection-episode",
      "display": "Kidney Rejection Episode",
      "definition": "An episode of acute or chronic rejection of the kidney allograft."
    },
    {
      "code": "liver-early-allograft-dysfunction",
      "display": "Liver Early Allograft Dysfunction",
      "definition": "Early dysfunction of the liver allograft in the initial post-transplant period."
    },
    {
      "code": "liver-primary-non-function",
      "display": "Liver Primary Non-Function",
      "definition": "Liver allograft that never achieves function, requiring urgent re-transplantation."
    },
    {
      "code": "liver-rejection-episode",
      "display": "Liver Rejection Episode",
      "definition": "An episode of acute or chronic rejection of the liver allograft."
    },
    {
      "code": "microangiopathy",
      "display": "Microangiopathy",
      "definition": "Thrombotic microangiopathy affecting small blood vessels."
    },
    {
      "code": "mortality",
      "display": "Mortality",
      "definition": "Death of the patient."
    },
    {
      "code": "mtor-inhibitors-toxicity",
      "display": "mTOR Inhibitors Toxicity",
      "definition": "Adverse effects attributable to mTOR-inhibitor immunosuppression."
    },
    {
      "code": "mycophenolate-toxicity",
      "display": "Mycophenolate Toxicity",
      "definition": "Adverse effects attributable to mycophenolate immunosuppression."
    },
    {
      "code": "pres",
      "display": "PRES",
      "definition": "Posterior reversible encephalopathy syndrome (PRES)."
    },
    {
      "code": "ptld",
      "display": "PTLD",
      "definition": "Post-transplant lymphoproliferative disorder (PTLD)."
    },
    {
      "code": "relapse-primary-immunomediated-disease",
      "display": "Relapse Primary Immunomediated Disease",
      "definition": "Recurrence of the primary immune-mediated disease that led to transplantation."
    },
    {
      "code": "renal-cni-toxicity",
      "display": "Renal CNI Toxicity",
      "definition": "Calcineurin-inhibitor-induced renal toxicity."
    },
    {
      "code": "urological-complications",
      "display": "Urological Complications",
      "definition": "Post-transplant complications of the urinary tract (e.g. obstruction, leak, reflux)."
    },
    {
      "code": "vascular-complications",
      "display": "Vascular Complications",
      "definition": "Post-transplant vascular complications (e.g. thrombosis, stenosis)."
    }
  ]
}